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Drug Metabolism & Disposition

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Table of Contents

September 01, 2011; Volume 39,Issue 9

Articles

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    Monoclonal Antibodies with Identical Fc Sequences Can Bind to FcRn Differentially with Pharmacokinetic Consequences
    Weirong Wang, Ping Lu, Yulin Fang, Lora Hamuro, Tamara Pittman, Brian Carr, Jerome Hochman and Thomayant Prueksaritanont
    Drug Metabolism and Disposition September 2011, 39 (9) 1469-1477; DOI: https://doi.org/10.1124/dmd.111.039453
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    pH-Dependent Transport of Pemetrexed by Breast Cancer Resistance Protein
    Li Li, Yuk Yin Sham, Zsolt Bikadi and William F. Elmquist
    Drug Metabolism and Disposition September 2011, 39 (9) 1478-1485; DOI: https://doi.org/10.1124/dmd.111.039370
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    Hepatic UDP-Glucuronosyltransferase Is Responsible for Eslicarbazepine Glucuronidation
    Ana I. Loureiro, Carlos Fernandes-Lopes, Maria J. Bonifácio, Lyndon C. Wright and Patricio Soares-da-Silva
    Drug Metabolism and Disposition September 2011, 39 (9) 1486-1494; DOI: https://doi.org/10.1124/dmd.111.038620
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    Impact of Intestinal Glucuronidation on the Pharmacokinetics of Raloxifene
    Keigo Kosaka, Norifumi Sakai, Yuya Endo, Yuga Fukuhara, Minoru Tsuda-Tsukimoto, Tatsuyuki Ohtsuka, Ichiro Kino, Tomohiko Tanimoto, Naomi Takeba, Masakatsu Takahashi and Toshiyuki Kume
    Drug Metabolism and Disposition September 2011, 39 (9) 1495-1502; DOI: https://doi.org/10.1124/dmd.111.040030
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    Culture Period-Dependent Changes in the Uptake of Transporter Substrates in Sandwich-Cultured Rat and Human Hepatocytes
    Naoki Kotani, Kazuya Maeda, Takao Watanabe, Mariko Hiramatsu, Li-kun Gong, Yi-an Bi, Toshiaki Takezawa, Hiroyuki Kusuhara and Yuichi Sugiyama
    Drug Metabolism and Disposition September 2011, 39 (9) 1503-1510; DOI: https://doi.org/10.1124/dmd.111.038968
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    Bioactivation of Glafenine by Human Liver Microsomes and Peroxidases: Identification of Electrophilic Iminoquinone Species and GSH Conjugates
    Bo Wen and David J. Moore
    Drug Metabolism and Disposition September 2011, 39 (9) 1511-1521; DOI: https://doi.org/10.1124/dmd.111.039396
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    Inhibitory Effects of Commonly Used Herbal Extracts on UDP-Glucuronosyltransferase 1A4, 1A6, and 1A9 Enzyme Activities
    Mohamed-Eslam F. Mohamed and Reginald F. Frye
    Drug Metabolism and Disposition September 2011, 39 (9) 1522-1528; DOI: https://doi.org/10.1124/dmd.111.039602
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    Ocular Pharmacokinetics of Dorzolamide and Brinzolamide After Single and Multiple Topical Dosing: Implications for Effects on Ocular Blood Flow
    Rajendra S. Kadam, Gajanan Jadhav, Miller Ogidigben and Uday B. Kompella
    Drug Metabolism and Disposition September 2011, 39 (9) 1529-1537; DOI: https://doi.org/10.1124/dmd.111.040055
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    Sequential Metabolism of Sesamin by Cytochrome P450 and UDP-Glucuronosyltransferase in Human Liver
    Kaori Yasuda, Shinichi Ikushiro, Masaki Kamakura, Eiji Munetsuna, Miho Ohta and Toshiyuki Sakaki
    Drug Metabolism and Disposition September 2011, 39 (9) 1538-1545; DOI: https://doi.org/10.1124/dmd.111.039875
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    Evaluation of CYP2C8 Inhibition In Vitro: Utility of Montelukast as a Selective CYP2C8 Probe Substrate
    Brooke M. VandenBrink, Robert S. Foti, Dan A. Rock, Larry C. Wienkers and Jan L. Wahlstrom
    Drug Metabolism and Disposition September 2011, 39 (9) 1546-1554; DOI: https://doi.org/10.1124/dmd.111.039065
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    Disposition and Metabolism of Ticagrelor, a Novel P2Y12 Receptor Antagonist, in Mice, Rats, and Marmosets
    Yan Li, Claire Landqvist and Scott W. Grimm
    Drug Metabolism and Disposition September 2011, 39 (9) 1555-1567; DOI: https://doi.org/10.1124/dmd.111.039669
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    Efficient Screening of Cytochrome P450 BM3 Mutants for Their Metabolic Activity and Diversity toward a Wide Set of Drug-Like Molecules in Chemical Space
    Jelle Reinen, Jolanda S. van Leeuwen, Yongmin Li, Lifang Sun, Peter D. J. Grootenhuis, Caroline J. Decker, John Saunders, Nico P. E. Vermeulen and Jan N. M. Commandeur
    Drug Metabolism and Disposition September 2011, 39 (9) 1568-1576; DOI: https://doi.org/10.1124/dmd.111.039461
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    Production of 22-Hydroxy Metabolites of Vitamin D3 by Cytochrome P450scc (CYP11A1) and Analysis of Their Biological Activities on Skin Cells
    Robert C. Tuckey, Wei Li, Haleem Z. Shehabi, Zorica Janjetovic, Minh N. Nguyen, Tae-Kang Kim, Jianjun Chen, Danielle E. Howell, Heather A. E. Benson, Trevor Sweatman, Donna M. Baldisseri and Andrzej Slominski
    Drug Metabolism and Disposition September 2011, 39 (9) 1577-1588; DOI: https://doi.org/10.1124/dmd.111.040071
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    Preclinical Disposition (In Vitro) of Novel μ-Opioid Receptor Selective Antagonists
    Pallabi Mitra, Jürgen Venitz, Yunyun Yuan, Yan Zhang and Phillip M. Gerk
    Drug Metabolism and Disposition September 2011, 39 (9) 1589-1596; DOI: https://doi.org/10.1124/dmd.111.038588
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    From Single Compounds to Herbal Extract: A Strategy to Systematically Characterize the Metabolites of Licorice in Rats
    Cheng Xiang, Xue Qiao, Qing Wang, Rui Li, Wenjuan Miao, Dean Guo and Min Ye
    Drug Metabolism and Disposition September 2011, 39 (9) 1597-1608; DOI: https://doi.org/10.1124/dmd.111.038695
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    Preclinical Species and Human Disposition of PF-04971729, a Selective Inhibitor of the Sodium-Dependent Glucose Cotransporter 2 and Clinical Candidate for the Treatment of Type 2 Diabetes Mellitus
    Amit S. Kalgutkar, Meera Tugnait, Tong Zhu, Emi Kimoto, Zhuang Miao, Vincent Mascitti, Xin Yang, Beijing Tan, Robert L. Walsky, Jonathan Chupka, Bo Feng and Ralph P. Robinson
    Drug Metabolism and Disposition September 2011, 39 (9) 1609-1619; DOI: https://doi.org/10.1124/dmd.111.040675
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    Metabolism of [14C]GSK977779 in Rats and Its Implication with the Observed Covalent Binding
    Catherine D. Tsalta, Armina Madatian, Ernest M. Schubert, Fangming Xia, William M. Hardesty, Yanli Deng, Jennifer L. Seymour and Peter D. Gorycki
    Drug Metabolism and Disposition September 2011, 39 (9) 1620-1632; DOI: https://doi.org/10.1124/dmd.110.036467
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    Physiologically Based Pharmacokinetic Modeling of Intestinal First-Pass Metabolism of CYP3A Substrates with High Intestinal Extraction
    Michael Gertz, J. Brian Houston and Aleksandra Galetin
    Drug Metabolism and Disposition September 2011, 39 (9) 1633-1642; DOI: https://doi.org/10.1124/dmd.111.039248
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    Oral Absorption of Clarithromycin Is Nearly Abolished by Chronic Comedication of Rifampicin in Foals
    Jette Peters, Wiebke Block, Stefan Oswald, Johanna Freyer, Markus Grube, Heyo K. Kroemer, Marc Lämmer, Dieter Lütjohann, Monica Venner and Werner Siegmund
    Drug Metabolism and Disposition September 2011, 39 (9) 1643-1649; DOI: https://doi.org/10.1124/dmd.111.039206
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    UGT1A6 and UGT2B15 Polymorphisms and Acetaminophen Conjugation in Response to a Randomized, Controlled Diet of Select Fruits and Vegetables
    Sandi L. Navarro, Yu Chen, Lin Li, Shuying S. Li, Jyh-Lurn Chang, Yvonne Schwarz, Irena B. King, John D. Potter, Jeannette Bigler and Johanna W. Lampe
    Drug Metabolism and Disposition September 2011, 39 (9) 1650-1657; DOI: https://doi.org/10.1124/dmd.111.039149
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    In Vitro Characterization of the Metabolic Pathways and Cytochrome P450 Inhibition and Induction Potential of BMS-690514, an ErbB/Vascular Endothelial Growth Factor Receptor Inhibitor
    Haizheng Hong, Hong Su, Li Ma, Ming Yao, Ramaswamy A. Iyer, W. Griffith Humphreys and Lisa J. Christopher
    Drug Metabolism and Disposition September 2011, 39 (9) 1658-1667; DOI: https://doi.org/10.1124/dmd.111.039776
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    A Novel Biotransformation of Alkyl Aminopyrrolidine to Aminopiperidine Ring by Human CYP3A
    Yuping Chen, Gary L. Skiles, Magang Shou, Dean Hickman and Faye Hsieh
    Drug Metabolism and Disposition September 2011, 39 (9) 1668-1673; DOI: https://doi.org/10.1124/dmd.111.039750
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    1-Aminobenzotriazole, a Known Cytochrome P450 Inhibitor, Is a Substrate and Inhibitor of N-Acetyltransferase
    Q. Sun, T. W. Harper, E. A. Dierks, L. Zhang, S. Chang, A. D. Rodrigues and P. Marathe
    Drug Metabolism and Disposition September 2011, 39 (9) 1674-1679; DOI: https://doi.org/10.1124/dmd.111.039834
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    Colonic Catabolism of Ellagitannins, Ellagic Acid, and Raspberry Anthocyanins: In Vivo and In Vitro Studies
    Rocío González-Barrio, Christine A. Edwards and Alan Crozier
    Drug Metabolism and Disposition September 2011, 39 (9) 1680-1688; DOI: https://doi.org/10.1124/dmd.111.039651
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    Paracetamol-Induced Hypothermia Is Independent of Cannabinoids and Transient Receptor Potential Vanilloid-1 and Is Not Mediated by AM404
    Samir S. Ayoub, Gareth Pryce, Michael P. Seed, Christopher Bolton, Roderick J. Flower and David Baker
    Drug Metabolism and Disposition September 2011, 39 (9) 1689-1695; DOI: https://doi.org/10.1124/dmd.111.038638
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    Novel Pathway of Metabolic Activation of Bisphenol A-Related Compounds for Estrogenic Activity
    Katsuhiro Okuda, Tomoko Fukuuchi, Masufumi Takiguchi and Shin'ichi Yoshihara
    Drug Metabolism and Disposition September 2011, 39 (9) 1696-1703; DOI: https://doi.org/10.1124/dmd.111.040121
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    Interaction of N-(2-Hydroxypropyl)methacrylamide Copolymer-Doxorubicin Conjugates with Human Liver Microsomal Cytochromes P450: Comparison with Free Doxorubicin
    Vlastimil Mašek, Eva Anzenbacherová, Tomáš Etrych, Jiří Strohalm, Karel Ulbrich and Pavel Anzenbacher
    Drug Metabolism and Disposition September 2011, 39 (9) 1704-1710; DOI: https://doi.org/10.1124/dmd.110.037986
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    Application of the Fluorescent Probe 1-Anilinonaphthalene-8-Sulfonate to the Measurement of the Nonspecific Binding of Drugs to Human Liver Microsomes
    James A. McLure, Donald J. Birkett, David J. Elliot, J. Andrew Williams, Andrew Rowland and John O. Miners
    Drug Metabolism and Disposition September 2011, 39 (9) 1711-1717; DOI: https://doi.org/10.1124/dmd.111.039354
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    Gestation Time-Dependent Pharmacokinetics of Intravenous (+)-Methamphetamine in Rats
    Sarah White, Elizabeth Laurenzana, Howard Hendrickson, W. Brooks Gentry and S. Michael Owens
    Drug Metabolism and Disposition September 2011, 39 (9) 1718-1726; DOI: https://doi.org/10.1124/dmd.111.039446
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    Metabolism of Methylisoeugenol in Liver Microsomes of Human, Rat, and Bovine Origin
    Alexander T. Cartus, Karl-Heinz Merz and Dieter Schrenk
    Drug Metabolism and Disposition September 2011, 39 (9) 1727-1733; DOI: https://doi.org/10.1124/dmd.111.038851
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    Metabolism and Disposition of Eltrombopag, an Oral, Nonpeptide Thrombopoietin Receptor Agonist, in Healthy Human Subjects
    Yanli Deng, Armina Madatian, Mary Beth Wire, Carolyn Bowen, Jung Wook Park, Daphne Williams, Bin Peng, Ernest Schubert, Frances Gorycki, Mark Levy and Peter D. Gorycki
    Drug Metabolism and Disposition September 2011, 39 (9) 1734-1746; DOI: https://doi.org/10.1124/dmd.111.040170
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    Investigations of Hydrazine Cleavage of Eltrombopag in Humans
    Yanli Deng, Martin Rogers, Caroline Sychterz, Kimberly Talley, Yanwen Qian, David Bershas, May Ho, Wei Shi, Emile P. Chen, Cosette Serabjit-Singh and Peter D. Gorycki
    Drug Metabolism and Disposition September 2011, 39 (9) 1747-1754; DOI: https://doi.org/10.1124/dmd.111.040188
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    Characterization of the Inhibitory Effects of N-Butylpyridinium Chloride and Structurally Related Ionic Liquids on Organic Cation Transporters 1/2 and Human Toxic Extrusion Transporters 1/2-K In Vitro and In Vivo
    Yaofeng Cheng, Lucy J. Martinez-Guerrero, Stephen H. Wright, Robert K. Kuester, Michelle J. Hooth and I. Glenn Sipes
    Drug Metabolism and Disposition September 2011, 39 (9) 1755-1761; DOI: https://doi.org/10.1124/dmd.110.035865
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    Metabolism and Disposition of Isoflavone Conjugated Metabolites in Humans after Ingestion of Kinako
    Kaori Hosoda, Takashi Furuta and Kazuo Ishii
    Drug Metabolism and Disposition September 2011, 39 (9) 1762-1767; DOI: https://doi.org/10.1124/dmd.111.038281
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    In Vitro Metabolism of the Mycotoxin Enniatin B in Different Species and Cytochrome P450 Enzyme Phenotyping by Chemical Inhibitors
    Christiane K. Fæste, Lada Ivanova and Silvio Uhlig
    Drug Metabolism and Disposition September 2011, 39 (9) 1768-1776; DOI: https://doi.org/10.1124/dmd.111.039529

Erratum

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    Correction to “A Refined Cytochrome P540 IC50 Shift Assay for Reliably Identifying CYP3A Time-Dependent Inhibitors”
    Drug Metabolism and Disposition September 2011, 39 (9) 1777; DOI: https://doi.org/10.1124/dmd.39.9.1777
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Drug Metabolism and Disposition: 39 (9)
Drug Metabolism and Disposition
Vol. 39, Issue 9
1 Sep 2011
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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