Table of Contents

Articles

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  Monoclonal Antibodies with Identical Fc Sequences Can Bind to FcRn Differentially with Pharmacokinetic Consequences

  Weirong Wang, Ping Lu, Yulin Fang, Lora Hamuro, Tamara Pittman, Brian Carr, Jerome Hochman and Thomayant Prueksaritanont

  Drug Metabolism and Disposition September 2011, 39 (9) 1469-1477; DOI: https://doi.org/10.1124/dmd.111.039453
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  pH-Dependent Transport of Pemetrexed by Breast Cancer Resistance Protein

  Li Li, Yuk Yin Sham, Zsolt Bikadi and William F. Elmquist

  Drug Metabolism and Disposition September 2011, 39 (9) 1478-1485; DOI: https://doi.org/10.1124/dmd.111.039370
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  Hepatic UDP-Glucuronosyltransferase Is Responsible for Eslicarbazepine Glucuronidation

  Ana I. Loureiro, Carlos Fernandes-Lopes, Maria J. Bonifácio, Lyndon C. Wright and Patricio Soares-da-Silva

  Drug Metabolism and Disposition September 2011, 39 (9) 1486-1494; DOI: https://doi.org/10.1124/dmd.111.038620
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  Impact of Intestinal Glucuronidation on the Pharmacokinetics of Raloxifene

  Keigo Kosaka, Norifumi Sakai, Yuya Endo, Yuga Fukuhara, Minoru Tsuda-Tsukimoto, Tatsuyuki Ohtsuka, Ichiro Kino, Tomohiko Tanimoto, Naomi Takeba, Masakatsu Takahashi and Toshiyuki Kume

  Drug Metabolism and Disposition September 2011, 39 (9) 1495-1502; DOI: https://doi.org/10.1124/dmd.111.040030
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  Culture Period-Dependent Changes in the Uptake of Transporter Substrates in Sandwich-Cultured Rat and Human Hepatocytes

  Naoki Kotani, Kazuya Maeda, Takao Watanabe, Mariko Hiramatsu, Li-kun Gong, Yi-an Bi, Toshiaki Takezawa, Hiroyuki Kusuhara and Yuichi Sugiyama

  Drug Metabolism and Disposition September 2011, 39 (9) 1503-1510; DOI: https://doi.org/10.1124/dmd.111.038968
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  Bioactivation of Glafenine by Human Liver Microsomes and Peroxidases: Identification of Electrophilic Iminoquinone Species and GSH Conjugates

  Bo Wen and David J. Moore

  Drug Metabolism and Disposition September 2011, 39 (9) 1511-1521; DOI: https://doi.org/10.1124/dmd.111.039396
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  Inhibitory Effects of Commonly Used Herbal Extracts on UDP-Glucuronosyltransferase 1A4, 1A6, and 1A9 Enzyme Activities

  Mohamed-Eslam F. Mohamed and Reginald F. Frye

  Drug Metabolism and Disposition September 2011, 39 (9) 1522-1528; DOI: https://doi.org/10.1124/dmd.111.039602
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  Ocular Pharmacokinetics of Dorzolamide and Brinzolamide After Single and Multiple Topical Dosing: Implications for Effects on Ocular Blood Flow

  Rajendra S. Kadam, Gajanan Jadhav, Miller Ogidigben and Uday B. Kompella

  Drug Metabolism and Disposition September 2011, 39 (9) 1529-1537; DOI: https://doi.org/10.1124/dmd.111.040055
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  Sequential Metabolism of Sesamin by Cytochrome P450 and UDP-Glucuronosyltransferase in Human Liver

  Kaori Yasuda, Shinichi Ikushiro, Masaki Kamakura, Eiji Munetsuna, Miho Ohta and Toshiyuki Sakaki

  Drug Metabolism and Disposition September 2011, 39 (9) 1538-1545; DOI: https://doi.org/10.1124/dmd.111.039875
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  Evaluation of CYP2C8 Inhibition In Vitro: Utility of Montelukast as a Selective CYP2C8 Probe Substrate

  Brooke M. VandenBrink, Robert S. Foti, Dan A. Rock, Larry C. Wienkers and Jan L. Wahlstrom

  Drug Metabolism and Disposition September 2011, 39 (9) 1546-1554; DOI: https://doi.org/10.1124/dmd.111.039065
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  Disposition and Metabolism of Ticagrelor, a Novel P2Y₁₂ Receptor Antagonist, in Mice, Rats, and Marmosets

  Yan Li, Claire Landqvist and Scott W. Grimm

  Drug Metabolism and Disposition September 2011, 39 (9) 1555-1567; DOI: https://doi.org/10.1124/dmd.111.039669
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  Efficient Screening of Cytochrome P450 BM3 Mutants for Their Metabolic Activity and Diversity toward a Wide Set of Drug-Like Molecules in Chemical Space

  Jelle Reinen, Jolanda S. van Leeuwen, Yongmin Li, Lifang Sun, Peter D. J. Grootenhuis, Caroline J. Decker, John Saunders, Nico P. E. Vermeulen and Jan N. M. Commandeur

  Drug Metabolism and Disposition September 2011, 39 (9) 1568-1576; DOI: https://doi.org/10.1124/dmd.111.039461
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  Production of 22-Hydroxy Metabolites of Vitamin D₃ by Cytochrome P450scc (CYP11A1) and Analysis of Their Biological Activities on Skin Cells

  Robert C. Tuckey, Wei Li, Haleem Z. Shehabi, Zorica Janjetovic, Minh N. Nguyen, Tae-Kang Kim, Jianjun Chen, Danielle E. Howell, Heather A. E. Benson, Trevor Sweatman, Donna M. Baldisseri and Andrzej Slominski

  Drug Metabolism and Disposition September 2011, 39 (9) 1577-1588; DOI: https://doi.org/10.1124/dmd.111.040071
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  Preclinical Disposition (In Vitro) of Novel μ-Opioid Receptor Selective Antagonists

  Pallabi Mitra, Jürgen Venitz, Yunyun Yuan, Yan Zhang and Phillip M. Gerk

  Drug Metabolism and Disposition September 2011, 39 (9) 1589-1596; DOI: https://doi.org/10.1124/dmd.111.038588
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  From Single Compounds to Herbal Extract: A Strategy to Systematically Characterize the Metabolites of Licorice in Rats

  Cheng Xiang, Xue Qiao, Qing Wang, Rui Li, Wenjuan Miao, Dean Guo and Min Ye

  Drug Metabolism and Disposition September 2011, 39 (9) 1597-1608; DOI: https://doi.org/10.1124/dmd.111.038695
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  Preclinical Species and Human Disposition of PF-04971729, a Selective Inhibitor of the Sodium-Dependent Glucose Cotransporter 2 and Clinical Candidate for the Treatment of Type 2 Diabetes Mellitus

  Amit S. Kalgutkar, Meera Tugnait, Tong Zhu, Emi Kimoto, Zhuang Miao, Vincent Mascitti, Xin Yang, Beijing Tan, Robert L. Walsky, Jonathan Chupka, Bo Feng and Ralph P. Robinson

  Drug Metabolism and Disposition September 2011, 39 (9) 1609-1619; DOI: https://doi.org/10.1124/dmd.111.040675
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  Metabolism of [¹⁴C]GSK977779 in Rats and Its Implication with the Observed Covalent Binding

  Catherine D. Tsalta, Armina Madatian, Ernest M. Schubert, Fangming Xia, William M. Hardesty, Yanli Deng, Jennifer L. Seymour and Peter D. Gorycki

  Drug Metabolism and Disposition September 2011, 39 (9) 1620-1632; DOI: https://doi.org/10.1124/dmd.110.036467
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  Physiologically Based Pharmacokinetic Modeling of Intestinal First-Pass Metabolism of CYP3A Substrates with High Intestinal Extraction

  Michael Gertz, J. Brian Houston and Aleksandra Galetin

  Drug Metabolism and Disposition September 2011, 39 (9) 1633-1642; DOI: https://doi.org/10.1124/dmd.111.039248
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  Oral Absorption of Clarithromycin Is Nearly Abolished by Chronic Comedication of Rifampicin in Foals

  Jette Peters, Wiebke Block, Stefan Oswald, Johanna Freyer, Markus Grube, Heyo K. Kroemer, Marc Lämmer, Dieter Lütjohann, Monica Venner and Werner Siegmund

  Drug Metabolism and Disposition September 2011, 39 (9) 1643-1649; DOI: https://doi.org/10.1124/dmd.111.039206
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  UGT1A6 and UGT2B15 Polymorphisms and Acetaminophen Conjugation in Response to a Randomized, Controlled Diet of Select Fruits and Vegetables

  Sandi L. Navarro, Yu Chen, Lin Li, Shuying S. Li, Jyh-Lurn Chang, Yvonne Schwarz, Irena B. King, John D. Potter, Jeannette Bigler and Johanna W. Lampe

  Drug Metabolism and Disposition September 2011, 39 (9) 1650-1657; DOI: https://doi.org/10.1124/dmd.111.039149
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  In Vitro Characterization of the Metabolic Pathways and Cytochrome P450 Inhibition and Induction Potential of BMS-690514, an ErbB/Vascular Endothelial Growth Factor Receptor Inhibitor

  Haizheng Hong, Hong Su, Li Ma, Ming Yao, Ramaswamy A. Iyer, W. Griffith Humphreys and Lisa J. Christopher

  Drug Metabolism and Disposition September 2011, 39 (9) 1658-1667; DOI: https://doi.org/10.1124/dmd.111.039776
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  A Novel Biotransformation of Alkyl Aminopyrrolidine to Aminopiperidine Ring by Human CYP3A

  Yuping Chen, Gary L. Skiles, Magang Shou, Dean Hickman and Faye Hsieh

  Drug Metabolism and Disposition September 2011, 39 (9) 1668-1673; DOI: https://doi.org/10.1124/dmd.111.039750
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  1-Aminobenzotriazole, a Known Cytochrome P450 Inhibitor, Is a Substrate and Inhibitor of N-Acetyltransferase

  Q. Sun, T. W. Harper, E. A. Dierks, L. Zhang, S. Chang, A. D. Rodrigues and P. Marathe

  Drug Metabolism and Disposition September 2011, 39 (9) 1674-1679; DOI: https://doi.org/10.1124/dmd.111.039834
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  Colonic Catabolism of Ellagitannins, Ellagic Acid, and Raspberry Anthocyanins: In Vivo and In Vitro Studies

  Rocío González-Barrio, Christine A. Edwards and Alan Crozier

  Drug Metabolism and Disposition September 2011, 39 (9) 1680-1688; DOI: https://doi.org/10.1124/dmd.111.039651
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  Paracetamol-Induced Hypothermia Is Independent of Cannabinoids and Transient Receptor Potential Vanilloid-1 and Is Not Mediated by AM404

  Samir S. Ayoub, Gareth Pryce, Michael P. Seed, Christopher Bolton, Roderick J. Flower and David Baker

  Drug Metabolism and Disposition September 2011, 39 (9) 1689-1695; DOI: https://doi.org/10.1124/dmd.111.038638
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  Novel Pathway of Metabolic Activation of Bisphenol A-Related Compounds for Estrogenic Activity

  Katsuhiro Okuda, Tomoko Fukuuchi, Masufumi Takiguchi and Shin'ichi Yoshihara

  Drug Metabolism and Disposition September 2011, 39 (9) 1696-1703; DOI: https://doi.org/10.1124/dmd.111.040121
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  Interaction of N-(2-Hydroxypropyl)methacrylamide Copolymer-Doxorubicin Conjugates with Human Liver Microsomal Cytochromes P450: Comparison with Free Doxorubicin

  Vlastimil Mašek, Eva Anzenbacherová, Tomáš Etrych, Jiří Strohalm, Karel Ulbrich and Pavel Anzenbacher

  Drug Metabolism and Disposition September 2011, 39 (9) 1704-1710; DOI: https://doi.org/10.1124/dmd.110.037986
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  Application of the Fluorescent Probe 1-Anilinonaphthalene-8-Sulfonate to the Measurement of the Nonspecific Binding of Drugs to Human Liver Microsomes

  James A. McLure, Donald J. Birkett, David J. Elliot, J. Andrew Williams, Andrew Rowland and John O. Miners

  Drug Metabolism and Disposition September 2011, 39 (9) 1711-1717; DOI: https://doi.org/10.1124/dmd.111.039354
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  Gestation Time-Dependent Pharmacokinetics of Intravenous (+)-Methamphetamine in Rats

  Sarah White, Elizabeth Laurenzana, Howard Hendrickson, W. Brooks Gentry and S. Michael Owens

  Drug Metabolism and Disposition September 2011, 39 (9) 1718-1726; DOI: https://doi.org/10.1124/dmd.111.039446
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  Metabolism of Methylisoeugenol in Liver Microsomes of Human, Rat, and Bovine Origin

  Alexander T. Cartus, Karl-Heinz Merz and Dieter Schrenk

  Drug Metabolism and Disposition September 2011, 39 (9) 1727-1733; DOI: https://doi.org/10.1124/dmd.111.038851
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  Metabolism and Disposition of Eltrombopag, an Oral, Nonpeptide Thrombopoietin Receptor Agonist, in Healthy Human Subjects

  Yanli Deng, Armina Madatian, Mary Beth Wire, Carolyn Bowen, Jung Wook Park, Daphne Williams, Bin Peng, Ernest Schubert, Frances Gorycki, Mark Levy and Peter D. Gorycki

  Drug Metabolism and Disposition September 2011, 39 (9) 1734-1746; DOI: https://doi.org/10.1124/dmd.111.040170
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  Investigations of Hydrazine Cleavage of Eltrombopag in Humans

  Yanli Deng, Martin Rogers, Caroline Sychterz, Kimberly Talley, Yanwen Qian, David Bershas, May Ho, Wei Shi, Emile P. Chen, Cosette Serabjit-Singh and Peter D. Gorycki

  Drug Metabolism and Disposition September 2011, 39 (9) 1747-1754; DOI: https://doi.org/10.1124/dmd.111.040188
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  Characterization of the Inhibitory Effects of N-Butylpyridinium Chloride and Structurally Related Ionic Liquids on Organic Cation Transporters 1/2 and Human Toxic Extrusion Transporters 1/2-K In Vitro and In Vivo

  Yaofeng Cheng, Lucy J. Martinez-Guerrero, Stephen H. Wright, Robert K. Kuester, Michelle J. Hooth and I. Glenn Sipes

  Drug Metabolism and Disposition September 2011, 39 (9) 1755-1761; DOI: https://doi.org/10.1124/dmd.110.035865
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  Metabolism and Disposition of Isoflavone Conjugated Metabolites in Humans after Ingestion of Kinako

  Kaori Hosoda, Takashi Furuta and Kazuo Ishii

  Drug Metabolism and Disposition September 2011, 39 (9) 1762-1767; DOI: https://doi.org/10.1124/dmd.111.038281
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  In Vitro Metabolism of the Mycotoxin Enniatin B in Different Species and Cytochrome P450 Enzyme Phenotyping by Chemical Inhibitors

  Christiane K. Fæste, Lada Ivanova and Silvio Uhlig

  Drug Metabolism and Disposition September 2011, 39 (9) 1768-1776; DOI: https://doi.org/10.1124/dmd.111.039529