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Research ArticleArticle

Culture Period-Dependent Changes in the Uptake of Transporter Substrates in Sandwich-Cultured Rat and Human Hepatocytes

Naoki Kotani, Kazuya Maeda, Takao Watanabe, Mariko Hiramatsu, Li-kun Gong, Yi-an Bi, Toshiaki Takezawa, Hiroyuki Kusuhara and Yuichi Sugiyama
Drug Metabolism and Disposition September 2011, 39 (9) 1503-1510; DOI: https://doi.org/10.1124/dmd.111.038968

Article Information

vol. 39 no. 9 1503-1510
DOI 
https://doi.org/10.1124/dmd.111.038968
PubMed 
21673128
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 18, 2011
  • Accepted June 13, 2011
  • Published online August 19, 2011.

Article Versions

Copyright & Usage 
Copyright © 2011 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Naoki Kotani,
  2. Kazuya Maeda,
  3. Takao Watanabe,
  4. Mariko Hiramatsu,
  5. Li-kun Gong,
  6. Yi-an Bi,
  7. Toshiaki Takezawa,
  8. Hiroyuki Kusuhara and
  9. Yuichi Sugiyama
  1. Graduate School of Pharmaceutical Sciences, the University of Tokyo, Tokyo, Japan (N.K., K.M., T.W., M.H., H.K., Y.S.); Center for Drug Safety and Evaluation Research, State Key Laboratory of New Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (L.G.); Pfizer Global Research and Development, Groton, Connecticut (Y.B.); and Laboratory of Animal Cell Biology, National Institute of Agrobiological Sciences, Ibaraki, Japan (T.T.)
  1. Address correspondence to:
    Dr. Yuichi Sugiyama, Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033 Japan. E-mail: sugiyama{at}mol.f.u-tokyo.ac.jp
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Research ArticleArticle

Culture Period-Dependent Changes in the Uptake of Transporter Substrates in Sandwich-Cultured Rat and Human Hepatocytes

Naoki Kotani, Kazuya Maeda, Takao Watanabe, Mariko Hiramatsu, Li-kun Gong, Yi-an Bi, Toshiaki Takezawa, Hiroyuki Kusuhara and Yuichi Sugiyama
Drug Metabolism and Disposition September 1, 2011, 39 (9) 1503-1510; DOI: https://doi.org/10.1124/dmd.111.038968
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