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Research ArticleArticle

Preclinical Species and Human Disposition of PF-04971729, a Selective Inhibitor of the Sodium-Dependent Glucose Cotransporter 2 and Clinical Candidate for the Treatment of Type 2 Diabetes Mellitus

Amit S. Kalgutkar, Meera Tugnait, Tong Zhu, Emi Kimoto, Zhuang Miao, Vincent Mascitti, Xin Yang, Beijing Tan, Robert L. Walsky, Jonathan Chupka, Bo Feng and Ralph P. Robinson
Drug Metabolism and Disposition September 2011, 39 (9) 1609-1619; DOI: https://doi.org/10.1124/dmd.111.040675

Article Information

vol. 39 no. 9 1609-1619
DOI 
https://doi.org/10.1124/dmd.111.040675
PubMed 
21690265
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received May 15, 2011
  • Accepted June 20, 2011
  • Published online August 19, 2011.

Article Versions

Copyright & Usage 
Copyright © 2011 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Amit S. Kalgutkar,
  2. Meera Tugnait,
  3. Tong Zhu,
  4. Emi Kimoto,
  5. Zhuang Miao,
  6. Vincent Mascitti,
  7. Xin Yang,
  8. Beijing Tan,
  9. Robert L. Walsky,
  10. Jonathan Chupka,
  11. Bo Feng and
  12. Ralph P. Robinson
  1. Pharmacokinetics, Dynamics and Metabolism Department (A.S.K., M.T., T.Z., E.K., Z.M., X.Y., B.T., R.L.W., J.C., B.F.) and Worldwide Medicinal Chemistry (V.M., R.P.R.), Pfizer Global Research and Development, Groton, Connecticut
  1. Address correspondence to:
    Dr. Amit S. Kalgutkar, Pharmacokinetics, Dynamics, and Metabolism Department, Pfizer Global Research and Development, Groton, CT 06340. E-mail: amit.kalgutkar{at}pfizer.com
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Research ArticleArticle

Preclinical Species and Human Disposition of PF-04971729, a Selective Inhibitor of the Sodium-Dependent Glucose Cotransporter 2 and Clinical Candidate for the Treatment of Type 2 Diabetes Mellitus

Amit S. Kalgutkar, Meera Tugnait, Tong Zhu, Emi Kimoto, Zhuang Miao, Vincent Mascitti, Xin Yang, Beijing Tan, Robert L. Walsky, Jonathan Chupka, Bo Feng and Ralph P. Robinson
Drug Metabolism and Disposition September 1, 2011, 39 (9) 1609-1619; DOI: https://doi.org/10.1124/dmd.111.040675
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