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Drug Metabolism & Disposition

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Table of Contents

January 01, 2012; Volume 40,Issue 1

Short Communication

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    Human Hepatic Cytochrome P450-Specific Metabolism of the Organophosphorus Pesticides Methyl Parathion and Diazinon
    Corie A. Ellison, Yuan Tian, James B. Knaak, Paul J. Kostyniak and James R. Olson
    Drug Metabolism and Disposition January 2012, 40 (1) 1-5; DOI: https://doi.org/10.1124/dmd.111.042572

Articles

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    A Semiphysiologically Based Pharmacokinetic Modeling Approach to Predict the Dose-Exposure Relationship of an Antiparasitic Prodrug/Active Metabolite Pair
    Grace Zhixia Yan, Claudia N. Generaux, Miyoung Yoon, Rachel B. Goldsmith, Richard R. Tidwell, James E. Hall, Carol A. Olson, Harvey J. Clewell, Kim L. R. Brouwer and Mary F. Paine
    Drug Metabolism and Disposition January 2012, 40 (1) 6-17; DOI: https://doi.org/10.1124/dmd.111.040063
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    CPY3A4-Mediated Lopinavir Bioactivation and Its Inhibition by Ritonavir
    Feng Li, Jie Lu and Xiaochao Ma
    Drug Metabolism and Disposition January 2012, 40 (1) 18-24; DOI: https://doi.org/10.1124/dmd.111.041400
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    In Vitro Glucuronidation of the Antibacterial Triclocarban and Its Oxidative Metabolites
    N. H. Schebb, B. Franze, R. Maul, A. Ranganathan and B. D. Hammock
    Drug Metabolism and Disposition January 2012, 40 (1) 25-31; DOI: https://doi.org/10.1124/dmd.111.042283
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    Bupropion Hydroxylation as a Selective Marker of Rat CYP2B1 Catalytic Activity
    Dumrongsak Pekthong, Coraline Desbans, Hélène Martin and Lysiane Richert
    Drug Metabolism and Disposition January 2012, 40 (1) 32-38; DOI: https://doi.org/10.1124/dmd.111.041368
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    Effects of Chronic Renal Failure on Brain Drug Transporters in Rats
    Judith Naud, Louis-Philippe Laurin, Josée Michaud, Stéphanie Beauchemin, Francois A. Leblond and Vincent Pichette
    Drug Metabolism and Disposition January 2012, 40 (1) 39-46; DOI: https://doi.org/10.1124/dmd.111.041145
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    Prediction of CYP2D6 Drug Interactions from In Vitro Data: Evidence for Substrate-Dependent Inhibition
    Brooke M. VandenBrink, Robert S. Foti, Dan A. Rock, Larry C. Wienkers and Jan L. Wahlstrom
    Drug Metabolism and Disposition January 2012, 40 (1) 47-53; DOI: https://doi.org/10.1124/dmd.111.041210
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    Potential Contribution of Cytochrome P450 2B6 to Hepatic 4-Hydroxycyclophosphamide Formation In Vitro and In Vivo
    Brianne S. Raccor, Adam J. Claessens, Jean C. Dinh, Julie R. Park, Douglas S. Hawkins, Sushma S. Thomas, Karen W. Makar, Jeannine S. McCune and Rheem A. Totah
    Drug Metabolism and Disposition January 2012, 40 (1) 54-63; DOI: https://doi.org/10.1124/dmd.111.039347
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    γ-Hydroxybutyrate Blood/Plasma Partitioning: Effect of Physiologic pH on Transport by Monocarboxylate Transporters
    Bridget L. Morse, Melanie A. Felmlee and Marilyn E. Morris
    Drug Metabolism and Disposition January 2012, 40 (1) 64-69; DOI: https://doi.org/10.1124/dmd.111.041285
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    Debrisoquine Metabolism and CYP2D Expression in Marmoset Liver Microsomes
    Brian R. Cooke, S. W. Annie Bligh, Z. Richard Cybulski, Costas Ioannides and Michael Hall
    Drug Metabolism and Disposition January 2012, 40 (1) 70-75; DOI: https://doi.org/10.1124/dmd.111.041566
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    Prediction of Human Metabolism of FK3453 by Aldehyde Oxidase Using Chimeric Mice Transplanted with Human or Rat Hepatocytes
    Seigo Sanoh, Kazuyoshi Nozaki, Hidetsugu Murai, Shigeyuki Terashita, Toshio Teramura and Shigeru Ohta
    Drug Metabolism and Disposition January 2012, 40 (1) 76-82; DOI: https://doi.org/10.1124/dmd.111.041954
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    Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities
    Sumio Ohtsuki, Olaf Schaefer, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Naoki Ishiguro, Wataru Kishimoto, Eva Ludwig-Schwellinger, Thomas Ebner and Tetsuya Terasaki
    Drug Metabolism and Disposition January 2012, 40 (1) 83-92; DOI: https://doi.org/10.1124/dmd.111.042259
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    Absolute Quantification and Differential Expression of Drug Transporters, Cytochrome P450 Enzymes, and UDP-Glucuronosyltransferases in Cultured Primary Human Hepatocytes
    Olaf Schaefer, Sumio Ohtsuki, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Atsushi Sakamoto, Naoki Ishiguro, Takehisa Matsumaru, Tetsuya Terasaki and Thomas Ebner
    Drug Metabolism and Disposition January 2012, 40 (1) 93-103; DOI: https://doi.org/10.1124/dmd.111.042275
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    Comparison of Cryopreserved HepaRG Cells with Cryopreserved Human Hepatocytes for Prediction of Clearance for 26 Drugs
    Ugo Zanelli, Nicola Pasquale Caradonna, David Hallifax, Elisa Turlizzi and J. Brian Houston
    Drug Metabolism and Disposition January 2012, 40 (1) 104-110; DOI: https://doi.org/10.1124/dmd.111.042309
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    Frequency of Undetected CYP2D6 Hybrid Genes in Clinical Samples: Impact on Phenotype Prediction
    John Logan Black, Denise L. Walker, Dennis J. O'Kane and Maria Harmandayan
    Drug Metabolism and Disposition January 2012, 40 (1) 111-119; DOI: https://doi.org/10.1124/dmd.111.040832
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    Cytoprotective Effect of 20(S)-Rg3 on Benzo[a]pyrene-Induced DNA Damage
    Po Ying Poon, Hoi Hin Kwok, Patrick Y. K. Yue, Mildred S. M. Yang, Nai Ki Mak, Chris K. C. Wong and Ricky N. S. Wong
    Drug Metabolism and Disposition January 2012, 40 (1) 120-129; DOI: https://doi.org/10.1124/dmd.111.039503
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    In Vitro Inhibition of the Bile Salt Export Pump Correlates with Risk of Cholestatic Drug-Induced Liver Injury in Humans
    Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber and J. Gerald Kenna
    Drug Metabolism and Disposition January 2012, 40 (1) 130-138; DOI: https://doi.org/10.1124/dmd.111.040758
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    Human Metabolism of Lapatinib, a Dual Kinase Inhibitor: Implications for Hepatotoxicity
    Stephen Castellino, Michael O'Mara, Kevin Koch, David J. Borts, Gary D. Bowers and Christopher MacLauchlin
    Drug Metabolism and Disposition January 2012, 40 (1) 139-150; DOI: https://doi.org/10.1124/dmd.111.040949
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    Interindividual Variability in Gene Expression Profiles in Human Hepatocytes and Comparison with HepaRG Cells
    Alexandra Rogue, Carine Lambert, Catherine Spire, Nancy Claude and André Guillouzo
    Drug Metabolism and Disposition January 2012, 40 (1) 151-158; DOI: https://doi.org/10.1124/dmd.111.042028
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    Prediction of Relative In Vivo Metabolite Exposure from In Vitro Data Using Two Model Drugs: Dextromethorphan and Omeprazole
    Justin D. Lutz and Nina Isoherranen
    Drug Metabolism and Disposition January 2012, 40 (1) 159-168; DOI: https://doi.org/10.1124/dmd.111.042200
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    Acetaminophen-Induced Hepatotoxicity in a Liver Tissue Model Consisting of Primary Hepatocytes Assembling around an Endothelial Cell Network
    Yu Toyoda, Miho Tamai, Kasumi Kashikura, Shunsuke Kobayashi, Yoichi Fujiyama, Tomoyoshi Soga and Yoh-ichi Tagawa
    Drug Metabolism and Disposition January 2012, 40 (1) 169-177; DOI: https://doi.org/10.1124/dmd.111.041137
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    Species-Dependent and Receptor-Selective Action of Bilobalide on the Function of Constitutive Androstane Receptor and Pregnane X Receptor
    Aik Jiang Lau, Guixiang Yang, Ganesh Rajaraman, Christie C. Baucom and Thomas K. H. Chang
    Drug Metabolism and Disposition January 2012, 40 (1) 178-186; DOI: https://doi.org/10.1124/dmd.111.042879
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    Effects of Omeprazole and Genetic Polymorphism of CYP2C19 on the Clopidogrel Active Metabolite
    Xavier Boulenc, Nassim Djebli, Juan Shi, Laurent Perrin, William Brian, Robert Van Horn and Fabrice Hurbin
    Drug Metabolism and Disposition January 2012, 40 (1) 187-197; DOI: https://doi.org/10.1124/dmd.111.040394
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    Phenotype of the Most Common “Slow Acetylator” Arylamine N-Acetyltransferase 1 Genetic Variant (NAT1*14B) Is Substrate-Dependent
    Lori M. Millner, Mark A. Doll, Jian Cai, J. Christopher States and David W. Hein
    Drug Metabolism and Disposition January 2012, 40 (1) 198-204; DOI: https://doi.org/10.1124/dmd.111.041855
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    Regulation of Cytochrome P450 4F11 by Nuclear Transcription Factor-κB
    Jordan C. Bell and Henry W. Strobel
    Drug Metabolism and Disposition January 2012, 40 (1) 205-211; DOI: https://doi.org/10.1124/dmd.111.041178
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    Brain Uptake of the Drug of Abuse γ-Hydroxybutyric Acid in Rats
    Samuel A. Roiko, Melanie A. Felmlee and Marilyn E. Morris
    Drug Metabolism and Disposition January 2012, 40 (1) 212-218; DOI: https://doi.org/10.1124/dmd.111.041749
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    Identification of the Oxidative and Conjugative Enzymes Involved in the Biotransformation of Brivanib
    Jiachang Gong, Jinping Gan and Ramaswamy A. Iyer
    Drug Metabolism and Disposition January 2012, 40 (1) 219-226; DOI: https://doi.org/10.1124/dmd.111.042457

Erratum

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    Correction to “Cytochrome P450 Pig Liver Pie: Determination of Individual Cytochrome P450 Isoform Contents in Microsomes from Two Pig Livers Using Liquid Chromatography in Conjunction with Mass Spectroscopy”
    Drug Metabolism and Disposition January 2012, 40 (1) 227; DOI: https://doi.org/10.1124/dmd.40.1.227
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Drug Metabolism and Disposition: 40 (1)
Drug Metabolism and Disposition
Vol. 40, Issue 1
1 Jan 2012
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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