Table of Contents

Articles

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  A Semiphysiologically Based Pharmacokinetic Modeling Approach to Predict the Dose-Exposure Relationship of an Antiparasitic Prodrug/Active Metabolite Pair

  Grace Zhixia Yan, Claudia N. Generaux, Miyoung Yoon, Rachel B. Goldsmith, Richard R. Tidwell, James E. Hall, Carol A. Olson, Harvey J. Clewell, Kim L. R. Brouwer and Mary F. Paine

  Drug Metabolism and Disposition January 2012, 40 (1) 6-17; DOI: https://doi.org/10.1124/dmd.111.040063
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  CPY3A4-Mediated Lopinavir Bioactivation and Its Inhibition by Ritonavir

  Feng Li, Jie Lu and Xiaochao Ma

  Drug Metabolism and Disposition January 2012, 40 (1) 18-24; DOI: https://doi.org/10.1124/dmd.111.041400
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  In Vitro Glucuronidation of the Antibacterial Triclocarban and Its Oxidative Metabolites

  N. H. Schebb, B. Franze, R. Maul, A. Ranganathan and B. D. Hammock

  Drug Metabolism and Disposition January 2012, 40 (1) 25-31; DOI: https://doi.org/10.1124/dmd.111.042283
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  Bupropion Hydroxylation as a Selective Marker of Rat CYP2B1 Catalytic Activity

  Dumrongsak Pekthong, Coraline Desbans, Hélène Martin and Lysiane Richert

  Drug Metabolism and Disposition January 2012, 40 (1) 32-38; DOI: https://doi.org/10.1124/dmd.111.041368
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  Effects of Chronic Renal Failure on Brain Drug Transporters in Rats

  Judith Naud, Louis-Philippe Laurin, Josée Michaud, Stéphanie Beauchemin, Francois A. Leblond and Vincent Pichette

  Drug Metabolism and Disposition January 2012, 40 (1) 39-46; DOI: https://doi.org/10.1124/dmd.111.041145
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  Prediction of CYP2D6 Drug Interactions from In Vitro Data: Evidence for Substrate-Dependent Inhibition

  Brooke M. VandenBrink, Robert S. Foti, Dan A. Rock, Larry C. Wienkers and Jan L. Wahlstrom

  Drug Metabolism and Disposition January 2012, 40 (1) 47-53; DOI: https://doi.org/10.1124/dmd.111.041210
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  Potential Contribution of Cytochrome P450 2B6 to Hepatic 4-Hydroxycyclophosphamide Formation In Vitro and In Vivo

  Brianne S. Raccor, Adam J. Claessens, Jean C. Dinh, Julie R. Park, Douglas S. Hawkins, Sushma S. Thomas, Karen W. Makar, Jeannine S. McCune and Rheem A. Totah

  Drug Metabolism and Disposition January 2012, 40 (1) 54-63; DOI: https://doi.org/10.1124/dmd.111.039347
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  γ-Hydroxybutyrate Blood/Plasma Partitioning: Effect of Physiologic pH on Transport by Monocarboxylate Transporters

  Bridget L. Morse, Melanie A. Felmlee and Marilyn E. Morris

  Drug Metabolism and Disposition January 2012, 40 (1) 64-69; DOI: https://doi.org/10.1124/dmd.111.041285
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  Debrisoquine Metabolism and CYP2D Expression in Marmoset Liver Microsomes

  Brian R. Cooke, S. W. Annie Bligh, Z. Richard Cybulski, Costas Ioannides and Michael Hall

  Drug Metabolism and Disposition January 2012, 40 (1) 70-75; DOI: https://doi.org/10.1124/dmd.111.041566
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  Prediction of Human Metabolism of FK3453 by Aldehyde Oxidase Using Chimeric Mice Transplanted with Human or Rat Hepatocytes

  Seigo Sanoh, Kazuyoshi Nozaki, Hidetsugu Murai, Shigeyuki Terashita, Toshio Teramura and Shigeru Ohta

  Drug Metabolism and Disposition January 2012, 40 (1) 76-82; DOI: https://doi.org/10.1124/dmd.111.041954
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  Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities

  Sumio Ohtsuki, Olaf Schaefer, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Naoki Ishiguro, Wataru Kishimoto, Eva Ludwig-Schwellinger, Thomas Ebner and Tetsuya Terasaki

  Drug Metabolism and Disposition January 2012, 40 (1) 83-92; DOI: https://doi.org/10.1124/dmd.111.042259
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  Absolute Quantification and Differential Expression of Drug Transporters, Cytochrome P450 Enzymes, and UDP-Glucuronosyltransferases in Cultured Primary Human Hepatocytes

  Olaf Schaefer, Sumio Ohtsuki, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Atsushi Sakamoto, Naoki Ishiguro, Takehisa Matsumaru, Tetsuya Terasaki and Thomas Ebner

  Drug Metabolism and Disposition January 2012, 40 (1) 93-103; DOI: https://doi.org/10.1124/dmd.111.042275
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  Comparison of Cryopreserved HepaRG Cells with Cryopreserved Human Hepatocytes for Prediction of Clearance for 26 Drugs

  Ugo Zanelli, Nicola Pasquale Caradonna, David Hallifax, Elisa Turlizzi and J. Brian Houston

  Drug Metabolism and Disposition January 2012, 40 (1) 104-110; DOI: https://doi.org/10.1124/dmd.111.042309
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  Frequency of Undetected CYP2D6 Hybrid Genes in Clinical Samples: Impact on Phenotype Prediction

  John Logan Black, Denise L. Walker, Dennis J. O'Kane and Maria Harmandayan

  Drug Metabolism and Disposition January 2012, 40 (1) 111-119; DOI: https://doi.org/10.1124/dmd.111.040832
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  Cytoprotective Effect of 20(S)-Rg3 on Benzo[a]pyrene-Induced DNA Damage

  Po Ying Poon, Hoi Hin Kwok, Patrick Y. K. Yue, Mildred S. M. Yang, Nai Ki Mak, Chris K. C. Wong and Ricky N. S. Wong

  Drug Metabolism and Disposition January 2012, 40 (1) 120-129; DOI: https://doi.org/10.1124/dmd.111.039503
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  In Vitro Inhibition of the Bile Salt Export Pump Correlates with Risk of Cholestatic Drug-Induced Liver Injury in Humans

  Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber and J. Gerald Kenna

  Drug Metabolism and Disposition January 2012, 40 (1) 130-138; DOI: https://doi.org/10.1124/dmd.111.040758
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  Human Metabolism of Lapatinib, a Dual Kinase Inhibitor: Implications for Hepatotoxicity

  Stephen Castellino, Michael O'Mara, Kevin Koch, David J. Borts, Gary D. Bowers and Christopher MacLauchlin

  Drug Metabolism and Disposition January 2012, 40 (1) 139-150; DOI: https://doi.org/10.1124/dmd.111.040949
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  Interindividual Variability in Gene Expression Profiles in Human Hepatocytes and Comparison with HepaRG Cells

  Alexandra Rogue, Carine Lambert, Catherine Spire, Nancy Claude and André Guillouzo

  Drug Metabolism and Disposition January 2012, 40 (1) 151-158; DOI: https://doi.org/10.1124/dmd.111.042028
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  Prediction of Relative In Vivo Metabolite Exposure from In Vitro Data Using Two Model Drugs: Dextromethorphan and Omeprazole

  Justin D. Lutz and Nina Isoherranen

  Drug Metabolism and Disposition January 2012, 40 (1) 159-168; DOI: https://doi.org/10.1124/dmd.111.042200
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  Acetaminophen-Induced Hepatotoxicity in a Liver Tissue Model Consisting of Primary Hepatocytes Assembling around an Endothelial Cell Network

  Yu Toyoda, Miho Tamai, Kasumi Kashikura, Shunsuke Kobayashi, Yoichi Fujiyama, Tomoyoshi Soga and Yoh-ichi Tagawa

  Drug Metabolism and Disposition January 2012, 40 (1) 169-177; DOI: https://doi.org/10.1124/dmd.111.041137
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  Species-Dependent and Receptor-Selective Action of Bilobalide on the Function of Constitutive Androstane Receptor and Pregnane X Receptor

  Aik Jiang Lau, Guixiang Yang, Ganesh Rajaraman, Christie C. Baucom and Thomas K. H. Chang

  Drug Metabolism and Disposition January 2012, 40 (1) 178-186; DOI: https://doi.org/10.1124/dmd.111.042879
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  Effects of Omeprazole and Genetic Polymorphism of CYP2C19 on the Clopidogrel Active Metabolite

  Xavier Boulenc, Nassim Djebli, Juan Shi, Laurent Perrin, William Brian, Robert Van Horn and Fabrice Hurbin

  Drug Metabolism and Disposition January 2012, 40 (1) 187-197; DOI: https://doi.org/10.1124/dmd.111.040394
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  Phenotype of the Most Common “Slow Acetylator” Arylamine N-Acetyltransferase 1 Genetic Variant (NAT1*14B) Is Substrate-Dependent

  Lori M. Millner, Mark A. Doll, Jian Cai, J. Christopher States and David W. Hein

  Drug Metabolism and Disposition January 2012, 40 (1) 198-204; DOI: https://doi.org/10.1124/dmd.111.041855
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  Regulation of Cytochrome P450 4F11 by Nuclear Transcription Factor-κB

  Jordan C. Bell and Henry W. Strobel

  Drug Metabolism and Disposition January 2012, 40 (1) 205-211; DOI: https://doi.org/10.1124/dmd.111.041178
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  Brain Uptake of the Drug of Abuse γ-Hydroxybutyric Acid in Rats

  Samuel A. Roiko, Melanie A. Felmlee and Marilyn E. Morris

  Drug Metabolism and Disposition January 2012, 40 (1) 212-218; DOI: https://doi.org/10.1124/dmd.111.041749
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  Identification of the Oxidative and Conjugative Enzymes Involved in the Biotransformation of Brivanib

  Jiachang Gong, Jinping Gan and Ramaswamy A. Iyer

  Drug Metabolism and Disposition January 2012, 40 (1) 219-226; DOI: https://doi.org/10.1124/dmd.111.042457