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Drug Metabolism & Disposition

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  • Articles
    • Current Issue
    • Fast Forward
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Index by author

January 01, 2012; Volume 40,Issue 1
  • A
  • B
  • C
  • D
  • E
  • F
  • G
  • H
  • I
  • J
  • K
  • L
  • M
  • N
  • O
  • P
  • Q
  • R
  • S
  • T
  • U
  • V
  • W
  • X
  • Y
  • Z

B

  1. Barber, Jane

    1. You have access
      In Vitro Inhibition of the Bile Salt Export Pump Correlates with Risk of Cholestatic Drug-Induced Liver Injury in Humans
      Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber and J. Gerald Kenna
      Drug Metabolism and Disposition January 2012, 40 (1) 130-138; DOI: https://doi.org/10.1124/dmd.111.040758
  2. Baucom, Christie C.

    1. You have access
      Species-Dependent and Receptor-Selective Action of Bilobalide on the Function of Constitutive Androstane Receptor and Pregnane X Receptor
      Aik Jiang Lau, Guixiang Yang, Ganesh Rajaraman, Christie C. Baucom and Thomas K. H. Chang
      Drug Metabolism and Disposition January 2012, 40 (1) 178-186; DOI: https://doi.org/10.1124/dmd.111.042879
  3. Beauchemin, Stéphanie

    1. You have access
      Effects of Chronic Renal Failure on Brain Drug Transporters in Rats
      Judith Naud, Louis-Philippe Laurin, Josée Michaud, Stéphanie Beauchemin, Francois A. Leblond and Vincent Pichette
      Drug Metabolism and Disposition January 2012, 40 (1) 39-46; DOI: https://doi.org/10.1124/dmd.111.041145
  4. Bell, Jordan C.

    1. You have access
      Regulation of Cytochrome P450 4F11 by Nuclear Transcription Factor-κB
      Jordan C. Bell and Henry W. Strobel
      Drug Metabolism and Disposition January 2012, 40 (1) 205-211; DOI: https://doi.org/10.1124/dmd.111.041178
  5. Black, John Logan

    1. You have access
      Frequency of Undetected CYP2D6 Hybrid Genes in Clinical Samples: Impact on Phenotype Prediction
      John Logan Black, Denise L. Walker, Dennis J. O'Kane and Maria Harmandayan
      Drug Metabolism and Disposition January 2012, 40 (1) 111-119; DOI: https://doi.org/10.1124/dmd.111.040832
  6. Bligh, S. W. Annie

    1. You have access
      Debrisoquine Metabolism and CYP2D Expression in Marmoset Liver Microsomes
      Brian R. Cooke, S. W. Annie Bligh, Z. Richard Cybulski, Costas Ioannides and Michael Hall
      Drug Metabolism and Disposition January 2012, 40 (1) 70-75; DOI: https://doi.org/10.1124/dmd.111.041566
  7. Borts, David J.

    1. You have access
      Human Metabolism of Lapatinib, a Dual Kinase Inhibitor: Implications for Hepatotoxicity
      Stephen Castellino, Michael O'Mara, Kevin Koch, David J. Borts, Gary D. Bowers and Christopher MacLauchlin
      Drug Metabolism and Disposition January 2012, 40 (1) 139-150; DOI: https://doi.org/10.1124/dmd.111.040949
  8. Boulenc, Xavier

    1. You have access
      Effects of Omeprazole and Genetic Polymorphism of CYP2C19 on the Clopidogrel Active Metabolite
      Xavier Boulenc, Nassim Djebli, Juan Shi, Laurent Perrin, William Brian, Robert Van Horn and Fabrice Hurbin
      Drug Metabolism and Disposition January 2012, 40 (1) 187-197; DOI: https://doi.org/10.1124/dmd.111.040394
  9. Bowers, Gary D.

    1. You have access
      Human Metabolism of Lapatinib, a Dual Kinase Inhibitor: Implications for Hepatotoxicity
      Stephen Castellino, Michael O'Mara, Kevin Koch, David J. Borts, Gary D. Bowers and Christopher MacLauchlin
      Drug Metabolism and Disposition January 2012, 40 (1) 139-150; DOI: https://doi.org/10.1124/dmd.111.040949
  10. Brian, William

    1. You have access
      Effects of Omeprazole and Genetic Polymorphism of CYP2C19 on the Clopidogrel Active Metabolite
      Xavier Boulenc, Nassim Djebli, Juan Shi, Laurent Perrin, William Brian, Robert Van Horn and Fabrice Hurbin
      Drug Metabolism and Disposition January 2012, 40 (1) 187-197; DOI: https://doi.org/10.1124/dmd.111.040394
  11. Brouwer, Kim L. R.

    1. You have access
      A Semiphysiologically Based Pharmacokinetic Modeling Approach to Predict the Dose-Exposure Relationship of an Antiparasitic Prodrug/Active Metabolite Pair
      Grace Zhixia Yan, Claudia N. Generaux, Miyoung Yoon, Rachel B. Goldsmith, Richard R. Tidwell, James E. Hall, Carol A. Olson, Harvey J. Clewell, Kim L. R. Brouwer and Mary F. Paine
      Drug Metabolism and Disposition January 2012, 40 (1) 6-17; DOI: https://doi.org/10.1124/dmd.111.040063

C

  1. Cai, Jian

    1. You have access
      Phenotype of the Most Common “Slow Acetylator” Arylamine N-Acetyltransferase 1 Genetic Variant (NAT1*14B) Is Substrate-Dependent
      Lori M. Millner, Mark A. Doll, Jian Cai, J. Christopher States and David W. Hein
      Drug Metabolism and Disposition January 2012, 40 (1) 198-204; DOI: https://doi.org/10.1124/dmd.111.041855
  2. Caradonna, Nicola Pasquale

    1. You have access
      Comparison of Cryopreserved HepaRG Cells with Cryopreserved Human Hepatocytes for Prediction of Clearance for 26 Drugs
      Ugo Zanelli, Nicola Pasquale Caradonna, David Hallifax, Elisa Turlizzi and J. Brian Houston
      Drug Metabolism and Disposition January 2012, 40 (1) 104-110; DOI: https://doi.org/10.1124/dmd.111.042309
  3. Castellino, Stephen

    1. You have access
      Human Metabolism of Lapatinib, a Dual Kinase Inhibitor: Implications for Hepatotoxicity
      Stephen Castellino, Michael O'Mara, Kevin Koch, David J. Borts, Gary D. Bowers and Christopher MacLauchlin
      Drug Metabolism and Disposition January 2012, 40 (1) 139-150; DOI: https://doi.org/10.1124/dmd.111.040949
  4. Chang, Thomas K. H.

    1. You have access
      Species-Dependent and Receptor-Selective Action of Bilobalide on the Function of Constitutive Androstane Receptor and Pregnane X Receptor
      Aik Jiang Lau, Guixiang Yang, Ganesh Rajaraman, Christie C. Baucom and Thomas K. H. Chang
      Drug Metabolism and Disposition January 2012, 40 (1) 178-186; DOI: https://doi.org/10.1124/dmd.111.042879
  5. Claessens, Adam J.

    1. You have access
      Potential Contribution of Cytochrome P450 2B6 to Hepatic 4-Hydroxycyclophosphamide Formation In Vitro and In Vivo
      Brianne S. Raccor, Adam J. Claessens, Jean C. Dinh, Julie R. Park, Douglas S. Hawkins, Sushma S. Thomas, Karen W. Makar, Jeannine S. McCune and Rheem A. Totah
      Drug Metabolism and Disposition January 2012, 40 (1) 54-63; DOI: https://doi.org/10.1124/dmd.111.039347
  6. Claude, Nancy

    1. You have access
      Interindividual Variability in Gene Expression Profiles in Human Hepatocytes and Comparison with HepaRG Cells
      Alexandra Rogue, Carine Lambert, Catherine Spire, Nancy Claude and André Guillouzo
      Drug Metabolism and Disposition January 2012, 40 (1) 151-158; DOI: https://doi.org/10.1124/dmd.111.042028
  7. Clewell, Harvey J.

    1. You have access
      A Semiphysiologically Based Pharmacokinetic Modeling Approach to Predict the Dose-Exposure Relationship of an Antiparasitic Prodrug/Active Metabolite Pair
      Grace Zhixia Yan, Claudia N. Generaux, Miyoung Yoon, Rachel B. Goldsmith, Richard R. Tidwell, James E. Hall, Carol A. Olson, Harvey J. Clewell, Kim L. R. Brouwer and Mary F. Paine
      Drug Metabolism and Disposition January 2012, 40 (1) 6-17; DOI: https://doi.org/10.1124/dmd.111.040063
  8. Cooke, Brian R.

    1. You have access
      Debrisoquine Metabolism and CYP2D Expression in Marmoset Liver Microsomes
      Brian R. Cooke, S. W. Annie Bligh, Z. Richard Cybulski, Costas Ioannides and Michael Hall
      Drug Metabolism and Disposition January 2012, 40 (1) 70-75; DOI: https://doi.org/10.1124/dmd.111.041566
  9. Cybulski, Z. Richard

    1. You have access
      Debrisoquine Metabolism and CYP2D Expression in Marmoset Liver Microsomes
      Brian R. Cooke, S. W. Annie Bligh, Z. Richard Cybulski, Costas Ioannides and Michael Hall
      Drug Metabolism and Disposition January 2012, 40 (1) 70-75; DOI: https://doi.org/10.1124/dmd.111.041566

D

  1. Dawson, Sarah

    1. You have access
      In Vitro Inhibition of the Bile Salt Export Pump Correlates with Risk of Cholestatic Drug-Induced Liver Injury in Humans
      Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber and J. Gerald Kenna
      Drug Metabolism and Disposition January 2012, 40 (1) 130-138; DOI: https://doi.org/10.1124/dmd.111.040758
  2. Desbans, Coraline

    1. You have access
      Bupropion Hydroxylation as a Selective Marker of Rat CYP2B1 Catalytic Activity
      Dumrongsak Pekthong, Coraline Desbans, Hélène Martin and Lysiane Richert
      Drug Metabolism and Disposition January 2012, 40 (1) 32-38; DOI: https://doi.org/10.1124/dmd.111.041368
  3. Dinh, Jean C.

    1. You have access
      Potential Contribution of Cytochrome P450 2B6 to Hepatic 4-Hydroxycyclophosphamide Formation In Vitro and In Vivo
      Brianne S. Raccor, Adam J. Claessens, Jean C. Dinh, Julie R. Park, Douglas S. Hawkins, Sushma S. Thomas, Karen W. Makar, Jeannine S. McCune and Rheem A. Totah
      Drug Metabolism and Disposition January 2012, 40 (1) 54-63; DOI: https://doi.org/10.1124/dmd.111.039347
  4. Djebli, Nassim

    1. You have access
      Effects of Omeprazole and Genetic Polymorphism of CYP2C19 on the Clopidogrel Active Metabolite
      Xavier Boulenc, Nassim Djebli, Juan Shi, Laurent Perrin, William Brian, Robert Van Horn and Fabrice Hurbin
      Drug Metabolism and Disposition January 2012, 40 (1) 187-197; DOI: https://doi.org/10.1124/dmd.111.040394
  5. Doll, Mark A.

    1. You have access
      Phenotype of the Most Common “Slow Acetylator” Arylamine N-Acetyltransferase 1 Genetic Variant (NAT1*14B) Is Substrate-Dependent
      Lori M. Millner, Mark A. Doll, Jian Cai, J. Christopher States and David W. Hein
      Drug Metabolism and Disposition January 2012, 40 (1) 198-204; DOI: https://doi.org/10.1124/dmd.111.041855

E

  1. Ebner, Thomas

    1. You have access
      Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities
      Sumio Ohtsuki, Olaf Schaefer, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Naoki Ishiguro, Wataru Kishimoto, Eva Ludwig-Schwellinger, Thomas Ebner and Tetsuya Terasaki
      Drug Metabolism and Disposition January 2012, 40 (1) 83-92; DOI: https://doi.org/10.1124/dmd.111.042259
    2. You have access
      Absolute Quantification and Differential Expression of Drug Transporters, Cytochrome P450 Enzymes, and UDP-Glucuronosyltransferases in Cultured Primary Human Hepatocytes
      Olaf Schaefer, Sumio Ohtsuki, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Atsushi Sakamoto, Naoki Ishiguro, Takehisa Matsumaru, Tetsuya Terasaki and Thomas Ebner
      Drug Metabolism and Disposition January 2012, 40 (1) 93-103; DOI: https://doi.org/10.1124/dmd.111.042275
  2. Ellison, Corie A.

    1. You have access
      Human Hepatic Cytochrome P450-Specific Metabolism of the Organophosphorus Pesticides Methyl Parathion and Diazinon
      Corie A. Ellison, Yuan Tian, James B. Knaak, Paul J. Kostyniak and James R. Olson
      Drug Metabolism and Disposition January 2012, 40 (1) 1-5; DOI: https://doi.org/10.1124/dmd.111.042572

F

  1. Felmlee, Melanie A.

    1. You have access
      γ-Hydroxybutyrate Blood/Plasma Partitioning: Effect of Physiologic pH on Transport by Monocarboxylate Transporters
      Bridget L. Morse, Melanie A. Felmlee and Marilyn E. Morris
      Drug Metabolism and Disposition January 2012, 40 (1) 64-69; DOI: https://doi.org/10.1124/dmd.111.041285
    2. You have access
      Brain Uptake of the Drug of Abuse γ-Hydroxybutyric Acid in Rats
      Samuel A. Roiko, Melanie A. Felmlee and Marilyn E. Morris
      Drug Metabolism and Disposition January 2012, 40 (1) 212-218; DOI: https://doi.org/10.1124/dmd.111.041749
  2. Foti, Robert S.

    1. You have access
      Prediction of CYP2D6 Drug Interactions from In Vitro Data: Evidence for Substrate-Dependent Inhibition
      Brooke M. VandenBrink, Robert S. Foti, Dan A. Rock, Larry C. Wienkers and Jan L. Wahlstrom
      Drug Metabolism and Disposition January 2012, 40 (1) 47-53; DOI: https://doi.org/10.1124/dmd.111.041210
  3. Franze, B.

    1. You have access
      In Vitro Glucuronidation of the Antibacterial Triclocarban and Its Oxidative Metabolites
      N. H. Schebb, B. Franze, R. Maul, A. Ranganathan and B. D. Hammock
      Drug Metabolism and Disposition January 2012, 40 (1) 25-31; DOI: https://doi.org/10.1124/dmd.111.042283
  4. Fujiyama, Yoichi

    1. You have access
      Acetaminophen-Induced Hepatotoxicity in a Liver Tissue Model Consisting of Primary Hepatocytes Assembling around an Endothelial Cell Network
      Yu Toyoda, Miho Tamai, Kasumi Kashikura, Shunsuke Kobayashi, Yoichi Fujiyama, Tomoyoshi Soga and Yoh-ichi Tagawa
      Drug Metabolism and Disposition January 2012, 40 (1) 169-177; DOI: https://doi.org/10.1124/dmd.111.041137

G

  1. Gan, Jinping

    1. You have access
      Identification of the Oxidative and Conjugative Enzymes Involved in the Biotransformation of Brivanib
      Jiachang Gong, Jinping Gan and Ramaswamy A. Iyer
      Drug Metabolism and Disposition January 2012, 40 (1) 219-226; DOI: https://doi.org/10.1124/dmd.111.042457
  2. Generaux, Claudia N.

    1. You have access
      A Semiphysiologically Based Pharmacokinetic Modeling Approach to Predict the Dose-Exposure Relationship of an Antiparasitic Prodrug/Active Metabolite Pair
      Grace Zhixia Yan, Claudia N. Generaux, Miyoung Yoon, Rachel B. Goldsmith, Richard R. Tidwell, James E. Hall, Carol A. Olson, Harvey J. Clewell, Kim L. R. Brouwer and Mary F. Paine
      Drug Metabolism and Disposition January 2012, 40 (1) 6-17; DOI: https://doi.org/10.1124/dmd.111.040063
  3. Goldsmith, Rachel B.

    1. You have access
      A Semiphysiologically Based Pharmacokinetic Modeling Approach to Predict the Dose-Exposure Relationship of an Antiparasitic Prodrug/Active Metabolite Pair
      Grace Zhixia Yan, Claudia N. Generaux, Miyoung Yoon, Rachel B. Goldsmith, Richard R. Tidwell, James E. Hall, Carol A. Olson, Harvey J. Clewell, Kim L. R. Brouwer and Mary F. Paine
      Drug Metabolism and Disposition January 2012, 40 (1) 6-17; DOI: https://doi.org/10.1124/dmd.111.040063
  4. Gong, Jiachang

    1. You have access
      Identification of the Oxidative and Conjugative Enzymes Involved in the Biotransformation of Brivanib
      Jiachang Gong, Jinping Gan and Ramaswamy A. Iyer
      Drug Metabolism and Disposition January 2012, 40 (1) 219-226; DOI: https://doi.org/10.1124/dmd.111.042457
  5. Guillouzo, André

    1. You have access
      Interindividual Variability in Gene Expression Profiles in Human Hepatocytes and Comparison with HepaRG Cells
      Alexandra Rogue, Carine Lambert, Catherine Spire, Nancy Claude and André Guillouzo
      Drug Metabolism and Disposition January 2012, 40 (1) 151-158; DOI: https://doi.org/10.1124/dmd.111.042028

H

  1. Hall, James E.

    1. You have access
      A Semiphysiologically Based Pharmacokinetic Modeling Approach to Predict the Dose-Exposure Relationship of an Antiparasitic Prodrug/Active Metabolite Pair
      Grace Zhixia Yan, Claudia N. Generaux, Miyoung Yoon, Rachel B. Goldsmith, Richard R. Tidwell, James E. Hall, Carol A. Olson, Harvey J. Clewell, Kim L. R. Brouwer and Mary F. Paine
      Drug Metabolism and Disposition January 2012, 40 (1) 6-17; DOI: https://doi.org/10.1124/dmd.111.040063
  2. Hall, Michael

    1. You have access
      Debrisoquine Metabolism and CYP2D Expression in Marmoset Liver Microsomes
      Brian R. Cooke, S. W. Annie Bligh, Z. Richard Cybulski, Costas Ioannides and Michael Hall
      Drug Metabolism and Disposition January 2012, 40 (1) 70-75; DOI: https://doi.org/10.1124/dmd.111.041566
  3. Hallifax, David

    1. You have access
      Comparison of Cryopreserved HepaRG Cells with Cryopreserved Human Hepatocytes for Prediction of Clearance for 26 Drugs
      Ugo Zanelli, Nicola Pasquale Caradonna, David Hallifax, Elisa Turlizzi and J. Brian Houston
      Drug Metabolism and Disposition January 2012, 40 (1) 104-110; DOI: https://doi.org/10.1124/dmd.111.042309
  4. Hammock, B. D.

    1. You have access
      In Vitro Glucuronidation of the Antibacterial Triclocarban and Its Oxidative Metabolites
      N. H. Schebb, B. Franze, R. Maul, A. Ranganathan and B. D. Hammock
      Drug Metabolism and Disposition January 2012, 40 (1) 25-31; DOI: https://doi.org/10.1124/dmd.111.042283
  5. Harmandayan, Maria

    1. You have access
      Frequency of Undetected CYP2D6 Hybrid Genes in Clinical Samples: Impact on Phenotype Prediction
      John Logan Black, Denise L. Walker, Dennis J. O'Kane and Maria Harmandayan
      Drug Metabolism and Disposition January 2012, 40 (1) 111-119; DOI: https://doi.org/10.1124/dmd.111.040832
  6. Hawkins, Douglas S.

    1. You have access
      Potential Contribution of Cytochrome P450 2B6 to Hepatic 4-Hydroxycyclophosphamide Formation In Vitro and In Vivo
      Brianne S. Raccor, Adam J. Claessens, Jean C. Dinh, Julie R. Park, Douglas S. Hawkins, Sushma S. Thomas, Karen W. Makar, Jeannine S. McCune and Rheem A. Totah
      Drug Metabolism and Disposition January 2012, 40 (1) 54-63; DOI: https://doi.org/10.1124/dmd.111.039347
  7. Hein, David W.

    1. You have access
      Phenotype of the Most Common “Slow Acetylator” Arylamine N-Acetyltransferase 1 Genetic Variant (NAT1*14B) Is Substrate-Dependent
      Lori M. Millner, Mark A. Doll, Jian Cai, J. Christopher States and David W. Hein
      Drug Metabolism and Disposition January 2012, 40 (1) 198-204; DOI: https://doi.org/10.1124/dmd.111.041855
  8. Houston, J. Brian

    1. You have access
      Comparison of Cryopreserved HepaRG Cells with Cryopreserved Human Hepatocytes for Prediction of Clearance for 26 Drugs
      Ugo Zanelli, Nicola Pasquale Caradonna, David Hallifax, Elisa Turlizzi and J. Brian Houston
      Drug Metabolism and Disposition January 2012, 40 (1) 104-110; DOI: https://doi.org/10.1124/dmd.111.042309
  9. Hurbin, Fabrice

    1. You have access
      Effects of Omeprazole and Genetic Polymorphism of CYP2C19 on the Clopidogrel Active Metabolite
      Xavier Boulenc, Nassim Djebli, Juan Shi, Laurent Perrin, William Brian, Robert Van Horn and Fabrice Hurbin
      Drug Metabolism and Disposition January 2012, 40 (1) 187-197; DOI: https://doi.org/10.1124/dmd.111.040394

I

  1. Inoue, Tae

    1. You have access
      Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities
      Sumio Ohtsuki, Olaf Schaefer, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Naoki Ishiguro, Wataru Kishimoto, Eva Ludwig-Schwellinger, Thomas Ebner and Tetsuya Terasaki
      Drug Metabolism and Disposition January 2012, 40 (1) 83-92; DOI: https://doi.org/10.1124/dmd.111.042259
    2. You have access
      Absolute Quantification and Differential Expression of Drug Transporters, Cytochrome P450 Enzymes, and UDP-Glucuronosyltransferases in Cultured Primary Human Hepatocytes
      Olaf Schaefer, Sumio Ohtsuki, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Atsushi Sakamoto, Naoki Ishiguro, Takehisa Matsumaru, Tetsuya Terasaki and Thomas Ebner
      Drug Metabolism and Disposition January 2012, 40 (1) 93-103; DOI: https://doi.org/10.1124/dmd.111.042275
  2. Ioannides, Costas

    1. You have access
      Debrisoquine Metabolism and CYP2D Expression in Marmoset Liver Microsomes
      Brian R. Cooke, S. W. Annie Bligh, Z. Richard Cybulski, Costas Ioannides and Michael Hall
      Drug Metabolism and Disposition January 2012, 40 (1) 70-75; DOI: https://doi.org/10.1124/dmd.111.041566
  3. Ishiguro, Naoki

    1. You have access
      Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities
      Sumio Ohtsuki, Olaf Schaefer, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Naoki Ishiguro, Wataru Kishimoto, Eva Ludwig-Schwellinger, Thomas Ebner and Tetsuya Terasaki
      Drug Metabolism and Disposition January 2012, 40 (1) 83-92; DOI: https://doi.org/10.1124/dmd.111.042259
    2. You have access
      Absolute Quantification and Differential Expression of Drug Transporters, Cytochrome P450 Enzymes, and UDP-Glucuronosyltransferases in Cultured Primary Human Hepatocytes
      Olaf Schaefer, Sumio Ohtsuki, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Atsushi Sakamoto, Naoki Ishiguro, Takehisa Matsumaru, Tetsuya Terasaki and Thomas Ebner
      Drug Metabolism and Disposition January 2012, 40 (1) 93-103; DOI: https://doi.org/10.1124/dmd.111.042275
  4. Isoherranen, Nina

    1. You have access
      Prediction of Relative In Vivo Metabolite Exposure from In Vitro Data Using Two Model Drugs: Dextromethorphan and Omeprazole
      Justin D. Lutz and Nina Isoherranen
      Drug Metabolism and Disposition January 2012, 40 (1) 159-168; DOI: https://doi.org/10.1124/dmd.111.042200
  5. Iyer, Ramaswamy A.

    1. You have access
      Identification of the Oxidative and Conjugative Enzymes Involved in the Biotransformation of Brivanib
      Jiachang Gong, Jinping Gan and Ramaswamy A. Iyer
      Drug Metabolism and Disposition January 2012, 40 (1) 219-226; DOI: https://doi.org/10.1124/dmd.111.042457

K

  1. Kashikura, Kasumi

    1. You have access
      Acetaminophen-Induced Hepatotoxicity in a Liver Tissue Model Consisting of Primary Hepatocytes Assembling around an Endothelial Cell Network
      Yu Toyoda, Miho Tamai, Kasumi Kashikura, Shunsuke Kobayashi, Yoichi Fujiyama, Tomoyoshi Soga and Yoh-ichi Tagawa
      Drug Metabolism and Disposition January 2012, 40 (1) 169-177; DOI: https://doi.org/10.1124/dmd.111.041137
  2. Kawakami, Hirotaka

    1. You have access
      Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities
      Sumio Ohtsuki, Olaf Schaefer, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Naoki Ishiguro, Wataru Kishimoto, Eva Ludwig-Schwellinger, Thomas Ebner and Tetsuya Terasaki
      Drug Metabolism and Disposition January 2012, 40 (1) 83-92; DOI: https://doi.org/10.1124/dmd.111.042259
    2. You have access
      Absolute Quantification and Differential Expression of Drug Transporters, Cytochrome P450 Enzymes, and UDP-Glucuronosyltransferases in Cultured Primary Human Hepatocytes
      Olaf Schaefer, Sumio Ohtsuki, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Atsushi Sakamoto, Naoki Ishiguro, Takehisa Matsumaru, Tetsuya Terasaki and Thomas Ebner
      Drug Metabolism and Disposition January 2012, 40 (1) 93-103; DOI: https://doi.org/10.1124/dmd.111.042275
  3. Kenna, J. Gerald

    1. You have access
      In Vitro Inhibition of the Bile Salt Export Pump Correlates with Risk of Cholestatic Drug-Induced Liver Injury in Humans
      Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber and J. Gerald Kenna
      Drug Metabolism and Disposition January 2012, 40 (1) 130-138; DOI: https://doi.org/10.1124/dmd.111.040758
  4. Kishimoto, Wataru

    1. You have access
      Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities
      Sumio Ohtsuki, Olaf Schaefer, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Naoki Ishiguro, Wataru Kishimoto, Eva Ludwig-Schwellinger, Thomas Ebner and Tetsuya Terasaki
      Drug Metabolism and Disposition January 2012, 40 (1) 83-92; DOI: https://doi.org/10.1124/dmd.111.042259
  5. Knaak, James B.

    1. You have access
      Human Hepatic Cytochrome P450-Specific Metabolism of the Organophosphorus Pesticides Methyl Parathion and Diazinon
      Corie A. Ellison, Yuan Tian, James B. Knaak, Paul J. Kostyniak and James R. Olson
      Drug Metabolism and Disposition January 2012, 40 (1) 1-5; DOI: https://doi.org/10.1124/dmd.111.042572
  6. Kobayashi, Shunsuke

    1. You have access
      Acetaminophen-Induced Hepatotoxicity in a Liver Tissue Model Consisting of Primary Hepatocytes Assembling around an Endothelial Cell Network
      Yu Toyoda, Miho Tamai, Kasumi Kashikura, Shunsuke Kobayashi, Yoichi Fujiyama, Tomoyoshi Soga and Yoh-ichi Tagawa
      Drug Metabolism and Disposition January 2012, 40 (1) 169-177; DOI: https://doi.org/10.1124/dmd.111.041137
  7. Koch, Kevin

    1. You have access
      Human Metabolism of Lapatinib, a Dual Kinase Inhibitor: Implications for Hepatotoxicity
      Stephen Castellino, Michael O'Mara, Kevin Koch, David J. Borts, Gary D. Bowers and Christopher MacLauchlin
      Drug Metabolism and Disposition January 2012, 40 (1) 139-150; DOI: https://doi.org/10.1124/dmd.111.040949
  8. Kostyniak, Paul J.

    1. You have access
      Human Hepatic Cytochrome P450-Specific Metabolism of the Organophosphorus Pesticides Methyl Parathion and Diazinon
      Corie A. Ellison, Yuan Tian, James B. Knaak, Paul J. Kostyniak and James R. Olson
      Drug Metabolism and Disposition January 2012, 40 (1) 1-5; DOI: https://doi.org/10.1124/dmd.111.042572
  9. Kwok, Hoi Hin

    1. You have access
      Cytoprotective Effect of 20(S)-Rg3 on Benzo[a]pyrene-Induced DNA Damage
      Po Ying Poon, Hoi Hin Kwok, Patrick Y. K. Yue, Mildred S. M. Yang, Nai Ki Mak, Chris K. C. Wong and Ricky N. S. Wong
      Drug Metabolism and Disposition January 2012, 40 (1) 120-129; DOI: https://doi.org/10.1124/dmd.111.039503

L

  1. Lambert, Carine

    1. You have access
      Interindividual Variability in Gene Expression Profiles in Human Hepatocytes and Comparison with HepaRG Cells
      Alexandra Rogue, Carine Lambert, Catherine Spire, Nancy Claude and André Guillouzo
      Drug Metabolism and Disposition January 2012, 40 (1) 151-158; DOI: https://doi.org/10.1124/dmd.111.042028
  2. Lau, Aik Jiang

    1. You have access
      Species-Dependent and Receptor-Selective Action of Bilobalide on the Function of Constitutive Androstane Receptor and Pregnane X Receptor
      Aik Jiang Lau, Guixiang Yang, Ganesh Rajaraman, Christie C. Baucom and Thomas K. H. Chang
      Drug Metabolism and Disposition January 2012, 40 (1) 178-186; DOI: https://doi.org/10.1124/dmd.111.042879
  3. Laurin, Louis-Philippe

    1. You have access
      Effects of Chronic Renal Failure on Brain Drug Transporters in Rats
      Judith Naud, Louis-Philippe Laurin, Josée Michaud, Stéphanie Beauchemin, Francois A. Leblond and Vincent Pichette
      Drug Metabolism and Disposition January 2012, 40 (1) 39-46; DOI: https://doi.org/10.1124/dmd.111.041145
  4. Leblond, Francois A.

    1. You have access
      Effects of Chronic Renal Failure on Brain Drug Transporters in Rats
      Judith Naud, Louis-Philippe Laurin, Josée Michaud, Stéphanie Beauchemin, Francois A. Leblond and Vincent Pichette
      Drug Metabolism and Disposition January 2012, 40 (1) 39-46; DOI: https://doi.org/10.1124/dmd.111.041145
  5. Li, Feng

    1. You have access
      CPY3A4-Mediated Lopinavir Bioactivation and Its Inhibition by Ritonavir
      Feng Li, Jie Lu and Xiaochao Ma
      Drug Metabolism and Disposition January 2012, 40 (1) 18-24; DOI: https://doi.org/10.1124/dmd.111.041400
  6. Liehner, Stephanie

    1. You have access
      Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities
      Sumio Ohtsuki, Olaf Schaefer, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Naoki Ishiguro, Wataru Kishimoto, Eva Ludwig-Schwellinger, Thomas Ebner and Tetsuya Terasaki
      Drug Metabolism and Disposition January 2012, 40 (1) 83-92; DOI: https://doi.org/10.1124/dmd.111.042259
    2. You have access
      Absolute Quantification and Differential Expression of Drug Transporters, Cytochrome P450 Enzymes, and UDP-Glucuronosyltransferases in Cultured Primary Human Hepatocytes
      Olaf Schaefer, Sumio Ohtsuki, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Atsushi Sakamoto, Naoki Ishiguro, Takehisa Matsumaru, Tetsuya Terasaki and Thomas Ebner
      Drug Metabolism and Disposition January 2012, 40 (1) 93-103; DOI: https://doi.org/10.1124/dmd.111.042275
  7. Lu, Jie

    1. You have access
      CPY3A4-Mediated Lopinavir Bioactivation and Its Inhibition by Ritonavir
      Feng Li, Jie Lu and Xiaochao Ma
      Drug Metabolism and Disposition January 2012, 40 (1) 18-24; DOI: https://doi.org/10.1124/dmd.111.041400
  8. Ludwig-Schwellinger, Eva

    1. You have access
      Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities
      Sumio Ohtsuki, Olaf Schaefer, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Naoki Ishiguro, Wataru Kishimoto, Eva Ludwig-Schwellinger, Thomas Ebner and Tetsuya Terasaki
      Drug Metabolism and Disposition January 2012, 40 (1) 83-92; DOI: https://doi.org/10.1124/dmd.111.042259
  9. Lutz, Justin D.

    1. You have access
      Prediction of Relative In Vivo Metabolite Exposure from In Vitro Data Using Two Model Drugs: Dextromethorphan and Omeprazole
      Justin D. Lutz and Nina Isoherranen
      Drug Metabolism and Disposition January 2012, 40 (1) 159-168; DOI: https://doi.org/10.1124/dmd.111.042200

M

  1. Ma, Xiaochao

    1. You have access
      CPY3A4-Mediated Lopinavir Bioactivation and Its Inhibition by Ritonavir
      Feng Li, Jie Lu and Xiaochao Ma
      Drug Metabolism and Disposition January 2012, 40 (1) 18-24; DOI: https://doi.org/10.1124/dmd.111.041400
  2. MacLauchlin, Christopher

    1. You have access
      Human Metabolism of Lapatinib, a Dual Kinase Inhibitor: Implications for Hepatotoxicity
      Stephen Castellino, Michael O'Mara, Kevin Koch, David J. Borts, Gary D. Bowers and Christopher MacLauchlin
      Drug Metabolism and Disposition January 2012, 40 (1) 139-150; DOI: https://doi.org/10.1124/dmd.111.040949
  3. Mak, Nai Ki

    1. You have access
      Cytoprotective Effect of 20(S)-Rg3 on Benzo[a]pyrene-Induced DNA Damage
      Po Ying Poon, Hoi Hin Kwok, Patrick Y. K. Yue, Mildred S. M. Yang, Nai Ki Mak, Chris K. C. Wong and Ricky N. S. Wong
      Drug Metabolism and Disposition January 2012, 40 (1) 120-129; DOI: https://doi.org/10.1124/dmd.111.039503
  4. Makar, Karen W.

    1. You have access
      Potential Contribution of Cytochrome P450 2B6 to Hepatic 4-Hydroxycyclophosphamide Formation In Vitro and In Vivo
      Brianne S. Raccor, Adam J. Claessens, Jean C. Dinh, Julie R. Park, Douglas S. Hawkins, Sushma S. Thomas, Karen W. Makar, Jeannine S. McCune and Rheem A. Totah
      Drug Metabolism and Disposition January 2012, 40 (1) 54-63; DOI: https://doi.org/10.1124/dmd.111.039347
  5. Martin, Hélène

    1. You have access
      Bupropion Hydroxylation as a Selective Marker of Rat CYP2B1 Catalytic Activity
      Dumrongsak Pekthong, Coraline Desbans, Hélène Martin and Lysiane Richert
      Drug Metabolism and Disposition January 2012, 40 (1) 32-38; DOI: https://doi.org/10.1124/dmd.111.041368
  6. Matsumaru, Takehisa

    1. You have access
      Absolute Quantification and Differential Expression of Drug Transporters, Cytochrome P450 Enzymes, and UDP-Glucuronosyltransferases in Cultured Primary Human Hepatocytes
      Olaf Schaefer, Sumio Ohtsuki, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Atsushi Sakamoto, Naoki Ishiguro, Takehisa Matsumaru, Tetsuya Terasaki and Thomas Ebner
      Drug Metabolism and Disposition January 2012, 40 (1) 93-103; DOI: https://doi.org/10.1124/dmd.111.042275
  7. Maul, R.

    1. You have access
      In Vitro Glucuronidation of the Antibacterial Triclocarban and Its Oxidative Metabolites
      N. H. Schebb, B. Franze, R. Maul, A. Ranganathan and B. D. Hammock
      Drug Metabolism and Disposition January 2012, 40 (1) 25-31; DOI: https://doi.org/10.1124/dmd.111.042283
  8. McCune, Jeannine S.

    1. You have access
      Potential Contribution of Cytochrome P450 2B6 to Hepatic 4-Hydroxycyclophosphamide Formation In Vitro and In Vivo
      Brianne S. Raccor, Adam J. Claessens, Jean C. Dinh, Julie R. Park, Douglas S. Hawkins, Sushma S. Thomas, Karen W. Makar, Jeannine S. McCune and Rheem A. Totah
      Drug Metabolism and Disposition January 2012, 40 (1) 54-63; DOI: https://doi.org/10.1124/dmd.111.039347
  9. Michaud, Josée

    1. You have access
      Effects of Chronic Renal Failure on Brain Drug Transporters in Rats
      Judith Naud, Louis-Philippe Laurin, Josée Michaud, Stéphanie Beauchemin, Francois A. Leblond and Vincent Pichette
      Drug Metabolism and Disposition January 2012, 40 (1) 39-46; DOI: https://doi.org/10.1124/dmd.111.041145
  10. Millner, Lori M.

    1. You have access
      Phenotype of the Most Common “Slow Acetylator” Arylamine N-Acetyltransferase 1 Genetic Variant (NAT1*14B) Is Substrate-Dependent
      Lori M. Millner, Mark A. Doll, Jian Cai, J. Christopher States and David W. Hein
      Drug Metabolism and Disposition January 2012, 40 (1) 198-204; DOI: https://doi.org/10.1124/dmd.111.041855
  11. Morris, Marilyn E.

    1. You have access
      γ-Hydroxybutyrate Blood/Plasma Partitioning: Effect of Physiologic pH on Transport by Monocarboxylate Transporters
      Bridget L. Morse, Melanie A. Felmlee and Marilyn E. Morris
      Drug Metabolism and Disposition January 2012, 40 (1) 64-69; DOI: https://doi.org/10.1124/dmd.111.041285
    2. You have access
      Brain Uptake of the Drug of Abuse γ-Hydroxybutyric Acid in Rats
      Samuel A. Roiko, Melanie A. Felmlee and Marilyn E. Morris
      Drug Metabolism and Disposition January 2012, 40 (1) 212-218; DOI: https://doi.org/10.1124/dmd.111.041749
  12. Morse, Bridget L.

    1. You have access
      γ-Hydroxybutyrate Blood/Plasma Partitioning: Effect of Physiologic pH on Transport by Monocarboxylate Transporters
      Bridget L. Morse, Melanie A. Felmlee and Marilyn E. Morris
      Drug Metabolism and Disposition January 2012, 40 (1) 64-69; DOI: https://doi.org/10.1124/dmd.111.041285
  13. Murai, Hidetsugu

    1. You have access
      Prediction of Human Metabolism of FK3453 by Aldehyde Oxidase Using Chimeric Mice Transplanted with Human or Rat Hepatocytes
      Seigo Sanoh, Kazuyoshi Nozaki, Hidetsugu Murai, Shigeyuki Terashita, Toshio Teramura and Shigeru Ohta
      Drug Metabolism and Disposition January 2012, 40 (1) 76-82; DOI: https://doi.org/10.1124/dmd.111.041954

N

  1. Naud, Judith

    1. You have access
      Effects of Chronic Renal Failure on Brain Drug Transporters in Rats
      Judith Naud, Louis-Philippe Laurin, Josée Michaud, Stéphanie Beauchemin, Francois A. Leblond and Vincent Pichette
      Drug Metabolism and Disposition January 2012, 40 (1) 39-46; DOI: https://doi.org/10.1124/dmd.111.041145
  2. Nozaki, Kazuyoshi

    1. You have access
      Prediction of Human Metabolism of FK3453 by Aldehyde Oxidase Using Chimeric Mice Transplanted with Human or Rat Hepatocytes
      Seigo Sanoh, Kazuyoshi Nozaki, Hidetsugu Murai, Shigeyuki Terashita, Toshio Teramura and Shigeru Ohta
      Drug Metabolism and Disposition January 2012, 40 (1) 76-82; DOI: https://doi.org/10.1124/dmd.111.041954

O

  1. O'Kane, Dennis J.

    1. You have access
      Frequency of Undetected CYP2D6 Hybrid Genes in Clinical Samples: Impact on Phenotype Prediction
      John Logan Black, Denise L. Walker, Dennis J. O'Kane and Maria Harmandayan
      Drug Metabolism and Disposition January 2012, 40 (1) 111-119; DOI: https://doi.org/10.1124/dmd.111.040832
  2. O'Mara, Michael

    1. You have access
      Human Metabolism of Lapatinib, a Dual Kinase Inhibitor: Implications for Hepatotoxicity
      Stephen Castellino, Michael O'Mara, Kevin Koch, David J. Borts, Gary D. Bowers and Christopher MacLauchlin
      Drug Metabolism and Disposition January 2012, 40 (1) 139-150; DOI: https://doi.org/10.1124/dmd.111.040949
  3. Ohta, Shigeru

    1. You have access
      Prediction of Human Metabolism of FK3453 by Aldehyde Oxidase Using Chimeric Mice Transplanted with Human or Rat Hepatocytes
      Seigo Sanoh, Kazuyoshi Nozaki, Hidetsugu Murai, Shigeyuki Terashita, Toshio Teramura and Shigeru Ohta
      Drug Metabolism and Disposition January 2012, 40 (1) 76-82; DOI: https://doi.org/10.1124/dmd.111.041954
  4. Ohtsuki, Sumio

    1. You have access
      Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities
      Sumio Ohtsuki, Olaf Schaefer, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Naoki Ishiguro, Wataru Kishimoto, Eva Ludwig-Schwellinger, Thomas Ebner and Tetsuya Terasaki
      Drug Metabolism and Disposition January 2012, 40 (1) 83-92; DOI: https://doi.org/10.1124/dmd.111.042259
    2. You have access
      Absolute Quantification and Differential Expression of Drug Transporters, Cytochrome P450 Enzymes, and UDP-Glucuronosyltransferases in Cultured Primary Human Hepatocytes
      Olaf Schaefer, Sumio Ohtsuki, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Atsushi Sakamoto, Naoki Ishiguro, Takehisa Matsumaru, Tetsuya Terasaki and Thomas Ebner
      Drug Metabolism and Disposition January 2012, 40 (1) 93-103; DOI: https://doi.org/10.1124/dmd.111.042275
  5. Olson, Carol A.

    1. You have access
      A Semiphysiologically Based Pharmacokinetic Modeling Approach to Predict the Dose-Exposure Relationship of an Antiparasitic Prodrug/Active Metabolite Pair
      Grace Zhixia Yan, Claudia N. Generaux, Miyoung Yoon, Rachel B. Goldsmith, Richard R. Tidwell, James E. Hall, Carol A. Olson, Harvey J. Clewell, Kim L. R. Brouwer and Mary F. Paine
      Drug Metabolism and Disposition January 2012, 40 (1) 6-17; DOI: https://doi.org/10.1124/dmd.111.040063
  6. Olson, James R.

    1. You have access
      Human Hepatic Cytochrome P450-Specific Metabolism of the Organophosphorus Pesticides Methyl Parathion and Diazinon
      Corie A. Ellison, Yuan Tian, James B. Knaak, Paul J. Kostyniak and James R. Olson
      Drug Metabolism and Disposition January 2012, 40 (1) 1-5; DOI: https://doi.org/10.1124/dmd.111.042572

P

  1. Paine, Mary F.

    1. You have access
      A Semiphysiologically Based Pharmacokinetic Modeling Approach to Predict the Dose-Exposure Relationship of an Antiparasitic Prodrug/Active Metabolite Pair
      Grace Zhixia Yan, Claudia N. Generaux, Miyoung Yoon, Rachel B. Goldsmith, Richard R. Tidwell, James E. Hall, Carol A. Olson, Harvey J. Clewell, Kim L. R. Brouwer and Mary F. Paine
      Drug Metabolism and Disposition January 2012, 40 (1) 6-17; DOI: https://doi.org/10.1124/dmd.111.040063
  2. Park, Julie R.

    1. You have access
      Potential Contribution of Cytochrome P450 2B6 to Hepatic 4-Hydroxycyclophosphamide Formation In Vitro and In Vivo
      Brianne S. Raccor, Adam J. Claessens, Jean C. Dinh, Julie R. Park, Douglas S. Hawkins, Sushma S. Thomas, Karen W. Makar, Jeannine S. McCune and Rheem A. Totah
      Drug Metabolism and Disposition January 2012, 40 (1) 54-63; DOI: https://doi.org/10.1124/dmd.111.039347
  3. Paul, Nikki

    1. You have access
      In Vitro Inhibition of the Bile Salt Export Pump Correlates with Risk of Cholestatic Drug-Induced Liver Injury in Humans
      Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber and J. Gerald Kenna
      Drug Metabolism and Disposition January 2012, 40 (1) 130-138; DOI: https://doi.org/10.1124/dmd.111.040758
  4. Pekthong, Dumrongsak

    1. You have access
      Bupropion Hydroxylation as a Selective Marker of Rat CYP2B1 Catalytic Activity
      Dumrongsak Pekthong, Coraline Desbans, Hélène Martin and Lysiane Richert
      Drug Metabolism and Disposition January 2012, 40 (1) 32-38; DOI: https://doi.org/10.1124/dmd.111.041368
  5. Perrin, Laurent

    1. You have access
      Effects of Omeprazole and Genetic Polymorphism of CYP2C19 on the Clopidogrel Active Metabolite
      Xavier Boulenc, Nassim Djebli, Juan Shi, Laurent Perrin, William Brian, Robert Van Horn and Fabrice Hurbin
      Drug Metabolism and Disposition January 2012, 40 (1) 187-197; DOI: https://doi.org/10.1124/dmd.111.040394
  6. Pichette, Vincent

    1. You have access
      Effects of Chronic Renal Failure on Brain Drug Transporters in Rats
      Judith Naud, Louis-Philippe Laurin, Josée Michaud, Stéphanie Beauchemin, Francois A. Leblond and Vincent Pichette
      Drug Metabolism and Disposition January 2012, 40 (1) 39-46; DOI: https://doi.org/10.1124/dmd.111.041145
  7. Poon, Po Ying

    1. You have access
      Cytoprotective Effect of 20(S)-Rg3 on Benzo[a]pyrene-Induced DNA Damage
      Po Ying Poon, Hoi Hin Kwok, Patrick Y. K. Yue, Mildred S. M. Yang, Nai Ki Mak, Chris K. C. Wong and Ricky N. S. Wong
      Drug Metabolism and Disposition January 2012, 40 (1) 120-129; DOI: https://doi.org/10.1124/dmd.111.039503

R

  1. Raccor, Brianne S.

    1. You have access
      Potential Contribution of Cytochrome P450 2B6 to Hepatic 4-Hydroxycyclophosphamide Formation In Vitro and In Vivo
      Brianne S. Raccor, Adam J. Claessens, Jean C. Dinh, Julie R. Park, Douglas S. Hawkins, Sushma S. Thomas, Karen W. Makar, Jeannine S. McCune and Rheem A. Totah
      Drug Metabolism and Disposition January 2012, 40 (1) 54-63; DOI: https://doi.org/10.1124/dmd.111.039347
  2. Rajaraman, Ganesh

    1. You have access
      Species-Dependent and Receptor-Selective Action of Bilobalide on the Function of Constitutive Androstane Receptor and Pregnane X Receptor
      Aik Jiang Lau, Guixiang Yang, Ganesh Rajaraman, Christie C. Baucom and Thomas K. H. Chang
      Drug Metabolism and Disposition January 2012, 40 (1) 178-186; DOI: https://doi.org/10.1124/dmd.111.042879
  3. Ranganathan, A.

    1. You have access
      In Vitro Glucuronidation of the Antibacterial Triclocarban and Its Oxidative Metabolites
      N. H. Schebb, B. Franze, R. Maul, A. Ranganathan and B. D. Hammock
      Drug Metabolism and Disposition January 2012, 40 (1) 25-31; DOI: https://doi.org/10.1124/dmd.111.042283
  4. Richert, Lysiane

    1. You have access
      Bupropion Hydroxylation as a Selective Marker of Rat CYP2B1 Catalytic Activity
      Dumrongsak Pekthong, Coraline Desbans, Hélène Martin and Lysiane Richert
      Drug Metabolism and Disposition January 2012, 40 (1) 32-38; DOI: https://doi.org/10.1124/dmd.111.041368
  5. Rock, Dan A.

    1. You have access
      Prediction of CYP2D6 Drug Interactions from In Vitro Data: Evidence for Substrate-Dependent Inhibition
      Brooke M. VandenBrink, Robert S. Foti, Dan A. Rock, Larry C. Wienkers and Jan L. Wahlstrom
      Drug Metabolism and Disposition January 2012, 40 (1) 47-53; DOI: https://doi.org/10.1124/dmd.111.041210
  6. Rogue, Alexandra

    1. You have access
      Interindividual Variability in Gene Expression Profiles in Human Hepatocytes and Comparison with HepaRG Cells
      Alexandra Rogue, Carine Lambert, Catherine Spire, Nancy Claude and André Guillouzo
      Drug Metabolism and Disposition January 2012, 40 (1) 151-158; DOI: https://doi.org/10.1124/dmd.111.042028
  7. Roiko, Samuel A.

    1. You have access
      Brain Uptake of the Drug of Abuse γ-Hydroxybutyric Acid in Rats
      Samuel A. Roiko, Melanie A. Felmlee and Marilyn E. Morris
      Drug Metabolism and Disposition January 2012, 40 (1) 212-218; DOI: https://doi.org/10.1124/dmd.111.041749

S

  1. Saito, Asami

    1. You have access
      Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities
      Sumio Ohtsuki, Olaf Schaefer, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Naoki Ishiguro, Wataru Kishimoto, Eva Ludwig-Schwellinger, Thomas Ebner and Tetsuya Terasaki
      Drug Metabolism and Disposition January 2012, 40 (1) 83-92; DOI: https://doi.org/10.1124/dmd.111.042259
    2. You have access
      Absolute Quantification and Differential Expression of Drug Transporters, Cytochrome P450 Enzymes, and UDP-Glucuronosyltransferases in Cultured Primary Human Hepatocytes
      Olaf Schaefer, Sumio Ohtsuki, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Atsushi Sakamoto, Naoki Ishiguro, Takehisa Matsumaru, Tetsuya Terasaki and Thomas Ebner
      Drug Metabolism and Disposition January 2012, 40 (1) 93-103; DOI: https://doi.org/10.1124/dmd.111.042275
  2. Sakamoto, Atsushi

    1. You have access
      Absolute Quantification and Differential Expression of Drug Transporters, Cytochrome P450 Enzymes, and UDP-Glucuronosyltransferases in Cultured Primary Human Hepatocytes
      Olaf Schaefer, Sumio Ohtsuki, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Atsushi Sakamoto, Naoki Ishiguro, Takehisa Matsumaru, Tetsuya Terasaki and Thomas Ebner
      Drug Metabolism and Disposition January 2012, 40 (1) 93-103; DOI: https://doi.org/10.1124/dmd.111.042275
  3. Sanoh, Seigo

    1. You have access
      Prediction of Human Metabolism of FK3453 by Aldehyde Oxidase Using Chimeric Mice Transplanted with Human or Rat Hepatocytes
      Seigo Sanoh, Kazuyoshi Nozaki, Hidetsugu Murai, Shigeyuki Terashita, Toshio Teramura and Shigeru Ohta
      Drug Metabolism and Disposition January 2012, 40 (1) 76-82; DOI: https://doi.org/10.1124/dmd.111.041954
  4. Schaefer, Olaf

    1. You have access
      Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities
      Sumio Ohtsuki, Olaf Schaefer, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Naoki Ishiguro, Wataru Kishimoto, Eva Ludwig-Schwellinger, Thomas Ebner and Tetsuya Terasaki
      Drug Metabolism and Disposition January 2012, 40 (1) 83-92; DOI: https://doi.org/10.1124/dmd.111.042259
    2. You have access
      Absolute Quantification and Differential Expression of Drug Transporters, Cytochrome P450 Enzymes, and UDP-Glucuronosyltransferases in Cultured Primary Human Hepatocytes
      Olaf Schaefer, Sumio Ohtsuki, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Atsushi Sakamoto, Naoki Ishiguro, Takehisa Matsumaru, Tetsuya Terasaki and Thomas Ebner
      Drug Metabolism and Disposition January 2012, 40 (1) 93-103; DOI: https://doi.org/10.1124/dmd.111.042275
  5. Schebb, N. H.

    1. You have access
      In Vitro Glucuronidation of the Antibacterial Triclocarban and Its Oxidative Metabolites
      N. H. Schebb, B. Franze, R. Maul, A. Ranganathan and B. D. Hammock
      Drug Metabolism and Disposition January 2012, 40 (1) 25-31; DOI: https://doi.org/10.1124/dmd.111.042283
  6. Shi, Juan

    1. You have access
      Effects of Omeprazole and Genetic Polymorphism of CYP2C19 on the Clopidogrel Active Metabolite
      Xavier Boulenc, Nassim Djebli, Juan Shi, Laurent Perrin, William Brian, Robert Van Horn and Fabrice Hurbin
      Drug Metabolism and Disposition January 2012, 40 (1) 187-197; DOI: https://doi.org/10.1124/dmd.111.040394
  7. Soga, Tomoyoshi

    1. You have access
      Acetaminophen-Induced Hepatotoxicity in a Liver Tissue Model Consisting of Primary Hepatocytes Assembling around an Endothelial Cell Network
      Yu Toyoda, Miho Tamai, Kasumi Kashikura, Shunsuke Kobayashi, Yoichi Fujiyama, Tomoyoshi Soga and Yoh-ichi Tagawa
      Drug Metabolism and Disposition January 2012, 40 (1) 169-177; DOI: https://doi.org/10.1124/dmd.111.041137
  8. Spire, Catherine

    1. You have access
      Interindividual Variability in Gene Expression Profiles in Human Hepatocytes and Comparison with HepaRG Cells
      Alexandra Rogue, Carine Lambert, Catherine Spire, Nancy Claude and André Guillouzo
      Drug Metabolism and Disposition January 2012, 40 (1) 151-158; DOI: https://doi.org/10.1124/dmd.111.042028
  9. Stahl, Simone

    1. You have access
      In Vitro Inhibition of the Bile Salt Export Pump Correlates with Risk of Cholestatic Drug-Induced Liver Injury in Humans
      Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber and J. Gerald Kenna
      Drug Metabolism and Disposition January 2012, 40 (1) 130-138; DOI: https://doi.org/10.1124/dmd.111.040758
  10. States, J. Christopher

    1. You have access
      Phenotype of the Most Common “Slow Acetylator” Arylamine N-Acetyltransferase 1 Genetic Variant (NAT1*14B) Is Substrate-Dependent
      Lori M. Millner, Mark A. Doll, Jian Cai, J. Christopher States and David W. Hein
      Drug Metabolism and Disposition January 2012, 40 (1) 198-204; DOI: https://doi.org/10.1124/dmd.111.041855
  11. Strobel, Henry W.

    1. You have access
      Regulation of Cytochrome P450 4F11 by Nuclear Transcription Factor-κB
      Jordan C. Bell and Henry W. Strobel
      Drug Metabolism and Disposition January 2012, 40 (1) 205-211; DOI: https://doi.org/10.1124/dmd.111.041178

T

  1. Tagawa, Yoh-ichi

    1. You have access
      Acetaminophen-Induced Hepatotoxicity in a Liver Tissue Model Consisting of Primary Hepatocytes Assembling around an Endothelial Cell Network
      Yu Toyoda, Miho Tamai, Kasumi Kashikura, Shunsuke Kobayashi, Yoichi Fujiyama, Tomoyoshi Soga and Yoh-ichi Tagawa
      Drug Metabolism and Disposition January 2012, 40 (1) 169-177; DOI: https://doi.org/10.1124/dmd.111.041137
  2. Tamai, Miho

    1. You have access
      Acetaminophen-Induced Hepatotoxicity in a Liver Tissue Model Consisting of Primary Hepatocytes Assembling around an Endothelial Cell Network
      Yu Toyoda, Miho Tamai, Kasumi Kashikura, Shunsuke Kobayashi, Yoichi Fujiyama, Tomoyoshi Soga and Yoh-ichi Tagawa
      Drug Metabolism and Disposition January 2012, 40 (1) 169-177; DOI: https://doi.org/10.1124/dmd.111.041137
  3. Teramura, Toshio

    1. You have access
      Prediction of Human Metabolism of FK3453 by Aldehyde Oxidase Using Chimeric Mice Transplanted with Human or Rat Hepatocytes
      Seigo Sanoh, Kazuyoshi Nozaki, Hidetsugu Murai, Shigeyuki Terashita, Toshio Teramura and Shigeru Ohta
      Drug Metabolism and Disposition January 2012, 40 (1) 76-82; DOI: https://doi.org/10.1124/dmd.111.041954
  4. Terasaki, Tetsuya

    1. You have access
      Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities
      Sumio Ohtsuki, Olaf Schaefer, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Naoki Ishiguro, Wataru Kishimoto, Eva Ludwig-Schwellinger, Thomas Ebner and Tetsuya Terasaki
      Drug Metabolism and Disposition January 2012, 40 (1) 83-92; DOI: https://doi.org/10.1124/dmd.111.042259
    2. You have access
      Absolute Quantification and Differential Expression of Drug Transporters, Cytochrome P450 Enzymes, and UDP-Glucuronosyltransferases in Cultured Primary Human Hepatocytes
      Olaf Schaefer, Sumio Ohtsuki, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Atsushi Sakamoto, Naoki Ishiguro, Takehisa Matsumaru, Tetsuya Terasaki and Thomas Ebner
      Drug Metabolism and Disposition January 2012, 40 (1) 93-103; DOI: https://doi.org/10.1124/dmd.111.042275
  5. Terashita, Shigeyuki

    1. You have access
      Prediction of Human Metabolism of FK3453 by Aldehyde Oxidase Using Chimeric Mice Transplanted with Human or Rat Hepatocytes
      Seigo Sanoh, Kazuyoshi Nozaki, Hidetsugu Murai, Shigeyuki Terashita, Toshio Teramura and Shigeru Ohta
      Drug Metabolism and Disposition January 2012, 40 (1) 76-82; DOI: https://doi.org/10.1124/dmd.111.041954
  6. Thomas, Sushma S.

    1. You have access
      Potential Contribution of Cytochrome P450 2B6 to Hepatic 4-Hydroxycyclophosphamide Formation In Vitro and In Vivo
      Brianne S. Raccor, Adam J. Claessens, Jean C. Dinh, Julie R. Park, Douglas S. Hawkins, Sushma S. Thomas, Karen W. Makar, Jeannine S. McCune and Rheem A. Totah
      Drug Metabolism and Disposition January 2012, 40 (1) 54-63; DOI: https://doi.org/10.1124/dmd.111.039347
  7. Tian, Yuan

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      Human Hepatic Cytochrome P450-Specific Metabolism of the Organophosphorus Pesticides Methyl Parathion and Diazinon
      Corie A. Ellison, Yuan Tian, James B. Knaak, Paul J. Kostyniak and James R. Olson
      Drug Metabolism and Disposition January 2012, 40 (1) 1-5; DOI: https://doi.org/10.1124/dmd.111.042572
  8. Tidwell, Richard R.

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      A Semiphysiologically Based Pharmacokinetic Modeling Approach to Predict the Dose-Exposure Relationship of an Antiparasitic Prodrug/Active Metabolite Pair
      Grace Zhixia Yan, Claudia N. Generaux, Miyoung Yoon, Rachel B. Goldsmith, Richard R. Tidwell, James E. Hall, Carol A. Olson, Harvey J. Clewell, Kim L. R. Brouwer and Mary F. Paine
      Drug Metabolism and Disposition January 2012, 40 (1) 6-17; DOI: https://doi.org/10.1124/dmd.111.040063
  9. Totah, Rheem A.

    1. You have access
      Potential Contribution of Cytochrome P450 2B6 to Hepatic 4-Hydroxycyclophosphamide Formation In Vitro and In Vivo
      Brianne S. Raccor, Adam J. Claessens, Jean C. Dinh, Julie R. Park, Douglas S. Hawkins, Sushma S. Thomas, Karen W. Makar, Jeannine S. McCune and Rheem A. Totah
      Drug Metabolism and Disposition January 2012, 40 (1) 54-63; DOI: https://doi.org/10.1124/dmd.111.039347
  10. Toyoda, Yu

    1. You have access
      Acetaminophen-Induced Hepatotoxicity in a Liver Tissue Model Consisting of Primary Hepatocytes Assembling around an Endothelial Cell Network
      Yu Toyoda, Miho Tamai, Kasumi Kashikura, Shunsuke Kobayashi, Yoichi Fujiyama, Tomoyoshi Soga and Yoh-ichi Tagawa
      Drug Metabolism and Disposition January 2012, 40 (1) 169-177; DOI: https://doi.org/10.1124/dmd.111.041137
  11. Turlizzi, Elisa

    1. You have access
      Comparison of Cryopreserved HepaRG Cells with Cryopreserved Human Hepatocytes for Prediction of Clearance for 26 Drugs
      Ugo Zanelli, Nicola Pasquale Caradonna, David Hallifax, Elisa Turlizzi and J. Brian Houston
      Drug Metabolism and Disposition January 2012, 40 (1) 104-110; DOI: https://doi.org/10.1124/dmd.111.042309

V

  1. VandenBrink, Brooke M.

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      Prediction of CYP2D6 Drug Interactions from In Vitro Data: Evidence for Substrate-Dependent Inhibition
      Brooke M. VandenBrink, Robert S. Foti, Dan A. Rock, Larry C. Wienkers and Jan L. Wahlstrom
      Drug Metabolism and Disposition January 2012, 40 (1) 47-53; DOI: https://doi.org/10.1124/dmd.111.041210
  2. Van Horn, Robert

    1. You have access
      Effects of Omeprazole and Genetic Polymorphism of CYP2C19 on the Clopidogrel Active Metabolite
      Xavier Boulenc, Nassim Djebli, Juan Shi, Laurent Perrin, William Brian, Robert Van Horn and Fabrice Hurbin
      Drug Metabolism and Disposition January 2012, 40 (1) 187-197; DOI: https://doi.org/10.1124/dmd.111.040394

W

  1. Wahlstrom, Jan L.

    1. You have access
      Prediction of CYP2D6 Drug Interactions from In Vitro Data: Evidence for Substrate-Dependent Inhibition
      Brooke M. VandenBrink, Robert S. Foti, Dan A. Rock, Larry C. Wienkers and Jan L. Wahlstrom
      Drug Metabolism and Disposition January 2012, 40 (1) 47-53; DOI: https://doi.org/10.1124/dmd.111.041210
  2. Walker, Denise L.

    1. You have access
      Frequency of Undetected CYP2D6 Hybrid Genes in Clinical Samples: Impact on Phenotype Prediction
      John Logan Black, Denise L. Walker, Dennis J. O'Kane and Maria Harmandayan
      Drug Metabolism and Disposition January 2012, 40 (1) 111-119; DOI: https://doi.org/10.1124/dmd.111.040832
  3. Wienkers, Larry C.

    1. You have access
      Prediction of CYP2D6 Drug Interactions from In Vitro Data: Evidence for Substrate-Dependent Inhibition
      Brooke M. VandenBrink, Robert S. Foti, Dan A. Rock, Larry C. Wienkers and Jan L. Wahlstrom
      Drug Metabolism and Disposition January 2012, 40 (1) 47-53; DOI: https://doi.org/10.1124/dmd.111.041210
  4. Wong, Chris K. C.

    1. You have access
      Cytoprotective Effect of 20(S)-Rg3 on Benzo[a]pyrene-Induced DNA Damage
      Po Ying Poon, Hoi Hin Kwok, Patrick Y. K. Yue, Mildred S. M. Yang, Nai Ki Mak, Chris K. C. Wong and Ricky N. S. Wong
      Drug Metabolism and Disposition January 2012, 40 (1) 120-129; DOI: https://doi.org/10.1124/dmd.111.039503
  5. Wong, Ricky N. S.

    1. You have access
      Cytoprotective Effect of 20(S)-Rg3 on Benzo[a]pyrene-Induced DNA Damage
      Po Ying Poon, Hoi Hin Kwok, Patrick Y. K. Yue, Mildred S. M. Yang, Nai Ki Mak, Chris K. C. Wong and Ricky N. S. Wong
      Drug Metabolism and Disposition January 2012, 40 (1) 120-129; DOI: https://doi.org/10.1124/dmd.111.039503

Y

  1. Yan, Grace Zhixia

    1. You have access
      A Semiphysiologically Based Pharmacokinetic Modeling Approach to Predict the Dose-Exposure Relationship of an Antiparasitic Prodrug/Active Metabolite Pair
      Grace Zhixia Yan, Claudia N. Generaux, Miyoung Yoon, Rachel B. Goldsmith, Richard R. Tidwell, James E. Hall, Carol A. Olson, Harvey J. Clewell, Kim L. R. Brouwer and Mary F. Paine
      Drug Metabolism and Disposition January 2012, 40 (1) 6-17; DOI: https://doi.org/10.1124/dmd.111.040063
  2. Yang, Guixiang

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      Species-Dependent and Receptor-Selective Action of Bilobalide on the Function of Constitutive Androstane Receptor and Pregnane X Receptor
      Aik Jiang Lau, Guixiang Yang, Ganesh Rajaraman, Christie C. Baucom and Thomas K. H. Chang
      Drug Metabolism and Disposition January 2012, 40 (1) 178-186; DOI: https://doi.org/10.1124/dmd.111.042879
  3. Yang, Mildred S. M.

    1. You have access
      Cytoprotective Effect of 20(S)-Rg3 on Benzo[a]pyrene-Induced DNA Damage
      Po Ying Poon, Hoi Hin Kwok, Patrick Y. K. Yue, Mildred S. M. Yang, Nai Ki Mak, Chris K. C. Wong and Ricky N. S. Wong
      Drug Metabolism and Disposition January 2012, 40 (1) 120-129; DOI: https://doi.org/10.1124/dmd.111.039503
  4. Yoon, Miyoung

    1. You have access
      A Semiphysiologically Based Pharmacokinetic Modeling Approach to Predict the Dose-Exposure Relationship of an Antiparasitic Prodrug/Active Metabolite Pair
      Grace Zhixia Yan, Claudia N. Generaux, Miyoung Yoon, Rachel B. Goldsmith, Richard R. Tidwell, James E. Hall, Carol A. Olson, Harvey J. Clewell, Kim L. R. Brouwer and Mary F. Paine
      Drug Metabolism and Disposition January 2012, 40 (1) 6-17; DOI: https://doi.org/10.1124/dmd.111.040063
  5. Yue, Patrick Y. K.

    1. You have access
      Cytoprotective Effect of 20(S)-Rg3 on Benzo[a]pyrene-Induced DNA Damage
      Po Ying Poon, Hoi Hin Kwok, Patrick Y. K. Yue, Mildred S. M. Yang, Nai Ki Mak, Chris K. C. Wong and Ricky N. S. Wong
      Drug Metabolism and Disposition January 2012, 40 (1) 120-129; DOI: https://doi.org/10.1124/dmd.111.039503

Z

  1. Zanelli, Ugo

    1. You have access
      Comparison of Cryopreserved HepaRG Cells with Cryopreserved Human Hepatocytes for Prediction of Clearance for 26 Drugs
      Ugo Zanelli, Nicola Pasquale Caradonna, David Hallifax, Elisa Turlizzi and J. Brian Houston
      Drug Metabolism and Disposition January 2012, 40 (1) 104-110; DOI: https://doi.org/10.1124/dmd.111.042309
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Drug Metabolism and Disposition: 40 (1)
Drug Metabolism and Disposition
Vol. 40, Issue 1
1 Jan 2012
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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