Advertisement

Index by author

January 01, 2012; Volume 40,Issue 1

B

  1. Barber, Jane

    1. In Vitro Inhibition of the Bile Salt Export Pump Correlates with Risk of Cholestatic Drug-Induced Liver Injury in Humans
      Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber and J. Gerald Kenna
      Drug Metabolism and Disposition January 2012, 40 (1) 130-138; DOI: https://doi.org/10.1124/dmd.111.040758

  2. Baucom, Christie C.

    1. Species-Dependent and Receptor-Selective Action of Bilobalide on the Function of Constitutive Androstane Receptor and Pregnane X Receptor
      Aik Jiang Lau, Guixiang Yang, Ganesh Rajaraman, Christie C. Baucom and Thomas K. H. Chang
      Drug Metabolism and Disposition January 2012, 40 (1) 178-186; DOI: https://doi.org/10.1124/dmd.111.042879

  3. Beauchemin, Stéphanie

    1. Effects of Chronic Renal Failure on Brain Drug Transporters in Rats
      Judith Naud, Louis-Philippe Laurin, Josée Michaud, Stéphanie Beauchemin, Francois A. Leblond and Vincent Pichette
      Drug Metabolism and Disposition January 2012, 40 (1) 39-46; DOI: https://doi.org/10.1124/dmd.111.041145

  4. Bell, Jordan C.

    1. Regulation of Cytochrome P450 4F11 by Nuclear Transcription Factor-κB
      Jordan C. Bell and Henry W. Strobel
      Drug Metabolism and Disposition January 2012, 40 (1) 205-211; DOI: https://doi.org/10.1124/dmd.111.041178

  5. Black, John Logan

    1. Frequency of Undetected CYP2D6 Hybrid Genes in Clinical Samples: Impact on Phenotype Prediction
      John Logan Black, Denise L. Walker, Dennis J. O'Kane and Maria Harmandayan
      Drug Metabolism and Disposition January 2012, 40 (1) 111-119; DOI: https://doi.org/10.1124/dmd.111.040832

  6. Bligh, S. W. Annie

    1. Debrisoquine Metabolism and CYP2D Expression in Marmoset Liver Microsomes
      Brian R. Cooke, S. W. Annie Bligh, Z. Richard Cybulski, Costas Ioannides and Michael Hall
      Drug Metabolism and Disposition January 2012, 40 (1) 70-75; DOI: https://doi.org/10.1124/dmd.111.041566

  7. Borts, David J.

    1. Human Metabolism of Lapatinib, a Dual Kinase Inhibitor: Implications for Hepatotoxicity
      Stephen Castellino, Michael O'Mara, Kevin Koch, David J. Borts, Gary D. Bowers and Christopher MacLauchlin
      Drug Metabolism and Disposition January 2012, 40 (1) 139-150; DOI: https://doi.org/10.1124/dmd.111.040949

  8. Boulenc, Xavier

    1. Effects of Omeprazole and Genetic Polymorphism of CYP2C19 on the Clopidogrel Active Metabolite
      Xavier Boulenc, Nassim Djebli, Juan Shi, Laurent Perrin, William Brian, Robert Van Horn and Fabrice Hurbin
      Drug Metabolism and Disposition January 2012, 40 (1) 187-197; DOI: https://doi.org/10.1124/dmd.111.040394

  9. Bowers, Gary D.

    1. Human Metabolism of Lapatinib, a Dual Kinase Inhibitor: Implications for Hepatotoxicity
      Stephen Castellino, Michael O'Mara, Kevin Koch, David J. Borts, Gary D. Bowers and Christopher MacLauchlin
      Drug Metabolism and Disposition January 2012, 40 (1) 139-150; DOI: https://doi.org/10.1124/dmd.111.040949

  10. Brian, William

    1. Effects of Omeprazole and Genetic Polymorphism of CYP2C19 on the Clopidogrel Active Metabolite
      Xavier Boulenc, Nassim Djebli, Juan Shi, Laurent Perrin, William Brian, Robert Van Horn and Fabrice Hurbin
      Drug Metabolism and Disposition January 2012, 40 (1) 187-197; DOI: https://doi.org/10.1124/dmd.111.040394

  11. Brouwer, Kim L. R.

    1. A Semiphysiologically Based Pharmacokinetic Modeling Approach to Predict the Dose-Exposure Relationship of an Antiparasitic Prodrug/Active Metabolite Pair
      Grace Zhixia Yan, Claudia N. Generaux, Miyoung Yoon, Rachel B. Goldsmith, Richard R. Tidwell, James E. Hall, Carol A. Olson, Harvey J. Clewell, Kim L. R. Brouwer and Mary F. Paine
      Drug Metabolism and Disposition January 2012, 40 (1) 6-17; DOI: https://doi.org/10.1124/dmd.111.040063

C

  1. Cai, Jian

    1. Phenotype of the Most Common “Slow Acetylator” Arylamine N-Acetyltransferase 1 Genetic Variant (NAT1*14B) Is Substrate-Dependent
      Lori M. Millner, Mark A. Doll, Jian Cai, J. Christopher States and David W. Hein
      Drug Metabolism and Disposition January 2012, 40 (1) 198-204; DOI: https://doi.org/10.1124/dmd.111.041855

  2. Caradonna, Nicola Pasquale

    1. Comparison of Cryopreserved HepaRG Cells with Cryopreserved Human Hepatocytes for Prediction of Clearance for 26 Drugs
      Ugo Zanelli, Nicola Pasquale Caradonna, David Hallifax, Elisa Turlizzi and J. Brian Houston
      Drug Metabolism and Disposition January 2012, 40 (1) 104-110; DOI: https://doi.org/10.1124/dmd.111.042309

  3. Castellino, Stephen

    1. Human Metabolism of Lapatinib, a Dual Kinase Inhibitor: Implications for Hepatotoxicity
      Stephen Castellino, Michael O'Mara, Kevin Koch, David J. Borts, Gary D. Bowers and Christopher MacLauchlin
      Drug Metabolism and Disposition January 2012, 40 (1) 139-150; DOI: https://doi.org/10.1124/dmd.111.040949

  4. Chang, Thomas K. H.

    1. Species-Dependent and Receptor-Selective Action of Bilobalide on the Function of Constitutive Androstane Receptor and Pregnane X Receptor
      Aik Jiang Lau, Guixiang Yang, Ganesh Rajaraman, Christie C. Baucom and Thomas K. H. Chang
      Drug Metabolism and Disposition January 2012, 40 (1) 178-186; DOI: https://doi.org/10.1124/dmd.111.042879

  5. Claessens, Adam J.

    1. Potential Contribution of Cytochrome P450 2B6 to Hepatic 4-Hydroxycyclophosphamide Formation In Vitro and In Vivo
      Brianne S. Raccor, Adam J. Claessens, Jean C. Dinh, Julie R. Park, Douglas S. Hawkins, Sushma S. Thomas, Karen W. Makar, Jeannine S. McCune and Rheem A. Totah
      Drug Metabolism and Disposition January 2012, 40 (1) 54-63; DOI: https://doi.org/10.1124/dmd.111.039347

  6. Claude, Nancy

    1. Interindividual Variability in Gene Expression Profiles in Human Hepatocytes and Comparison with HepaRG Cells
      Alexandra Rogue, Carine Lambert, Catherine Spire, Nancy Claude and André Guillouzo
      Drug Metabolism and Disposition January 2012, 40 (1) 151-158; DOI: https://doi.org/10.1124/dmd.111.042028

  7. Clewell, Harvey J.

    1. A Semiphysiologically Based Pharmacokinetic Modeling Approach to Predict the Dose-Exposure Relationship of an Antiparasitic Prodrug/Active Metabolite Pair
      Grace Zhixia Yan, Claudia N. Generaux, Miyoung Yoon, Rachel B. Goldsmith, Richard R. Tidwell, James E. Hall, Carol A. Olson, Harvey J. Clewell, Kim L. R. Brouwer and Mary F. Paine
      Drug Metabolism and Disposition January 2012, 40 (1) 6-17; DOI: https://doi.org/10.1124/dmd.111.040063

  8. Cooke, Brian R.

    1. Debrisoquine Metabolism and CYP2D Expression in Marmoset Liver Microsomes
      Brian R. Cooke, S. W. Annie Bligh, Z. Richard Cybulski, Costas Ioannides and Michael Hall
      Drug Metabolism and Disposition January 2012, 40 (1) 70-75; DOI: https://doi.org/10.1124/dmd.111.041566

  9. Cybulski, Z. Richard

    1. Debrisoquine Metabolism and CYP2D Expression in Marmoset Liver Microsomes
      Brian R. Cooke, S. W. Annie Bligh, Z. Richard Cybulski, Costas Ioannides and Michael Hall
      Drug Metabolism and Disposition January 2012, 40 (1) 70-75; DOI: https://doi.org/10.1124/dmd.111.041566

D

  1. Dawson, Sarah

    1. In Vitro Inhibition of the Bile Salt Export Pump Correlates with Risk of Cholestatic Drug-Induced Liver Injury in Humans
      Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber and J. Gerald Kenna
      Drug Metabolism and Disposition January 2012, 40 (1) 130-138; DOI: https://doi.org/10.1124/dmd.111.040758

  2. Desbans, Coraline

    1. Bupropion Hydroxylation as a Selective Marker of Rat CYP2B1 Catalytic Activity
      Dumrongsak Pekthong, Coraline Desbans, Hélène Martin and Lysiane Richert
      Drug Metabolism and Disposition January 2012, 40 (1) 32-38; DOI: https://doi.org/10.1124/dmd.111.041368

  3. Dinh, Jean C.

    1. Potential Contribution of Cytochrome P450 2B6 to Hepatic 4-Hydroxycyclophosphamide Formation In Vitro and In Vivo
      Brianne S. Raccor, Adam J. Claessens, Jean C. Dinh, Julie R. Park, Douglas S. Hawkins, Sushma S. Thomas, Karen W. Makar, Jeannine S. McCune and Rheem A. Totah
      Drug Metabolism and Disposition January 2012, 40 (1) 54-63; DOI: https://doi.org/10.1124/dmd.111.039347

  4. Djebli, Nassim

    1. Effects of Omeprazole and Genetic Polymorphism of CYP2C19 on the Clopidogrel Active Metabolite
      Xavier Boulenc, Nassim Djebli, Juan Shi, Laurent Perrin, William Brian, Robert Van Horn and Fabrice Hurbin
      Drug Metabolism and Disposition January 2012, 40 (1) 187-197; DOI: https://doi.org/10.1124/dmd.111.040394

  5. Doll, Mark A.

    1. Phenotype of the Most Common “Slow Acetylator” Arylamine N-Acetyltransferase 1 Genetic Variant (NAT1*14B) Is Substrate-Dependent
      Lori M. Millner, Mark A. Doll, Jian Cai, J. Christopher States and David W. Hein
      Drug Metabolism and Disposition January 2012, 40 (1) 198-204; DOI: https://doi.org/10.1124/dmd.111.041855

E

  1. Ebner, Thomas

    1. Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities
      Sumio Ohtsuki, Olaf Schaefer, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Naoki Ishiguro, Wataru Kishimoto, Eva Ludwig-Schwellinger, Thomas Ebner and Tetsuya Terasaki
      Drug Metabolism and Disposition January 2012, 40 (1) 83-92; DOI: https://doi.org/10.1124/dmd.111.042259
    2. Absolute Quantification and Differential Expression of Drug Transporters, Cytochrome P450 Enzymes, and UDP-Glucuronosyltransferases in Cultured Primary Human Hepatocytes
      Olaf Schaefer, Sumio Ohtsuki, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Atsushi Sakamoto, Naoki Ishiguro, Takehisa Matsumaru, Tetsuya Terasaki and Thomas Ebner
      Drug Metabolism and Disposition January 2012, 40 (1) 93-103; DOI: https://doi.org/10.1124/dmd.111.042275

  2. Ellison, Corie A.

    1. Human Hepatic Cytochrome P450-Specific Metabolism of the Organophosphorus Pesticides Methyl Parathion and Diazinon
      Corie A. Ellison, Yuan Tian, James B. Knaak, Paul J. Kostyniak and James R. Olson
      Drug Metabolism and Disposition January 2012, 40 (1) 1-5; DOI: https://doi.org/10.1124/dmd.111.042572

F

  1. Felmlee, Melanie A.

    1. γ-Hydroxybutyrate Blood/Plasma Partitioning: Effect of Physiologic pH on Transport by Monocarboxylate Transporters
      Bridget L. Morse, Melanie A. Felmlee and Marilyn E. Morris
      Drug Metabolism and Disposition January 2012, 40 (1) 64-69; DOI: https://doi.org/10.1124/dmd.111.041285
    2. Brain Uptake of the Drug of Abuse γ-Hydroxybutyric Acid in Rats
      Samuel A. Roiko, Melanie A. Felmlee and Marilyn E. Morris
      Drug Metabolism and Disposition January 2012, 40 (1) 212-218; DOI: https://doi.org/10.1124/dmd.111.041749

  2. Foti, Robert S.

    1. Prediction of CYP2D6 Drug Interactions from In Vitro Data: Evidence for Substrate-Dependent Inhibition
      Brooke M. VandenBrink, Robert S. Foti, Dan A. Rock, Larry C. Wienkers and Jan L. Wahlstrom
      Drug Metabolism and Disposition January 2012, 40 (1) 47-53; DOI: https://doi.org/10.1124/dmd.111.041210

  3. Franze, B.

    1. In Vitro Glucuronidation of the Antibacterial Triclocarban and Its Oxidative Metabolites
      N. H. Schebb, B. Franze, R. Maul, A. Ranganathan and B. D. Hammock
      Drug Metabolism and Disposition January 2012, 40 (1) 25-31; DOI: https://doi.org/10.1124/dmd.111.042283

  4. Fujiyama, Yoichi

    1. Acetaminophen-Induced Hepatotoxicity in a Liver Tissue Model Consisting of Primary Hepatocytes Assembling around an Endothelial Cell Network
      Yu Toyoda, Miho Tamai, Kasumi Kashikura, Shunsuke Kobayashi, Yoichi Fujiyama, Tomoyoshi Soga and Yoh-ichi Tagawa
      Drug Metabolism and Disposition January 2012, 40 (1) 169-177; DOI: https://doi.org/10.1124/dmd.111.041137

G

  1. Gan, Jinping

    1. Identification of the Oxidative and Conjugative Enzymes Involved in the Biotransformation of Brivanib
      Jiachang Gong, Jinping Gan and Ramaswamy A. Iyer
      Drug Metabolism and Disposition January 2012, 40 (1) 219-226; DOI: https://doi.org/10.1124/dmd.111.042457

  2. Generaux, Claudia N.

    1. A Semiphysiologically Based Pharmacokinetic Modeling Approach to Predict the Dose-Exposure Relationship of an Antiparasitic Prodrug/Active Metabolite Pair
      Grace Zhixia Yan, Claudia N. Generaux, Miyoung Yoon, Rachel B. Goldsmith, Richard R. Tidwell, James E. Hall, Carol A. Olson, Harvey J. Clewell, Kim L. R. Brouwer and Mary F. Paine
      Drug Metabolism and Disposition January 2012, 40 (1) 6-17; DOI: https://doi.org/10.1124/dmd.111.040063

  3. Goldsmith, Rachel B.

    1. A Semiphysiologically Based Pharmacokinetic Modeling Approach to Predict the Dose-Exposure Relationship of an Antiparasitic Prodrug/Active Metabolite Pair
      Grace Zhixia Yan, Claudia N. Generaux, Miyoung Yoon, Rachel B. Goldsmith, Richard R. Tidwell, James E. Hall, Carol A. Olson, Harvey J. Clewell, Kim L. R. Brouwer and Mary F. Paine
      Drug Metabolism and Disposition January 2012, 40 (1) 6-17; DOI: https://doi.org/10.1124/dmd.111.040063

  4. Gong, Jiachang

    1. Identification of the Oxidative and Conjugative Enzymes Involved in the Biotransformation of Brivanib
      Jiachang Gong, Jinping Gan and Ramaswamy A. Iyer
      Drug Metabolism and Disposition January 2012, 40 (1) 219-226; DOI: https://doi.org/10.1124/dmd.111.042457

  5. Guillouzo, André

    1. Interindividual Variability in Gene Expression Profiles in Human Hepatocytes and Comparison with HepaRG Cells
      Alexandra Rogue, Carine Lambert, Catherine Spire, Nancy Claude and André Guillouzo
      Drug Metabolism and Disposition January 2012, 40 (1) 151-158; DOI: https://doi.org/10.1124/dmd.111.042028

H

  1. Hall, James E.

    1. A Semiphysiologically Based Pharmacokinetic Modeling Approach to Predict the Dose-Exposure Relationship of an Antiparasitic Prodrug/Active Metabolite Pair
      Grace Zhixia Yan, Claudia N. Generaux, Miyoung Yoon, Rachel B. Goldsmith, Richard R. Tidwell, James E. Hall, Carol A. Olson, Harvey J. Clewell, Kim L. R. Brouwer and Mary F. Paine
      Drug Metabolism and Disposition January 2012, 40 (1) 6-17; DOI: https://doi.org/10.1124/dmd.111.040063

  2. Hall, Michael

    1. Debrisoquine Metabolism and CYP2D Expression in Marmoset Liver Microsomes
      Brian R. Cooke, S. W. Annie Bligh, Z. Richard Cybulski, Costas Ioannides and Michael Hall
      Drug Metabolism and Disposition January 2012, 40 (1) 70-75; DOI: https://doi.org/10.1124/dmd.111.041566

  3. Hallifax, David

    1. Comparison of Cryopreserved HepaRG Cells with Cryopreserved Human Hepatocytes for Prediction of Clearance for 26 Drugs
      Ugo Zanelli, Nicola Pasquale Caradonna, David Hallifax, Elisa Turlizzi and J. Brian Houston
      Drug Metabolism and Disposition January 2012, 40 (1) 104-110; DOI: https://doi.org/10.1124/dmd.111.042309

  4. Hammock, B. D.

    1. In Vitro Glucuronidation of the Antibacterial Triclocarban and Its Oxidative Metabolites
      N. H. Schebb, B. Franze, R. Maul, A. Ranganathan and B. D. Hammock
      Drug Metabolism and Disposition January 2012, 40 (1) 25-31; DOI: https://doi.org/10.1124/dmd.111.042283

  5. Harmandayan, Maria

    1. Frequency of Undetected CYP2D6 Hybrid Genes in Clinical Samples: Impact on Phenotype Prediction
      John Logan Black, Denise L. Walker, Dennis J. O'Kane and Maria Harmandayan
      Drug Metabolism and Disposition January 2012, 40 (1) 111-119; DOI: https://doi.org/10.1124/dmd.111.040832

  6. Hawkins, Douglas S.

    1. Potential Contribution of Cytochrome P450 2B6 to Hepatic 4-Hydroxycyclophosphamide Formation In Vitro and In Vivo
      Brianne S. Raccor, Adam J. Claessens, Jean C. Dinh, Julie R. Park, Douglas S. Hawkins, Sushma S. Thomas, Karen W. Makar, Jeannine S. McCune and Rheem A. Totah
      Drug Metabolism and Disposition January 2012, 40 (1) 54-63; DOI: https://doi.org/10.1124/dmd.111.039347

  7. Hein, David W.

    1. Phenotype of the Most Common “Slow Acetylator” Arylamine N-Acetyltransferase 1 Genetic Variant (NAT1*14B) Is Substrate-Dependent
      Lori M. Millner, Mark A. Doll, Jian Cai, J. Christopher States and David W. Hein
      Drug Metabolism and Disposition January 2012, 40 (1) 198-204; DOI: https://doi.org/10.1124/dmd.111.041855

  8. Houston, J. Brian

    1. Comparison of Cryopreserved HepaRG Cells with Cryopreserved Human Hepatocytes for Prediction of Clearance for 26 Drugs
      Ugo Zanelli, Nicola Pasquale Caradonna, David Hallifax, Elisa Turlizzi and J. Brian Houston
      Drug Metabolism and Disposition January 2012, 40 (1) 104-110; DOI: https://doi.org/10.1124/dmd.111.042309

  9. Hurbin, Fabrice

    1. Effects of Omeprazole and Genetic Polymorphism of CYP2C19 on the Clopidogrel Active Metabolite
      Xavier Boulenc, Nassim Djebli, Juan Shi, Laurent Perrin, William Brian, Robert Van Horn and Fabrice Hurbin
      Drug Metabolism and Disposition January 2012, 40 (1) 187-197; DOI: https://doi.org/10.1124/dmd.111.040394

I

  1. Inoue, Tae

    1. Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities
      Sumio Ohtsuki, Olaf Schaefer, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Naoki Ishiguro, Wataru Kishimoto, Eva Ludwig-Schwellinger, Thomas Ebner and Tetsuya Terasaki
      Drug Metabolism and Disposition January 2012, 40 (1) 83-92; DOI: https://doi.org/10.1124/dmd.111.042259
    2. Absolute Quantification and Differential Expression of Drug Transporters, Cytochrome P450 Enzymes, and UDP-Glucuronosyltransferases in Cultured Primary Human Hepatocytes
      Olaf Schaefer, Sumio Ohtsuki, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Atsushi Sakamoto, Naoki Ishiguro, Takehisa Matsumaru, Tetsuya Terasaki and Thomas Ebner
      Drug Metabolism and Disposition January 2012, 40 (1) 93-103; DOI: https://doi.org/10.1124/dmd.111.042275

  2. Ioannides, Costas

    1. Debrisoquine Metabolism and CYP2D Expression in Marmoset Liver Microsomes
      Brian R. Cooke, S. W. Annie Bligh, Z. Richard Cybulski, Costas Ioannides and Michael Hall
      Drug Metabolism and Disposition January 2012, 40 (1) 70-75; DOI: https://doi.org/10.1124/dmd.111.041566

  3. Ishiguro, Naoki

    1. Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities
      Sumio Ohtsuki, Olaf Schaefer, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Naoki Ishiguro, Wataru Kishimoto, Eva Ludwig-Schwellinger, Thomas Ebner and Tetsuya Terasaki
      Drug Metabolism and Disposition January 2012, 40 (1) 83-92; DOI: https://doi.org/10.1124/dmd.111.042259
    2. Absolute Quantification and Differential Expression of Drug Transporters, Cytochrome P450 Enzymes, and UDP-Glucuronosyltransferases in Cultured Primary Human Hepatocytes
      Olaf Schaefer, Sumio Ohtsuki, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Atsushi Sakamoto, Naoki Ishiguro, Takehisa Matsumaru, Tetsuya Terasaki and Thomas Ebner
      Drug Metabolism and Disposition January 2012, 40 (1) 93-103; DOI: https://doi.org/10.1124/dmd.111.042275

  4. Isoherranen, Nina

    1. Prediction of Relative In Vivo Metabolite Exposure from In Vitro Data Using Two Model Drugs: Dextromethorphan and Omeprazole
      Justin D. Lutz and Nina Isoherranen
      Drug Metabolism and Disposition January 2012, 40 (1) 159-168; DOI: https://doi.org/10.1124/dmd.111.042200

  5. Iyer, Ramaswamy A.

    1. Identification of the Oxidative and Conjugative Enzymes Involved in the Biotransformation of Brivanib
      Jiachang Gong, Jinping Gan and Ramaswamy A. Iyer
      Drug Metabolism and Disposition January 2012, 40 (1) 219-226; DOI: https://doi.org/10.1124/dmd.111.042457

K

  1. Kashikura, Kasumi

    1. Acetaminophen-Induced Hepatotoxicity in a Liver Tissue Model Consisting of Primary Hepatocytes Assembling around an Endothelial Cell Network
      Yu Toyoda, Miho Tamai, Kasumi Kashikura, Shunsuke Kobayashi, Yoichi Fujiyama, Tomoyoshi Soga and Yoh-ichi Tagawa
      Drug Metabolism and Disposition January 2012, 40 (1) 169-177; DOI: https://doi.org/10.1124/dmd.111.041137

  2. Kawakami, Hirotaka

    1. Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities
      Sumio Ohtsuki, Olaf Schaefer, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Naoki Ishiguro, Wataru Kishimoto, Eva Ludwig-Schwellinger, Thomas Ebner and Tetsuya Terasaki
      Drug Metabolism and Disposition January 2012, 40 (1) 83-92; DOI: https://doi.org/10.1124/dmd.111.042259
    2. Absolute Quantification and Differential Expression of Drug Transporters, Cytochrome P450 Enzymes, and UDP-Glucuronosyltransferases in Cultured Primary Human Hepatocytes
      Olaf Schaefer, Sumio Ohtsuki, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Atsushi Sakamoto, Naoki Ishiguro, Takehisa Matsumaru, Tetsuya Terasaki and Thomas Ebner
      Drug Metabolism and Disposition January 2012, 40 (1) 93-103; DOI: https://doi.org/10.1124/dmd.111.042275

  3. Kenna, J. Gerald

    1. In Vitro Inhibition of the Bile Salt Export Pump Correlates with Risk of Cholestatic Drug-Induced Liver Injury in Humans
      Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber and J. Gerald Kenna
      Drug Metabolism and Disposition January 2012, 40 (1) 130-138; DOI: https://doi.org/10.1124/dmd.111.040758

  4. Kishimoto, Wataru

    1. Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities
      Sumio Ohtsuki, Olaf Schaefer, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Naoki Ishiguro, Wataru Kishimoto, Eva Ludwig-Schwellinger, Thomas Ebner and Tetsuya Terasaki
      Drug Metabolism and Disposition January 2012, 40 (1) 83-92; DOI: https://doi.org/10.1124/dmd.111.042259

  5. Knaak, James B.

    1. Human Hepatic Cytochrome P450-Specific Metabolism of the Organophosphorus Pesticides Methyl Parathion and Diazinon
      Corie A. Ellison, Yuan Tian, James B. Knaak, Paul J. Kostyniak and James R. Olson
      Drug Metabolism and Disposition January 2012, 40 (1) 1-5; DOI: https://doi.org/10.1124/dmd.111.042572

  6. Kobayashi, Shunsuke

    1. Acetaminophen-Induced Hepatotoxicity in a Liver Tissue Model Consisting of Primary Hepatocytes Assembling around an Endothelial Cell Network
      Yu Toyoda, Miho Tamai, Kasumi Kashikura, Shunsuke Kobayashi, Yoichi Fujiyama, Tomoyoshi Soga and Yoh-ichi Tagawa
      Drug Metabolism and Disposition January 2012, 40 (1) 169-177; DOI: https://doi.org/10.1124/dmd.111.041137

  7. Koch, Kevin

    1. Human Metabolism of Lapatinib, a Dual Kinase Inhibitor: Implications for Hepatotoxicity
      Stephen Castellino, Michael O'Mara, Kevin Koch, David J. Borts, Gary D. Bowers and Christopher MacLauchlin
      Drug Metabolism and Disposition January 2012, 40 (1) 139-150; DOI: https://doi.org/10.1124/dmd.111.040949

  8. Kostyniak, Paul J.

    1. Human Hepatic Cytochrome P450-Specific Metabolism of the Organophosphorus Pesticides Methyl Parathion and Diazinon
      Corie A. Ellison, Yuan Tian, James B. Knaak, Paul J. Kostyniak and James R. Olson
      Drug Metabolism and Disposition January 2012, 40 (1) 1-5; DOI: https://doi.org/10.1124/dmd.111.042572

  9. Kwok, Hoi Hin

    1. Cytoprotective Effect of 20(S)-Rg3 on Benzo[a]pyrene-Induced DNA Damage
      Po Ying Poon, Hoi Hin Kwok, Patrick Y. K. Yue, Mildred S. M. Yang, Nai Ki Mak, Chris K. C. Wong and Ricky N. S. Wong
      Drug Metabolism and Disposition January 2012, 40 (1) 120-129; DOI: https://doi.org/10.1124/dmd.111.039503

L

  1. Lambert, Carine

    1. Interindividual Variability in Gene Expression Profiles in Human Hepatocytes and Comparison with HepaRG Cells
      Alexandra Rogue, Carine Lambert, Catherine Spire, Nancy Claude and André Guillouzo
      Drug Metabolism and Disposition January 2012, 40 (1) 151-158; DOI: https://doi.org/10.1124/dmd.111.042028

  2. Lau, Aik Jiang

    1. Species-Dependent and Receptor-Selective Action of Bilobalide on the Function of Constitutive Androstane Receptor and Pregnane X Receptor
      Aik Jiang Lau, Guixiang Yang, Ganesh Rajaraman, Christie C. Baucom and Thomas K. H. Chang
      Drug Metabolism and Disposition January 2012, 40 (1) 178-186; DOI: https://doi.org/10.1124/dmd.111.042879

  3. Laurin, Louis-Philippe

    1. Effects of Chronic Renal Failure on Brain Drug Transporters in Rats
      Judith Naud, Louis-Philippe Laurin, Josée Michaud, Stéphanie Beauchemin, Francois A. Leblond and Vincent Pichette
      Drug Metabolism and Disposition January 2012, 40 (1) 39-46; DOI: https://doi.org/10.1124/dmd.111.041145

  4. Leblond, Francois A.

    1. Effects of Chronic Renal Failure on Brain Drug Transporters in Rats
      Judith Naud, Louis-Philippe Laurin, Josée Michaud, Stéphanie Beauchemin, Francois A. Leblond and Vincent Pichette
      Drug Metabolism and Disposition January 2012, 40 (1) 39-46; DOI: https://doi.org/10.1124/dmd.111.041145

  5. Li, Feng

    1. CPY3A4-Mediated Lopinavir Bioactivation and Its Inhibition by Ritonavir
      Feng Li, Jie Lu and Xiaochao Ma
      Drug Metabolism and Disposition January 2012, 40 (1) 18-24; DOI: https://doi.org/10.1124/dmd.111.041400

  6. Liehner, Stephanie

    1. Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities
      Sumio Ohtsuki, Olaf Schaefer, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Naoki Ishiguro, Wataru Kishimoto, Eva Ludwig-Schwellinger, Thomas Ebner and Tetsuya Terasaki
      Drug Metabolism and Disposition January 2012, 40 (1) 83-92; DOI: https://doi.org/10.1124/dmd.111.042259
    2. Absolute Quantification and Differential Expression of Drug Transporters, Cytochrome P450 Enzymes, and UDP-Glucuronosyltransferases in Cultured Primary Human Hepatocytes
      Olaf Schaefer, Sumio Ohtsuki, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Atsushi Sakamoto, Naoki Ishiguro, Takehisa Matsumaru, Tetsuya Terasaki and Thomas Ebner
      Drug Metabolism and Disposition January 2012, 40 (1) 93-103; DOI: https://doi.org/10.1124/dmd.111.042275

  7. Lu, Jie

    1. CPY3A4-Mediated Lopinavir Bioactivation and Its Inhibition by Ritonavir
      Feng Li, Jie Lu and Xiaochao Ma
      Drug Metabolism and Disposition January 2012, 40 (1) 18-24; DOI: https://doi.org/10.1124/dmd.111.041400

  8. Ludwig-Schwellinger, Eva

    1. Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities
      Sumio Ohtsuki, Olaf Schaefer, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Naoki Ishiguro, Wataru Kishimoto, Eva Ludwig-Schwellinger, Thomas Ebner and Tetsuya Terasaki
      Drug Metabolism and Disposition January 2012, 40 (1) 83-92; DOI: https://doi.org/10.1124/dmd.111.042259

  9. Lutz, Justin D.

    1. Prediction of Relative In Vivo Metabolite Exposure from In Vitro Data Using Two Model Drugs: Dextromethorphan and Omeprazole
      Justin D. Lutz and Nina Isoherranen
      Drug Metabolism and Disposition January 2012, 40 (1) 159-168; DOI: https://doi.org/10.1124/dmd.111.042200

M

  1. Ma, Xiaochao

    1. CPY3A4-Mediated Lopinavir Bioactivation and Its Inhibition by Ritonavir
      Feng Li, Jie Lu and Xiaochao Ma
      Drug Metabolism and Disposition January 2012, 40 (1) 18-24; DOI: https://doi.org/10.1124/dmd.111.041400

  2. MacLauchlin, Christopher

    1. Human Metabolism of Lapatinib, a Dual Kinase Inhibitor: Implications for Hepatotoxicity
      Stephen Castellino, Michael O'Mara, Kevin Koch, David J. Borts, Gary D. Bowers and Christopher MacLauchlin
      Drug Metabolism and Disposition January 2012, 40 (1) 139-150; DOI: https://doi.org/10.1124/dmd.111.040949

  3. Mak, Nai Ki

    1. Cytoprotective Effect of 20(S)-Rg3 on Benzo[a]pyrene-Induced DNA Damage
      Po Ying Poon, Hoi Hin Kwok, Patrick Y. K. Yue, Mildred S. M. Yang, Nai Ki Mak, Chris K. C. Wong and Ricky N. S. Wong
      Drug Metabolism and Disposition January 2012, 40 (1) 120-129; DOI: https://doi.org/10.1124/dmd.111.039503

  4. Makar, Karen W.

    1. Potential Contribution of Cytochrome P450 2B6 to Hepatic 4-Hydroxycyclophosphamide Formation In Vitro and In Vivo
      Brianne S. Raccor, Adam J. Claessens, Jean C. Dinh, Julie R. Park, Douglas S. Hawkins, Sushma S. Thomas, Karen W. Makar, Jeannine S. McCune and Rheem A. Totah
      Drug Metabolism and Disposition January 2012, 40 (1) 54-63; DOI: https://doi.org/10.1124/dmd.111.039347

  5. Martin, Hélène

    1. Bupropion Hydroxylation as a Selective Marker of Rat CYP2B1 Catalytic Activity
      Dumrongsak Pekthong, Coraline Desbans, Hélène Martin and Lysiane Richert
      Drug Metabolism and Disposition January 2012, 40 (1) 32-38; DOI: https://doi.org/10.1124/dmd.111.041368

  6. Matsumaru, Takehisa

    1. Absolute Quantification and Differential Expression of Drug Transporters, Cytochrome P450 Enzymes, and UDP-Glucuronosyltransferases in Cultured Primary Human Hepatocytes
      Olaf Schaefer, Sumio Ohtsuki, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Atsushi Sakamoto, Naoki Ishiguro, Takehisa Matsumaru, Tetsuya Terasaki and Thomas Ebner
      Drug Metabolism and Disposition January 2012, 40 (1) 93-103; DOI: https://doi.org/10.1124/dmd.111.042275

  7. Maul, R.

    1. In Vitro Glucuronidation of the Antibacterial Triclocarban and Its Oxidative Metabolites
      N. H. Schebb, B. Franze, R. Maul, A. Ranganathan and B. D. Hammock
      Drug Metabolism and Disposition January 2012, 40 (1) 25-31; DOI: https://doi.org/10.1124/dmd.111.042283

  8. McCune, Jeannine S.

    1. Potential Contribution of Cytochrome P450 2B6 to Hepatic 4-Hydroxycyclophosphamide Formation In Vitro and In Vivo
      Brianne S. Raccor, Adam J. Claessens, Jean C. Dinh, Julie R. Park, Douglas S. Hawkins, Sushma S. Thomas, Karen W. Makar, Jeannine S. McCune and Rheem A. Totah
      Drug Metabolism and Disposition January 2012, 40 (1) 54-63; DOI: https://doi.org/10.1124/dmd.111.039347

  9. Michaud, Josée

    1. Effects of Chronic Renal Failure on Brain Drug Transporters in Rats
      Judith Naud, Louis-Philippe Laurin, Josée Michaud, Stéphanie Beauchemin, Francois A. Leblond and Vincent Pichette
      Drug Metabolism and Disposition January 2012, 40 (1) 39-46; DOI: https://doi.org/10.1124/dmd.111.041145

  10. Millner, Lori M.

    1. Phenotype of the Most Common “Slow Acetylator” Arylamine N-Acetyltransferase 1 Genetic Variant (NAT1*14B) Is Substrate-Dependent
      Lori M. Millner, Mark A. Doll, Jian Cai, J. Christopher States and David W. Hein
      Drug Metabolism and Disposition January 2012, 40 (1) 198-204; DOI: https://doi.org/10.1124/dmd.111.041855

  11. Morris, Marilyn E.

    1. γ-Hydroxybutyrate Blood/Plasma Partitioning: Effect of Physiologic pH on Transport by Monocarboxylate Transporters
      Bridget L. Morse, Melanie A. Felmlee and Marilyn E. Morris
      Drug Metabolism and Disposition January 2012, 40 (1) 64-69; DOI: https://doi.org/10.1124/dmd.111.041285
    2. Brain Uptake of the Drug of Abuse γ-Hydroxybutyric Acid in Rats
      Samuel A. Roiko, Melanie A. Felmlee and Marilyn E. Morris
      Drug Metabolism and Disposition January 2012, 40 (1) 212-218; DOI: https://doi.org/10.1124/dmd.111.041749

  12. Morse, Bridget L.

    1. γ-Hydroxybutyrate Blood/Plasma Partitioning: Effect of Physiologic pH on Transport by Monocarboxylate Transporters
      Bridget L. Morse, Melanie A. Felmlee and Marilyn E. Morris
      Drug Metabolism and Disposition January 2012, 40 (1) 64-69; DOI: https://doi.org/10.1124/dmd.111.041285

  13. Murai, Hidetsugu

    1. Prediction of Human Metabolism of FK3453 by Aldehyde Oxidase Using Chimeric Mice Transplanted with Human or Rat Hepatocytes
      Seigo Sanoh, Kazuyoshi Nozaki, Hidetsugu Murai, Shigeyuki Terashita, Toshio Teramura and Shigeru Ohta
      Drug Metabolism and Disposition January 2012, 40 (1) 76-82; DOI: https://doi.org/10.1124/dmd.111.041954

N

  1. Naud, Judith

    1. Effects of Chronic Renal Failure on Brain Drug Transporters in Rats
      Judith Naud, Louis-Philippe Laurin, Josée Michaud, Stéphanie Beauchemin, Francois A. Leblond and Vincent Pichette
      Drug Metabolism and Disposition January 2012, 40 (1) 39-46; DOI: https://doi.org/10.1124/dmd.111.041145

  2. Nozaki, Kazuyoshi

    1. Prediction of Human Metabolism of FK3453 by Aldehyde Oxidase Using Chimeric Mice Transplanted with Human or Rat Hepatocytes
      Seigo Sanoh, Kazuyoshi Nozaki, Hidetsugu Murai, Shigeyuki Terashita, Toshio Teramura and Shigeru Ohta
      Drug Metabolism and Disposition January 2012, 40 (1) 76-82; DOI: https://doi.org/10.1124/dmd.111.041954

O

  1. O'Kane, Dennis J.

    1. Frequency of Undetected CYP2D6 Hybrid Genes in Clinical Samples: Impact on Phenotype Prediction
      John Logan Black, Denise L. Walker, Dennis J. O'Kane and Maria Harmandayan
      Drug Metabolism and Disposition January 2012, 40 (1) 111-119; DOI: https://doi.org/10.1124/dmd.111.040832

  2. O'Mara, Michael

    1. Human Metabolism of Lapatinib, a Dual Kinase Inhibitor: Implications for Hepatotoxicity
      Stephen Castellino, Michael O'Mara, Kevin Koch, David J. Borts, Gary D. Bowers and Christopher MacLauchlin
      Drug Metabolism and Disposition January 2012, 40 (1) 139-150; DOI: https://doi.org/10.1124/dmd.111.040949

  3. Ohta, Shigeru

    1. Prediction of Human Metabolism of FK3453 by Aldehyde Oxidase Using Chimeric Mice Transplanted with Human or Rat Hepatocytes
      Seigo Sanoh, Kazuyoshi Nozaki, Hidetsugu Murai, Shigeyuki Terashita, Toshio Teramura and Shigeru Ohta
      Drug Metabolism and Disposition January 2012, 40 (1) 76-82; DOI: https://doi.org/10.1124/dmd.111.041954

  4. Ohtsuki, Sumio

    1. Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities
      Sumio Ohtsuki, Olaf Schaefer, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Naoki Ishiguro, Wataru Kishimoto, Eva Ludwig-Schwellinger, Thomas Ebner and Tetsuya Terasaki
      Drug Metabolism and Disposition January 2012, 40 (1) 83-92; DOI: https://doi.org/10.1124/dmd.111.042259
    2. Absolute Quantification and Differential Expression of Drug Transporters, Cytochrome P450 Enzymes, and UDP-Glucuronosyltransferases in Cultured Primary Human Hepatocytes
      Olaf Schaefer, Sumio Ohtsuki, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Atsushi Sakamoto, Naoki Ishiguro, Takehisa Matsumaru, Tetsuya Terasaki and Thomas Ebner
      Drug Metabolism and Disposition January 2012, 40 (1) 93-103; DOI: https://doi.org/10.1124/dmd.111.042275

  5. Olson, Carol A.

    1. A Semiphysiologically Based Pharmacokinetic Modeling Approach to Predict the Dose-Exposure Relationship of an Antiparasitic Prodrug/Active Metabolite Pair
      Grace Zhixia Yan, Claudia N. Generaux, Miyoung Yoon, Rachel B. Goldsmith, Richard R. Tidwell, James E. Hall, Carol A. Olson, Harvey J. Clewell, Kim L. R. Brouwer and Mary F. Paine
      Drug Metabolism and Disposition January 2012, 40 (1) 6-17; DOI: https://doi.org/10.1124/dmd.111.040063

  6. Olson, James R.

    1. Human Hepatic Cytochrome P450-Specific Metabolism of the Organophosphorus Pesticides Methyl Parathion and Diazinon
      Corie A. Ellison, Yuan Tian, James B. Knaak, Paul J. Kostyniak and James R. Olson
      Drug Metabolism and Disposition January 2012, 40 (1) 1-5; DOI: https://doi.org/10.1124/dmd.111.042572

P

  1. Paine, Mary F.

    1. A Semiphysiologically Based Pharmacokinetic Modeling Approach to Predict the Dose-Exposure Relationship of an Antiparasitic Prodrug/Active Metabolite Pair
      Grace Zhixia Yan, Claudia N. Generaux, Miyoung Yoon, Rachel B. Goldsmith, Richard R. Tidwell, James E. Hall, Carol A. Olson, Harvey J. Clewell, Kim L. R. Brouwer and Mary F. Paine
      Drug Metabolism and Disposition January 2012, 40 (1) 6-17; DOI: https://doi.org/10.1124/dmd.111.040063

  2. Park, Julie R.

    1. Potential Contribution of Cytochrome P450 2B6 to Hepatic 4-Hydroxycyclophosphamide Formation In Vitro and In Vivo
      Brianne S. Raccor, Adam J. Claessens, Jean C. Dinh, Julie R. Park, Douglas S. Hawkins, Sushma S. Thomas, Karen W. Makar, Jeannine S. McCune and Rheem A. Totah
      Drug Metabolism and Disposition January 2012, 40 (1) 54-63; DOI: https://doi.org/10.1124/dmd.111.039347

  3. Paul, Nikki

    1. In Vitro Inhibition of the Bile Salt Export Pump Correlates with Risk of Cholestatic Drug-Induced Liver Injury in Humans
      Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber and J. Gerald Kenna
      Drug Metabolism and Disposition January 2012, 40 (1) 130-138; DOI: https://doi.org/10.1124/dmd.111.040758

  4. Pekthong, Dumrongsak

    1. Bupropion Hydroxylation as a Selective Marker of Rat CYP2B1 Catalytic Activity
      Dumrongsak Pekthong, Coraline Desbans, Hélène Martin and Lysiane Richert
      Drug Metabolism and Disposition January 2012, 40 (1) 32-38; DOI: https://doi.org/10.1124/dmd.111.041368

  5. Perrin, Laurent

    1. Effects of Omeprazole and Genetic Polymorphism of CYP2C19 on the Clopidogrel Active Metabolite
      Xavier Boulenc, Nassim Djebli, Juan Shi, Laurent Perrin, William Brian, Robert Van Horn and Fabrice Hurbin
      Drug Metabolism and Disposition January 2012, 40 (1) 187-197; DOI: https://doi.org/10.1124/dmd.111.040394

  6. Pichette, Vincent

    1. Effects of Chronic Renal Failure on Brain Drug Transporters in Rats
      Judith Naud, Louis-Philippe Laurin, Josée Michaud, Stéphanie Beauchemin, Francois A. Leblond and Vincent Pichette
      Drug Metabolism and Disposition January 2012, 40 (1) 39-46; DOI: https://doi.org/10.1124/dmd.111.041145

  7. Poon, Po Ying

    1. Cytoprotective Effect of 20(S)-Rg3 on Benzo[a]pyrene-Induced DNA Damage
      Po Ying Poon, Hoi Hin Kwok, Patrick Y. K. Yue, Mildred S. M. Yang, Nai Ki Mak, Chris K. C. Wong and Ricky N. S. Wong
      Drug Metabolism and Disposition January 2012, 40 (1) 120-129; DOI: https://doi.org/10.1124/dmd.111.039503

R

  1. Raccor, Brianne S.

    1. Potential Contribution of Cytochrome P450 2B6 to Hepatic 4-Hydroxycyclophosphamide Formation In Vitro and In Vivo
      Brianne S. Raccor, Adam J. Claessens, Jean C. Dinh, Julie R. Park, Douglas S. Hawkins, Sushma S. Thomas, Karen W. Makar, Jeannine S. McCune and Rheem A. Totah
      Drug Metabolism and Disposition January 2012, 40 (1) 54-63; DOI: https://doi.org/10.1124/dmd.111.039347

  2. Rajaraman, Ganesh

    1. Species-Dependent and Receptor-Selective Action of Bilobalide on the Function of Constitutive Androstane Receptor and Pregnane X Receptor
      Aik Jiang Lau, Guixiang Yang, Ganesh Rajaraman, Christie C. Baucom and Thomas K. H. Chang
      Drug Metabolism and Disposition January 2012, 40 (1) 178-186; DOI: https://doi.org/10.1124/dmd.111.042879

  3. Ranganathan, A.

    1. In Vitro Glucuronidation of the Antibacterial Triclocarban and Its Oxidative Metabolites
      N. H. Schebb, B. Franze, R. Maul, A. Ranganathan and B. D. Hammock
      Drug Metabolism and Disposition January 2012, 40 (1) 25-31; DOI: https://doi.org/10.1124/dmd.111.042283

  4. Richert, Lysiane

    1. Bupropion Hydroxylation as a Selective Marker of Rat CYP2B1 Catalytic Activity
      Dumrongsak Pekthong, Coraline Desbans, Hélène Martin and Lysiane Richert
      Drug Metabolism and Disposition January 2012, 40 (1) 32-38; DOI: https://doi.org/10.1124/dmd.111.041368

  5. Rock, Dan A.

    1. Prediction of CYP2D6 Drug Interactions from In Vitro Data: Evidence for Substrate-Dependent Inhibition
      Brooke M. VandenBrink, Robert S. Foti, Dan A. Rock, Larry C. Wienkers and Jan L. Wahlstrom
      Drug Metabolism and Disposition January 2012, 40 (1) 47-53; DOI: https://doi.org/10.1124/dmd.111.041210

  6. Rogue, Alexandra

    1. Interindividual Variability in Gene Expression Profiles in Human Hepatocytes and Comparison with HepaRG Cells
      Alexandra Rogue, Carine Lambert, Catherine Spire, Nancy Claude and André Guillouzo
      Drug Metabolism and Disposition January 2012, 40 (1) 151-158; DOI: https://doi.org/10.1124/dmd.111.042028

  7. Roiko, Samuel A.

    1. Brain Uptake of the Drug of Abuse γ-Hydroxybutyric Acid in Rats
      Samuel A. Roiko, Melanie A. Felmlee and Marilyn E. Morris
      Drug Metabolism and Disposition January 2012, 40 (1) 212-218; DOI: https://doi.org/10.1124/dmd.111.041749

S

  1. Saito, Asami

    1. Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities
      Sumio Ohtsuki, Olaf Schaefer, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Naoki Ishiguro, Wataru Kishimoto, Eva Ludwig-Schwellinger, Thomas Ebner and Tetsuya Terasaki
      Drug Metabolism and Disposition January 2012, 40 (1) 83-92; DOI: https://doi.org/10.1124/dmd.111.042259
    2. Absolute Quantification and Differential Expression of Drug Transporters, Cytochrome P450 Enzymes, and UDP-Glucuronosyltransferases in Cultured Primary Human Hepatocytes
      Olaf Schaefer, Sumio Ohtsuki, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Atsushi Sakamoto, Naoki Ishiguro, Takehisa Matsumaru, Tetsuya Terasaki and Thomas Ebner
      Drug Metabolism and Disposition January 2012, 40 (1) 93-103; DOI: https://doi.org/10.1124/dmd.111.042275

  2. Sakamoto, Atsushi

    1. Absolute Quantification and Differential Expression of Drug Transporters, Cytochrome P450 Enzymes, and UDP-Glucuronosyltransferases in Cultured Primary Human Hepatocytes
      Olaf Schaefer, Sumio Ohtsuki, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Atsushi Sakamoto, Naoki Ishiguro, Takehisa Matsumaru, Tetsuya Terasaki and Thomas Ebner
      Drug Metabolism and Disposition January 2012, 40 (1) 93-103; DOI: https://doi.org/10.1124/dmd.111.042275

  3. Sanoh, Seigo

    1. Prediction of Human Metabolism of FK3453 by Aldehyde Oxidase Using Chimeric Mice Transplanted with Human or Rat Hepatocytes
      Seigo Sanoh, Kazuyoshi Nozaki, Hidetsugu Murai, Shigeyuki Terashita, Toshio Teramura and Shigeru Ohta
      Drug Metabolism and Disposition January 2012, 40 (1) 76-82; DOI: https://doi.org/10.1124/dmd.111.041954

  4. Schaefer, Olaf

    1. Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities
      Sumio Ohtsuki, Olaf Schaefer, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Naoki Ishiguro, Wataru Kishimoto, Eva Ludwig-Schwellinger, Thomas Ebner and Tetsuya Terasaki
      Drug Metabolism and Disposition January 2012, 40 (1) 83-92; DOI: https://doi.org/10.1124/dmd.111.042259
    2. Absolute Quantification and Differential Expression of Drug Transporters, Cytochrome P450 Enzymes, and UDP-Glucuronosyltransferases in Cultured Primary Human Hepatocytes
      Olaf Schaefer, Sumio Ohtsuki, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Atsushi Sakamoto, Naoki Ishiguro, Takehisa Matsumaru, Tetsuya Terasaki and Thomas Ebner
      Drug Metabolism and Disposition January 2012, 40 (1) 93-103; DOI: https://doi.org/10.1124/dmd.111.042275

  5. Schebb, N. H.

    1. In Vitro Glucuronidation of the Antibacterial Triclocarban and Its Oxidative Metabolites
      N. H. Schebb, B. Franze, R. Maul, A. Ranganathan and B. D. Hammock
      Drug Metabolism and Disposition January 2012, 40 (1) 25-31; DOI: https://doi.org/10.1124/dmd.111.042283

  6. Shi, Juan

    1. Effects of Omeprazole and Genetic Polymorphism of CYP2C19 on the Clopidogrel Active Metabolite
      Xavier Boulenc, Nassim Djebli, Juan Shi, Laurent Perrin, William Brian, Robert Van Horn and Fabrice Hurbin
      Drug Metabolism and Disposition January 2012, 40 (1) 187-197; DOI: https://doi.org/10.1124/dmd.111.040394

  7. Soga, Tomoyoshi

    1. Acetaminophen-Induced Hepatotoxicity in a Liver Tissue Model Consisting of Primary Hepatocytes Assembling around an Endothelial Cell Network
      Yu Toyoda, Miho Tamai, Kasumi Kashikura, Shunsuke Kobayashi, Yoichi Fujiyama, Tomoyoshi Soga and Yoh-ichi Tagawa
      Drug Metabolism and Disposition January 2012, 40 (1) 169-177; DOI: https://doi.org/10.1124/dmd.111.041137

  8. Spire, Catherine

    1. Interindividual Variability in Gene Expression Profiles in Human Hepatocytes and Comparison with HepaRG Cells
      Alexandra Rogue, Carine Lambert, Catherine Spire, Nancy Claude and André Guillouzo
      Drug Metabolism and Disposition January 2012, 40 (1) 151-158; DOI: https://doi.org/10.1124/dmd.111.042028

  9. Stahl, Simone

    1. In Vitro Inhibition of the Bile Salt Export Pump Correlates with Risk of Cholestatic Drug-Induced Liver Injury in Humans
      Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber and J. Gerald Kenna
      Drug Metabolism and Disposition January 2012, 40 (1) 130-138; DOI: https://doi.org/10.1124/dmd.111.040758

  10. States, J. Christopher

    1. Phenotype of the Most Common “Slow Acetylator” Arylamine N-Acetyltransferase 1 Genetic Variant (NAT1*14B) Is Substrate-Dependent
      Lori M. Millner, Mark A. Doll, Jian Cai, J. Christopher States and David W. Hein
      Drug Metabolism and Disposition January 2012, 40 (1) 198-204; DOI: https://doi.org/10.1124/dmd.111.041855

  11. Strobel, Henry W.

    1. Regulation of Cytochrome P450 4F11 by Nuclear Transcription Factor-κB
      Jordan C. Bell and Henry W. Strobel
      Drug Metabolism and Disposition January 2012, 40 (1) 205-211; DOI: https://doi.org/10.1124/dmd.111.041178

T

  1. Tagawa, Yoh-ichi

    1. Acetaminophen-Induced Hepatotoxicity in a Liver Tissue Model Consisting of Primary Hepatocytes Assembling around an Endothelial Cell Network
      Yu Toyoda, Miho Tamai, Kasumi Kashikura, Shunsuke Kobayashi, Yoichi Fujiyama, Tomoyoshi Soga and Yoh-ichi Tagawa
      Drug Metabolism and Disposition January 2012, 40 (1) 169-177; DOI: https://doi.org/10.1124/dmd.111.041137

  2. Tamai, Miho

    1. Acetaminophen-Induced Hepatotoxicity in a Liver Tissue Model Consisting of Primary Hepatocytes Assembling around an Endothelial Cell Network
      Yu Toyoda, Miho Tamai, Kasumi Kashikura, Shunsuke Kobayashi, Yoichi Fujiyama, Tomoyoshi Soga and Yoh-ichi Tagawa
      Drug Metabolism and Disposition January 2012, 40 (1) 169-177; DOI: https://doi.org/10.1124/dmd.111.041137

  3. Teramura, Toshio

    1. Prediction of Human Metabolism of FK3453 by Aldehyde Oxidase Using Chimeric Mice Transplanted with Human or Rat Hepatocytes
      Seigo Sanoh, Kazuyoshi Nozaki, Hidetsugu Murai, Shigeyuki Terashita, Toshio Teramura and Shigeru Ohta
      Drug Metabolism and Disposition January 2012, 40 (1) 76-82; DOI: https://doi.org/10.1124/dmd.111.041954

  4. Terasaki, Tetsuya

    1. Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities
      Sumio Ohtsuki, Olaf Schaefer, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Naoki Ishiguro, Wataru Kishimoto, Eva Ludwig-Schwellinger, Thomas Ebner and Tetsuya Terasaki
      Drug Metabolism and Disposition January 2012, 40 (1) 83-92; DOI: https://doi.org/10.1124/dmd.111.042259
    2. Absolute Quantification and Differential Expression of Drug Transporters, Cytochrome P450 Enzymes, and UDP-Glucuronosyltransferases in Cultured Primary Human Hepatocytes
      Olaf Schaefer, Sumio Ohtsuki, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Atsushi Sakamoto, Naoki Ishiguro, Takehisa Matsumaru, Tetsuya Terasaki and Thomas Ebner
      Drug Metabolism and Disposition January 2012, 40 (1) 93-103; DOI: https://doi.org/10.1124/dmd.111.042275

  5. Terashita, Shigeyuki

    1. Prediction of Human Metabolism of FK3453 by Aldehyde Oxidase Using Chimeric Mice Transplanted with Human or Rat Hepatocytes
      Seigo Sanoh, Kazuyoshi Nozaki, Hidetsugu Murai, Shigeyuki Terashita, Toshio Teramura and Shigeru Ohta
      Drug Metabolism and Disposition January 2012, 40 (1) 76-82; DOI: https://doi.org/10.1124/dmd.111.041954

  6. Thomas, Sushma S.

    1. Potential Contribution of Cytochrome P450 2B6 to Hepatic 4-Hydroxycyclophosphamide Formation In Vitro and In Vivo
      Brianne S. Raccor, Adam J. Claessens, Jean C. Dinh, Julie R. Park, Douglas S. Hawkins, Sushma S. Thomas, Karen W. Makar, Jeannine S. McCune and Rheem A. Totah
      Drug Metabolism and Disposition January 2012, 40 (1) 54-63; DOI: https://doi.org/10.1124/dmd.111.039347

  7. Tian, Yuan

    1. Human Hepatic Cytochrome P450-Specific Metabolism of the Organophosphorus Pesticides Methyl Parathion and Diazinon
      Corie A. Ellison, Yuan Tian, James B. Knaak, Paul J. Kostyniak and James R. Olson
      Drug Metabolism and Disposition January 2012, 40 (1) 1-5; DOI: https://doi.org/10.1124/dmd.111.042572

  8. Tidwell, Richard R.

    1. A Semiphysiologically Based Pharmacokinetic Modeling Approach to Predict the Dose-Exposure Relationship of an Antiparasitic Prodrug/Active Metabolite Pair
      Grace Zhixia Yan, Claudia N. Generaux, Miyoung Yoon, Rachel B. Goldsmith, Richard R. Tidwell, James E. Hall, Carol A. Olson, Harvey J. Clewell, Kim L. R. Brouwer and Mary F. Paine
      Drug Metabolism and Disposition January 2012, 40 (1) 6-17; DOI: https://doi.org/10.1124/dmd.111.040063

  9. Totah, Rheem A.

    1. Potential Contribution of Cytochrome P450 2B6 to Hepatic 4-Hydroxycyclophosphamide Formation In Vitro and In Vivo
      Brianne S. Raccor, Adam J. Claessens, Jean C. Dinh, Julie R. Park, Douglas S. Hawkins, Sushma S. Thomas, Karen W. Makar, Jeannine S. McCune and Rheem A. Totah
      Drug Metabolism and Disposition January 2012, 40 (1) 54-63; DOI: https://doi.org/10.1124/dmd.111.039347

  10. Toyoda, Yu

    1. Acetaminophen-Induced Hepatotoxicity in a Liver Tissue Model Consisting of Primary Hepatocytes Assembling around an Endothelial Cell Network
      Yu Toyoda, Miho Tamai, Kasumi Kashikura, Shunsuke Kobayashi, Yoichi Fujiyama, Tomoyoshi Soga and Yoh-ichi Tagawa
      Drug Metabolism and Disposition January 2012, 40 (1) 169-177; DOI: https://doi.org/10.1124/dmd.111.041137

  11. Turlizzi, Elisa

    1. Comparison of Cryopreserved HepaRG Cells with Cryopreserved Human Hepatocytes for Prediction of Clearance for 26 Drugs
      Ugo Zanelli, Nicola Pasquale Caradonna, David Hallifax, Elisa Turlizzi and J. Brian Houston
      Drug Metabolism and Disposition January 2012, 40 (1) 104-110; DOI: https://doi.org/10.1124/dmd.111.042309

V

  1. VandenBrink, Brooke M.

    1. Prediction of CYP2D6 Drug Interactions from In Vitro Data: Evidence for Substrate-Dependent Inhibition
      Brooke M. VandenBrink, Robert S. Foti, Dan A. Rock, Larry C. Wienkers and Jan L. Wahlstrom
      Drug Metabolism and Disposition January 2012, 40 (1) 47-53; DOI: https://doi.org/10.1124/dmd.111.041210

  2. Van Horn, Robert

    1. Effects of Omeprazole and Genetic Polymorphism of CYP2C19 on the Clopidogrel Active Metabolite
      Xavier Boulenc, Nassim Djebli, Juan Shi, Laurent Perrin, William Brian, Robert Van Horn and Fabrice Hurbin
      Drug Metabolism and Disposition January 2012, 40 (1) 187-197; DOI: https://doi.org/10.1124/dmd.111.040394

W

  1. Wahlstrom, Jan L.

    1. Prediction of CYP2D6 Drug Interactions from In Vitro Data: Evidence for Substrate-Dependent Inhibition
      Brooke M. VandenBrink, Robert S. Foti, Dan A. Rock, Larry C. Wienkers and Jan L. Wahlstrom
      Drug Metabolism and Disposition January 2012, 40 (1) 47-53; DOI: https://doi.org/10.1124/dmd.111.041210

  2. Walker, Denise L.

    1. Frequency of Undetected CYP2D6 Hybrid Genes in Clinical Samples: Impact on Phenotype Prediction
      John Logan Black, Denise L. Walker, Dennis J. O'Kane and Maria Harmandayan
      Drug Metabolism and Disposition January 2012, 40 (1) 111-119; DOI: https://doi.org/10.1124/dmd.111.040832

  3. Wienkers, Larry C.

    1. Prediction of CYP2D6 Drug Interactions from In Vitro Data: Evidence for Substrate-Dependent Inhibition
      Brooke M. VandenBrink, Robert S. Foti, Dan A. Rock, Larry C. Wienkers and Jan L. Wahlstrom
      Drug Metabolism and Disposition January 2012, 40 (1) 47-53; DOI: https://doi.org/10.1124/dmd.111.041210

  4. Wong, Chris K. C.

    1. Cytoprotective Effect of 20(S)-Rg3 on Benzo[a]pyrene-Induced DNA Damage
      Po Ying Poon, Hoi Hin Kwok, Patrick Y. K. Yue, Mildred S. M. Yang, Nai Ki Mak, Chris K. C. Wong and Ricky N. S. Wong
      Drug Metabolism and Disposition January 2012, 40 (1) 120-129; DOI: https://doi.org/10.1124/dmd.111.039503

  5. Wong, Ricky N. S.

    1. Cytoprotective Effect of 20(S)-Rg3 on Benzo[a]pyrene-Induced DNA Damage
      Po Ying Poon, Hoi Hin Kwok, Patrick Y. K. Yue, Mildred S. M. Yang, Nai Ki Mak, Chris K. C. Wong and Ricky N. S. Wong
      Drug Metabolism and Disposition January 2012, 40 (1) 120-129; DOI: https://doi.org/10.1124/dmd.111.039503

Y

  1. Yan, Grace Zhixia

    1. A Semiphysiologically Based Pharmacokinetic Modeling Approach to Predict the Dose-Exposure Relationship of an Antiparasitic Prodrug/Active Metabolite Pair
      Grace Zhixia Yan, Claudia N. Generaux, Miyoung Yoon, Rachel B. Goldsmith, Richard R. Tidwell, James E. Hall, Carol A. Olson, Harvey J. Clewell, Kim L. R. Brouwer and Mary F. Paine
      Drug Metabolism and Disposition January 2012, 40 (1) 6-17; DOI: https://doi.org/10.1124/dmd.111.040063

  2. Yang, Guixiang

    1. Species-Dependent and Receptor-Selective Action of Bilobalide on the Function of Constitutive Androstane Receptor and Pregnane X Receptor
      Aik Jiang Lau, Guixiang Yang, Ganesh Rajaraman, Christie C. Baucom and Thomas K. H. Chang
      Drug Metabolism and Disposition January 2012, 40 (1) 178-186; DOI: https://doi.org/10.1124/dmd.111.042879

  3. Yang, Mildred S. M.

    1. Cytoprotective Effect of 20(S)-Rg3 on Benzo[a]pyrene-Induced DNA Damage
      Po Ying Poon, Hoi Hin Kwok, Patrick Y. K. Yue, Mildred S. M. Yang, Nai Ki Mak, Chris K. C. Wong and Ricky N. S. Wong
      Drug Metabolism and Disposition January 2012, 40 (1) 120-129; DOI: https://doi.org/10.1124/dmd.111.039503

  4. Yoon, Miyoung

    1. A Semiphysiologically Based Pharmacokinetic Modeling Approach to Predict the Dose-Exposure Relationship of an Antiparasitic Prodrug/Active Metabolite Pair
      Grace Zhixia Yan, Claudia N. Generaux, Miyoung Yoon, Rachel B. Goldsmith, Richard R. Tidwell, James E. Hall, Carol A. Olson, Harvey J. Clewell, Kim L. R. Brouwer and Mary F. Paine
      Drug Metabolism and Disposition January 2012, 40 (1) 6-17; DOI: https://doi.org/10.1124/dmd.111.040063

  5. Yue, Patrick Y. K.

    1. Cytoprotective Effect of 20(S)-Rg3 on Benzo[a]pyrene-Induced DNA Damage
      Po Ying Poon, Hoi Hin Kwok, Patrick Y. K. Yue, Mildred S. M. Yang, Nai Ki Mak, Chris K. C. Wong and Ricky N. S. Wong
      Drug Metabolism and Disposition January 2012, 40 (1) 120-129; DOI: https://doi.org/10.1124/dmd.111.039503

Z

  1. Zanelli, Ugo

    1. Comparison of Cryopreserved HepaRG Cells with Cryopreserved Human Hepatocytes for Prediction of Clearance for 26 Drugs
      Ugo Zanelli, Nicola Pasquale Caradonna, David Hallifax, Elisa Turlizzi and J. Brian Houston
      Drug Metabolism and Disposition January 2012, 40 (1) 104-110; DOI: https://doi.org/10.1124/dmd.111.042309
Back to top

In this issue

Advertisement