In Vitro Inhibition of the Bile Salt Export Pump Correlates with Risk of Cholestatic Drug-Induced Liver Injury in Humans

Address correspondence to:
Sarah Dawson, AstraZeneca Pharmaceuticals, Molecular Toxicology, Safety Assessment UK, Mereside, Alderley Park Macclesfield, Cheshire SK10 4TG, UK. E-mail: sarah.dawson{at}astrazeneca.com

Parts of this work were previously presented at the following conferences: Stahl S, Dawson S, Barber J, Paul N, and Kenna JG (2010) BSEP inhibition and risk of drug induced liver injury in man. 49th Annual Meeting & ToxExpo; 2010 Mar 7–11; Salt Lake City, UT. Abstract 2122. Society of Toxicology, Reston, VA; Dawson S, Stahl S, Barber J, Summers C, Paul N, and Kenna JG (2010) Evaluation of the relationship between inhibition of the bile salt export pump in vitro and risk of drug-induced liver injury in man. Toxicology 278:356.

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