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Research ArticleArticle

Human Metabolism of Lapatinib, a Dual Kinase Inhibitor: Implications for Hepatotoxicity

Stephen Castellino, Michael O'Mara, Kevin Koch, David J. Borts, Gary D. Bowers and Christopher MacLauchlin
Drug Metabolism and Disposition January 2012, 40 (1) 139-150; DOI: https://doi.org/10.1124/dmd.111.040949

Article Information

vol. 40 no. 1 139-150
DOI 
https://doi.org/10.1124/dmd.111.040949
PubMed 
21965624
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received June 1, 2011
  • Accepted September 30, 2011
  • Published online December 16, 2011.

Article Versions

Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Stephen Castellino,
  2. Michael O'Mara,
  3. Kevin Koch,
  4. David J. Borts,
  5. Gary D. Bowers and
  6. Christopher MacLauchlin
  1. Department of Drug Metabolism and Pharmacokinetics (S.C., M.O., G.D.B., C.M.) and Department of Clinical Pharmacokinetics (K.K.), GlaxoSmithKline, Research Triangle Park, North Carolina; and Field Analytics, BASF Plant Science, Ames, Iowa (D.J.B.)
  1. Address correspondence to:
    Dr. Stephen Castellino, GlaxoSmithKline, 5 Moore Dr., Research Triangle Park, NC 27709. E-mail: steve.x.castellino{at}gsk.com
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Research ArticleArticle

HUMAN METABOLISM OF LAPATINIB: HEPATOTOXICITY IMPLICATIONS

Stephen Castellino, Michael O'Mara, Kevin Koch, David J. Borts, Gary D. Bowers and Christopher MacLauchlin
Drug Metabolism and Disposition January 1, 2012, 40 (1) 139-150; DOI: https://doi.org/10.1124/dmd.111.040949
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