Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities

Division of Membrane Transport and Drug Targeting, Department of Biochemical Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan (S.O., H.K., T.I., T.T.); Department of Pharmacokinetics and Nonclinical Safety, Nippon Boehringer Ingelheim Co., Ltd., Kobe, Japan (O.S., A.S., N.I., W.K.); and Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim GmbH & Co. KG, Biberach, Germany (S.L., E.L.-S., T.E.)

Address correspondence to:
Dr. Tetsuya Terasaki, Professor, Division of Membrane Transport and Drug Targeting Laboratory, Department of Biochemical Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku Sendai 980-8578, Japan. E-mail: terasaki.tetsuya{at}m.tohoku.ac.jp

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