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Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities

Sumio Ohtsuki, Olaf Schaefer, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Naoki Ishiguro, Wataru Kishimoto, Eva Ludwig-Schwellinger, Thomas Ebner and Tetsuya Terasaki
Drug Metabolism and Disposition January 2012, 40 (1) 83-92; DOI: https://doi.org/10.1124/dmd.111.042259

Article Information

vol. 40 no. 1 83-92
DOI 
https://doi.org/10.1124/dmd.111.042259
PubMed 
21994437
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received August 8, 2011
  • Accepted October 12, 2011
  • Published online December 16, 2011.

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Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Sumio Ohtsuki,
  2. Olaf Schaefer,
  3. Hirotaka Kawakami,
  4. Tae Inoue,
  5. Stephanie Liehner,
  6. Asami Saito,
  7. Naoki Ishiguro,
  8. Wataru Kishimoto,
  9. Eva Ludwig-Schwellinger,
  10. Thomas Ebner and
  11. Tetsuya Terasaki
  1. Division of Membrane Transport and Drug Targeting, Department of Biochemical Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan (S.O., H.K., T.I., T.T.); Department of Pharmacokinetics and Nonclinical Safety, Nippon Boehringer Ingelheim Co., Ltd., Kobe, Japan (O.S., A.S., N.I., W.K.); and Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim GmbH & Co. KG, Biberach, Germany (S.L., E.L.-S., T.E.)
  1. Address correspondence to:
    Dr. Tetsuya Terasaki, Professor, Division of Membrane Transport and Drug Targeting Laboratory, Department of Biochemical Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku Sendai 980-8578, Japan. E-mail: terasaki.tetsuya{at}m.tohoku.ac.jp
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PROTEIN LEVELS OF P450, UGT, AND TRANSPORTERS IN HUMAN LIVER

Sumio Ohtsuki, Olaf Schaefer, Hirotaka Kawakami, Tae Inoue, Stephanie Liehner, Asami Saito, Naoki Ishiguro, Wataru Kishimoto, Eva Ludwig-Schwellinger, Thomas Ebner and Tetsuya Terasaki
Drug Metabolism and Disposition January 1, 2012, 40 (1) 83-92; DOI: https://doi.org/10.1124/dmd.111.042259
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