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Drug Metabolism & Disposition

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Table of Contents

October 01, 2012; Volume 40,Issue 10

Commentary

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    Commentary: Theoretical Predictions of Flow Effects on Intestinal and Systemic Availability in Physiologically Based Pharmacokinetic Intestine Models: The Traditional Model, Segregated Flow Model, and QGut Model
    K. Sandy Pang and Edwin C. Y. Chow
    Drug Metabolism and Disposition October 2012, 40 (10) 1869-1877; DOI: https://doi.org/10.1124/dmd.112.045872

Short Communication

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    Selective Expression of CYP2A13 in Human Pancreatic α-Islet Cells
    Yu Guo, Liang-Ru Zhu, Gang Lu, Hui Wang and Jun-Yan Hong
    Drug Metabolism and Disposition October 2012, 40 (10) 1878-1882; DOI: https://doi.org/10.1124/dmd.112.046359

Articles

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    Breast Cancer Resistance Protein (ABCG2) Determines Distribution of Genistein Phase II Metabolites: Reevaluation of the Roles of ABCG2 in the Disposition of Genistein
    Zhen Yang, Wei Zhu, Song Gao, Taijun Yin, Wen Jiang and Ming Hu
    Drug Metabolism and Disposition October 2012, 40 (10) 1883-1893; DOI: https://doi.org/10.1124/dmd.111.043901
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    Selective Modulation of Hepatic Cytochrome P450 and Flavin Monooxygenase 3 Expression during Citrobacter rodentium Infection in Severe Combined Immune-Deficient Mice
    Beatrice A. Nyagode, William J. Watkins, Ryan D. Kinloch and Edward T. Morgan
    Drug Metabolism and Disposition October 2012, 40 (10) 1894-1899; DOI: https://doi.org/10.1124/dmd.112.046557
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    Key Role of Nuclear Factor-κB in the Cellular Pharmacokinetics of Adriamycin in MCF-7/Adr Cells: The Potential Mechanism for Synergy with 20(S)-Ginsenoside Rh2
    Jingwei Zhang, Meng Lu, Fang Zhou, Haopeng Sun, Gang Hao, Xiaolan Wu and Guangji Wang
    Drug Metabolism and Disposition October 2012, 40 (10) 1900-1908; DOI: https://doi.org/10.1124/dmd.112.045187
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    Microdialysis Evaluation of Clozapine and N-Desmethylclozapine Pharmacokinetics in Rat Brain
    Thomas I. F. H. Cremers, Gunnar Flik, Corry Hofland and Robert E. Stratford
    Drug Metabolism and Disposition October 2012, 40 (10) 1909-1916; DOI: https://doi.org/10.1124/dmd.112.045682
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    Comparison of Metabolism of Sesamin and Episesamin by Drug-Metabolizing Enzymes in Human Liver
    Kaori Yasuda, Shinichi Ikushiro, Shuto Wakayama, Toshimasa Itoh, Keiko Yamamoto, Masaki Kamakura, Eiji Munetsuna, Miho Ohta and Toshiyuki Sakaki
    Drug Metabolism and Disposition October 2012, 40 (10) 1917-1926; DOI: https://doi.org/10.1124/dmd.112.045906
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    In Vitro Characterization of the Drug-Drug Interaction Potential of Catabolites of Antibody-Maytansinoid Conjugates
    John A. Davis, Dan A. Rock, Larry C. Wienkers and Josh T. Pearson
    Drug Metabolism and Disposition October 2012, 40 (10) 1927-1934; DOI: https://doi.org/10.1124/dmd.112.046169
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    Human UDP-Glucuronosyltransferase Expression in Insect Cells: Ratio of Active to Inactive Recombinant Proteins and the Effects of a C-Terminal His-Tag on Glucuronidation Kinetics
    Hongbo Zhang, Anne-Sisko Patana, Peter I. Mackenzie, Shinichi Ikushiro, Adrian Goldman and Moshe Finel
    Drug Metabolism and Disposition October 2012, 40 (10) 1935-1944; DOI: https://doi.org/10.1124/dmd.112.046086
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    The Effects on Metabolic Clearance when Administering a Potent CYP3A Autoinducer with the Prototypic CYP3A Inhibitor, Ketoconazole
    Mosun A. Ayan-Oshodi, Brian A. Willis, William F. Annes, Stephen L. Lowe, Stuart Friedrich, Amparo de la Peña, Wei Zhang, Thomas Brown, Stephen D. Wise and Stephen D. Hall
    Drug Metabolism and Disposition October 2012, 40 (10) 1945-1952; DOI: https://doi.org/10.1124/dmd.112.046060
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    Xenobiotic Metabolism and Disposition in Human Lung Cell Models: Comparison with In Vivo Expression Profiles
    Elisabeth Courcot, Julie Leclerc, Jean-Jacques Lafitte, Eric Mensier, Sophie Jaillard, Philippe Gosset, Pirouz Shirali, Nicolas Pottier, Franck Broly and Jean-Marc Lo-Guidice
    Drug Metabolism and Disposition October 2012, 40 (10) 1953-1965; DOI: https://doi.org/10.1124/dmd.112.046896
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    High-Resolution Mass Spectrometry Elucidates Metabonate (False Metabolite) Formation from Alkylamine Drugs during In Vitro Metabolite Profiling
    Joanna E. Barbara, Faraz Kazmi, Seema Muranjan, Paul C. Toren and Andrew Parkinson
    Drug Metabolism and Disposition October 2012, 40 (10) 1966-1975; DOI: https://doi.org/10.1124/dmd.112.047027
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    CYP2E1 Metabolism of Styrene Involves Allostery
    Jessica H. Hartman, Gunnar Boysen and Grover P. Miller
    Drug Metabolism and Disposition October 2012, 40 (10) 1976-1983; DOI: https://doi.org/10.1124/dmd.112.046698
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    Human Liver Methionine Cycle: MAT1A and GNMT Gene Resequencing, Functional Genomics, and Hepatic Genotype-Phenotype Correlation
    Yuan Ji, Kendra K. S. Nordgren, Yubo Chai, Scott J. Hebbring, Gregory D. Jenkins, Ryan P. Abo, Yi Peng, Linda L. Pelleymounter, Irene Moon, Bruce W. Eckloff, Xiaoshan Chai, Jianping Zhang, Brooke L. Fridley, Vivien C. Yee, Eric D. Wieben and Richard M. Weinshilboum
    Drug Metabolism and Disposition October 2012, 40 (10) 1984-1992; DOI: https://doi.org/10.1124/dmd.112.046953
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    In Vivo-Formed versus Preformed Metabolite Kinetics of trans-Resveratrol-3-sulfate and trans-Resveratrol-3-glucuronide
    Satish Sharan, Otito F. Iwuchukwu, Daniel J. Canney, Cheryl L. Zimmerman and Swati Nagar
    Drug Metabolism and Disposition October 2012, 40 (10) 1993-2001; DOI: https://doi.org/10.1124/dmd.112.046417
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    Acetylenic Linkers in Lead Compounds: A Study of the Stability of the Propargyl-Linked Antifolates
    Wangda Zhou, Kishore Viswanathan, Dennis Hill, Amy C. Anderson and Dennis L. Wright
    Drug Metabolism and Disposition October 2012, 40 (10) 2002-2008; DOI: https://doi.org/10.1124/dmd.112.046870
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    Mechanistic Studies on the Absorption and Disposition of Scutellarin in Humans: Selective OATP2B1-Mediated Hepatic Uptake Is a Likely Key Determinant for Its Unique Pharmacokinetic Characteristics
    Chunying Gao, Hongjian Zhang, Zitao Guo, Tiangeng You, Xiaoyan Chen and Dafang Zhong
    Drug Metabolism and Disposition October 2012, 40 (10) 2009-2020; DOI: https://doi.org/10.1124/dmd.112.047183
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    Glycemic Control and Chronic Dosing of Rhesus Monkeys with a Fusion Protein of Iduronidase and a Monoclonal Antibody Against the Human Insulin Receptor
    Ruben J. Boado, Eric Ka-Wai Hui, Jeff Zhiqiang Lu and William M. Pardridge
    Drug Metabolism and Disposition October 2012, 40 (10) 2021-2025; DOI: https://doi.org/10.1124/dmd.112.046375
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    Absolute Oral Bioavailability and Metabolic Turnover of β-Sitosterol in Healthy Subjects
    Guus Duchateau, Brett Cochrane, Sam Windebank, Justyna Herudzinska, Davindera Sanghera, Angela Burian, Markus Müller, Markus Zeitlinger and Graham Lappin
    Drug Metabolism and Disposition October 2012, 40 (10) 2026-2030; DOI: https://doi.org/10.1124/dmd.112.046623
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    Regulation of Pregnane X Receptor (PXR) Function and UGT1A1 Gene Expression by Posttranslational Modification of PXR Protein
    Junko Sugatani, Takahiro Uchida, Masatoshi Kurosawa, Masahiko Yamaguchi, Yasuhiro Yamazaki, Akira Ikari and Masao Miwa
    Drug Metabolism and Disposition October 2012, 40 (10) 2031-2040; DOI: https://doi.org/10.1124/dmd.112.046748
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    In Vitro Studies on the Oxidative Metabolism of 20(S)-Ginsenoside Rh2 in Human, Monkey, Dog, Rat, and Mouse Liver Microsomes, and Human Liver S9
    Liang Li, Xiaoyan Chen, Jialan Zhou and Dafang Zhong
    Drug Metabolism and Disposition October 2012, 40 (10) 2041-2053; DOI: https://doi.org/10.1124/dmd.112.046995
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Drug Metabolism and Disposition: 40 (10)
Drug Metabolism and Disposition
Vol. 40, Issue 10
1 Oct 2012
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