Table of Contents

Articles

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  Breast Cancer Resistance Protein (ABCG2) Determines Distribution of Genistein Phase II Metabolites: Reevaluation of the Roles of ABCG2 in the Disposition of Genistein

  Zhen Yang, Wei Zhu, Song Gao, Taijun Yin, Wen Jiang and Ming Hu

  Drug Metabolism and Disposition October 2012, 40 (10) 1883-1893; DOI: https://doi.org/10.1124/dmd.111.043901
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  Selective Modulation of Hepatic Cytochrome P450 and Flavin Monooxygenase 3 Expression during Citrobacter rodentium Infection in Severe Combined Immune-Deficient Mice

  Beatrice A. Nyagode, William J. Watkins, Ryan D. Kinloch and Edward T. Morgan

  Drug Metabolism and Disposition October 2012, 40 (10) 1894-1899; DOI: https://doi.org/10.1124/dmd.112.046557
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  Key Role of Nuclear Factor-κB in the Cellular Pharmacokinetics of Adriamycin in MCF-7/Adr Cells: The Potential Mechanism for Synergy with 20(S)-Ginsenoside Rh2

  Jingwei Zhang, Meng Lu, Fang Zhou, Haopeng Sun, Gang Hao, Xiaolan Wu and Guangji Wang

  Drug Metabolism and Disposition October 2012, 40 (10) 1900-1908; DOI: https://doi.org/10.1124/dmd.112.045187
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  Microdialysis Evaluation of Clozapine and N-Desmethylclozapine Pharmacokinetics in Rat Brain

  Thomas I. F. H. Cremers, Gunnar Flik, Corry Hofland and Robert E. Stratford

  Drug Metabolism and Disposition October 2012, 40 (10) 1909-1916; DOI: https://doi.org/10.1124/dmd.112.045682
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  Comparison of Metabolism of Sesamin and Episesamin by Drug-Metabolizing Enzymes in Human Liver

  Kaori Yasuda, Shinichi Ikushiro, Shuto Wakayama, Toshimasa Itoh, Keiko Yamamoto, Masaki Kamakura, Eiji Munetsuna, Miho Ohta and Toshiyuki Sakaki

  Drug Metabolism and Disposition October 2012, 40 (10) 1917-1926; DOI: https://doi.org/10.1124/dmd.112.045906
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  In Vitro Characterization of the Drug-Drug Interaction Potential of Catabolites of Antibody-Maytansinoid Conjugates

  John A. Davis, Dan A. Rock, Larry C. Wienkers and Josh T. Pearson

  Drug Metabolism and Disposition October 2012, 40 (10) 1927-1934; DOI: https://doi.org/10.1124/dmd.112.046169
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  Human UDP-Glucuronosyltransferase Expression in Insect Cells: Ratio of Active to Inactive Recombinant Proteins and the Effects of a C-Terminal His-Tag on Glucuronidation Kinetics

  Hongbo Zhang, Anne-Sisko Patana, Peter I. Mackenzie, Shinichi Ikushiro, Adrian Goldman and Moshe Finel

  Drug Metabolism and Disposition October 2012, 40 (10) 1935-1944; DOI: https://doi.org/10.1124/dmd.112.046086
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  The Effects on Metabolic Clearance when Administering a Potent CYP3A Autoinducer with the Prototypic CYP3A Inhibitor, Ketoconazole

  Mosun A. Ayan-Oshodi, Brian A. Willis, William F. Annes, Stephen L. Lowe, Stuart Friedrich, Amparo de la Peña, Wei Zhang, Thomas Brown, Stephen D. Wise and Stephen D. Hall

  Drug Metabolism and Disposition October 2012, 40 (10) 1945-1952; DOI: https://doi.org/10.1124/dmd.112.046060
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  Xenobiotic Metabolism and Disposition in Human Lung Cell Models: Comparison with In Vivo Expression Profiles

  Elisabeth Courcot, Julie Leclerc, Jean-Jacques Lafitte, Eric Mensier, Sophie Jaillard, Philippe Gosset, Pirouz Shirali, Nicolas Pottier, Franck Broly and Jean-Marc Lo-Guidice

  Drug Metabolism and Disposition October 2012, 40 (10) 1953-1965; DOI: https://doi.org/10.1124/dmd.112.046896
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  High-Resolution Mass Spectrometry Elucidates Metabonate (False Metabolite) Formation from Alkylamine Drugs during In Vitro Metabolite Profiling

  Joanna E. Barbara, Faraz Kazmi, Seema Muranjan, Paul C. Toren and Andrew Parkinson

  Drug Metabolism and Disposition October 2012, 40 (10) 1966-1975; DOI: https://doi.org/10.1124/dmd.112.047027
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  CYP2E1 Metabolism of Styrene Involves Allostery

  Jessica H. Hartman, Gunnar Boysen and Grover P. Miller

  Drug Metabolism and Disposition October 2012, 40 (10) 1976-1983; DOI: https://doi.org/10.1124/dmd.112.046698
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  Human Liver Methionine Cycle: MAT1A and GNMT Gene Resequencing, Functional Genomics, and Hepatic Genotype-Phenotype Correlation

  Yuan Ji, Kendra K. S. Nordgren, Yubo Chai, Scott J. Hebbring, Gregory D. Jenkins, Ryan P. Abo, Yi Peng, Linda L. Pelleymounter, Irene Moon, Bruce W. Eckloff, Xiaoshan Chai, Jianping Zhang, Brooke L. Fridley, Vivien C. Yee, Eric D. Wieben and Richard M. Weinshilboum

  Drug Metabolism and Disposition October 2012, 40 (10) 1984-1992; DOI: https://doi.org/10.1124/dmd.112.046953
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  In Vivo-Formed versus Preformed Metabolite Kinetics of trans-Resveratrol-3-sulfate and trans-Resveratrol-3-glucuronide

  Satish Sharan, Otito F. Iwuchukwu, Daniel J. Canney, Cheryl L. Zimmerman and Swati Nagar

  Drug Metabolism and Disposition October 2012, 40 (10) 1993-2001; DOI: https://doi.org/10.1124/dmd.112.046417
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  Acetylenic Linkers in Lead Compounds: A Study of the Stability of the Propargyl-Linked Antifolates

  Wangda Zhou, Kishore Viswanathan, Dennis Hill, Amy C. Anderson and Dennis L. Wright

  Drug Metabolism and Disposition October 2012, 40 (10) 2002-2008; DOI: https://doi.org/10.1124/dmd.112.046870
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  Mechanistic Studies on the Absorption and Disposition of Scutellarin in Humans: Selective OATP2B1-Mediated Hepatic Uptake Is a Likely Key Determinant for Its Unique Pharmacokinetic Characteristics

  Chunying Gao, Hongjian Zhang, Zitao Guo, Tiangeng You, Xiaoyan Chen and Dafang Zhong

  Drug Metabolism and Disposition October 2012, 40 (10) 2009-2020; DOI: https://doi.org/10.1124/dmd.112.047183
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  Glycemic Control and Chronic Dosing of Rhesus Monkeys with a Fusion Protein of Iduronidase and a Monoclonal Antibody Against the Human Insulin Receptor

  Ruben J. Boado, Eric Ka-Wai Hui, Jeff Zhiqiang Lu and William M. Pardridge

  Drug Metabolism and Disposition October 2012, 40 (10) 2021-2025; DOI: https://doi.org/10.1124/dmd.112.046375
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  Absolute Oral Bioavailability and Metabolic Turnover of β-Sitosterol in Healthy Subjects

  Guus Duchateau, Brett Cochrane, Sam Windebank, Justyna Herudzinska, Davindera Sanghera, Angela Burian, Markus Müller, Markus Zeitlinger and Graham Lappin

  Drug Metabolism and Disposition October 2012, 40 (10) 2026-2030; DOI: https://doi.org/10.1124/dmd.112.046623
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  Regulation of Pregnane X Receptor (PXR) Function and UGT1A1 Gene Expression by Posttranslational Modification of PXR Protein

  Junko Sugatani, Takahiro Uchida, Masatoshi Kurosawa, Masahiko Yamaguchi, Yasuhiro Yamazaki, Akira Ikari and Masao Miwa

  Drug Metabolism and Disposition October 2012, 40 (10) 2031-2040; DOI: https://doi.org/10.1124/dmd.112.046748
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  In Vitro Studies on the Oxidative Metabolism of 20(S)-Ginsenoside Rh2 in Human, Monkey, Dog, Rat, and Mouse Liver Microsomes, and Human Liver S9

  Liang Li, Xiaoyan Chen, Jialan Zhou and Dafang Zhong

  Drug Metabolism and Disposition October 2012, 40 (10) 2041-2053; DOI: https://doi.org/10.1124/dmd.112.046995