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Research ArticleArticle

Key Role of Nuclear Factor-κB in the Cellular Pharmacokinetics of Adriamycin in MCF-7/Adr Cells: The Potential Mechanism for Synergy with 20(S)-Ginsenoside Rh2

Jingwei Zhang, Meng Lu, Fang Zhou, Haopeng Sun, Gang Hao, Xiaolan Wu and Guangji Wang
Drug Metabolism and Disposition October 2012, 40 (10) 1900-1908; DOI: https://doi.org/10.1124/dmd.112.045187
Jingwei Zhang
Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, China (J.Z., M.L., F.Z., G.H., X.W., G.W.); and Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, Jiangsu, China (H.S.)
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Meng Lu
Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, China (J.Z., M.L., F.Z., G.H., X.W., G.W.); and Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, Jiangsu, China (H.S.)
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Fang Zhou
Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, China (J.Z., M.L., F.Z., G.H., X.W., G.W.); and Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, Jiangsu, China (H.S.)
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Haopeng Sun
Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, China (J.Z., M.L., F.Z., G.H., X.W., G.W.); and Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, Jiangsu, China (H.S.)
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Gang Hao
Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, China (J.Z., M.L., F.Z., G.H., X.W., G.W.); and Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, Jiangsu, China (H.S.)
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Xiaolan Wu
Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, China (J.Z., M.L., F.Z., G.H., X.W., G.W.); and Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, Jiangsu, China (H.S.)
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Guangji Wang
Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, China (J.Z., M.L., F.Z., G.H., X.W., G.W.); and Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, Jiangsu, China (H.S.)
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Article Information

vol. 40 no. 10 1900-1908
DOI 
https://doi.org/10.1124/dmd.112.045187
PubMed 
22745335

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 20, 2012
  • Accepted June 27, 2012
  • Published online September 17, 2012.

Article Versions

  • Earlier version (June 27, 2012 - 10:43).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jingwei Zhang,
  2. Meng Lu,
  3. Fang Zhou,
  4. Haopeng Sun,
  5. Gang Hao,
  6. Xiaolan Wu, and
  7. Guangji Wang
  1. Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, China (J.Z., M.L., F.Z., G.H., X.W., G.W.); and Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, Jiangsu, China (H.S.)
  1. Address correspondence to:
    Prof. Guangji Wang, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009, Jiangsu, China. E-mail: guangjiwang{at}hotmail.com
  1. J.Z., M.L., and F.Z. contributed equally to this work.

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Drug Metabolism and Disposition: 40 (10)
Drug Metabolism and Disposition
Vol. 40, Issue 10
1 Oct 2012
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Research ArticleArticle

NF-κB REGULATES CELLULAR PHARMACOKINETICS OF ADRIAMYCIN

Jingwei Zhang, Meng Lu, Fang Zhou, Haopeng Sun, Gang Hao, Xiaolan Wu and Guangji Wang
Drug Metabolism and Disposition October 1, 2012, 40 (10) 1900-1908; DOI: https://doi.org/10.1124/dmd.112.045187

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Research ArticleArticle

NF-κB REGULATES CELLULAR PHARMACOKINETICS OF ADRIAMYCIN

Jingwei Zhang, Meng Lu, Fang Zhou, Haopeng Sun, Gang Hao, Xiaolan Wu and Guangji Wang
Drug Metabolism and Disposition October 1, 2012, 40 (10) 1900-1908; DOI: https://doi.org/10.1124/dmd.112.045187
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