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Research ArticleArticle

Comparison of Metabolism of Sesamin and Episesamin by Drug-Metabolizing Enzymes in Human Liver

Kaori Yasuda, Shinichi Ikushiro, Shuto Wakayama, Toshimasa Itoh, Keiko Yamamoto, Masaki Kamakura, Eiji Munetsuna, Miho Ohta and Toshiyuki Sakaki
Drug Metabolism and Disposition October 2012, 40 (10) 1917-1926; DOI: https://doi.org/10.1124/dmd.112.045906
Kaori Yasuda
Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Imizu, Toyama, Japan (K.Y., S.I., M.K., E.M., T.S.); Laboratory of Drug Design and Medicinal Chemistry, Showa Pharmaceutical University, Machida, Tokyo, Japan (S.W., T.I., K.Y.); and Development Nourishment Department, Soai University, Suminoe, Osaka, Japan (M.O.)
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Shinichi Ikushiro
Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Imizu, Toyama, Japan (K.Y., S.I., M.K., E.M., T.S.); Laboratory of Drug Design and Medicinal Chemistry, Showa Pharmaceutical University, Machida, Tokyo, Japan (S.W., T.I., K.Y.); and Development Nourishment Department, Soai University, Suminoe, Osaka, Japan (M.O.)
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Shuto Wakayama
Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Imizu, Toyama, Japan (K.Y., S.I., M.K., E.M., T.S.); Laboratory of Drug Design and Medicinal Chemistry, Showa Pharmaceutical University, Machida, Tokyo, Japan (S.W., T.I., K.Y.); and Development Nourishment Department, Soai University, Suminoe, Osaka, Japan (M.O.)
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Toshimasa Itoh
Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Imizu, Toyama, Japan (K.Y., S.I., M.K., E.M., T.S.); Laboratory of Drug Design and Medicinal Chemistry, Showa Pharmaceutical University, Machida, Tokyo, Japan (S.W., T.I., K.Y.); and Development Nourishment Department, Soai University, Suminoe, Osaka, Japan (M.O.)
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Keiko Yamamoto
Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Imizu, Toyama, Japan (K.Y., S.I., M.K., E.M., T.S.); Laboratory of Drug Design and Medicinal Chemistry, Showa Pharmaceutical University, Machida, Tokyo, Japan (S.W., T.I., K.Y.); and Development Nourishment Department, Soai University, Suminoe, Osaka, Japan (M.O.)
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Masaki Kamakura
Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Imizu, Toyama, Japan (K.Y., S.I., M.K., E.M., T.S.); Laboratory of Drug Design and Medicinal Chemistry, Showa Pharmaceutical University, Machida, Tokyo, Japan (S.W., T.I., K.Y.); and Development Nourishment Department, Soai University, Suminoe, Osaka, Japan (M.O.)
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Eiji Munetsuna
Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Imizu, Toyama, Japan (K.Y., S.I., M.K., E.M., T.S.); Laboratory of Drug Design and Medicinal Chemistry, Showa Pharmaceutical University, Machida, Tokyo, Japan (S.W., T.I., K.Y.); and Development Nourishment Department, Soai University, Suminoe, Osaka, Japan (M.O.)
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Miho Ohta
Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Imizu, Toyama, Japan (K.Y., S.I., M.K., E.M., T.S.); Laboratory of Drug Design and Medicinal Chemistry, Showa Pharmaceutical University, Machida, Tokyo, Japan (S.W., T.I., K.Y.); and Development Nourishment Department, Soai University, Suminoe, Osaka, Japan (M.O.)
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Toshiyuki Sakaki
Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Imizu, Toyama, Japan (K.Y., S.I., M.K., E.M., T.S.); Laboratory of Drug Design and Medicinal Chemistry, Showa Pharmaceutical University, Machida, Tokyo, Japan (S.W., T.I., K.Y.); and Development Nourishment Department, Soai University, Suminoe, Osaka, Japan (M.O.)
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Article Information

vol. 40 no. 10 1917-1926
DOI 
https://doi.org/10.1124/dmd.112.045906
PubMed 
22752007

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received March 27, 2012
  • Accepted June 29, 2012
  • Published online September 17, 2012.

Article Versions

  • Earlier version (June 29, 2012 - 08:16).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Kaori Yasuda,
  2. Shinichi Ikushiro,
  3. Shuto Wakayama,
  4. Toshimasa Itoh,
  5. Keiko Yamamoto,
  6. Masaki Kamakura,
  7. Eiji Munetsuna,
  8. Miho Ohta, and
  9. Toshiyuki Sakaki
  1. Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Imizu, Toyama, Japan (K.Y., S.I., M.K., E.M., T.S.); Laboratory of Drug Design and Medicinal Chemistry, Showa Pharmaceutical University, Machida, Tokyo, Japan (S.W., T.I., K.Y.); and Development Nourishment Department, Soai University, Suminoe, Osaka, Japan (M.O.)
  1. Address correspondence to:
    Toshiyuki Sakaki, Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan. E-mail: tsakaki{at}pu-toyama.ac.jp
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Drug Metabolism and Disposition: 40 (10)
Drug Metabolism and Disposition
Vol. 40, Issue 10
1 Oct 2012
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Research ArticleArticle

METABOLISM OF SESAMIN AND EPISESAMIN IN HUMANS

Kaori Yasuda, Shinichi Ikushiro, Shuto Wakayama, Toshimasa Itoh, Keiko Yamamoto, Masaki Kamakura, Eiji Munetsuna, Miho Ohta and Toshiyuki Sakaki
Drug Metabolism and Disposition October 1, 2012, 40 (10) 1917-1926; DOI: https://doi.org/10.1124/dmd.112.045906

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Research ArticleArticle

METABOLISM OF SESAMIN AND EPISESAMIN IN HUMANS

Kaori Yasuda, Shinichi Ikushiro, Shuto Wakayama, Toshimasa Itoh, Keiko Yamamoto, Masaki Kamakura, Eiji Munetsuna, Miho Ohta and Toshiyuki Sakaki
Drug Metabolism and Disposition October 1, 2012, 40 (10) 1917-1926; DOI: https://doi.org/10.1124/dmd.112.045906
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