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Research ArticleArticle

High-Resolution Mass Spectrometry Elucidates Metabonate (False Metabolite) Formation from Alkylamine Drugs during In Vitro Metabolite Profiling

Joanna E. Barbara, Faraz Kazmi, Seema Muranjan, Paul C. Toren and Andrew Parkinson
Drug Metabolism and Disposition October 2012, 40 (10) 1966-1975; DOI: https://doi.org/10.1124/dmd.112.047027
Joanna E. Barbara
XenoTech, LLC, Lenexa, Kansas (J.E.B., F.K., S.M., P.C.T.); and XPD Consulting, Shawnee, Kansas (A.P.)
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Faraz Kazmi
XenoTech, LLC, Lenexa, Kansas (J.E.B., F.K., S.M., P.C.T.); and XPD Consulting, Shawnee, Kansas (A.P.)
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Seema Muranjan
XenoTech, LLC, Lenexa, Kansas (J.E.B., F.K., S.M., P.C.T.); and XPD Consulting, Shawnee, Kansas (A.P.)
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Paul C. Toren
XenoTech, LLC, Lenexa, Kansas (J.E.B., F.K., S.M., P.C.T.); and XPD Consulting, Shawnee, Kansas (A.P.)
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Andrew Parkinson
XenoTech, LLC, Lenexa, Kansas (J.E.B., F.K., S.M., P.C.T.); and XPD Consulting, Shawnee, Kansas (A.P.)
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Article Information

vol. 40 no. 10 1966-1975
DOI 
https://doi.org/10.1124/dmd.112.047027
PubMed 
22798552

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received June 6, 2012
  • Accepted July 13, 2012
  • Published online September 17, 2012.

Article Versions

  • Earlier version (July 13, 2012 - 12:00).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Joanna E. Barbara,
  2. Faraz Kazmi,
  3. Seema Muranjan,
  4. Paul C. Toren, and
  5. Andrew Parkinson
  1. XenoTech, LLC, Lenexa, Kansas (J.E.B., F.K., S.M., P.C.T.); and XPD Consulting, Shawnee, Kansas (A.P.)
  1. Address correspondence to:
    Dr. Joanna Barbara, XenoTech, LLC, 16825 West 116th St., Lenexa, KS 66219. E-mail jbarbara{at}xenotechllc.com
  1. Portions of this work were presented as follows: Barbara JE, Kazmi F, Toren PC, and Parkinson A (2010) Accurate mass spectrometry elucidates a misleading metabonate formed from amine-containing drugs in reactive metabolite screening assays. Ninth ISSX Meeting; 2010 Sept 4–8; Istanbul, Turkey. International Society for the Study of Xenobiotics, Washington, DC.

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Drug Metabolism and Disposition: 40 (10)
Drug Metabolism and Disposition
Vol. 40, Issue 10
1 Oct 2012
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Research ArticleArticle

IN VITRO METABONATE FORMATION FROM ALKYLAMINES

Joanna E. Barbara, Faraz Kazmi, Seema Muranjan, Paul C. Toren and Andrew Parkinson
Drug Metabolism and Disposition October 1, 2012, 40 (10) 1966-1975; DOI: https://doi.org/10.1124/dmd.112.047027

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Research ArticleArticle

IN VITRO METABONATE FORMATION FROM ALKYLAMINES

Joanna E. Barbara, Faraz Kazmi, Seema Muranjan, Paul C. Toren and Andrew Parkinson
Drug Metabolism and Disposition October 1, 2012, 40 (10) 1966-1975; DOI: https://doi.org/10.1124/dmd.112.047027
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