Research ArticleArticle
Human Liver Methionine Cycle: MAT1A and GNMT Gene Resequencing, Functional Genomics, and Hepatic Genotype-Phenotype Correlation
Yuan Ji, Kendra K. S. Nordgren, Yubo Chai, Scott J. Hebbring, Gregory D. Jenkins, Ryan P. Abo, Yi Peng, Linda L. Pelleymounter, Irene Moon, Bruce W. Eckloff, Xiaoshan Chai, Jianping Zhang, Brooke L. Fridley, Vivien C. Yee, Eric D. Wieben and Richard M. Weinshilboum
Drug Metabolism and Disposition October 2012, 40 (10) 1984-1992; DOI: https://doi.org/10.1124/dmd.112.046953
Yuan Ji
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
Kendra K. S. Nordgren
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
Yubo Chai
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
Scott J. Hebbring
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
Gregory D. Jenkins
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
Ryan P. Abo
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
Yi Peng
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
Linda L. Pelleymounter
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
Irene Moon
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
Bruce W. Eckloff
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
Xiaoshan Chai
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
Jianping Zhang
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
Brooke L. Fridley
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
Vivien C. Yee
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
Eric D. Wieben
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
Richard M. Weinshilboum
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
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Research ArticleArticle
MAT1A AND GNMT SEQUENCE VARIATION AND FUNCTIONAL GENOMICS
Yuan Ji, Kendra K. S. Nordgren, Yubo Chai, Scott J. Hebbring, Gregory D. Jenkins, Ryan P. Abo, Yi Peng, Linda L. Pelleymounter, Irene Moon, Bruce W. Eckloff, Xiaoshan Chai, Jianping Zhang, Brooke L. Fridley, Vivien C. Yee, Eric D. Wieben and Richard M. Weinshilboum
Drug Metabolism and Disposition October 1, 2012, 40 (10) 1984-1992; DOI: https://doi.org/10.1124/dmd.112.046953
Research ArticleArticle
MAT1A AND GNMT SEQUENCE VARIATION AND FUNCTIONAL GENOMICS
Yuan Ji, Kendra K. S. Nordgren, Yubo Chai, Scott J. Hebbring, Gregory D. Jenkins, Ryan P. Abo, Yi Peng, Linda L. Pelleymounter, Irene Moon, Bruce W. Eckloff, Xiaoshan Chai, Jianping Zhang, Brooke L. Fridley, Vivien C. Yee, Eric D. Wieben and Richard M. Weinshilboum
Drug Metabolism and Disposition October 1, 2012, 40 (10) 1984-1992; DOI: https://doi.org/10.1124/dmd.112.046953
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