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Research ArticleArticle

Human Liver Methionine Cycle: MAT1A and GNMT Gene Resequencing, Functional Genomics, and Hepatic Genotype-Phenotype Correlation

Yuan Ji, Kendra K. S. Nordgren, Yubo Chai, Scott J. Hebbring, Gregory D. Jenkins, Ryan P. Abo, Yi Peng, Linda L. Pelleymounter, Irene Moon, Bruce W. Eckloff, Xiaoshan Chai, Jianping Zhang, Brooke L. Fridley, Vivien C. Yee, Eric D. Wieben and Richard M. Weinshilboum
Drug Metabolism and Disposition October 2012, 40 (10) 1984-1992; DOI: https://doi.org/10.1124/dmd.112.046953
Yuan Ji
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
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Kendra K. S. Nordgren
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
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Yubo Chai
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
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Scott J. Hebbring
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
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Gregory D. Jenkins
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
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Ryan P. Abo
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
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Yi Peng
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
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Linda L. Pelleymounter
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
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Irene Moon
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
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Bruce W. Eckloff
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
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Xiaoshan Chai
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
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Jianping Zhang
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
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Brooke L. Fridley
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
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Vivien C. Yee
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
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Eric D. Wieben
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
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Richard M. Weinshilboum
Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
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Article Information

vol. 40 no. 10 1984-1992
DOI 
https://doi.org/10.1124/dmd.112.046953
PubMed 
22807109

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received May 26, 2012
  • Accepted July 17, 2012
  • Published online September 17, 2012.

Article Versions

  • Earlier version (July 17, 2012 - 09:16).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yuan Ji,
  2. Kendra K. S. Nordgren,
  3. Yubo Chai,
  4. Scott J. Hebbring,
  5. Gregory D. Jenkins,
  6. Ryan P. Abo,
  7. Yi Peng,
  8. Linda L. Pelleymounter,
  9. Irene Moon,
  10. Bruce W. Eckloff,
  11. Xiaoshan Chai,
  12. Jianping Zhang,
  13. Brooke L. Fridley,
  14. Vivien C. Yee,
  15. Eric D. Wieben, and
  16. Richard M. Weinshilboum
  1. Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics (Y.J., K.K.S.N., Y.C., S.J.H., R.P.A., L.L.P., I.M., X.C., J.Z., R.M.W.), Division of Biomedical Statistical and Informatics, Department of Health Sciences Research (G.D.J., B.L.F.), and Department of Biochemistry and Molecular Biology (B.W.E., E.D.W.), Mayo Clinic, Rochester, Minnesota; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (Y.P., V.C.Y.); and College of Pharmacy, Jinan University, Guangzhou, Peoples Republic of China (J.Z.)
  1. Address correspondence to:
    Dr. Richard M. Weinshilboum, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First St. SW, Rochester, MN 55905. E-mail: weinshilboum.richard{at}mayo.edu
  1. Y.J. and K.K.S.N. contributed equally to this work.

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Drug Metabolism and Disposition: 40 (10)
Drug Metabolism and Disposition
Vol. 40, Issue 10
1 Oct 2012
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Research ArticleArticle

MAT1A AND GNMT SEQUENCE VARIATION AND FUNCTIONAL GENOMICS

Yuan Ji, Kendra K. S. Nordgren, Yubo Chai, Scott J. Hebbring, Gregory D. Jenkins, Ryan P. Abo, Yi Peng, Linda L. Pelleymounter, Irene Moon, Bruce W. Eckloff, Xiaoshan Chai, Jianping Zhang, Brooke L. Fridley, Vivien C. Yee, Eric D. Wieben and Richard M. Weinshilboum
Drug Metabolism and Disposition October 1, 2012, 40 (10) 1984-1992; DOI: https://doi.org/10.1124/dmd.112.046953

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Research ArticleArticle

MAT1A AND GNMT SEQUENCE VARIATION AND FUNCTIONAL GENOMICS

Yuan Ji, Kendra K. S. Nordgren, Yubo Chai, Scott J. Hebbring, Gregory D. Jenkins, Ryan P. Abo, Yi Peng, Linda L. Pelleymounter, Irene Moon, Bruce W. Eckloff, Xiaoshan Chai, Jianping Zhang, Brooke L. Fridley, Vivien C. Yee, Eric D. Wieben and Richard M. Weinshilboum
Drug Metabolism and Disposition October 1, 2012, 40 (10) 1984-1992; DOI: https://doi.org/10.1124/dmd.112.046953
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