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Research ArticleArticle

Acetylenic Linkers in Lead Compounds: A Study of the Stability of the Propargyl-Linked Antifolates

Wangda Zhou, Kishore Viswanathan, Dennis Hill, Amy C. Anderson and Dennis L. Wright
Drug Metabolism and Disposition October 2012, 40 (10) 2002-2008; DOI: https://doi.org/10.1124/dmd.112.046870
Wangda Zhou
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut
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Kishore Viswanathan
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut
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Dennis Hill
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut
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Amy C. Anderson
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut
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Dennis L. Wright
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut
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Article Information

vol. 40 no. 10 2002-2008
DOI 
https://doi.org/10.1124/dmd.112.046870
PubMed 
22815313

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received May 22, 2012
  • Accepted July 18, 2012
  • Published online September 17, 2012.

Article Versions

  • Earlier version (July 18, 2012 - 10:21).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Wangda Zhou,
  2. Kishore Viswanathan,
  3. Dennis Hill,
  4. Amy C. Anderson, and
  5. Dennis L. Wright
  1. Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut
  1. Address correspondence to:
    Dennis L. Wright, Department of Pharmaceutical Sciences, 69 N. Eagleville Rd., University of Connecticut, Storrs, CT 06269. E-mail: dennis.wright{at}uconn.edu
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Drug Metabolism and Disposition: 40 (10)
Drug Metabolism and Disposition
Vol. 40, Issue 10
1 Oct 2012
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Research ArticleArticle

STABILITY AND THE PROPARGYL-LINKED ANTIFOLATES

Wangda Zhou, Kishore Viswanathan, Dennis Hill, Amy C. Anderson and Dennis L. Wright
Drug Metabolism and Disposition October 1, 2012, 40 (10) 2002-2008; DOI: https://doi.org/10.1124/dmd.112.046870

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Research ArticleArticle

STABILITY AND THE PROPARGYL-LINKED ANTIFOLATES

Wangda Zhou, Kishore Viswanathan, Dennis Hill, Amy C. Anderson and Dennis L. Wright
Drug Metabolism and Disposition October 1, 2012, 40 (10) 2002-2008; DOI: https://doi.org/10.1124/dmd.112.046870
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