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Mechanistic Studies on the Absorption and Disposition of Scutellarin in Humans: Selective OATP2B1-Mediated Hepatic Uptake Is a Likely Key Determinant for Its Unique Pharmacokinetic Characteristics

Chunying Gao, Hongjian Zhang, Zitao Guo, Tiangeng You, Xiaoyan Chen and Dafang Zhong
Drug Metabolism and Disposition October 2012, 40 (10) 2009-2020; DOI: https://doi.org/10.1124/dmd.112.047183

Article Information

vol. 40 no. 10 2009-2020
DOI 
https://doi.org/10.1124/dmd.112.047183
PubMed 
22822035
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received June 11, 2012
  • Accepted July 20, 2012
  • Published online September 17, 2012.

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Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Chunying Gao,
  2. Hongjian Zhang,
  3. Zitao Guo,
  4. Tiangeng You,
  5. Xiaoyan Chen, and
  6. Dafang Zhong
  1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (C.G., X.C., Z.G., D.Z.); College of Pharmaceutical Sciences, Soochow University, Suzhou, People's Republic of China (H.Z.); and Shanghai East Hospital, Shanghai, China (T.Y.)
  1. Address correspondence to:
    Dafang Zhong, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Rd., Shanghai 201203, China. E-mail: dfzhong{at}mail.shcnc.ac.cn
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Research ArticleArticle

ABSORPTION AND DISPOSITION OF SCUTELLARIN IN HUMANS

Chunying Gao, Hongjian Zhang, Zitao Guo, Tiangeng You, Xiaoyan Chen and Dafang Zhong
Drug Metabolism and Disposition October 1, 2012, 40 (10) 2009-2020; DOI: https://doi.org/10.1124/dmd.112.047183
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