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Research ArticleArticle

Absolute Oral Bioavailability and Metabolic Turnover of β-Sitosterol in Healthy Subjects

Guus Duchateau, Brett Cochrane, Sam Windebank, Justyna Herudzinska, Davindera Sanghera, Angela Burian, Markus Müller, Markus Zeitlinger and Graham Lappin
Drug Metabolism and Disposition October 2012, 40 (10) 2026-2030; DOI: https://doi.org/10.1124/dmd.112.046623
Guus Duchateau
Unilever R&D, Vlaardingen, The Netherlands (G.D.); Unilever Safety & Environmental Assurance Centre, Colworth, United Kingdom (B.C., S.W.); Xceleron Ltd., York, United Kingdom (J.H., D.S., G.L.); and Medical University of Vienna, Vienna, Austria (A.B., M.M., M.Z.)
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Brett Cochrane
Unilever R&D, Vlaardingen, The Netherlands (G.D.); Unilever Safety & Environmental Assurance Centre, Colworth, United Kingdom (B.C., S.W.); Xceleron Ltd., York, United Kingdom (J.H., D.S., G.L.); and Medical University of Vienna, Vienna, Austria (A.B., M.M., M.Z.)
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Sam Windebank
Unilever R&D, Vlaardingen, The Netherlands (G.D.); Unilever Safety & Environmental Assurance Centre, Colworth, United Kingdom (B.C., S.W.); Xceleron Ltd., York, United Kingdom (J.H., D.S., G.L.); and Medical University of Vienna, Vienna, Austria (A.B., M.M., M.Z.)
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Justyna Herudzinska
Unilever R&D, Vlaardingen, The Netherlands (G.D.); Unilever Safety & Environmental Assurance Centre, Colworth, United Kingdom (B.C., S.W.); Xceleron Ltd., York, United Kingdom (J.H., D.S., G.L.); and Medical University of Vienna, Vienna, Austria (A.B., M.M., M.Z.)
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Davindera Sanghera
Unilever R&D, Vlaardingen, The Netherlands (G.D.); Unilever Safety & Environmental Assurance Centre, Colworth, United Kingdom (B.C., S.W.); Xceleron Ltd., York, United Kingdom (J.H., D.S., G.L.); and Medical University of Vienna, Vienna, Austria (A.B., M.M., M.Z.)
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Angela Burian
Unilever R&D, Vlaardingen, The Netherlands (G.D.); Unilever Safety & Environmental Assurance Centre, Colworth, United Kingdom (B.C., S.W.); Xceleron Ltd., York, United Kingdom (J.H., D.S., G.L.); and Medical University of Vienna, Vienna, Austria (A.B., M.M., M.Z.)
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Markus Müller
Unilever R&D, Vlaardingen, The Netherlands (G.D.); Unilever Safety & Environmental Assurance Centre, Colworth, United Kingdom (B.C., S.W.); Xceleron Ltd., York, United Kingdom (J.H., D.S., G.L.); and Medical University of Vienna, Vienna, Austria (A.B., M.M., M.Z.)
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Markus Zeitlinger
Unilever R&D, Vlaardingen, The Netherlands (G.D.); Unilever Safety & Environmental Assurance Centre, Colworth, United Kingdom (B.C., S.W.); Xceleron Ltd., York, United Kingdom (J.H., D.S., G.L.); and Medical University of Vienna, Vienna, Austria (A.B., M.M., M.Z.)
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Graham Lappin
Unilever R&D, Vlaardingen, The Netherlands (G.D.); Unilever Safety & Environmental Assurance Centre, Colworth, United Kingdom (B.C., S.W.); Xceleron Ltd., York, United Kingdom (J.H., D.S., G.L.); and Medical University of Vienna, Vienna, Austria (A.B., M.M., M.Z.)
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Article Information

vol. 40 no. 10 2026-2030
DOI 
https://doi.org/10.1124/dmd.112.046623
PubMed 
22826463

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received May 4, 2012
  • Accepted July 23, 2012
  • Published online September 17, 2012.

Article Versions

  • Earlier version (July 23, 2012 - 08:51).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Guus Duchateau,
  2. Brett Cochrane,
  3. Sam Windebank,
  4. Justyna Herudzinska,
  5. Davindera Sanghera,
  6. Angela Burian,
  7. Markus Müller,
  8. Markus Zeitlinger, and
  9. Graham Lappin
  1. Unilever R&D, Vlaardingen, The Netherlands (G.D.); Unilever Safety & Environmental Assurance Centre, Colworth, United Kingdom (B.C., S.W.); Xceleron Ltd., York, United Kingdom (J.H., D.S., G.L.); and Medical University of Vienna, Vienna, Austria (A.B., M.M., M.Z.)
  1. Address correspondence to:
    Dr. Guus Duchateau, Unilever R&D, Olivier van Noortlaan 120, 3133 AT Vlaardingen, The Netherlands. E-mail: guus.duchateau{at}unilever.com
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Drug Metabolism and Disposition: 40 (10)
Drug Metabolism and Disposition
Vol. 40, Issue 10
1 Oct 2012
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Research ArticleArticle

METABOLISM OF SITOSTEROL

Guus Duchateau, Brett Cochrane, Sam Windebank, Justyna Herudzinska, Davindera Sanghera, Angela Burian, Markus Müller, Markus Zeitlinger and Graham Lappin
Drug Metabolism and Disposition October 1, 2012, 40 (10) 2026-2030; DOI: https://doi.org/10.1124/dmd.112.046623

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Research ArticleArticle

METABOLISM OF SITOSTEROL

Guus Duchateau, Brett Cochrane, Sam Windebank, Justyna Herudzinska, Davindera Sanghera, Angela Burian, Markus Müller, Markus Zeitlinger and Graham Lappin
Drug Metabolism and Disposition October 1, 2012, 40 (10) 2026-2030; DOI: https://doi.org/10.1124/dmd.112.046623
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