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Drug Metabolism & Disposition

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Table of Contents

November 01, 2012; Volume 40,Issue 11

Short Communication

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    Characterization of THLE-Cytochrome P450 (P450) Cell Lines: Gene Expression Background and Relationship to P450-Enzyme Activity
    Yalda Soltanpour, Constanze Hilgendorf, Marie M. Ahlström, Alison J. Foster, J. Gerry Kenna, Anne Petersen and Anna-Lena Ungell
    Drug Metabolism and Disposition November 2012, 40 (11) 2054-2058; DOI: https://doi.org/10.1124/dmd.112.045815

Articles

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    Vitamin D Receptor Activation Enhances Benzo[a]pyrene Metabolism via CYP1A1 Expression in Macrophages
    Manabu Matsunawa, Daisuke Akagi, Shigeyuki Uno, Kaori Endo-Umeda, Sachiko Yamada, Kazumasa Ikeda and Makoto Makishima
    Drug Metabolism and Disposition November 2012, 40 (11) 2059-2066; DOI: https://doi.org/10.1124/dmd.112.046839
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    Pharmacokinetics of Oral d-Serine in d-Amino Acid Oxidase Knockout Mice
    Rana Rais, Ajit G. Thomas, Krystyna Wozniak, Ying Wu, Hanna Jaaro-Peled, Akira Sawa, Christine A. Strick, Sandra J. Engle, Nicholas J. Brandon, Camilo Rojas, Barbara S. Slusher and Takashi Tsukamoto
    Drug Metabolism and Disposition November 2012, 40 (11) 2067-2073; DOI: https://doi.org/10.1124/dmd.112.046482
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    Oxidative ipso Substitution of 2,4-Difluoro-benzylphthalazines: Identification of a Rare Stable Quinone Methide and Subsequent GSH Conjugate
    Mithat Gunduz, Upendra A. Argikar, Amin Kamel, Kevin Colizza, Jennifer L. Bushee, Amanda Cirello, Franco Lombardo and Shawn Harriman
    Drug Metabolism and Disposition November 2012, 40 (11) 2074-2080; DOI: https://doi.org/10.1124/dmd.112.046268
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    ATP Serves as an Endogenous Inhibitor of UDP-Glucuronosyltransferase (UGT): A New Insight into the Latency of UGT
    Yuji Ishii, Kie An, Yoshio Nishimura and Hideyuki Yamada
    Drug Metabolism and Disposition November 2012, 40 (11) 2081-2089; DOI: https://doi.org/10.1124/dmd.112.046862
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    Assessment of the Drug Interaction Risk for Remogliflozin Etabonate, a Sodium-Dependent Glucose Cotransporter-2 Inhibitor: Evidence from In Vitro, Human Mass Balance, and Ketoconazole Interaction Studies
    James F. Sigafoos, Gary D. Bowers, Stephen Castellino, Amanda G. Culp, David S. Wagner, Melinda J. Reese, Joan E. Humphreys, Elizabeth K. Hussey, Robin L. O'Connor Semmes, Anita Kapur, Wenli Tao, Robert L. Dobbins and Joseph W. Polli
    Drug Metabolism and Disposition November 2012, 40 (11) 2090-2101; DOI: https://doi.org/10.1124/dmd.112.047258
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    The Role of a Basolateral Transporter in Rosuvastatin Transport and Its Interplay with Apical Breast Cancer Resistance Protein in Polarized Cell Monolayer Systems
    Jibin Li, Ying Wang, Wei Zhang, Yuehua Huang, Kristin Hein and Ismael J. Hidalgo
    Drug Metabolism and Disposition November 2012, 40 (11) 2102-2108; DOI: https://doi.org/10.1124/dmd.112.045666
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    Metabolism and Pharmacokinetics of Mangiferin in Conventional Rats, Pseudo-Germ-Free Rats, and Streptozotocin-Induced Diabetic Rats
    Huihui Liu, Bin Wu, Guoyu Pan, Lei He, Zhixiong Li, Mingsong Fan, Longhai Jian, Mingcang Chen, Ke Wang and Chenggang Huang
    Drug Metabolism and Disposition November 2012, 40 (11) 2109-2118; DOI: https://doi.org/10.1124/dmd.112.045849
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    Cytochrome P450 2S1 Depletion Enhances Cell Proliferation and Migration in Bronchial Epithelial Cells, in Part, through Modulation of Prostaglandin E2 Synthesis
    T. W. Madanayake, T. P. Fidler, T. M. Fresquez, N. Bajaj and A. M. Rowland
    Drug Metabolism and Disposition November 2012, 40 (11) 2119-2125; DOI: https://doi.org/10.1124/dmd.112.046466
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    Chronic Doxorubicin Cardiotoxicity Modulates Cardiac Cytochrome P450-Mediated Arachidonic Acid Metabolism in Rats
    Abdulaziz M. S. Alsaad, Beshay N. M. Zordoky, Ahmed A. El-Sherbeni and Ayman O. S. El-Kadi
    Drug Metabolism and Disposition November 2012, 40 (11) 2126-2135; DOI: https://doi.org/10.1124/dmd.112.046631
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    Impact of Organic Solvents on Cytochrome P450 Probe Reactions: Filling the Gap with (S)-Warfarin and Midazolam Hydroxylation
    Vanessa González-Pérez, Elizabeth A. Connolly, Arlene S. Bridges, Larry C. Wienkers and Mary F. Paine
    Drug Metabolism and Disposition November 2012, 40 (11) 2136-2142; DOI: https://doi.org/10.1124/dmd.112.047134
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    Metabolism, Excretion, and Pharmacokinetics of ((3,3-Difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a Dipeptidyl Peptidase Inhibitor, in Rat, Dog and Human
    Raman Sharma, Hao Sun, David W. Piotrowski, Tim F. Ryder, Shawn D. Doran, Haiqing Dai and Chandra Prakash
    Drug Metabolism and Disposition November 2012, 40 (11) 2143-2161; DOI: https://doi.org/10.1124/dmd.112.047316
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    An Evaluation of Using Rat-Derived Single-Dose Neuropharmacokinetic Parameters to Project Accurately Large Animal Unbound Brain Drug Concentrations
    Angela C. Doran, Sarah M. Osgood, Jessica Y. Mancuso and Christopher L. Shaffer
    Drug Metabolism and Disposition November 2012, 40 (11) 2162-2173; DOI: https://doi.org/10.1124/dmd.112.046391
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    Cytochrome P450-Mediated Oxidative Metabolism of Abused Synthetic Cannabinoids Found in K2/Spice: Identification of Novel Cannabinoid Receptor Ligands
    Krishna C. Chimalakonda, Kathryn A. Seely, Stacie M. Bratton, Lisa K. Brents, Cindy L. Moran, Gregory W. Endres, Laura P. James, Paul F. Hollenberg, Paul L. Prather, Anna Radominska-Pandya and Jeffery H. Moran
    Drug Metabolism and Disposition November 2012, 40 (11) 2174-2184; DOI: https://doi.org/10.1124/dmd.112.047530
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    Novel Bioactivation Mechanism of Reactive Metabolite Formation from Phenyl Methyl-Isoxazoles
    Johan Bylund, Istvan Macsari, Yevgeni Besidski, Susanne Olofsson, Carl Petersson, Per I. Arvidsson and Tjerk Bueters
    Drug Metabolism and Disposition November 2012, 40 (11) 2185-2191; DOI: https://doi.org/10.1124/dmd.112.047431
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    UDP-Glucuronic Acid Binds First and the Aglycone Substrate Binds Second to Form a Ternary Complex in UGT1A9-Catalyzed Reactions, in Both the Presence and Absence of Bovine Serum Albumin
    Nenad Manevski, Jari Yli-Kauhaluoma and Moshe Finel
    Drug Metabolism and Disposition November 2012, 40 (11) 2192-2203; DOI: https://doi.org/10.1124/dmd.112.047746
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    Utility of DPX2 Cells for Predicting CYP3A Induction-Mediated Drug-Drug Interactions and Associated Structure-Activity Relationships
    Odette A. Fahmi, Judy L. Raucy, Elsa Ponce, Saleema Hassanali and Jerome M. Lasker
    Drug Metabolism and Disposition November 2012, 40 (11) 2204-2211; DOI: https://doi.org/10.1124/dmd.112.047456
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    Generation and Characterization of a Novel Multidrug Resistance Protein 2 Humanized Mouse Line
    Nico Scheer, Praveen Balimane, Michael D. Hayward, Sandra Buechel, Gunther Kauselmann and C. Roland Wolf
    Drug Metabolism and Disposition November 2012, 40 (11) 2212-2218; DOI: https://doi.org/10.1124/dmd.112.047605

Letters to the Editor

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    Reevaluation of the Roles of ABCG2 in the Disposition of Genistein
    Ana I. Álvarez, Fernando Vallejo, Borja Barrera, Gracia Merino, Julio G. Prieto, Francisco Tomás-Barberán and Juan C. Espín
    Drug Metabolism and Disposition November 2012, 40 (11) 2219; DOI: https://doi.org/10.1124/dmd.112.048140
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    Response to Letter to the Editor on “Breast Cancer Resistance Protein (ABCG2) Determines Distribution of Genistein Phase II Metabolites: Reevaluation of the Roles of ABCG2 in the Disposition of Genistein”
    Zhen Yang, Wei Zhu, Song Gao, Taijun Yin, Wen Jiang and Ming Hu
    Drug Metabolism and Disposition November 2012, 40 (11) 2219-2220; DOI: https://doi.org/10.1124/dmd.112.048363
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In this issue

Drug Metabolism and Disposition: 40 (11)
Drug Metabolism and Disposition
Vol. 40, Issue 11
1 Nov 2012
  • Table of Contents
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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