Table of Contents

Articles

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  Vitamin D Receptor Activation Enhances Benzo[a]pyrene Metabolism via CYP1A1 Expression in Macrophages

  Manabu Matsunawa, Daisuke Akagi, Shigeyuki Uno, Kaori Endo-Umeda, Sachiko Yamada, Kazumasa Ikeda and Makoto Makishima

  Drug Metabolism and Disposition November 2012, 40 (11) 2059-2066; DOI: https://doi.org/10.1124/dmd.112.046839
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  Pharmacokinetics of Oral d-Serine in d-Amino Acid Oxidase Knockout Mice

  Rana Rais, Ajit G. Thomas, Krystyna Wozniak, Ying Wu, Hanna Jaaro-Peled, Akira Sawa, Christine A. Strick, Sandra J. Engle, Nicholas J. Brandon, Camilo Rojas, Barbara S. Slusher and Takashi Tsukamoto

  Drug Metabolism and Disposition November 2012, 40 (11) 2067-2073; DOI: https://doi.org/10.1124/dmd.112.046482
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  Oxidative ipso Substitution of 2,4-Difluoro-benzylphthalazines: Identification of a Rare Stable Quinone Methide and Subsequent GSH Conjugate

  Mithat Gunduz, Upendra A. Argikar, Amin Kamel, Kevin Colizza, Jennifer L. Bushee, Amanda Cirello, Franco Lombardo and Shawn Harriman

  Drug Metabolism and Disposition November 2012, 40 (11) 2074-2080; DOI: https://doi.org/10.1124/dmd.112.046268
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  ATP Serves as an Endogenous Inhibitor of UDP-Glucuronosyltransferase (UGT): A New Insight into the Latency of UGT

  Yuji Ishii, Kie An, Yoshio Nishimura and Hideyuki Yamada

  Drug Metabolism and Disposition November 2012, 40 (11) 2081-2089; DOI: https://doi.org/10.1124/dmd.112.046862
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  Assessment of the Drug Interaction Risk for Remogliflozin Etabonate, a Sodium-Dependent Glucose Cotransporter-2 Inhibitor: Evidence from In Vitro, Human Mass Balance, and Ketoconazole Interaction Studies

  James F. Sigafoos, Gary D. Bowers, Stephen Castellino, Amanda G. Culp, David S. Wagner, Melinda J. Reese, Joan E. Humphreys, Elizabeth K. Hussey, Robin L. O'Connor Semmes, Anita Kapur, Wenli Tao, Robert L. Dobbins and Joseph W. Polli

  Drug Metabolism and Disposition November 2012, 40 (11) 2090-2101; DOI: https://doi.org/10.1124/dmd.112.047258
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  The Role of a Basolateral Transporter in Rosuvastatin Transport and Its Interplay with Apical Breast Cancer Resistance Protein in Polarized Cell Monolayer Systems

  Jibin Li, Ying Wang, Wei Zhang, Yuehua Huang, Kristin Hein and Ismael J. Hidalgo

  Drug Metabolism and Disposition November 2012, 40 (11) 2102-2108; DOI: https://doi.org/10.1124/dmd.112.045666
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  Metabolism and Pharmacokinetics of Mangiferin in Conventional Rats, Pseudo-Germ-Free Rats, and Streptozotocin-Induced Diabetic Rats

  Huihui Liu, Bin Wu, Guoyu Pan, Lei He, Zhixiong Li, Mingsong Fan, Longhai Jian, Mingcang Chen, Ke Wang and Chenggang Huang

  Drug Metabolism and Disposition November 2012, 40 (11) 2109-2118; DOI: https://doi.org/10.1124/dmd.112.045849
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  Cytochrome P450 2S1 Depletion Enhances Cell Proliferation and Migration in Bronchial Epithelial Cells, in Part, through Modulation of Prostaglandin E₂ Synthesis

  T. W. Madanayake, T. P. Fidler, T. M. Fresquez, N. Bajaj and A. M. Rowland

  Drug Metabolism and Disposition November 2012, 40 (11) 2119-2125; DOI: https://doi.org/10.1124/dmd.112.046466
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  Chronic Doxorubicin Cardiotoxicity Modulates Cardiac Cytochrome P450-Mediated Arachidonic Acid Metabolism in Rats

  Abdulaziz M. S. Alsaad, Beshay N. M. Zordoky, Ahmed A. El-Sherbeni and Ayman O. S. El-Kadi

  Drug Metabolism and Disposition November 2012, 40 (11) 2126-2135; DOI: https://doi.org/10.1124/dmd.112.046631
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  Impact of Organic Solvents on Cytochrome P450 Probe Reactions: Filling the Gap with (S)-Warfarin and Midazolam Hydroxylation

  Vanessa González-Pérez, Elizabeth A. Connolly, Arlene S. Bridges, Larry C. Wienkers and Mary F. Paine

  Drug Metabolism and Disposition November 2012, 40 (11) 2136-2142; DOI: https://doi.org/10.1124/dmd.112.047134
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  Metabolism, Excretion, and Pharmacokinetics of ((3,3-Difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a Dipeptidyl Peptidase Inhibitor, in Rat, Dog and Human

  Raman Sharma, Hao Sun, David W. Piotrowski, Tim F. Ryder, Shawn D. Doran, Haiqing Dai and Chandra Prakash

  Drug Metabolism and Disposition November 2012, 40 (11) 2143-2161; DOI: https://doi.org/10.1124/dmd.112.047316
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  An Evaluation of Using Rat-Derived Single-Dose Neuropharmacokinetic Parameters to Project Accurately Large Animal Unbound Brain Drug Concentrations

  Angela C. Doran, Sarah M. Osgood, Jessica Y. Mancuso and Christopher L. Shaffer

  Drug Metabolism and Disposition November 2012, 40 (11) 2162-2173; DOI: https://doi.org/10.1124/dmd.112.046391
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  Cytochrome P450-Mediated Oxidative Metabolism of Abused Synthetic Cannabinoids Found in K2/Spice: Identification of Novel Cannabinoid Receptor Ligands

  Krishna C. Chimalakonda, Kathryn A. Seely, Stacie M. Bratton, Lisa K. Brents, Cindy L. Moran, Gregory W. Endres, Laura P. James, Paul F. Hollenberg, Paul L. Prather, Anna Radominska-Pandya and Jeffery H. Moran

  Drug Metabolism and Disposition November 2012, 40 (11) 2174-2184; DOI: https://doi.org/10.1124/dmd.112.047530
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  Novel Bioactivation Mechanism of Reactive Metabolite Formation from Phenyl Methyl-Isoxazoles

  Johan Bylund, Istvan Macsari, Yevgeni Besidski, Susanne Olofsson, Carl Petersson, Per I. Arvidsson and Tjerk Bueters

  Drug Metabolism and Disposition November 2012, 40 (11) 2185-2191; DOI: https://doi.org/10.1124/dmd.112.047431
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  UDP-Glucuronic Acid Binds First and the Aglycone Substrate Binds Second to Form a Ternary Complex in UGT1A9-Catalyzed Reactions, in Both the Presence and Absence of Bovine Serum Albumin

  Nenad Manevski, Jari Yli-Kauhaluoma and Moshe Finel

  Drug Metabolism and Disposition November 2012, 40 (11) 2192-2203; DOI: https://doi.org/10.1124/dmd.112.047746
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  Utility of DPX2 Cells for Predicting CYP3A Induction-Mediated Drug-Drug Interactions and Associated Structure-Activity Relationships

  Odette A. Fahmi, Judy L. Raucy, Elsa Ponce, Saleema Hassanali and Jerome M. Lasker

  Drug Metabolism and Disposition November 2012, 40 (11) 2204-2211; DOI: https://doi.org/10.1124/dmd.112.047456
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  Generation and Characterization of a Novel Multidrug Resistance Protein 2 Humanized Mouse Line

  Nico Scheer, Praveen Balimane, Michael D. Hayward, Sandra Buechel, Gunther Kauselmann and C. Roland Wolf

  Drug Metabolism and Disposition November 2012, 40 (11) 2212-2218; DOI: https://doi.org/10.1124/dmd.112.047605