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Index by author

November 01, 2012; Volume 40,Issue 11

A

  1. Ahlström, Marie M.

    1. Characterization of THLE-Cytochrome P450 (P450) Cell Lines: Gene Expression Background and Relationship to P450-Enzyme Activity
      Yalda Soltanpour, Constanze Hilgendorf, Marie M. Ahlström, Alison J. Foster, J. Gerry Kenna, Anne Petersen and Anna-Lena Ungell
      Drug Metabolism and Disposition November 2012, 40 (11) 2054-2058; DOI: https://doi.org/10.1124/dmd.112.045815

  2. Akagi, Daisuke

    1. Vitamin D Receptor Activation Enhances Benzo[a]pyrene Metabolism via CYP1A1 Expression in Macrophages
      Manabu Matsunawa, Daisuke Akagi, Shigeyuki Uno, Kaori Endo-Umeda, Sachiko Yamada, Kazumasa Ikeda and Makoto Makishima
      Drug Metabolism and Disposition November 2012, 40 (11) 2059-2066; DOI: https://doi.org/10.1124/dmd.112.046839

  3. Alsaad, Abdulaziz M. S.

    1. Chronic Doxorubicin Cardiotoxicity Modulates Cardiac Cytochrome P450-Mediated Arachidonic Acid Metabolism in Rats
      Abdulaziz M. S. Alsaad, Beshay N. M. Zordoky, Ahmed A. El-Sherbeni and Ayman O. S. El-Kadi
      Drug Metabolism and Disposition November 2012, 40 (11) 2126-2135; DOI: https://doi.org/10.1124/dmd.112.046631

  4. Álvarez, Ana I.

    1. Reevaluation of the Roles of ABCG2 in the Disposition of Genistein
      Ana I. Álvarez, Fernando Vallejo, Borja Barrera, Gracia Merino, Julio G. Prieto, Francisco Tomás-Barberán and Juan C. Espín
      Drug Metabolism and Disposition November 2012, 40 (11) 2219; DOI: https://doi.org/10.1124/dmd.112.048140

  5. An, Kie

    1. ATP Serves as an Endogenous Inhibitor of UDP-Glucuronosyltransferase (UGT): A New Insight into the Latency of UGT
      Yuji Ishii, Kie An, Yoshio Nishimura and Hideyuki Yamada
      Drug Metabolism and Disposition November 2012, 40 (11) 2081-2089; DOI: https://doi.org/10.1124/dmd.112.046862

  6. Argikar, Upendra A.

    1. Oxidative ipso Substitution of 2,4-Difluoro-benzylphthalazines: Identification of a Rare Stable Quinone Methide and Subsequent GSH Conjugate
      Mithat Gunduz, Upendra A. Argikar, Amin Kamel, Kevin Colizza, Jennifer L. Bushee, Amanda Cirello, Franco Lombardo and Shawn Harriman
      Drug Metabolism and Disposition November 2012, 40 (11) 2074-2080; DOI: https://doi.org/10.1124/dmd.112.046268

  7. Arvidsson, Per I.

    1. Novel Bioactivation Mechanism of Reactive Metabolite Formation from Phenyl Methyl-Isoxazoles
      Johan Bylund, Istvan Macsari, Yevgeni Besidski, Susanne Olofsson, Carl Petersson, Per I. Arvidsson and Tjerk Bueters
      Drug Metabolism and Disposition November 2012, 40 (11) 2185-2191; DOI: https://doi.org/10.1124/dmd.112.047431

B

  1. Bajaj, N.

    1. Cytochrome P450 2S1 Depletion Enhances Cell Proliferation and Migration in Bronchial Epithelial Cells, in Part, through Modulation of Prostaglandin E2 Synthesis
      T. W. Madanayake, T. P. Fidler, T. M. Fresquez, N. Bajaj and A. M. Rowland
      Drug Metabolism and Disposition November 2012, 40 (11) 2119-2125; DOI: https://doi.org/10.1124/dmd.112.046466

  2. Balimane, Praveen

    1. Generation and Characterization of a Novel Multidrug Resistance Protein 2 Humanized Mouse Line
      Nico Scheer, Praveen Balimane, Michael D. Hayward, Sandra Buechel, Gunther Kauselmann and C. Roland Wolf
      Drug Metabolism and Disposition November 2012, 40 (11) 2212-2218; DOI: https://doi.org/10.1124/dmd.112.047605

  3. Barrera, Borja

    1. Reevaluation of the Roles of ABCG2 in the Disposition of Genistein
      Ana I. Álvarez, Fernando Vallejo, Borja Barrera, Gracia Merino, Julio G. Prieto, Francisco Tomás-Barberán and Juan C. Espín
      Drug Metabolism and Disposition November 2012, 40 (11) 2219; DOI: https://doi.org/10.1124/dmd.112.048140

  4. Besidski, Yevgeni

    1. Novel Bioactivation Mechanism of Reactive Metabolite Formation from Phenyl Methyl-Isoxazoles
      Johan Bylund, Istvan Macsari, Yevgeni Besidski, Susanne Olofsson, Carl Petersson, Per I. Arvidsson and Tjerk Bueters
      Drug Metabolism and Disposition November 2012, 40 (11) 2185-2191; DOI: https://doi.org/10.1124/dmd.112.047431

  5. Bowers, Gary D.

    1. Assessment of the Drug Interaction Risk for Remogliflozin Etabonate, a Sodium-Dependent Glucose Cotransporter-2 Inhibitor: Evidence from In Vitro, Human Mass Balance, and Ketoconazole Interaction Studies
      James F. Sigafoos, Gary D. Bowers, Stephen Castellino, Amanda G. Culp, David S. Wagner, Melinda J. Reese, Joan E. Humphreys, Elizabeth K. Hussey, Robin L. O'Connor Semmes, Anita Kapur, Wenli Tao, Robert L. Dobbins and Joseph W. Polli
      Drug Metabolism and Disposition November 2012, 40 (11) 2090-2101; DOI: https://doi.org/10.1124/dmd.112.047258

  6. Brandon, Nicholas J.

    1. Pharmacokinetics of Oral d-Serine in d-Amino Acid Oxidase Knockout Mice
      Rana Rais, Ajit G. Thomas, Krystyna Wozniak, Ying Wu, Hanna Jaaro-Peled, Akira Sawa, Christine A. Strick, Sandra J. Engle, Nicholas J. Brandon, Camilo Rojas, Barbara S. Slusher and Takashi Tsukamoto
      Drug Metabolism and Disposition November 2012, 40 (11) 2067-2073; DOI: https://doi.org/10.1124/dmd.112.046482

  7. Bratton, Stacie M.

    1. Cytochrome P450-Mediated Oxidative Metabolism of Abused Synthetic Cannabinoids Found in K2/Spice: Identification of Novel Cannabinoid Receptor Ligands
      Krishna C. Chimalakonda, Kathryn A. Seely, Stacie M. Bratton, Lisa K. Brents, Cindy L. Moran, Gregory W. Endres, Laura P. James, Paul F. Hollenberg, Paul L. Prather, Anna Radominska-Pandya and Jeffery H. Moran
      Drug Metabolism and Disposition November 2012, 40 (11) 2174-2184; DOI: https://doi.org/10.1124/dmd.112.047530

  8. Brents, Lisa K.

    1. Cytochrome P450-Mediated Oxidative Metabolism of Abused Synthetic Cannabinoids Found in K2/Spice: Identification of Novel Cannabinoid Receptor Ligands
      Krishna C. Chimalakonda, Kathryn A. Seely, Stacie M. Bratton, Lisa K. Brents, Cindy L. Moran, Gregory W. Endres, Laura P. James, Paul F. Hollenberg, Paul L. Prather, Anna Radominska-Pandya and Jeffery H. Moran
      Drug Metabolism and Disposition November 2012, 40 (11) 2174-2184; DOI: https://doi.org/10.1124/dmd.112.047530

  9. Bridges, Arlene S.

    1. Impact of Organic Solvents on Cytochrome P450 Probe Reactions: Filling the Gap with (S)-Warfarin and Midazolam Hydroxylation
      Vanessa González-Pérez, Elizabeth A. Connolly, Arlene S. Bridges, Larry C. Wienkers and Mary F. Paine
      Drug Metabolism and Disposition November 2012, 40 (11) 2136-2142; DOI: https://doi.org/10.1124/dmd.112.047134

  10. Buechel, Sandra

    1. Generation and Characterization of a Novel Multidrug Resistance Protein 2 Humanized Mouse Line
      Nico Scheer, Praveen Balimane, Michael D. Hayward, Sandra Buechel, Gunther Kauselmann and C. Roland Wolf
      Drug Metabolism and Disposition November 2012, 40 (11) 2212-2218; DOI: https://doi.org/10.1124/dmd.112.047605

  11. Bueters, Tjerk

    1. Novel Bioactivation Mechanism of Reactive Metabolite Formation from Phenyl Methyl-Isoxazoles
      Johan Bylund, Istvan Macsari, Yevgeni Besidski, Susanne Olofsson, Carl Petersson, Per I. Arvidsson and Tjerk Bueters
      Drug Metabolism and Disposition November 2012, 40 (11) 2185-2191; DOI: https://doi.org/10.1124/dmd.112.047431

  12. Bushee, Jennifer L.

    1. Oxidative ipso Substitution of 2,4-Difluoro-benzylphthalazines: Identification of a Rare Stable Quinone Methide and Subsequent GSH Conjugate
      Mithat Gunduz, Upendra A. Argikar, Amin Kamel, Kevin Colizza, Jennifer L. Bushee, Amanda Cirello, Franco Lombardo and Shawn Harriman
      Drug Metabolism and Disposition November 2012, 40 (11) 2074-2080; DOI: https://doi.org/10.1124/dmd.112.046268

  13. Bylund, Johan

    1. Novel Bioactivation Mechanism of Reactive Metabolite Formation from Phenyl Methyl-Isoxazoles
      Johan Bylund, Istvan Macsari, Yevgeni Besidski, Susanne Olofsson, Carl Petersson, Per I. Arvidsson and Tjerk Bueters
      Drug Metabolism and Disposition November 2012, 40 (11) 2185-2191; DOI: https://doi.org/10.1124/dmd.112.047431

C

  1. Castellino, Stephen

    1. Assessment of the Drug Interaction Risk for Remogliflozin Etabonate, a Sodium-Dependent Glucose Cotransporter-2 Inhibitor: Evidence from In Vitro, Human Mass Balance, and Ketoconazole Interaction Studies
      James F. Sigafoos, Gary D. Bowers, Stephen Castellino, Amanda G. Culp, David S. Wagner, Melinda J. Reese, Joan E. Humphreys, Elizabeth K. Hussey, Robin L. O'Connor Semmes, Anita Kapur, Wenli Tao, Robert L. Dobbins and Joseph W. Polli
      Drug Metabolism and Disposition November 2012, 40 (11) 2090-2101; DOI: https://doi.org/10.1124/dmd.112.047258

  2. Chen, Mingcang

    1. Metabolism and Pharmacokinetics of Mangiferin in Conventional Rats, Pseudo-Germ-Free Rats, and Streptozotocin-Induced Diabetic Rats
      Huihui Liu, Bin Wu, Guoyu Pan, Lei He, Zhixiong Li, Mingsong Fan, Longhai Jian, Mingcang Chen, Ke Wang and Chenggang Huang
      Drug Metabolism and Disposition November 2012, 40 (11) 2109-2118; DOI: https://doi.org/10.1124/dmd.112.045849

  3. Chimalakonda, Krishna C.

    1. Cytochrome P450-Mediated Oxidative Metabolism of Abused Synthetic Cannabinoids Found in K2/Spice: Identification of Novel Cannabinoid Receptor Ligands
      Krishna C. Chimalakonda, Kathryn A. Seely, Stacie M. Bratton, Lisa K. Brents, Cindy L. Moran, Gregory W. Endres, Laura P. James, Paul F. Hollenberg, Paul L. Prather, Anna Radominska-Pandya and Jeffery H. Moran
      Drug Metabolism and Disposition November 2012, 40 (11) 2174-2184; DOI: https://doi.org/10.1124/dmd.112.047530

  4. Cirello, Amanda

    1. Oxidative ipso Substitution of 2,4-Difluoro-benzylphthalazines: Identification of a Rare Stable Quinone Methide and Subsequent GSH Conjugate
      Mithat Gunduz, Upendra A. Argikar, Amin Kamel, Kevin Colizza, Jennifer L. Bushee, Amanda Cirello, Franco Lombardo and Shawn Harriman
      Drug Metabolism and Disposition November 2012, 40 (11) 2074-2080; DOI: https://doi.org/10.1124/dmd.112.046268

  5. Colizza, Kevin

    1. Oxidative ipso Substitution of 2,4-Difluoro-benzylphthalazines: Identification of a Rare Stable Quinone Methide and Subsequent GSH Conjugate
      Mithat Gunduz, Upendra A. Argikar, Amin Kamel, Kevin Colizza, Jennifer L. Bushee, Amanda Cirello, Franco Lombardo and Shawn Harriman
      Drug Metabolism and Disposition November 2012, 40 (11) 2074-2080; DOI: https://doi.org/10.1124/dmd.112.046268

  6. Connolly, Elizabeth A.

    1. Impact of Organic Solvents on Cytochrome P450 Probe Reactions: Filling the Gap with (S)-Warfarin and Midazolam Hydroxylation
      Vanessa González-Pérez, Elizabeth A. Connolly, Arlene S. Bridges, Larry C. Wienkers and Mary F. Paine
      Drug Metabolism and Disposition November 2012, 40 (11) 2136-2142; DOI: https://doi.org/10.1124/dmd.112.047134

  7. Culp, Amanda G.

    1. Assessment of the Drug Interaction Risk for Remogliflozin Etabonate, a Sodium-Dependent Glucose Cotransporter-2 Inhibitor: Evidence from In Vitro, Human Mass Balance, and Ketoconazole Interaction Studies
      James F. Sigafoos, Gary D. Bowers, Stephen Castellino, Amanda G. Culp, David S. Wagner, Melinda J. Reese, Joan E. Humphreys, Elizabeth K. Hussey, Robin L. O'Connor Semmes, Anita Kapur, Wenli Tao, Robert L. Dobbins and Joseph W. Polli
      Drug Metabolism and Disposition November 2012, 40 (11) 2090-2101; DOI: https://doi.org/10.1124/dmd.112.047258

D

  1. Dai, Haiqing

    1. Metabolism, Excretion, and Pharmacokinetics of ((3,3-Difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a Dipeptidyl Peptidase Inhibitor, in Rat, Dog and Human
      Raman Sharma, Hao Sun, David W. Piotrowski, Tim F. Ryder, Shawn D. Doran, Haiqing Dai and Chandra Prakash
      Drug Metabolism and Disposition November 2012, 40 (11) 2143-2161; DOI: https://doi.org/10.1124/dmd.112.047316

  2. Dobbins, Robert L.

    1. Assessment of the Drug Interaction Risk for Remogliflozin Etabonate, a Sodium-Dependent Glucose Cotransporter-2 Inhibitor: Evidence from In Vitro, Human Mass Balance, and Ketoconazole Interaction Studies
      James F. Sigafoos, Gary D. Bowers, Stephen Castellino, Amanda G. Culp, David S. Wagner, Melinda J. Reese, Joan E. Humphreys, Elizabeth K. Hussey, Robin L. O'Connor Semmes, Anita Kapur, Wenli Tao, Robert L. Dobbins and Joseph W. Polli
      Drug Metabolism and Disposition November 2012, 40 (11) 2090-2101; DOI: https://doi.org/10.1124/dmd.112.047258

  3. Doran, Angela C.

    1. An Evaluation of Using Rat-Derived Single-Dose Neuropharmacokinetic Parameters to Project Accurately Large Animal Unbound Brain Drug Concentrations
      Angela C. Doran, Sarah M. Osgood, Jessica Y. Mancuso and Christopher L. Shaffer
      Drug Metabolism and Disposition November 2012, 40 (11) 2162-2173; DOI: https://doi.org/10.1124/dmd.112.046391

  4. Doran, Shawn D.

    1. Metabolism, Excretion, and Pharmacokinetics of ((3,3-Difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a Dipeptidyl Peptidase Inhibitor, in Rat, Dog and Human
      Raman Sharma, Hao Sun, David W. Piotrowski, Tim F. Ryder, Shawn D. Doran, Haiqing Dai and Chandra Prakash
      Drug Metabolism and Disposition November 2012, 40 (11) 2143-2161; DOI: https://doi.org/10.1124/dmd.112.047316

E

  1. El-Kadi, Ayman O. S.

    1. Chronic Doxorubicin Cardiotoxicity Modulates Cardiac Cytochrome P450-Mediated Arachidonic Acid Metabolism in Rats
      Abdulaziz M. S. Alsaad, Beshay N. M. Zordoky, Ahmed A. El-Sherbeni and Ayman O. S. El-Kadi
      Drug Metabolism and Disposition November 2012, 40 (11) 2126-2135; DOI: https://doi.org/10.1124/dmd.112.046631

  2. El-Sherbeni, Ahmed A.

    1. Chronic Doxorubicin Cardiotoxicity Modulates Cardiac Cytochrome P450-Mediated Arachidonic Acid Metabolism in Rats
      Abdulaziz M. S. Alsaad, Beshay N. M. Zordoky, Ahmed A. El-Sherbeni and Ayman O. S. El-Kadi
      Drug Metabolism and Disposition November 2012, 40 (11) 2126-2135; DOI: https://doi.org/10.1124/dmd.112.046631

  3. Endo-Umeda, Kaori

    1. Vitamin D Receptor Activation Enhances Benzo[a]pyrene Metabolism via CYP1A1 Expression in Macrophages
      Manabu Matsunawa, Daisuke Akagi, Shigeyuki Uno, Kaori Endo-Umeda, Sachiko Yamada, Kazumasa Ikeda and Makoto Makishima
      Drug Metabolism and Disposition November 2012, 40 (11) 2059-2066; DOI: https://doi.org/10.1124/dmd.112.046839

  4. Endres, Gregory W.

    1. Cytochrome P450-Mediated Oxidative Metabolism of Abused Synthetic Cannabinoids Found in K2/Spice: Identification of Novel Cannabinoid Receptor Ligands
      Krishna C. Chimalakonda, Kathryn A. Seely, Stacie M. Bratton, Lisa K. Brents, Cindy L. Moran, Gregory W. Endres, Laura P. James, Paul F. Hollenberg, Paul L. Prather, Anna Radominska-Pandya and Jeffery H. Moran
      Drug Metabolism and Disposition November 2012, 40 (11) 2174-2184; DOI: https://doi.org/10.1124/dmd.112.047530

  5. Engle, Sandra J.

    1. Pharmacokinetics of Oral d-Serine in d-Amino Acid Oxidase Knockout Mice
      Rana Rais, Ajit G. Thomas, Krystyna Wozniak, Ying Wu, Hanna Jaaro-Peled, Akira Sawa, Christine A. Strick, Sandra J. Engle, Nicholas J. Brandon, Camilo Rojas, Barbara S. Slusher and Takashi Tsukamoto
      Drug Metabolism and Disposition November 2012, 40 (11) 2067-2073; DOI: https://doi.org/10.1124/dmd.112.046482

  6. Espín, Juan C.

    1. Reevaluation of the Roles of ABCG2 in the Disposition of Genistein
      Ana I. Álvarez, Fernando Vallejo, Borja Barrera, Gracia Merino, Julio G. Prieto, Francisco Tomás-Barberán and Juan C. Espín
      Drug Metabolism and Disposition November 2012, 40 (11) 2219; DOI: https://doi.org/10.1124/dmd.112.048140

F

  1. Fahmi, Odette A.

    1. Utility of DPX2 Cells for Predicting CYP3A Induction-Mediated Drug-Drug Interactions and Associated Structure-Activity Relationships
      Odette A. Fahmi, Judy L. Raucy, Elsa Ponce, Saleema Hassanali and Jerome M. Lasker
      Drug Metabolism and Disposition November 2012, 40 (11) 2204-2211; DOI: https://doi.org/10.1124/dmd.112.047456

  2. Fan, Mingsong

    1. Metabolism and Pharmacokinetics of Mangiferin in Conventional Rats, Pseudo-Germ-Free Rats, and Streptozotocin-Induced Diabetic Rats
      Huihui Liu, Bin Wu, Guoyu Pan, Lei He, Zhixiong Li, Mingsong Fan, Longhai Jian, Mingcang Chen, Ke Wang and Chenggang Huang
      Drug Metabolism and Disposition November 2012, 40 (11) 2109-2118; DOI: https://doi.org/10.1124/dmd.112.045849

  3. Fidler, T. P.

    1. Cytochrome P450 2S1 Depletion Enhances Cell Proliferation and Migration in Bronchial Epithelial Cells, in Part, through Modulation of Prostaglandin E2 Synthesis
      T. W. Madanayake, T. P. Fidler, T. M. Fresquez, N. Bajaj and A. M. Rowland
      Drug Metabolism and Disposition November 2012, 40 (11) 2119-2125; DOI: https://doi.org/10.1124/dmd.112.046466

  4. Finel, Moshe

    1. UDP-Glucuronic Acid Binds First and the Aglycone Substrate Binds Second to Form a Ternary Complex in UGT1A9-Catalyzed Reactions, in Both the Presence and Absence of Bovine Serum Albumin
      Nenad Manevski, Jari Yli-Kauhaluoma and Moshe Finel
      Drug Metabolism and Disposition November 2012, 40 (11) 2192-2203; DOI: https://doi.org/10.1124/dmd.112.047746

  5. Foster, Alison J.

    1. Characterization of THLE-Cytochrome P450 (P450) Cell Lines: Gene Expression Background and Relationship to P450-Enzyme Activity
      Yalda Soltanpour, Constanze Hilgendorf, Marie M. Ahlström, Alison J. Foster, J. Gerry Kenna, Anne Petersen and Anna-Lena Ungell
      Drug Metabolism and Disposition November 2012, 40 (11) 2054-2058; DOI: https://doi.org/10.1124/dmd.112.045815

  6. Fresquez, T. M.

    1. Cytochrome P450 2S1 Depletion Enhances Cell Proliferation and Migration in Bronchial Epithelial Cells, in Part, through Modulation of Prostaglandin E2 Synthesis
      T. W. Madanayake, T. P. Fidler, T. M. Fresquez, N. Bajaj and A. M. Rowland
      Drug Metabolism and Disposition November 2012, 40 (11) 2119-2125; DOI: https://doi.org/10.1124/dmd.112.046466

G

  1. Gao, Song

    1. Response to Letter to the Editor on “Breast Cancer Resistance Protein (ABCG2) Determines Distribution of Genistein Phase II Metabolites: Reevaluation of the Roles of ABCG2 in the Disposition of Genistein”
      Zhen Yang, Wei Zhu, Song Gao, Taijun Yin, Wen Jiang and Ming Hu
      Drug Metabolism and Disposition November 2012, 40 (11) 2219-2220; DOI: https://doi.org/10.1124/dmd.112.048363

  2. González-Pérez, Vanessa

    1. Impact of Organic Solvents on Cytochrome P450 Probe Reactions: Filling the Gap with (S)-Warfarin and Midazolam Hydroxylation
      Vanessa González-Pérez, Elizabeth A. Connolly, Arlene S. Bridges, Larry C. Wienkers and Mary F. Paine
      Drug Metabolism and Disposition November 2012, 40 (11) 2136-2142; DOI: https://doi.org/10.1124/dmd.112.047134

  3. Gunduz, Mithat

    1. Oxidative ipso Substitution of 2,4-Difluoro-benzylphthalazines: Identification of a Rare Stable Quinone Methide and Subsequent GSH Conjugate
      Mithat Gunduz, Upendra A. Argikar, Amin Kamel, Kevin Colizza, Jennifer L. Bushee, Amanda Cirello, Franco Lombardo and Shawn Harriman
      Drug Metabolism and Disposition November 2012, 40 (11) 2074-2080; DOI: https://doi.org/10.1124/dmd.112.046268

H

  1. Harriman, Shawn

    1. Oxidative ipso Substitution of 2,4-Difluoro-benzylphthalazines: Identification of a Rare Stable Quinone Methide and Subsequent GSH Conjugate
      Mithat Gunduz, Upendra A. Argikar, Amin Kamel, Kevin Colizza, Jennifer L. Bushee, Amanda Cirello, Franco Lombardo and Shawn Harriman
      Drug Metabolism and Disposition November 2012, 40 (11) 2074-2080; DOI: https://doi.org/10.1124/dmd.112.046268

  2. Hassanali, Saleema

    1. Utility of DPX2 Cells for Predicting CYP3A Induction-Mediated Drug-Drug Interactions and Associated Structure-Activity Relationships
      Odette A. Fahmi, Judy L. Raucy, Elsa Ponce, Saleema Hassanali and Jerome M. Lasker
      Drug Metabolism and Disposition November 2012, 40 (11) 2204-2211; DOI: https://doi.org/10.1124/dmd.112.047456

  3. Hayward, Michael D.

    1. Generation and Characterization of a Novel Multidrug Resistance Protein 2 Humanized Mouse Line
      Nico Scheer, Praveen Balimane, Michael D. Hayward, Sandra Buechel, Gunther Kauselmann and C. Roland Wolf
      Drug Metabolism and Disposition November 2012, 40 (11) 2212-2218; DOI: https://doi.org/10.1124/dmd.112.047605

  4. He, Lei

    1. Metabolism and Pharmacokinetics of Mangiferin in Conventional Rats, Pseudo-Germ-Free Rats, and Streptozotocin-Induced Diabetic Rats
      Huihui Liu, Bin Wu, Guoyu Pan, Lei He, Zhixiong Li, Mingsong Fan, Longhai Jian, Mingcang Chen, Ke Wang and Chenggang Huang
      Drug Metabolism and Disposition November 2012, 40 (11) 2109-2118; DOI: https://doi.org/10.1124/dmd.112.045849

  5. Hein, Kristin

    1. The Role of a Basolateral Transporter in Rosuvastatin Transport and Its Interplay with Apical Breast Cancer Resistance Protein in Polarized Cell Monolayer Systems
      Jibin Li, Ying Wang, Wei Zhang, Yuehua Huang, Kristin Hein and Ismael J. Hidalgo
      Drug Metabolism and Disposition November 2012, 40 (11) 2102-2108; DOI: https://doi.org/10.1124/dmd.112.045666

  6. Hidalgo, Ismael J.

    1. The Role of a Basolateral Transporter in Rosuvastatin Transport and Its Interplay with Apical Breast Cancer Resistance Protein in Polarized Cell Monolayer Systems
      Jibin Li, Ying Wang, Wei Zhang, Yuehua Huang, Kristin Hein and Ismael J. Hidalgo
      Drug Metabolism and Disposition November 2012, 40 (11) 2102-2108; DOI: https://doi.org/10.1124/dmd.112.045666

  7. Hilgendorf, Constanze

    1. Characterization of THLE-Cytochrome P450 (P450) Cell Lines: Gene Expression Background and Relationship to P450-Enzyme Activity
      Yalda Soltanpour, Constanze Hilgendorf, Marie M. Ahlström, Alison J. Foster, J. Gerry Kenna, Anne Petersen and Anna-Lena Ungell
      Drug Metabolism and Disposition November 2012, 40 (11) 2054-2058; DOI: https://doi.org/10.1124/dmd.112.045815

  8. Hollenberg, Paul F.

    1. Cytochrome P450-Mediated Oxidative Metabolism of Abused Synthetic Cannabinoids Found in K2/Spice: Identification of Novel Cannabinoid Receptor Ligands
      Krishna C. Chimalakonda, Kathryn A. Seely, Stacie M. Bratton, Lisa K. Brents, Cindy L. Moran, Gregory W. Endres, Laura P. James, Paul F. Hollenberg, Paul L. Prather, Anna Radominska-Pandya and Jeffery H. Moran
      Drug Metabolism and Disposition November 2012, 40 (11) 2174-2184; DOI: https://doi.org/10.1124/dmd.112.047530

  9. Hu, Ming

    1. Response to Letter to the Editor on “Breast Cancer Resistance Protein (ABCG2) Determines Distribution of Genistein Phase II Metabolites: Reevaluation of the Roles of ABCG2 in the Disposition of Genistein”
      Zhen Yang, Wei Zhu, Song Gao, Taijun Yin, Wen Jiang and Ming Hu
      Drug Metabolism and Disposition November 2012, 40 (11) 2219-2220; DOI: https://doi.org/10.1124/dmd.112.048363

  10. Huang, Chenggang

    1. Metabolism and Pharmacokinetics of Mangiferin in Conventional Rats, Pseudo-Germ-Free Rats, and Streptozotocin-Induced Diabetic Rats
      Huihui Liu, Bin Wu, Guoyu Pan, Lei He, Zhixiong Li, Mingsong Fan, Longhai Jian, Mingcang Chen, Ke Wang and Chenggang Huang
      Drug Metabolism and Disposition November 2012, 40 (11) 2109-2118; DOI: https://doi.org/10.1124/dmd.112.045849

  11. Huang, Yuehua

    1. The Role of a Basolateral Transporter in Rosuvastatin Transport and Its Interplay with Apical Breast Cancer Resistance Protein in Polarized Cell Monolayer Systems
      Jibin Li, Ying Wang, Wei Zhang, Yuehua Huang, Kristin Hein and Ismael J. Hidalgo
      Drug Metabolism and Disposition November 2012, 40 (11) 2102-2108; DOI: https://doi.org/10.1124/dmd.112.045666

  12. Humphreys, Joan E.

    1. Assessment of the Drug Interaction Risk for Remogliflozin Etabonate, a Sodium-Dependent Glucose Cotransporter-2 Inhibitor: Evidence from In Vitro, Human Mass Balance, and Ketoconazole Interaction Studies
      James F. Sigafoos, Gary D. Bowers, Stephen Castellino, Amanda G. Culp, David S. Wagner, Melinda J. Reese, Joan E. Humphreys, Elizabeth K. Hussey, Robin L. O'Connor Semmes, Anita Kapur, Wenli Tao, Robert L. Dobbins and Joseph W. Polli
      Drug Metabolism and Disposition November 2012, 40 (11) 2090-2101; DOI: https://doi.org/10.1124/dmd.112.047258

  13. Hussey, Elizabeth K.

    1. Assessment of the Drug Interaction Risk for Remogliflozin Etabonate, a Sodium-Dependent Glucose Cotransporter-2 Inhibitor: Evidence from In Vitro, Human Mass Balance, and Ketoconazole Interaction Studies
      James F. Sigafoos, Gary D. Bowers, Stephen Castellino, Amanda G. Culp, David S. Wagner, Melinda J. Reese, Joan E. Humphreys, Elizabeth K. Hussey, Robin L. O'Connor Semmes, Anita Kapur, Wenli Tao, Robert L. Dobbins and Joseph W. Polli
      Drug Metabolism and Disposition November 2012, 40 (11) 2090-2101; DOI: https://doi.org/10.1124/dmd.112.047258

I

  1. Ikeda, Kazumasa

    1. Vitamin D Receptor Activation Enhances Benzo[a]pyrene Metabolism via CYP1A1 Expression in Macrophages
      Manabu Matsunawa, Daisuke Akagi, Shigeyuki Uno, Kaori Endo-Umeda, Sachiko Yamada, Kazumasa Ikeda and Makoto Makishima
      Drug Metabolism and Disposition November 2012, 40 (11) 2059-2066; DOI: https://doi.org/10.1124/dmd.112.046839

  2. Ishii, Yuji

    1. ATP Serves as an Endogenous Inhibitor of UDP-Glucuronosyltransferase (UGT): A New Insight into the Latency of UGT
      Yuji Ishii, Kie An, Yoshio Nishimura and Hideyuki Yamada
      Drug Metabolism and Disposition November 2012, 40 (11) 2081-2089; DOI: https://doi.org/10.1124/dmd.112.046862

J

  1. Jaaro-Peled, Hanna

    1. Pharmacokinetics of Oral d-Serine in d-Amino Acid Oxidase Knockout Mice
      Rana Rais, Ajit G. Thomas, Krystyna Wozniak, Ying Wu, Hanna Jaaro-Peled, Akira Sawa, Christine A. Strick, Sandra J. Engle, Nicholas J. Brandon, Camilo Rojas, Barbara S. Slusher and Takashi Tsukamoto
      Drug Metabolism and Disposition November 2012, 40 (11) 2067-2073; DOI: https://doi.org/10.1124/dmd.112.046482

  2. James, Laura P.

    1. Cytochrome P450-Mediated Oxidative Metabolism of Abused Synthetic Cannabinoids Found in K2/Spice: Identification of Novel Cannabinoid Receptor Ligands
      Krishna C. Chimalakonda, Kathryn A. Seely, Stacie M. Bratton, Lisa K. Brents, Cindy L. Moran, Gregory W. Endres, Laura P. James, Paul F. Hollenberg, Paul L. Prather, Anna Radominska-Pandya and Jeffery H. Moran
      Drug Metabolism and Disposition November 2012, 40 (11) 2174-2184; DOI: https://doi.org/10.1124/dmd.112.047530

  3. Jian, Longhai

    1. Metabolism and Pharmacokinetics of Mangiferin in Conventional Rats, Pseudo-Germ-Free Rats, and Streptozotocin-Induced Diabetic Rats
      Huihui Liu, Bin Wu, Guoyu Pan, Lei He, Zhixiong Li, Mingsong Fan, Longhai Jian, Mingcang Chen, Ke Wang and Chenggang Huang
      Drug Metabolism and Disposition November 2012, 40 (11) 2109-2118; DOI: https://doi.org/10.1124/dmd.112.045849

  4. Jiang, Wen

    1. Response to Letter to the Editor on “Breast Cancer Resistance Protein (ABCG2) Determines Distribution of Genistein Phase II Metabolites: Reevaluation of the Roles of ABCG2 in the Disposition of Genistein”
      Zhen Yang, Wei Zhu, Song Gao, Taijun Yin, Wen Jiang and Ming Hu
      Drug Metabolism and Disposition November 2012, 40 (11) 2219-2220; DOI: https://doi.org/10.1124/dmd.112.048363

K

  1. Kamel, Amin

    1. Oxidative ipso Substitution of 2,4-Difluoro-benzylphthalazines: Identification of a Rare Stable Quinone Methide and Subsequent GSH Conjugate
      Mithat Gunduz, Upendra A. Argikar, Amin Kamel, Kevin Colizza, Jennifer L. Bushee, Amanda Cirello, Franco Lombardo and Shawn Harriman
      Drug Metabolism and Disposition November 2012, 40 (11) 2074-2080; DOI: https://doi.org/10.1124/dmd.112.046268

  2. Kapur, Anita

    1. Assessment of the Drug Interaction Risk for Remogliflozin Etabonate, a Sodium-Dependent Glucose Cotransporter-2 Inhibitor: Evidence from In Vitro, Human Mass Balance, and Ketoconazole Interaction Studies
      James F. Sigafoos, Gary D. Bowers, Stephen Castellino, Amanda G. Culp, David S. Wagner, Melinda J. Reese, Joan E. Humphreys, Elizabeth K. Hussey, Robin L. O'Connor Semmes, Anita Kapur, Wenli Tao, Robert L. Dobbins and Joseph W. Polli
      Drug Metabolism and Disposition November 2012, 40 (11) 2090-2101; DOI: https://doi.org/10.1124/dmd.112.047258

  3. Kauselmann, Gunther

    1. Generation and Characterization of a Novel Multidrug Resistance Protein 2 Humanized Mouse Line
      Nico Scheer, Praveen Balimane, Michael D. Hayward, Sandra Buechel, Gunther Kauselmann and C. Roland Wolf
      Drug Metabolism and Disposition November 2012, 40 (11) 2212-2218; DOI: https://doi.org/10.1124/dmd.112.047605

  4. Kenna, J. Gerry

    1. Characterization of THLE-Cytochrome P450 (P450) Cell Lines: Gene Expression Background and Relationship to P450-Enzyme Activity
      Yalda Soltanpour, Constanze Hilgendorf, Marie M. Ahlström, Alison J. Foster, J. Gerry Kenna, Anne Petersen and Anna-Lena Ungell
      Drug Metabolism and Disposition November 2012, 40 (11) 2054-2058; DOI: https://doi.org/10.1124/dmd.112.045815

L

  1. Lasker, Jerome M.

    1. Utility of DPX2 Cells for Predicting CYP3A Induction-Mediated Drug-Drug Interactions and Associated Structure-Activity Relationships
      Odette A. Fahmi, Judy L. Raucy, Elsa Ponce, Saleema Hassanali and Jerome M. Lasker
      Drug Metabolism and Disposition November 2012, 40 (11) 2204-2211; DOI: https://doi.org/10.1124/dmd.112.047456

  2. Li, Jibin

    1. The Role of a Basolateral Transporter in Rosuvastatin Transport and Its Interplay with Apical Breast Cancer Resistance Protein in Polarized Cell Monolayer Systems
      Jibin Li, Ying Wang, Wei Zhang, Yuehua Huang, Kristin Hein and Ismael J. Hidalgo
      Drug Metabolism and Disposition November 2012, 40 (11) 2102-2108; DOI: https://doi.org/10.1124/dmd.112.045666

  3. Li, Zhixiong

    1. Metabolism and Pharmacokinetics of Mangiferin in Conventional Rats, Pseudo-Germ-Free Rats, and Streptozotocin-Induced Diabetic Rats
      Huihui Liu, Bin Wu, Guoyu Pan, Lei He, Zhixiong Li, Mingsong Fan, Longhai Jian, Mingcang Chen, Ke Wang and Chenggang Huang
      Drug Metabolism and Disposition November 2012, 40 (11) 2109-2118; DOI: https://doi.org/10.1124/dmd.112.045849

  4. Liu, Huihui

    1. Metabolism and Pharmacokinetics of Mangiferin in Conventional Rats, Pseudo-Germ-Free Rats, and Streptozotocin-Induced Diabetic Rats
      Huihui Liu, Bin Wu, Guoyu Pan, Lei He, Zhixiong Li, Mingsong Fan, Longhai Jian, Mingcang Chen, Ke Wang and Chenggang Huang
      Drug Metabolism and Disposition November 2012, 40 (11) 2109-2118; DOI: https://doi.org/10.1124/dmd.112.045849

  5. Lombardo, Franco

    1. Oxidative ipso Substitution of 2,4-Difluoro-benzylphthalazines: Identification of a Rare Stable Quinone Methide and Subsequent GSH Conjugate
      Mithat Gunduz, Upendra A. Argikar, Amin Kamel, Kevin Colizza, Jennifer L. Bushee, Amanda Cirello, Franco Lombardo and Shawn Harriman
      Drug Metabolism and Disposition November 2012, 40 (11) 2074-2080; DOI: https://doi.org/10.1124/dmd.112.046268

M

  1. Macsari, Istvan

    1. Novel Bioactivation Mechanism of Reactive Metabolite Formation from Phenyl Methyl-Isoxazoles
      Johan Bylund, Istvan Macsari, Yevgeni Besidski, Susanne Olofsson, Carl Petersson, Per I. Arvidsson and Tjerk Bueters
      Drug Metabolism and Disposition November 2012, 40 (11) 2185-2191; DOI: https://doi.org/10.1124/dmd.112.047431

  2. Madanayake, T. W.

    1. Cytochrome P450 2S1 Depletion Enhances Cell Proliferation and Migration in Bronchial Epithelial Cells, in Part, through Modulation of Prostaglandin E2 Synthesis
      T. W. Madanayake, T. P. Fidler, T. M. Fresquez, N. Bajaj and A. M. Rowland
      Drug Metabolism and Disposition November 2012, 40 (11) 2119-2125; DOI: https://doi.org/10.1124/dmd.112.046466

  3. Makishima, Makoto

    1. Vitamin D Receptor Activation Enhances Benzo[a]pyrene Metabolism via CYP1A1 Expression in Macrophages
      Manabu Matsunawa, Daisuke Akagi, Shigeyuki Uno, Kaori Endo-Umeda, Sachiko Yamada, Kazumasa Ikeda and Makoto Makishima
      Drug Metabolism and Disposition November 2012, 40 (11) 2059-2066; DOI: https://doi.org/10.1124/dmd.112.046839

  4. Mancuso, Jessica Y.

    1. An Evaluation of Using Rat-Derived Single-Dose Neuropharmacokinetic Parameters to Project Accurately Large Animal Unbound Brain Drug Concentrations
      Angela C. Doran, Sarah M. Osgood, Jessica Y. Mancuso and Christopher L. Shaffer
      Drug Metabolism and Disposition November 2012, 40 (11) 2162-2173; DOI: https://doi.org/10.1124/dmd.112.046391

  5. Manevski, Nenad

    1. UDP-Glucuronic Acid Binds First and the Aglycone Substrate Binds Second to Form a Ternary Complex in UGT1A9-Catalyzed Reactions, in Both the Presence and Absence of Bovine Serum Albumin
      Nenad Manevski, Jari Yli-Kauhaluoma and Moshe Finel
      Drug Metabolism and Disposition November 2012, 40 (11) 2192-2203; DOI: https://doi.org/10.1124/dmd.112.047746

  6. Matsunawa, Manabu

    1. Vitamin D Receptor Activation Enhances Benzo[a]pyrene Metabolism via CYP1A1 Expression in Macrophages
      Manabu Matsunawa, Daisuke Akagi, Shigeyuki Uno, Kaori Endo-Umeda, Sachiko Yamada, Kazumasa Ikeda and Makoto Makishima
      Drug Metabolism and Disposition November 2012, 40 (11) 2059-2066; DOI: https://doi.org/10.1124/dmd.112.046839

  7. Merino, Gracia

    1. Reevaluation of the Roles of ABCG2 in the Disposition of Genistein
      Ana I. Álvarez, Fernando Vallejo, Borja Barrera, Gracia Merino, Julio G. Prieto, Francisco Tomás-Barberán and Juan C. Espín
      Drug Metabolism and Disposition November 2012, 40 (11) 2219; DOI: https://doi.org/10.1124/dmd.112.048140

  8. Moran, Cindy L.

    1. Cytochrome P450-Mediated Oxidative Metabolism of Abused Synthetic Cannabinoids Found in K2/Spice: Identification of Novel Cannabinoid Receptor Ligands
      Krishna C. Chimalakonda, Kathryn A. Seely, Stacie M. Bratton, Lisa K. Brents, Cindy L. Moran, Gregory W. Endres, Laura P. James, Paul F. Hollenberg, Paul L. Prather, Anna Radominska-Pandya and Jeffery H. Moran
      Drug Metabolism and Disposition November 2012, 40 (11) 2174-2184; DOI: https://doi.org/10.1124/dmd.112.047530

  9. Moran, Jeffery H.

    1. Cytochrome P450-Mediated Oxidative Metabolism of Abused Synthetic Cannabinoids Found in K2/Spice: Identification of Novel Cannabinoid Receptor Ligands
      Krishna C. Chimalakonda, Kathryn A. Seely, Stacie M. Bratton, Lisa K. Brents, Cindy L. Moran, Gregory W. Endres, Laura P. James, Paul F. Hollenberg, Paul L. Prather, Anna Radominska-Pandya and Jeffery H. Moran
      Drug Metabolism and Disposition November 2012, 40 (11) 2174-2184; DOI: https://doi.org/10.1124/dmd.112.047530

N

  1. Nishimura, Yoshio

    1. ATP Serves as an Endogenous Inhibitor of UDP-Glucuronosyltransferase (UGT): A New Insight into the Latency of UGT
      Yuji Ishii, Kie An, Yoshio Nishimura and Hideyuki Yamada
      Drug Metabolism and Disposition November 2012, 40 (11) 2081-2089; DOI: https://doi.org/10.1124/dmd.112.046862

O

  1. O'Connor Semmes, Robin L.

    1. Assessment of the Drug Interaction Risk for Remogliflozin Etabonate, a Sodium-Dependent Glucose Cotransporter-2 Inhibitor: Evidence from In Vitro, Human Mass Balance, and Ketoconazole Interaction Studies
      James F. Sigafoos, Gary D. Bowers, Stephen Castellino, Amanda G. Culp, David S. Wagner, Melinda J. Reese, Joan E. Humphreys, Elizabeth K. Hussey, Robin L. O'Connor Semmes, Anita Kapur, Wenli Tao, Robert L. Dobbins and Joseph W. Polli
      Drug Metabolism and Disposition November 2012, 40 (11) 2090-2101; DOI: https://doi.org/10.1124/dmd.112.047258

  2. Olofsson, Susanne

    1. Novel Bioactivation Mechanism of Reactive Metabolite Formation from Phenyl Methyl-Isoxazoles
      Johan Bylund, Istvan Macsari, Yevgeni Besidski, Susanne Olofsson, Carl Petersson, Per I. Arvidsson and Tjerk Bueters
      Drug Metabolism and Disposition November 2012, 40 (11) 2185-2191; DOI: https://doi.org/10.1124/dmd.112.047431

  3. Osgood, Sarah M.

    1. An Evaluation of Using Rat-Derived Single-Dose Neuropharmacokinetic Parameters to Project Accurately Large Animal Unbound Brain Drug Concentrations
      Angela C. Doran, Sarah M. Osgood, Jessica Y. Mancuso and Christopher L. Shaffer
      Drug Metabolism and Disposition November 2012, 40 (11) 2162-2173; DOI: https://doi.org/10.1124/dmd.112.046391

P

  1. Paine, Mary F.

    1. Impact of Organic Solvents on Cytochrome P450 Probe Reactions: Filling the Gap with (S)-Warfarin and Midazolam Hydroxylation
      Vanessa González-Pérez, Elizabeth A. Connolly, Arlene S. Bridges, Larry C. Wienkers and Mary F. Paine
      Drug Metabolism and Disposition November 2012, 40 (11) 2136-2142; DOI: https://doi.org/10.1124/dmd.112.047134

  2. Pan, Guoyu

    1. Metabolism and Pharmacokinetics of Mangiferin in Conventional Rats, Pseudo-Germ-Free Rats, and Streptozotocin-Induced Diabetic Rats
      Huihui Liu, Bin Wu, Guoyu Pan, Lei He, Zhixiong Li, Mingsong Fan, Longhai Jian, Mingcang Chen, Ke Wang and Chenggang Huang
      Drug Metabolism and Disposition November 2012, 40 (11) 2109-2118; DOI: https://doi.org/10.1124/dmd.112.045849

  3. Petersen, Anne

    1. Characterization of THLE-Cytochrome P450 (P450) Cell Lines: Gene Expression Background and Relationship to P450-Enzyme Activity
      Yalda Soltanpour, Constanze Hilgendorf, Marie M. Ahlström, Alison J. Foster, J. Gerry Kenna, Anne Petersen and Anna-Lena Ungell
      Drug Metabolism and Disposition November 2012, 40 (11) 2054-2058; DOI: https://doi.org/10.1124/dmd.112.045815

  4. Petersson, Carl

    1. Novel Bioactivation Mechanism of Reactive Metabolite Formation from Phenyl Methyl-Isoxazoles
      Johan Bylund, Istvan Macsari, Yevgeni Besidski, Susanne Olofsson, Carl Petersson, Per I. Arvidsson and Tjerk Bueters
      Drug Metabolism and Disposition November 2012, 40 (11) 2185-2191; DOI: https://doi.org/10.1124/dmd.112.047431

  5. Piotrowski, David W.

    1. Metabolism, Excretion, and Pharmacokinetics of ((3,3-Difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a Dipeptidyl Peptidase Inhibitor, in Rat, Dog and Human
      Raman Sharma, Hao Sun, David W. Piotrowski, Tim F. Ryder, Shawn D. Doran, Haiqing Dai and Chandra Prakash
      Drug Metabolism and Disposition November 2012, 40 (11) 2143-2161; DOI: https://doi.org/10.1124/dmd.112.047316

  6. Polli, Joseph W.

    1. Assessment of the Drug Interaction Risk for Remogliflozin Etabonate, a Sodium-Dependent Glucose Cotransporter-2 Inhibitor: Evidence from In Vitro, Human Mass Balance, and Ketoconazole Interaction Studies
      James F. Sigafoos, Gary D. Bowers, Stephen Castellino, Amanda G. Culp, David S. Wagner, Melinda J. Reese, Joan E. Humphreys, Elizabeth K. Hussey, Robin L. O'Connor Semmes, Anita Kapur, Wenli Tao, Robert L. Dobbins and Joseph W. Polli
      Drug Metabolism and Disposition November 2012, 40 (11) 2090-2101; DOI: https://doi.org/10.1124/dmd.112.047258

  7. Ponce, Elsa

    1. Utility of DPX2 Cells for Predicting CYP3A Induction-Mediated Drug-Drug Interactions and Associated Structure-Activity Relationships
      Odette A. Fahmi, Judy L. Raucy, Elsa Ponce, Saleema Hassanali and Jerome M. Lasker
      Drug Metabolism and Disposition November 2012, 40 (11) 2204-2211; DOI: https://doi.org/10.1124/dmd.112.047456

  8. Prakash, Chandra

    1. Metabolism, Excretion, and Pharmacokinetics of ((3,3-Difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a Dipeptidyl Peptidase Inhibitor, in Rat, Dog and Human
      Raman Sharma, Hao Sun, David W. Piotrowski, Tim F. Ryder, Shawn D. Doran, Haiqing Dai and Chandra Prakash
      Drug Metabolism and Disposition November 2012, 40 (11) 2143-2161; DOI: https://doi.org/10.1124/dmd.112.047316

  9. Prather, Paul L.

    1. Cytochrome P450-Mediated Oxidative Metabolism of Abused Synthetic Cannabinoids Found in K2/Spice: Identification of Novel Cannabinoid Receptor Ligands
      Krishna C. Chimalakonda, Kathryn A. Seely, Stacie M. Bratton, Lisa K. Brents, Cindy L. Moran, Gregory W. Endres, Laura P. James, Paul F. Hollenberg, Paul L. Prather, Anna Radominska-Pandya and Jeffery H. Moran
      Drug Metabolism and Disposition November 2012, 40 (11) 2174-2184; DOI: https://doi.org/10.1124/dmd.112.047530

  10. Prieto, Julio G.

    1. Reevaluation of the Roles of ABCG2 in the Disposition of Genistein
      Ana I. Álvarez, Fernando Vallejo, Borja Barrera, Gracia Merino, Julio G. Prieto, Francisco Tomás-Barberán and Juan C. Espín
      Drug Metabolism and Disposition November 2012, 40 (11) 2219; DOI: https://doi.org/10.1124/dmd.112.048140

R

  1. Radominska-Pandya, Anna

    1. Cytochrome P450-Mediated Oxidative Metabolism of Abused Synthetic Cannabinoids Found in K2/Spice: Identification of Novel Cannabinoid Receptor Ligands
      Krishna C. Chimalakonda, Kathryn A. Seely, Stacie M. Bratton, Lisa K. Brents, Cindy L. Moran, Gregory W. Endres, Laura P. James, Paul F. Hollenberg, Paul L. Prather, Anna Radominska-Pandya and Jeffery H. Moran
      Drug Metabolism and Disposition November 2012, 40 (11) 2174-2184; DOI: https://doi.org/10.1124/dmd.112.047530

  2. Rais, Rana

    1. Pharmacokinetics of Oral d-Serine in d-Amino Acid Oxidase Knockout Mice
      Rana Rais, Ajit G. Thomas, Krystyna Wozniak, Ying Wu, Hanna Jaaro-Peled, Akira Sawa, Christine A. Strick, Sandra J. Engle, Nicholas J. Brandon, Camilo Rojas, Barbara S. Slusher and Takashi Tsukamoto
      Drug Metabolism and Disposition November 2012, 40 (11) 2067-2073; DOI: https://doi.org/10.1124/dmd.112.046482

  3. Raucy, Judy L.

    1. Utility of DPX2 Cells for Predicting CYP3A Induction-Mediated Drug-Drug Interactions and Associated Structure-Activity Relationships
      Odette A. Fahmi, Judy L. Raucy, Elsa Ponce, Saleema Hassanali and Jerome M. Lasker
      Drug Metabolism and Disposition November 2012, 40 (11) 2204-2211; DOI: https://doi.org/10.1124/dmd.112.047456

  4. Reese, Melinda J.

    1. Assessment of the Drug Interaction Risk for Remogliflozin Etabonate, a Sodium-Dependent Glucose Cotransporter-2 Inhibitor: Evidence from In Vitro, Human Mass Balance, and Ketoconazole Interaction Studies
      James F. Sigafoos, Gary D. Bowers, Stephen Castellino, Amanda G. Culp, David S. Wagner, Melinda J. Reese, Joan E. Humphreys, Elizabeth K. Hussey, Robin L. O'Connor Semmes, Anita Kapur, Wenli Tao, Robert L. Dobbins and Joseph W. Polli
      Drug Metabolism and Disposition November 2012, 40 (11) 2090-2101; DOI: https://doi.org/10.1124/dmd.112.047258

  5. Rojas, Camilo

    1. Pharmacokinetics of Oral d-Serine in d-Amino Acid Oxidase Knockout Mice
      Rana Rais, Ajit G. Thomas, Krystyna Wozniak, Ying Wu, Hanna Jaaro-Peled, Akira Sawa, Christine A. Strick, Sandra J. Engle, Nicholas J. Brandon, Camilo Rojas, Barbara S. Slusher and Takashi Tsukamoto
      Drug Metabolism and Disposition November 2012, 40 (11) 2067-2073; DOI: https://doi.org/10.1124/dmd.112.046482

  6. Rowland, A. M.

    1. Cytochrome P450 2S1 Depletion Enhances Cell Proliferation and Migration in Bronchial Epithelial Cells, in Part, through Modulation of Prostaglandin E2 Synthesis
      T. W. Madanayake, T. P. Fidler, T. M. Fresquez, N. Bajaj and A. M. Rowland
      Drug Metabolism and Disposition November 2012, 40 (11) 2119-2125; DOI: https://doi.org/10.1124/dmd.112.046466

  7. Ryder, Tim F.

    1. Metabolism, Excretion, and Pharmacokinetics of ((3,3-Difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a Dipeptidyl Peptidase Inhibitor, in Rat, Dog and Human
      Raman Sharma, Hao Sun, David W. Piotrowski, Tim F. Ryder, Shawn D. Doran, Haiqing Dai and Chandra Prakash
      Drug Metabolism and Disposition November 2012, 40 (11) 2143-2161; DOI: https://doi.org/10.1124/dmd.112.047316

S

  1. Sawa, Akira

    1. Pharmacokinetics of Oral d-Serine in d-Amino Acid Oxidase Knockout Mice
      Rana Rais, Ajit G. Thomas, Krystyna Wozniak, Ying Wu, Hanna Jaaro-Peled, Akira Sawa, Christine A. Strick, Sandra J. Engle, Nicholas J. Brandon, Camilo Rojas, Barbara S. Slusher and Takashi Tsukamoto
      Drug Metabolism and Disposition November 2012, 40 (11) 2067-2073; DOI: https://doi.org/10.1124/dmd.112.046482

  2. Scheer, Nico

    1. Generation and Characterization of a Novel Multidrug Resistance Protein 2 Humanized Mouse Line
      Nico Scheer, Praveen Balimane, Michael D. Hayward, Sandra Buechel, Gunther Kauselmann and C. Roland Wolf
      Drug Metabolism and Disposition November 2012, 40 (11) 2212-2218; DOI: https://doi.org/10.1124/dmd.112.047605

  3. Seely, Kathryn A.

    1. Cytochrome P450-Mediated Oxidative Metabolism of Abused Synthetic Cannabinoids Found in K2/Spice: Identification of Novel Cannabinoid Receptor Ligands
      Krishna C. Chimalakonda, Kathryn A. Seely, Stacie M. Bratton, Lisa K. Brents, Cindy L. Moran, Gregory W. Endres, Laura P. James, Paul F. Hollenberg, Paul L. Prather, Anna Radominska-Pandya and Jeffery H. Moran
      Drug Metabolism and Disposition November 2012, 40 (11) 2174-2184; DOI: https://doi.org/10.1124/dmd.112.047530

  4. Shaffer, Christopher L.

    1. An Evaluation of Using Rat-Derived Single-Dose Neuropharmacokinetic Parameters to Project Accurately Large Animal Unbound Brain Drug Concentrations
      Angela C. Doran, Sarah M. Osgood, Jessica Y. Mancuso and Christopher L. Shaffer
      Drug Metabolism and Disposition November 2012, 40 (11) 2162-2173; DOI: https://doi.org/10.1124/dmd.112.046391

  5. Sharma, Raman

    1. Metabolism, Excretion, and Pharmacokinetics of ((3,3-Difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a Dipeptidyl Peptidase Inhibitor, in Rat, Dog and Human
      Raman Sharma, Hao Sun, David W. Piotrowski, Tim F. Ryder, Shawn D. Doran, Haiqing Dai and Chandra Prakash
      Drug Metabolism and Disposition November 2012, 40 (11) 2143-2161; DOI: https://doi.org/10.1124/dmd.112.047316

  6. Sigafoos, James F.

    1. Assessment of the Drug Interaction Risk for Remogliflozin Etabonate, a Sodium-Dependent Glucose Cotransporter-2 Inhibitor: Evidence from In Vitro, Human Mass Balance, and Ketoconazole Interaction Studies
      James F. Sigafoos, Gary D. Bowers, Stephen Castellino, Amanda G. Culp, David S. Wagner, Melinda J. Reese, Joan E. Humphreys, Elizabeth K. Hussey, Robin L. O'Connor Semmes, Anita Kapur, Wenli Tao, Robert L. Dobbins and Joseph W. Polli
      Drug Metabolism and Disposition November 2012, 40 (11) 2090-2101; DOI: https://doi.org/10.1124/dmd.112.047258

  7. Slusher, Barbara S.

    1. Pharmacokinetics of Oral d-Serine in d-Amino Acid Oxidase Knockout Mice
      Rana Rais, Ajit G. Thomas, Krystyna Wozniak, Ying Wu, Hanna Jaaro-Peled, Akira Sawa, Christine A. Strick, Sandra J. Engle, Nicholas J. Brandon, Camilo Rojas, Barbara S. Slusher and Takashi Tsukamoto
      Drug Metabolism and Disposition November 2012, 40 (11) 2067-2073; DOI: https://doi.org/10.1124/dmd.112.046482

  8. Soltanpour, Yalda

    1. Characterization of THLE-Cytochrome P450 (P450) Cell Lines: Gene Expression Background and Relationship to P450-Enzyme Activity
      Yalda Soltanpour, Constanze Hilgendorf, Marie M. Ahlström, Alison J. Foster, J. Gerry Kenna, Anne Petersen and Anna-Lena Ungell
      Drug Metabolism and Disposition November 2012, 40 (11) 2054-2058; DOI: https://doi.org/10.1124/dmd.112.045815

  9. Strick, Christine A.

    1. Pharmacokinetics of Oral d-Serine in d-Amino Acid Oxidase Knockout Mice
      Rana Rais, Ajit G. Thomas, Krystyna Wozniak, Ying Wu, Hanna Jaaro-Peled, Akira Sawa, Christine A. Strick, Sandra J. Engle, Nicholas J. Brandon, Camilo Rojas, Barbara S. Slusher and Takashi Tsukamoto
      Drug Metabolism and Disposition November 2012, 40 (11) 2067-2073; DOI: https://doi.org/10.1124/dmd.112.046482

  10. Sun, Hao

    1. Metabolism, Excretion, and Pharmacokinetics of ((3,3-Difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a Dipeptidyl Peptidase Inhibitor, in Rat, Dog and Human
      Raman Sharma, Hao Sun, David W. Piotrowski, Tim F. Ryder, Shawn D. Doran, Haiqing Dai and Chandra Prakash
      Drug Metabolism and Disposition November 2012, 40 (11) 2143-2161; DOI: https://doi.org/10.1124/dmd.112.047316

T

  1. Tao, Wenli

    1. Assessment of the Drug Interaction Risk for Remogliflozin Etabonate, a Sodium-Dependent Glucose Cotransporter-2 Inhibitor: Evidence from In Vitro, Human Mass Balance, and Ketoconazole Interaction Studies
      James F. Sigafoos, Gary D. Bowers, Stephen Castellino, Amanda G. Culp, David S. Wagner, Melinda J. Reese, Joan E. Humphreys, Elizabeth K. Hussey, Robin L. O'Connor Semmes, Anita Kapur, Wenli Tao, Robert L. Dobbins and Joseph W. Polli
      Drug Metabolism and Disposition November 2012, 40 (11) 2090-2101; DOI: https://doi.org/10.1124/dmd.112.047258

  2. Thomas, Ajit G.

    1. Pharmacokinetics of Oral d-Serine in d-Amino Acid Oxidase Knockout Mice
      Rana Rais, Ajit G. Thomas, Krystyna Wozniak, Ying Wu, Hanna Jaaro-Peled, Akira Sawa, Christine A. Strick, Sandra J. Engle, Nicholas J. Brandon, Camilo Rojas, Barbara S. Slusher and Takashi Tsukamoto
      Drug Metabolism and Disposition November 2012, 40 (11) 2067-2073; DOI: https://doi.org/10.1124/dmd.112.046482

  3. Tomás-Barberán, Francisco

    1. Reevaluation of the Roles of ABCG2 in the Disposition of Genistein
      Ana I. Álvarez, Fernando Vallejo, Borja Barrera, Gracia Merino, Julio G. Prieto, Francisco Tomás-Barberán and Juan C. Espín
      Drug Metabolism and Disposition November 2012, 40 (11) 2219; DOI: https://doi.org/10.1124/dmd.112.048140

  4. Tsukamoto, Takashi

    1. Pharmacokinetics of Oral d-Serine in d-Amino Acid Oxidase Knockout Mice
      Rana Rais, Ajit G. Thomas, Krystyna Wozniak, Ying Wu, Hanna Jaaro-Peled, Akira Sawa, Christine A. Strick, Sandra J. Engle, Nicholas J. Brandon, Camilo Rojas, Barbara S. Slusher and Takashi Tsukamoto
      Drug Metabolism and Disposition November 2012, 40 (11) 2067-2073; DOI: https://doi.org/10.1124/dmd.112.046482

U

  1. Ungell, Anna-Lena

    1. Characterization of THLE-Cytochrome P450 (P450) Cell Lines: Gene Expression Background and Relationship to P450-Enzyme Activity
      Yalda Soltanpour, Constanze Hilgendorf, Marie M. Ahlström, Alison J. Foster, J. Gerry Kenna, Anne Petersen and Anna-Lena Ungell
      Drug Metabolism and Disposition November 2012, 40 (11) 2054-2058; DOI: https://doi.org/10.1124/dmd.112.045815

  2. Uno, Shigeyuki

    1. Vitamin D Receptor Activation Enhances Benzo[a]pyrene Metabolism via CYP1A1 Expression in Macrophages
      Manabu Matsunawa, Daisuke Akagi, Shigeyuki Uno, Kaori Endo-Umeda, Sachiko Yamada, Kazumasa Ikeda and Makoto Makishima
      Drug Metabolism and Disposition November 2012, 40 (11) 2059-2066; DOI: https://doi.org/10.1124/dmd.112.046839

V

  1. Vallejo, Fernando

    1. Reevaluation of the Roles of ABCG2 in the Disposition of Genistein
      Ana I. Álvarez, Fernando Vallejo, Borja Barrera, Gracia Merino, Julio G. Prieto, Francisco Tomás-Barberán and Juan C. Espín
      Drug Metabolism and Disposition November 2012, 40 (11) 2219; DOI: https://doi.org/10.1124/dmd.112.048140

W

  1. Wagner, David S.

    1. Assessment of the Drug Interaction Risk for Remogliflozin Etabonate, a Sodium-Dependent Glucose Cotransporter-2 Inhibitor: Evidence from In Vitro, Human Mass Balance, and Ketoconazole Interaction Studies
      James F. Sigafoos, Gary D. Bowers, Stephen Castellino, Amanda G. Culp, David S. Wagner, Melinda J. Reese, Joan E. Humphreys, Elizabeth K. Hussey, Robin L. O'Connor Semmes, Anita Kapur, Wenli Tao, Robert L. Dobbins and Joseph W. Polli
      Drug Metabolism and Disposition November 2012, 40 (11) 2090-2101; DOI: https://doi.org/10.1124/dmd.112.047258

  2. Wang, Ke

    1. Metabolism and Pharmacokinetics of Mangiferin in Conventional Rats, Pseudo-Germ-Free Rats, and Streptozotocin-Induced Diabetic Rats
      Huihui Liu, Bin Wu, Guoyu Pan, Lei He, Zhixiong Li, Mingsong Fan, Longhai Jian, Mingcang Chen, Ke Wang and Chenggang Huang
      Drug Metabolism and Disposition November 2012, 40 (11) 2109-2118; DOI: https://doi.org/10.1124/dmd.112.045849

  3. Wang, Ying

    1. The Role of a Basolateral Transporter in Rosuvastatin Transport and Its Interplay with Apical Breast Cancer Resistance Protein in Polarized Cell Monolayer Systems
      Jibin Li, Ying Wang, Wei Zhang, Yuehua Huang, Kristin Hein and Ismael J. Hidalgo
      Drug Metabolism and Disposition November 2012, 40 (11) 2102-2108; DOI: https://doi.org/10.1124/dmd.112.045666

  4. Wienkers, Larry C.

    1. Impact of Organic Solvents on Cytochrome P450 Probe Reactions: Filling the Gap with (S)-Warfarin and Midazolam Hydroxylation
      Vanessa González-Pérez, Elizabeth A. Connolly, Arlene S. Bridges, Larry C. Wienkers and Mary F. Paine
      Drug Metabolism and Disposition November 2012, 40 (11) 2136-2142; DOI: https://doi.org/10.1124/dmd.112.047134

  5. Wolf, C. Roland

    1. Generation and Characterization of a Novel Multidrug Resistance Protein 2 Humanized Mouse Line
      Nico Scheer, Praveen Balimane, Michael D. Hayward, Sandra Buechel, Gunther Kauselmann and C. Roland Wolf
      Drug Metabolism and Disposition November 2012, 40 (11) 2212-2218; DOI: https://doi.org/10.1124/dmd.112.047605

  6. Wozniak, Krystyna

    1. Pharmacokinetics of Oral d-Serine in d-Amino Acid Oxidase Knockout Mice
      Rana Rais, Ajit G. Thomas, Krystyna Wozniak, Ying Wu, Hanna Jaaro-Peled, Akira Sawa, Christine A. Strick, Sandra J. Engle, Nicholas J. Brandon, Camilo Rojas, Barbara S. Slusher and Takashi Tsukamoto
      Drug Metabolism and Disposition November 2012, 40 (11) 2067-2073; DOI: https://doi.org/10.1124/dmd.112.046482

  7. Wu, Bin

    1. Metabolism and Pharmacokinetics of Mangiferin in Conventional Rats, Pseudo-Germ-Free Rats, and Streptozotocin-Induced Diabetic Rats
      Huihui Liu, Bin Wu, Guoyu Pan, Lei He, Zhixiong Li, Mingsong Fan, Longhai Jian, Mingcang Chen, Ke Wang and Chenggang Huang
      Drug Metabolism and Disposition November 2012, 40 (11) 2109-2118; DOI: https://doi.org/10.1124/dmd.112.045849

  8. Wu, Ying

    1. Pharmacokinetics of Oral d-Serine in d-Amino Acid Oxidase Knockout Mice
      Rana Rais, Ajit G. Thomas, Krystyna Wozniak, Ying Wu, Hanna Jaaro-Peled, Akira Sawa, Christine A. Strick, Sandra J. Engle, Nicholas J. Brandon, Camilo Rojas, Barbara S. Slusher and Takashi Tsukamoto
      Drug Metabolism and Disposition November 2012, 40 (11) 2067-2073; DOI: https://doi.org/10.1124/dmd.112.046482

Y

  1. Yamada, Hideyuki

    1. ATP Serves as an Endogenous Inhibitor of UDP-Glucuronosyltransferase (UGT): A New Insight into the Latency of UGT
      Yuji Ishii, Kie An, Yoshio Nishimura and Hideyuki Yamada
      Drug Metabolism and Disposition November 2012, 40 (11) 2081-2089; DOI: https://doi.org/10.1124/dmd.112.046862

  2. Yamada, Sachiko

    1. Vitamin D Receptor Activation Enhances Benzo[a]pyrene Metabolism via CYP1A1 Expression in Macrophages
      Manabu Matsunawa, Daisuke Akagi, Shigeyuki Uno, Kaori Endo-Umeda, Sachiko Yamada, Kazumasa Ikeda and Makoto Makishima
      Drug Metabolism and Disposition November 2012, 40 (11) 2059-2066; DOI: https://doi.org/10.1124/dmd.112.046839

  3. Yang, Zhen

    1. Response to Letter to the Editor on “Breast Cancer Resistance Protein (ABCG2) Determines Distribution of Genistein Phase II Metabolites: Reevaluation of the Roles of ABCG2 in the Disposition of Genistein”
      Zhen Yang, Wei Zhu, Song Gao, Taijun Yin, Wen Jiang and Ming Hu
      Drug Metabolism and Disposition November 2012, 40 (11) 2219-2220; DOI: https://doi.org/10.1124/dmd.112.048363

  4. Yin, Taijun

    1. Response to Letter to the Editor on “Breast Cancer Resistance Protein (ABCG2) Determines Distribution of Genistein Phase II Metabolites: Reevaluation of the Roles of ABCG2 in the Disposition of Genistein”
      Zhen Yang, Wei Zhu, Song Gao, Taijun Yin, Wen Jiang and Ming Hu
      Drug Metabolism and Disposition November 2012, 40 (11) 2219-2220; DOI: https://doi.org/10.1124/dmd.112.048363

  5. Yli-Kauhaluoma, Jari

    1. UDP-Glucuronic Acid Binds First and the Aglycone Substrate Binds Second to Form a Ternary Complex in UGT1A9-Catalyzed Reactions, in Both the Presence and Absence of Bovine Serum Albumin
      Nenad Manevski, Jari Yli-Kauhaluoma and Moshe Finel
      Drug Metabolism and Disposition November 2012, 40 (11) 2192-2203; DOI: https://doi.org/10.1124/dmd.112.047746

Z

  1. Zhang, Wei

    1. The Role of a Basolateral Transporter in Rosuvastatin Transport and Its Interplay with Apical Breast Cancer Resistance Protein in Polarized Cell Monolayer Systems
      Jibin Li, Ying Wang, Wei Zhang, Yuehua Huang, Kristin Hein and Ismael J. Hidalgo
      Drug Metabolism and Disposition November 2012, 40 (11) 2102-2108; DOI: https://doi.org/10.1124/dmd.112.045666

  2. Zhu, Wei

    1. Response to Letter to the Editor on “Breast Cancer Resistance Protein (ABCG2) Determines Distribution of Genistein Phase II Metabolites: Reevaluation of the Roles of ABCG2 in the Disposition of Genistein”
      Zhen Yang, Wei Zhu, Song Gao, Taijun Yin, Wen Jiang and Ming Hu
      Drug Metabolism and Disposition November 2012, 40 (11) 2219-2220; DOI: https://doi.org/10.1124/dmd.112.048363

  3. Zordoky, Beshay N. M.

    1. Chronic Doxorubicin Cardiotoxicity Modulates Cardiac Cytochrome P450-Mediated Arachidonic Acid Metabolism in Rats
      Abdulaziz M. S. Alsaad, Beshay N. M. Zordoky, Ahmed A. El-Sherbeni and Ayman O. S. El-Kadi
      Drug Metabolism and Disposition November 2012, 40 (11) 2126-2135; DOI: https://doi.org/10.1124/dmd.112.046631
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