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Research ArticleArticle

Pharmacokinetics of Oral d-Serine in d-Amino Acid Oxidase Knockout Mice

Rana Rais, Ajit G. Thomas, Krystyna Wozniak, Ying Wu, Hanna Jaaro-Peled, Akira Sawa, Christine A. Strick, Sandra J. Engle, Nicholas J. Brandon, Camilo Rojas, Barbara S. Slusher and Takashi Tsukamoto
Drug Metabolism and Disposition November 2012, 40 (11) 2067-2073; DOI: https://doi.org/10.1124/dmd.112.046482
Rana Rais
Department of Neurology (R.R., B.S.S., T.T.), Brain Science Institute (A.G.T., K.W., Y.W., C.R.), and Department of Psychiatry and Behavioral Sciences (H.J.-P., A.S.), Johns Hopkins University School of Medicine, Baltimore, Maryland; and Departments of Neuroscience (C.A.S., N.J.B.) and Pharmacokinetics, Dynamics and Metabolism (S.J.E.), Pfizer, Groton, Connecticut
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Ajit G. Thomas
Department of Neurology (R.R., B.S.S., T.T.), Brain Science Institute (A.G.T., K.W., Y.W., C.R.), and Department of Psychiatry and Behavioral Sciences (H.J.-P., A.S.), Johns Hopkins University School of Medicine, Baltimore, Maryland; and Departments of Neuroscience (C.A.S., N.J.B.) and Pharmacokinetics, Dynamics and Metabolism (S.J.E.), Pfizer, Groton, Connecticut
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Krystyna Wozniak
Department of Neurology (R.R., B.S.S., T.T.), Brain Science Institute (A.G.T., K.W., Y.W., C.R.), and Department of Psychiatry and Behavioral Sciences (H.J.-P., A.S.), Johns Hopkins University School of Medicine, Baltimore, Maryland; and Departments of Neuroscience (C.A.S., N.J.B.) and Pharmacokinetics, Dynamics and Metabolism (S.J.E.), Pfizer, Groton, Connecticut
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Ying Wu
Department of Neurology (R.R., B.S.S., T.T.), Brain Science Institute (A.G.T., K.W., Y.W., C.R.), and Department of Psychiatry and Behavioral Sciences (H.J.-P., A.S.), Johns Hopkins University School of Medicine, Baltimore, Maryland; and Departments of Neuroscience (C.A.S., N.J.B.) and Pharmacokinetics, Dynamics and Metabolism (S.J.E.), Pfizer, Groton, Connecticut
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Hanna Jaaro-Peled
Department of Neurology (R.R., B.S.S., T.T.), Brain Science Institute (A.G.T., K.W., Y.W., C.R.), and Department of Psychiatry and Behavioral Sciences (H.J.-P., A.S.), Johns Hopkins University School of Medicine, Baltimore, Maryland; and Departments of Neuroscience (C.A.S., N.J.B.) and Pharmacokinetics, Dynamics and Metabolism (S.J.E.), Pfizer, Groton, Connecticut
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Akira Sawa
Department of Neurology (R.R., B.S.S., T.T.), Brain Science Institute (A.G.T., K.W., Y.W., C.R.), and Department of Psychiatry and Behavioral Sciences (H.J.-P., A.S.), Johns Hopkins University School of Medicine, Baltimore, Maryland; and Departments of Neuroscience (C.A.S., N.J.B.) and Pharmacokinetics, Dynamics and Metabolism (S.J.E.), Pfizer, Groton, Connecticut
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Christine A. Strick
Department of Neurology (R.R., B.S.S., T.T.), Brain Science Institute (A.G.T., K.W., Y.W., C.R.), and Department of Psychiatry and Behavioral Sciences (H.J.-P., A.S.), Johns Hopkins University School of Medicine, Baltimore, Maryland; and Departments of Neuroscience (C.A.S., N.J.B.) and Pharmacokinetics, Dynamics and Metabolism (S.J.E.), Pfizer, Groton, Connecticut
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Sandra J. Engle
Department of Neurology (R.R., B.S.S., T.T.), Brain Science Institute (A.G.T., K.W., Y.W., C.R.), and Department of Psychiatry and Behavioral Sciences (H.J.-P., A.S.), Johns Hopkins University School of Medicine, Baltimore, Maryland; and Departments of Neuroscience (C.A.S., N.J.B.) and Pharmacokinetics, Dynamics and Metabolism (S.J.E.), Pfizer, Groton, Connecticut
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Nicholas J. Brandon
Department of Neurology (R.R., B.S.S., T.T.), Brain Science Institute (A.G.T., K.W., Y.W., C.R.), and Department of Psychiatry and Behavioral Sciences (H.J.-P., A.S.), Johns Hopkins University School of Medicine, Baltimore, Maryland; and Departments of Neuroscience (C.A.S., N.J.B.) and Pharmacokinetics, Dynamics and Metabolism (S.J.E.), Pfizer, Groton, Connecticut
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Camilo Rojas
Department of Neurology (R.R., B.S.S., T.T.), Brain Science Institute (A.G.T., K.W., Y.W., C.R.), and Department of Psychiatry and Behavioral Sciences (H.J.-P., A.S.), Johns Hopkins University School of Medicine, Baltimore, Maryland; and Departments of Neuroscience (C.A.S., N.J.B.) and Pharmacokinetics, Dynamics and Metabolism (S.J.E.), Pfizer, Groton, Connecticut
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Barbara S. Slusher
Department of Neurology (R.R., B.S.S., T.T.), Brain Science Institute (A.G.T., K.W., Y.W., C.R.), and Department of Psychiatry and Behavioral Sciences (H.J.-P., A.S.), Johns Hopkins University School of Medicine, Baltimore, Maryland; and Departments of Neuroscience (C.A.S., N.J.B.) and Pharmacokinetics, Dynamics and Metabolism (S.J.E.), Pfizer, Groton, Connecticut
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Takashi Tsukamoto
Department of Neurology (R.R., B.S.S., T.T.), Brain Science Institute (A.G.T., K.W., Y.W., C.R.), and Department of Psychiatry and Behavioral Sciences (H.J.-P., A.S.), Johns Hopkins University School of Medicine, Baltimore, Maryland; and Departments of Neuroscience (C.A.S., N.J.B.) and Pharmacokinetics, Dynamics and Metabolism (S.J.E.), Pfizer, Groton, Connecticut
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Article Information

vol. 40 no. 11 2067-2073
DOI 
https://doi.org/10.1124/dmd.112.046482
PubMed 
22837388

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received April 30, 2012
  • Accepted July 26, 2012
  • Published online October 17, 2012.

Article Versions

  • Earlier version (July 26, 2012 - 08:17).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Rana Rais,
  2. Ajit G. Thomas,
  3. Krystyna Wozniak,
  4. Ying Wu,
  5. Hanna Jaaro-Peled,
  6. Akira Sawa,
  7. Christine A. Strick,
  8. Sandra J. Engle,
  9. Nicholas J. Brandon,
  10. Camilo Rojas,
  11. Barbara S. Slusher, and
  12. Takashi Tsukamoto
  1. Department of Neurology (R.R., B.S.S., T.T.), Brain Science Institute (A.G.T., K.W., Y.W., C.R.), and Department of Psychiatry and Behavioral Sciences (H.J.-P., A.S.), Johns Hopkins University School of Medicine, Baltimore, Maryland; and Departments of Neuroscience (C.A.S., N.J.B.) and Pharmacokinetics, Dynamics and Metabolism (S.J.E.), Pfizer, Groton, Connecticut
  1. Address correspondence to:
    Takashi Tsukamoto, Department of Neurology, Johns Hopkins University, 855 N. Wolfe St., Baltimore, MD 21205. E-mail: ttsukamoto{at}jhmi.edu
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Drug Metabolism and Disposition: 40 (11)
Drug Metabolism and Disposition
Vol. 40, Issue 11
1 Nov 2012
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Research ArticleArticle

ORAL d-SERINE PK IN MICE LACKING DAAO

Rana Rais, Ajit G. Thomas, Krystyna Wozniak, Ying Wu, Hanna Jaaro-Peled, Akira Sawa, Christine A. Strick, Sandra J. Engle, Nicholas J. Brandon, Camilo Rojas, Barbara S. Slusher and Takashi Tsukamoto
Drug Metabolism and Disposition November 1, 2012, 40 (11) 2067-2073; DOI: https://doi.org/10.1124/dmd.112.046482

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Research ArticleArticle

ORAL d-SERINE PK IN MICE LACKING DAAO

Rana Rais, Ajit G. Thomas, Krystyna Wozniak, Ying Wu, Hanna Jaaro-Peled, Akira Sawa, Christine A. Strick, Sandra J. Engle, Nicholas J. Brandon, Camilo Rojas, Barbara S. Slusher and Takashi Tsukamoto
Drug Metabolism and Disposition November 1, 2012, 40 (11) 2067-2073; DOI: https://doi.org/10.1124/dmd.112.046482
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