Research ArticleArticle
Cytochrome P450-Mediated Oxidative Metabolism of Abused Synthetic Cannabinoids Found in K2/Spice: Identification of Novel Cannabinoid Receptor Ligands
Krishna C. Chimalakonda, Kathryn A. Seely, Stacie M. Bratton, Lisa K. Brents, Cindy L. Moran, Gregory W. Endres, Laura P. James, Paul F. Hollenberg, Paul L. Prather, Anna Radominska-Pandya and Jeffery H. Moran
Drug Metabolism and Disposition November 2012, 40 (11) 2174-2184; DOI: https://doi.org/10.1124/dmd.112.047530
Krishna C. Chimalakonda
Departments of Pharmacology and Toxicology (K.C.C., L.K.B., L.P.J., P.L.P., J.H.M.) and Biochemistry and Molecular Biology (S.M.B., A.R.-P.), College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas; Arkansas Department of Health, Arkansas Public Health Laboratory, Little Rock, Arkansas (K.A.S., J.H.M.); Arkansas State Crime Laboratory, Little Rock, Arkansas (C.L.M.); Clinical Pharmacology and Toxicology, Arkansas Children's Hospital and Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas (L.P.J.); Cayman Chemical Company, Ann Arbor, Michigan (G.W.E.); and Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan (P.F.H.)
Kathryn A. Seely
Departments of Pharmacology and Toxicology (K.C.C., L.K.B., L.P.J., P.L.P., J.H.M.) and Biochemistry and Molecular Biology (S.M.B., A.R.-P.), College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas; Arkansas Department of Health, Arkansas Public Health Laboratory, Little Rock, Arkansas (K.A.S., J.H.M.); Arkansas State Crime Laboratory, Little Rock, Arkansas (C.L.M.); Clinical Pharmacology and Toxicology, Arkansas Children's Hospital and Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas (L.P.J.); Cayman Chemical Company, Ann Arbor, Michigan (G.W.E.); and Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan (P.F.H.)
Stacie M. Bratton
Departments of Pharmacology and Toxicology (K.C.C., L.K.B., L.P.J., P.L.P., J.H.M.) and Biochemistry and Molecular Biology (S.M.B., A.R.-P.), College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas; Arkansas Department of Health, Arkansas Public Health Laboratory, Little Rock, Arkansas (K.A.S., J.H.M.); Arkansas State Crime Laboratory, Little Rock, Arkansas (C.L.M.); Clinical Pharmacology and Toxicology, Arkansas Children's Hospital and Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas (L.P.J.); Cayman Chemical Company, Ann Arbor, Michigan (G.W.E.); and Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan (P.F.H.)
Lisa K. Brents
Departments of Pharmacology and Toxicology (K.C.C., L.K.B., L.P.J., P.L.P., J.H.M.) and Biochemistry and Molecular Biology (S.M.B., A.R.-P.), College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas; Arkansas Department of Health, Arkansas Public Health Laboratory, Little Rock, Arkansas (K.A.S., J.H.M.); Arkansas State Crime Laboratory, Little Rock, Arkansas (C.L.M.); Clinical Pharmacology and Toxicology, Arkansas Children's Hospital and Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas (L.P.J.); Cayman Chemical Company, Ann Arbor, Michigan (G.W.E.); and Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan (P.F.H.)
Cindy L. Moran
Departments of Pharmacology and Toxicology (K.C.C., L.K.B., L.P.J., P.L.P., J.H.M.) and Biochemistry and Molecular Biology (S.M.B., A.R.-P.), College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas; Arkansas Department of Health, Arkansas Public Health Laboratory, Little Rock, Arkansas (K.A.S., J.H.M.); Arkansas State Crime Laboratory, Little Rock, Arkansas (C.L.M.); Clinical Pharmacology and Toxicology, Arkansas Children's Hospital and Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas (L.P.J.); Cayman Chemical Company, Ann Arbor, Michigan (G.W.E.); and Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan (P.F.H.)
Gregory W. Endres
Departments of Pharmacology and Toxicology (K.C.C., L.K.B., L.P.J., P.L.P., J.H.M.) and Biochemistry and Molecular Biology (S.M.B., A.R.-P.), College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas; Arkansas Department of Health, Arkansas Public Health Laboratory, Little Rock, Arkansas (K.A.S., J.H.M.); Arkansas State Crime Laboratory, Little Rock, Arkansas (C.L.M.); Clinical Pharmacology and Toxicology, Arkansas Children's Hospital and Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas (L.P.J.); Cayman Chemical Company, Ann Arbor, Michigan (G.W.E.); and Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan (P.F.H.)
Laura P. James
Departments of Pharmacology and Toxicology (K.C.C., L.K.B., L.P.J., P.L.P., J.H.M.) and Biochemistry and Molecular Biology (S.M.B., A.R.-P.), College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas; Arkansas Department of Health, Arkansas Public Health Laboratory, Little Rock, Arkansas (K.A.S., J.H.M.); Arkansas State Crime Laboratory, Little Rock, Arkansas (C.L.M.); Clinical Pharmacology and Toxicology, Arkansas Children's Hospital and Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas (L.P.J.); Cayman Chemical Company, Ann Arbor, Michigan (G.W.E.); and Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan (P.F.H.)
Paul F. Hollenberg
Departments of Pharmacology and Toxicology (K.C.C., L.K.B., L.P.J., P.L.P., J.H.M.) and Biochemistry and Molecular Biology (S.M.B., A.R.-P.), College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas; Arkansas Department of Health, Arkansas Public Health Laboratory, Little Rock, Arkansas (K.A.S., J.H.M.); Arkansas State Crime Laboratory, Little Rock, Arkansas (C.L.M.); Clinical Pharmacology and Toxicology, Arkansas Children's Hospital and Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas (L.P.J.); Cayman Chemical Company, Ann Arbor, Michigan (G.W.E.); and Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan (P.F.H.)
Paul L. Prather
Departments of Pharmacology and Toxicology (K.C.C., L.K.B., L.P.J., P.L.P., J.H.M.) and Biochemistry and Molecular Biology (S.M.B., A.R.-P.), College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas; Arkansas Department of Health, Arkansas Public Health Laboratory, Little Rock, Arkansas (K.A.S., J.H.M.); Arkansas State Crime Laboratory, Little Rock, Arkansas (C.L.M.); Clinical Pharmacology and Toxicology, Arkansas Children's Hospital and Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas (L.P.J.); Cayman Chemical Company, Ann Arbor, Michigan (G.W.E.); and Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan (P.F.H.)
Anna Radominska-Pandya
Departments of Pharmacology and Toxicology (K.C.C., L.K.B., L.P.J., P.L.P., J.H.M.) and Biochemistry and Molecular Biology (S.M.B., A.R.-P.), College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas; Arkansas Department of Health, Arkansas Public Health Laboratory, Little Rock, Arkansas (K.A.S., J.H.M.); Arkansas State Crime Laboratory, Little Rock, Arkansas (C.L.M.); Clinical Pharmacology and Toxicology, Arkansas Children's Hospital and Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas (L.P.J.); Cayman Chemical Company, Ann Arbor, Michigan (G.W.E.); and Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan (P.F.H.)
Jeffery H. Moran
Departments of Pharmacology and Toxicology (K.C.C., L.K.B., L.P.J., P.L.P., J.H.M.) and Biochemistry and Molecular Biology (S.M.B., A.R.-P.), College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas; Arkansas Department of Health, Arkansas Public Health Laboratory, Little Rock, Arkansas (K.A.S., J.H.M.); Arkansas State Crime Laboratory, Little Rock, Arkansas (C.L.M.); Clinical Pharmacology and Toxicology, Arkansas Children's Hospital and Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas (L.P.J.); Cayman Chemical Company, Ann Arbor, Michigan (G.W.E.); and Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan (P.F.H.)
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Research ArticleArticle
CYTOCHROME P450 METABOLISM OF SYNTHETIC CANNABINOIDS
Krishna C. Chimalakonda, Kathryn A. Seely, Stacie M. Bratton, Lisa K. Brents, Cindy L. Moran, Gregory W. Endres, Laura P. James, Paul F. Hollenberg, Paul L. Prather, Anna Radominska-Pandya and Jeffery H. Moran
Drug Metabolism and Disposition November 1, 2012, 40 (11) 2174-2184; DOI: https://doi.org/10.1124/dmd.112.047530
Research ArticleArticle
CYTOCHROME P450 METABOLISM OF SYNTHETIC CANNABINOIDS
Krishna C. Chimalakonda, Kathryn A. Seely, Stacie M. Bratton, Lisa K. Brents, Cindy L. Moran, Gregory W. Endres, Laura P. James, Paul F. Hollenberg, Paul L. Prather, Anna Radominska-Pandya and Jeffery H. Moran
Drug Metabolism and Disposition November 1, 2012, 40 (11) 2174-2184; DOI: https://doi.org/10.1124/dmd.112.047530
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