Table of Contents

Articles

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  Cytochrome P450 3A5 Plays a Prominent Role in the Oxidative Metabolism of the Anti-Human Immunodeficiency Virus Drug Maraviroc

  Yanhui Lu, Craig W. Hendrix and Namandjé N. Bumpus

  Drug Metabolism and Disposition December 2012, 40 (12) 2221-2230; DOI: https://doi.org/10.1124/dmd.112.048298
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  Assessment of Intestinal Availability of Various Drugs in the Oral Absorption Process Using Portal Vein-Cannulated Rats

  Yoshiki Matsuda, Yoshihiro Konno, Masahiro Satsukawa, Taro Kobayashi, Yu Takimoto, Kunihiko Morisaki and Shinji Yamashita

  Drug Metabolism and Disposition December 2012, 40 (12) 2231-2238; DOI: https://doi.org/10.1124/dmd.112.048223
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  Predicting the Drug Interaction Potential of AMG 853, a Dual Antagonist of the D-Prostanoid and Chemoattractant Receptor-Homologous Molecule Expressed on T Helper 2 Cells Receptors

  Robert S. Foti, Josh T. Pearson, Simon L. Wong, Julie A. Zalikowski, Michael D. Boudreaux, Samantha P. Prokop, John A. Davis, Christopher Banfield, Maurice G. Emery, Dan A. Rock, Jan L. Wahlstrom, Larry C. Wienkers and Benny M. Amore

  Drug Metabolism and Disposition December 2012, 40 (12) 2239-2249; DOI: https://doi.org/10.1124/dmd.112.047928
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  Pharmacokinetics, Biotransformation, and Mass Balance of Edoxaban, a Selective, Direct Factor Xa Inhibitor, in Humans

  Mohinder S. Bathala, Hiroshi Masumoto, Toshihiro Oguma, Ling He, Chris Lowrie and Jeanne Mendell

  Drug Metabolism and Disposition December 2012, 40 (12) 2250-2255; DOI: https://doi.org/10.1124/dmd.112.046888
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  Inhibition of Bupropion Metabolism by Selegiline: Mechanism-Based Inactivation of Human CYP2B6 and Characterization of Glutathione and Peptide Adducts

  Chitra Sridar, Cesar Kenaan and Paul F. Hollenberg

  Drug Metabolism and Disposition December 2012, 40 (12) 2256-2266; DOI: https://doi.org/10.1124/dmd.112.046979
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  Predictability of Metabolism of Ibuprofen and Naproxen Using Chimeric Mice with Human Hepatocytes

  Seigo Sanoh, Aya Horiguchi, Kazumi Sugihara, Yaichiro Kotake, Yoshitaka Tayama, Naoto Uramaru, Hiroki Ohshita, Chise Tateno, Toru Horie, Shigeyuki Kitamura and Shigeru Ohta

  Drug Metabolism and Disposition December 2012, 40 (12) 2267-2272; DOI: https://doi.org/10.1124/dmd.112.047555
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  Optimized Experimental Design for the Estimation of Enzyme Kinetic Parameters: An Experimental Evaluation

  Erik Sjögren, Petter Svanberg and Kajsa P. Kanebratt

  Drug Metabolism and Disposition December 2012, 40 (12) 2273-2279; DOI: https://doi.org/10.1124/dmd.112.047373
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  Bioactivation of the Cancer Chemopreventive Agent Tamoxifen to Quinone Methides by Cytochrome P4502B6 and Identification of the Modified Residue on the Apoprotein

  Chitra Sridar, Jaime D'Agostino and Paul F. Hollenberg

  Drug Metabolism and Disposition December 2012, 40 (12) 2280-2288; DOI: https://doi.org/10.1124/dmd.112.047266
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  Statistical Methods for Analysis of Time-Dependent Inhibition of Cytochrome P450 Enzymes

  Phillip Yates, Heather Eng, Li Di and R. Scott Obach

  Drug Metabolism and Disposition December 2012, 40 (12) 2289-2296; DOI: https://doi.org/10.1124/dmd.112.047233
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  Metabolism and Pharmacokinetics of JM6 in Mice: JM6 Is Not a Prodrug for Ro-61-8048

  Maria G. Beconi, Dawn Yates, Kathryn Lyons, Kim Matthews, Steve Clifton, Tania Mead, Michael Prime, Dirk Winkler, Catherine O'Connell, Daryl Walter, Leticia Toledo-Sherman, Ignacio Munoz-Sanjuan and Celia Dominguez

  Drug Metabolism and Disposition December 2012, 40 (12) 2297-2306; DOI: https://doi.org/10.1124/dmd.112.046532
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  Identification of Metabolites of Ganoderic Acid D by Ultra-Performance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry

  Chunru Cheng, Min Yang, Kate Yu, Shuhong Guan, Sijia Tao, Alan Millar, Xiaoyan Pang and Dean Guo

  Drug Metabolism and Disposition December 2012, 40 (12) 2307-2314; DOI: https://doi.org/10.1124/dmd.112.047506
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  Reversible Disulfide Formation of the Glutamate Carboxypeptidase II Inhibitor E2072 Results in Prolonged Systemic Exposures In Vivo

  Rana Rais, Randall Hoover, Krystyna Wozniak, Michelle A. Rudek, Takashi Tsukamoto, Jesse Alt, Camilo Rojas and Barbara S. Slusher

  Drug Metabolism and Disposition December 2012, 40 (12) 2315-2323; DOI: https://doi.org/10.1124/dmd.112.046821
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  Preferred Binding Orientations of Phenacetin in CYP1A1 and CYP1A2 Are Associated with Isoform-Selective Metabolism

  Qingbiao Huang, Rahul S. Deshmukh, Spencer S. Ericksen, Youbin Tu and Grazyna D. Szklarz

  Drug Metabolism and Disposition December 2012, 40 (12) 2324-2331; DOI: https://doi.org/10.1124/dmd.112.047308
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  Mitigating the Inhibition of Human Bile Salt Export Pump by Drugs: Opportunities Provided by Physicochemical Property Modulation, In Silico Modeling, and Structural Modification

  Daniel J. Warner, Hongming Chen, Louis-David Cantin, J. Gerry Kenna, Simone Stahl, Clare L. Walker and Tobias Noeske

  Drug Metabolism and Disposition December 2012, 40 (12) 2332-2341; DOI: https://doi.org/10.1124/dmd.112.047068
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  Pharmacokinetics, Bioavailability, Tissue Distribution, Excretion, and Metabolite Identification of Methoxyflavones in Kaempferia parviflora Extract in Rats

  Catheleeya Mekjaruskul, Michael Jay and Bungorn Sripanidkulchai

  Drug Metabolism and Disposition December 2012, 40 (12) 2342-2353; DOI: https://doi.org/10.1124/dmd.112.047142
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  Disposition and Metabolism of LY2452473, a Selective Androgen Receptor Modulator, in Humans

  Ping Yi, Jessica Fayer Rehmel, Kenneth Cassidy, Chad Hadden, Kristina Campanale, Nita Patel and Jason Johnson

  Drug Metabolism and Disposition December 2012, 40 (12) 2354-2364; DOI: https://doi.org/10.1124/dmd.112.047613
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  Pharmacokinetics of Pegylated Liposomal Doxorubicin Administered by Intraoperative Hyperthermic Intraperitoneal Chemotherapy to Patients with Advanced Ovarian Cancer and Peritoneal Carcinomatosis

  Emanuela Salvatorelli, Michele De Tursi, Pierantonio Menna, Consiglia Carella, Renato Massari, Antonella Colasante, Stefano Iacobelli and Giorgio Minotti

  Drug Metabolism and Disposition December 2012, 40 (12) 2365-2373; DOI: https://doi.org/10.1124/dmd.112.047480
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  Metabolic Chiral Inversion of Brivanib and Its Relevance to Safety and Pharmacology

  Jiachang Gong, Jinping Gan, Eric Masson, Shariq Syed, Yuan-Qing Xia, Daphne Williams, Janice Pursley, Mohammed Jemal, W. Griff Humphreys and Ramaswamy A. Iyer

  Drug Metabolism and Disposition December 2012, 40 (12) 2374-2380; DOI: https://doi.org/10.1124/dmd.112.047340