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Drug Metabolism & Disposition

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Table of Contents

December 01, 2012; Volume 40,Issue 12

Articles

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    Cytochrome P450 3A5 Plays a Prominent Role in the Oxidative Metabolism of the Anti-Human Immunodeficiency Virus Drug Maraviroc
    Yanhui Lu, Craig W. Hendrix and Namandjé N. Bumpus
    Drug Metabolism and Disposition December 2012, 40 (12) 2221-2230; DOI: https://doi.org/10.1124/dmd.112.048298
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    Assessment of Intestinal Availability of Various Drugs in the Oral Absorption Process Using Portal Vein-Cannulated Rats
    Yoshiki Matsuda, Yoshihiro Konno, Masahiro Satsukawa, Taro Kobayashi, Yu Takimoto, Kunihiko Morisaki and Shinji Yamashita
    Drug Metabolism and Disposition December 2012, 40 (12) 2231-2238; DOI: https://doi.org/10.1124/dmd.112.048223
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    Predicting the Drug Interaction Potential of AMG 853, a Dual Antagonist of the D-Prostanoid and Chemoattractant Receptor-Homologous Molecule Expressed on T Helper 2 Cells Receptors
    Robert S. Foti, Josh T. Pearson, Simon L. Wong, Julie A. Zalikowski, Michael D. Boudreaux, Samantha P. Prokop, John A. Davis, Christopher Banfield, Maurice G. Emery, Dan A. Rock, Jan L. Wahlstrom, Larry C. Wienkers and Benny M. Amore
    Drug Metabolism and Disposition December 2012, 40 (12) 2239-2249; DOI: https://doi.org/10.1124/dmd.112.047928
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    Pharmacokinetics, Biotransformation, and Mass Balance of Edoxaban, a Selective, Direct Factor Xa Inhibitor, in Humans
    Mohinder S. Bathala, Hiroshi Masumoto, Toshihiro Oguma, Ling He, Chris Lowrie and Jeanne Mendell
    Drug Metabolism and Disposition December 2012, 40 (12) 2250-2255; DOI: https://doi.org/10.1124/dmd.112.046888
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    Inhibition of Bupropion Metabolism by Selegiline: Mechanism-Based Inactivation of Human CYP2B6 and Characterization of Glutathione and Peptide Adducts
    Chitra Sridar, Cesar Kenaan and Paul F. Hollenberg
    Drug Metabolism and Disposition December 2012, 40 (12) 2256-2266; DOI: https://doi.org/10.1124/dmd.112.046979
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    Predictability of Metabolism of Ibuprofen and Naproxen Using Chimeric Mice with Human Hepatocytes
    Seigo Sanoh, Aya Horiguchi, Kazumi Sugihara, Yaichiro Kotake, Yoshitaka Tayama, Naoto Uramaru, Hiroki Ohshita, Chise Tateno, Toru Horie, Shigeyuki Kitamura and Shigeru Ohta
    Drug Metabolism and Disposition December 2012, 40 (12) 2267-2272; DOI: https://doi.org/10.1124/dmd.112.047555
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    Optimized Experimental Design for the Estimation of Enzyme Kinetic Parameters: An Experimental Evaluation
    Erik Sjögren, Petter Svanberg and Kajsa P. Kanebratt
    Drug Metabolism and Disposition December 2012, 40 (12) 2273-2279; DOI: https://doi.org/10.1124/dmd.112.047373
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    Bioactivation of the Cancer Chemopreventive Agent Tamoxifen to Quinone Methides by Cytochrome P4502B6 and Identification of the Modified Residue on the Apoprotein
    Chitra Sridar, Jaime D'Agostino and Paul F. Hollenberg
    Drug Metabolism and Disposition December 2012, 40 (12) 2280-2288; DOI: https://doi.org/10.1124/dmd.112.047266
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    Statistical Methods for Analysis of Time-Dependent Inhibition of Cytochrome P450 Enzymes
    Phillip Yates, Heather Eng, Li Di and R. Scott Obach
    Drug Metabolism and Disposition December 2012, 40 (12) 2289-2296; DOI: https://doi.org/10.1124/dmd.112.047233
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    Metabolism and Pharmacokinetics of JM6 in Mice: JM6 Is Not a Prodrug for Ro-61-8048
    Maria G. Beconi, Dawn Yates, Kathryn Lyons, Kim Matthews, Steve Clifton, Tania Mead, Michael Prime, Dirk Winkler, Catherine O'Connell, Daryl Walter, Leticia Toledo-Sherman, Ignacio Munoz-Sanjuan and Celia Dominguez
    Drug Metabolism and Disposition December 2012, 40 (12) 2297-2306; DOI: https://doi.org/10.1124/dmd.112.046532
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    Identification of Metabolites of Ganoderic Acid D by Ultra-Performance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry
    Chunru Cheng, Min Yang, Kate Yu, Shuhong Guan, Sijia Tao, Alan Millar, Xiaoyan Pang and Dean Guo
    Drug Metabolism and Disposition December 2012, 40 (12) 2307-2314; DOI: https://doi.org/10.1124/dmd.112.047506
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    Reversible Disulfide Formation of the Glutamate Carboxypeptidase II Inhibitor E2072 Results in Prolonged Systemic Exposures In Vivo
    Rana Rais, Randall Hoover, Krystyna Wozniak, Michelle A. Rudek, Takashi Tsukamoto, Jesse Alt, Camilo Rojas and Barbara S. Slusher
    Drug Metabolism and Disposition December 2012, 40 (12) 2315-2323; DOI: https://doi.org/10.1124/dmd.112.046821
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    Preferred Binding Orientations of Phenacetin in CYP1A1 and CYP1A2 Are Associated with Isoform-Selective Metabolism
    Qingbiao Huang, Rahul S. Deshmukh, Spencer S. Ericksen, Youbin Tu and Grazyna D. Szklarz
    Drug Metabolism and Disposition December 2012, 40 (12) 2324-2331; DOI: https://doi.org/10.1124/dmd.112.047308
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    Mitigating the Inhibition of Human Bile Salt Export Pump by Drugs: Opportunities Provided by Physicochemical Property Modulation, In Silico Modeling, and Structural Modification
    Daniel J. Warner, Hongming Chen, Louis-David Cantin, J. Gerry Kenna, Simone Stahl, Clare L. Walker and Tobias Noeske
    Drug Metabolism and Disposition December 2012, 40 (12) 2332-2341; DOI: https://doi.org/10.1124/dmd.112.047068
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    Pharmacokinetics, Bioavailability, Tissue Distribution, Excretion, and Metabolite Identification of Methoxyflavones in Kaempferia parviflora Extract in Rats
    Catheleeya Mekjaruskul, Michael Jay and Bungorn Sripanidkulchai
    Drug Metabolism and Disposition December 2012, 40 (12) 2342-2353; DOI: https://doi.org/10.1124/dmd.112.047142
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    Disposition and Metabolism of LY2452473, a Selective Androgen Receptor Modulator, in Humans
    Ping Yi, Jessica Fayer Rehmel, Kenneth Cassidy, Chad Hadden, Kristina Campanale, Nita Patel and Jason Johnson
    Drug Metabolism and Disposition December 2012, 40 (12) 2354-2364; DOI: https://doi.org/10.1124/dmd.112.047613
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    Pharmacokinetics of Pegylated Liposomal Doxorubicin Administered by Intraoperative Hyperthermic Intraperitoneal Chemotherapy to Patients with Advanced Ovarian Cancer and Peritoneal Carcinomatosis
    Emanuela Salvatorelli, Michele De Tursi, Pierantonio Menna, Consiglia Carella, Renato Massari, Antonella Colasante, Stefano Iacobelli and Giorgio Minotti
    Drug Metabolism and Disposition December 2012, 40 (12) 2365-2373; DOI: https://doi.org/10.1124/dmd.112.047480
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    Metabolic Chiral Inversion of Brivanib and Its Relevance to Safety and Pharmacology
    Jiachang Gong, Jinping Gan, Eric Masson, Shariq Syed, Yuan-Qing Xia, Daphne Williams, Janice Pursley, Mohammed Jemal, W. Griff Humphreys and Ramaswamy A. Iyer
    Drug Metabolism and Disposition December 2012, 40 (12) 2374-2380; DOI: https://doi.org/10.1124/dmd.112.047340

Errata

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    Correction to “Stereochemical Aspects of Itraconazole Metabolism In Vitro and In Vivo”
    Drug Metabolism and Disposition December 2012, 40 (12) 2381; DOI: https://doi.org/10.1124/dmd.40.12.2381
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    Correction to “In Vivo-Formed versus Preformed Metabolite Kinetics of trans-Resveratrol-3-sulfate and trans-Resveratrol-3-glucuronide”
    Drug Metabolism and Disposition December 2012, 40 (12) 2382; DOI: https://doi.org/10.1124/dmd.40.12.2382
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Drug Metabolism and Disposition: 40 (12)
Drug Metabolism and Disposition
Vol. 40, Issue 12
1 Dec 2012
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