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Drug Metabolism & Disposition

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Table of Contents

February 01, 2012; Volume 40,Issue 2

Short Communication

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    Phenacetin Pharmacokinetics in CYP1A2-Deficient Beagle Dogs
    Valerie J. Whiterock, Daniel G. Morgan, Kimberley A. Lentz, Tami L. Orcutt and Michael W. Sinz
    Drug Metabolism and Disposition February 2012, 40 (2) 228-231; DOI: https://doi.org/10.1124/dmd.111.041848

Articles

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    Prenatal and Postnatal Expression of Glutathione Transferase ζ 1 in Human Liver and the Roles of Haplotype and Subject Age in Determining Activity with Dichloroacetate
    Wenjun Li, Yuan Gu, Margaret O. James, Ronald N. Hines, Pippa Simpson, Taimour Langaee and Peter W. Stacpoole
    Drug Metabolism and Disposition February 2012, 40 (2) 232-239; DOI: https://doi.org/10.1124/dmd.111.041533
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    Human UDP-Glucuronosyltransferase Isoforms Involved in Haloperidol Glucuronidation and Quantitative Estimation of Their Contribution
    Yukiko Kato, Miki Nakajima, Shingo Oda, Tatsuki Fukami and Tsuyoshi Yokoi
    Drug Metabolism and Disposition February 2012, 40 (2) 240-248; DOI: https://doi.org/10.1124/dmd.111.042150
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    An Unusual Metabolic Pathway of Sipoglitazar, a Novel Antidiabetic Agent: Cytochrome P450-Catalyzed Oxidation of Sipoglitazar Acyl Glucuronide
    Mitsuhiro Nishihara, Miyako Sudo, Naohiro Kawaguchi, Junzo Takahashi, Yutaka Kiyota, Takahiro Kondo and Satoru Asahi
    Drug Metabolism and Disposition February 2012, 40 (2) 249-258; DOI: https://doi.org/10.1124/dmd.111.040105
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    UDP-Glucuronosyltransferase Expression in Mouse Liver Is Increased in Obesity- and Fasting-Induced Steatosis
    Jialin Xu, Supriya R. Kulkarni, Liya Li and Angela L. Slitt
    Drug Metabolism and Disposition February 2012, 40 (2) 259-266; DOI: https://doi.org/10.1124/dmd.111.039925
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    Characterization of Aldehyde Oxidase Enzyme Activity in Cryopreserved Human Hepatocytes
    J. Matthew Hutzler, Young-Sun Yang, Daniel Albaugh, Cody L. Fullenwider, Jennifer Schmenk and Michael B. Fisher
    Drug Metabolism and Disposition February 2012, 40 (2) 267-275; DOI: https://doi.org/10.1124/dmd.111.042861
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    Identification of UDP-Glucuronosyltransferases Responsible for the Glucuronidation of Darexaban, an Oral Factor Xa Inhibitor, in Human Liver and Intestine
    Toshifumi Shiraga, Kanako Yajima, Kenta Suzuki, Katsuhiro Suzuki, Tadashi Hashimoto, Takafumi Iwatsubo, Aiji Miyashita and Takashi Usui
    Drug Metabolism and Disposition February 2012, 40 (2) 276-282; DOI: https://doi.org/10.1124/dmd.111.042614
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    Characterization of a Human Keratinocyte HaCaT Cell Line Model to Study the Regulation of CYP2S1
    Alison D. McNeilly, Julie A. Woods, Sally H. Ibbotson, C. Roland Wolf and Gillian Smith
    Drug Metabolism and Disposition February 2012, 40 (2) 283-289; DOI: https://doi.org/10.1124/dmd.111.042085
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    Pharmacokinetics of Lisdexamfetamine Dimesylate after Targeted Gastrointestinal Release or Oral Administration in Healthy Adults
    James C. Ermer, Mary B. Haffey, Walter J. Doll, Patrick Martin, Erik P. Sandefer, Kerry Dennis, Mary Corcoran, Laura Trespidi and Richard C. Page
    Drug Metabolism and Disposition February 2012, 40 (2) 290-297; DOI: https://doi.org/10.1124/dmd.111.040691
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    Oxidative Modification of Rat Sulfotransferase 1A1 Activity in Hepatic Tissue Slices Correlates with Effects on the Purified Enzyme
    Jagadeesha K. Dammanahalli and Michael W. Duffel
    Drug Metabolism and Disposition February 2012, 40 (2) 298-303; DOI: https://doi.org/10.1124/dmd.111.042044
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    Use of Baculovirus BacMam Vectors for Expression of ABC Drug Transporters in Mammalian Cells
    Suneet Shukla, Candice Schwartz, Khyati Kapoor, Abdul Kouanda and Suresh V. Ambudkar
    Drug Metabolism and Disposition February 2012, 40 (2) 304-312; DOI: https://doi.org/10.1124/dmd.111.042721
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    Mass Balance Study of [14C]Eribulin in Patients with Advanced Solid Tumors
    Anne-Charlotte Dubbelman, Hilde Rosing, Robert S. Jansen, Marja Mergui-Roelvink, Alwin D. R. Huitema, Barbara Koetz, Margarita Lymboura, Larisa Reyderman, Arturo Lopez-Anaya, Jan H. M. Schellens and Jos H. Beijnen
    Drug Metabolism and Disposition February 2012, 40 (2) 313-321; DOI: https://doi.org/10.1124/dmd.111.042762
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    Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver
    Seigo Sanoh, Aya Horiguchi, Kazumi Sugihara, Yaichiro Kotake, Yoshitaka Tayama, Hiroki Ohshita, Chise Tateno, Toru Horie, Shigeyuki Kitamura and Shigeru Ohta
    Drug Metabolism and Disposition February 2012, 40 (2) 322-328; DOI: https://doi.org/10.1124/dmd.111.040923
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    Brain-Penetrating IgG-Iduronate 2-Sulfatase Fusion Protein for the Mouse
    Qing-Hui Zhou, Ruben J. Boado, Jeff Zhiqiang Lu, Eric Ka-Wai Hui and William M. Pardridge
    Drug Metabolism and Disposition February 2012, 40 (2) 329-335; DOI: https://doi.org/10.1124/dmd.111.042903
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    UDP-Glucuronosyltransferase (UGT) 1A9-Overexpressing HeLa Cells Is an Appropriate Tool to Delineate the Kinetic Interplay between Breast Cancer Resistance Protein (BRCP) and UGT and to Rapidly Identify the Glucuronide Substrates of BCRP
    Wen Jiang, Beibei Xu, Baojian Wu, Rong Yu and Ming Hu
    Drug Metabolism and Disposition February 2012, 40 (2) 336-345; DOI: https://doi.org/10.1124/dmd.111.041467
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    Enzymatic Characterization and Elucidation of the Catalytic Mechanism of a Recombinant Bovine Glycine N-Acyltransferase
    Christoffel P. S. Badenhorst, Maritza Jooste and Alberdina A. van Dijk
    Drug Metabolism and Disposition February 2012, 40 (2) 346-352; DOI: https://doi.org/10.1124/dmd.111.041657
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    Methylation of Catechins and Procyanidins by Rat and Human Catechol-O-Methyltransferase: Metabolite Profiling and Molecular Modeling Studies
    Christoph H. Weinert, Stefanie Wiese, Harshadrai M. Rawel, Tuba Esatbeyoglu, Peter Winterhalter, Thomas Homann and Sabine E. Kulling
    Drug Metabolism and Disposition February 2012, 40 (2) 353-359; DOI: https://doi.org/10.1124/dmd.111.041871
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    Effects of PEGylation and Immune Complex Formation on the Pharmacokinetics and Biodistribution of Recombinant Interleukin 10 in Mice
    Hamsell M. Alvarez, On-Yee So, SuChun Hsieh, Natasha Shinsky-Bjorde, Huiping Ma, Yaoli Song, Yinuo Pang, Melinda Marian and Enrique Escandón
    Drug Metabolism and Disposition February 2012, 40 (2) 360-373; DOI: https://doi.org/10.1124/dmd.111.042531
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    Paraoxonase 1 as a Major Bioactivating Hydrolase for Olmesartan Medoxomil in Human Blood Circulation: Molecular Identification and Contribution to Plasma Metabolism
    Tomoko Ishizuka, Izumi Fujimori, Atsuko Nishida, Hidetaka Sakurai, Yasushi Yoshigae, Kaori Nakahara, Atsushi Kurihara, Toshihiko Ikeda and Takashi Izumi
    Drug Metabolism and Disposition February 2012, 40 (2) 374-380; DOI: https://doi.org/10.1124/dmd.111.041475
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    Increased Systemic Exposure to Rhizoma Coptidis Alkaloids in Lipopolysaccharide-Pretreated Rats Attributable to Enhanced Intestinal Absorption
    Bing-Liang Ma, Meng-Kan Yao, Jie Zhong, Yue-Ming Ma, Cheng-Lu Gao, Jia-Sheng Wu, Fu-Rong Qiu, Chang-Hong Wang and Xin-Hong Wang
    Drug Metabolism and Disposition February 2012, 40 (2) 381-388; DOI: https://doi.org/10.1124/dmd.111.041152
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    Assessment of the Impact of CYP3A Polymorphisms on the Formation of α-Hydroxytamoxifen and N-Desmethyltamoxifen in Human Liver Microsomes
    Ganesh M. Mugundu, Larry Sallans, Yingying Guo, Elizabeth A. Shaughnessy and Pankaj B. Desai
    Drug Metabolism and Disposition February 2012, 40 (2) 389-396; DOI: https://doi.org/10.1124/dmd.111.039388
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    Predicting Phenolic Acid Absorption in Caco-2 Cells: A Theoretical Permeability Model and Mechanistic Study
    Tracy L. Farrell, Laure Poquet, Tristan P. Dew, Stuart Barber and Gary Williamson
    Drug Metabolism and Disposition February 2012, 40 (2) 397-406; DOI: https://doi.org/10.1124/dmd.111.041665

Accelerated Communication

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    Differential Modulation of Cytochrome P450 Activity and the Effect of 1-Aminobenzotriazole on Hepatic Transport in Sandwich-Cultured Human Hepatocytes
    Emi Kimoto, Robert Walsky, Hui Zhang, Yi-an Bi, Kevin M. Whalen, Young-Sun Yang, Collette Linder, Yongling Xiao, Ken Iseki, Katherine S. Fenner, Ayman F. El-Kattan and Yurong Lai
    Drug Metabolism and Disposition February 2012, 40 (2) 407-411; DOI: https://doi.org/10.1124/dmd.111.039297
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In this issue

Drug Metabolism and Disposition: 40 (2)
Drug Metabolism and Disposition
Vol. 40, Issue 2
1 Feb 2012
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
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  • Short Communication
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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