Table of Contents

Articles

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  Prenatal and Postnatal Expression of Glutathione Transferase ζ 1 in Human Liver and the Roles of Haplotype and Subject Age in Determining Activity with Dichloroacetate

  Wenjun Li, Yuan Gu, Margaret O. James, Ronald N. Hines, Pippa Simpson, Taimour Langaee and Peter W. Stacpoole

  Drug Metabolism and Disposition February 2012, 40 (2) 232-239; DOI: https://doi.org/10.1124/dmd.111.041533
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  Human UDP-Glucuronosyltransferase Isoforms Involved in Haloperidol Glucuronidation and Quantitative Estimation of Their Contribution

  Yukiko Kato, Miki Nakajima, Shingo Oda, Tatsuki Fukami and Tsuyoshi Yokoi

  Drug Metabolism and Disposition February 2012, 40 (2) 240-248; DOI: https://doi.org/10.1124/dmd.111.042150
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  An Unusual Metabolic Pathway of Sipoglitazar, a Novel Antidiabetic Agent: Cytochrome P450-Catalyzed Oxidation of Sipoglitazar Acyl Glucuronide

  Mitsuhiro Nishihara, Miyako Sudo, Naohiro Kawaguchi, Junzo Takahashi, Yutaka Kiyota, Takahiro Kondo and Satoru Asahi

  Drug Metabolism and Disposition February 2012, 40 (2) 249-258; DOI: https://doi.org/10.1124/dmd.111.040105
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  UDP-Glucuronosyltransferase Expression in Mouse Liver Is Increased in Obesity- and Fasting-Induced Steatosis

  Jialin Xu, Supriya R. Kulkarni, Liya Li and Angela L. Slitt

  Drug Metabolism and Disposition February 2012, 40 (2) 259-266; DOI: https://doi.org/10.1124/dmd.111.039925
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  Characterization of Aldehyde Oxidase Enzyme Activity in Cryopreserved Human Hepatocytes

  J. Matthew Hutzler, Young-Sun Yang, Daniel Albaugh, Cody L. Fullenwider, Jennifer Schmenk and Michael B. Fisher

  Drug Metabolism and Disposition February 2012, 40 (2) 267-275; DOI: https://doi.org/10.1124/dmd.111.042861
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  Identification of UDP-Glucuronosyltransferases Responsible for the Glucuronidation of Darexaban, an Oral Factor Xa Inhibitor, in Human Liver and Intestine

  Toshifumi Shiraga, Kanako Yajima, Kenta Suzuki, Katsuhiro Suzuki, Tadashi Hashimoto, Takafumi Iwatsubo, Aiji Miyashita and Takashi Usui

  Drug Metabolism and Disposition February 2012, 40 (2) 276-282; DOI: https://doi.org/10.1124/dmd.111.042614
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  Characterization of a Human Keratinocyte HaCaT Cell Line Model to Study the Regulation of CYP2S1

  Alison D. McNeilly, Julie A. Woods, Sally H. Ibbotson, C. Roland Wolf and Gillian Smith

  Drug Metabolism and Disposition February 2012, 40 (2) 283-289; DOI: https://doi.org/10.1124/dmd.111.042085
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  Pharmacokinetics of Lisdexamfetamine Dimesylate after Targeted Gastrointestinal Release or Oral Administration in Healthy Adults

  James C. Ermer, Mary B. Haffey, Walter J. Doll, Patrick Martin, Erik P. Sandefer, Kerry Dennis, Mary Corcoran, Laura Trespidi and Richard C. Page

  Drug Metabolism and Disposition February 2012, 40 (2) 290-297; DOI: https://doi.org/10.1124/dmd.111.040691
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  Oxidative Modification of Rat Sulfotransferase 1A1 Activity in Hepatic Tissue Slices Correlates with Effects on the Purified Enzyme

  Jagadeesha K. Dammanahalli and Michael W. Duffel

  Drug Metabolism and Disposition February 2012, 40 (2) 298-303; DOI: https://doi.org/10.1124/dmd.111.042044
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  Use of Baculovirus BacMam Vectors for Expression of ABC Drug Transporters in Mammalian Cells

  Suneet Shukla, Candice Schwartz, Khyati Kapoor, Abdul Kouanda and Suresh V. Ambudkar

  Drug Metabolism and Disposition February 2012, 40 (2) 304-312; DOI: https://doi.org/10.1124/dmd.111.042721
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  Mass Balance Study of [¹⁴C]Eribulin in Patients with Advanced Solid Tumors

  Anne-Charlotte Dubbelman, Hilde Rosing, Robert S. Jansen, Marja Mergui-Roelvink, Alwin D. R. Huitema, Barbara Koetz, Margarita Lymboura, Larisa Reyderman, Arturo Lopez-Anaya, Jan H. M. Schellens and Jos H. Beijnen

  Drug Metabolism and Disposition February 2012, 40 (2) 313-321; DOI: https://doi.org/10.1124/dmd.111.042762
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  Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver

  Seigo Sanoh, Aya Horiguchi, Kazumi Sugihara, Yaichiro Kotake, Yoshitaka Tayama, Hiroki Ohshita, Chise Tateno, Toru Horie, Shigeyuki Kitamura and Shigeru Ohta

  Drug Metabolism and Disposition February 2012, 40 (2) 322-328; DOI: https://doi.org/10.1124/dmd.111.040923
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  Brain-Penetrating IgG-Iduronate 2-Sulfatase Fusion Protein for the Mouse

  Qing-Hui Zhou, Ruben J. Boado, Jeff Zhiqiang Lu, Eric Ka-Wai Hui and William M. Pardridge

  Drug Metabolism and Disposition February 2012, 40 (2) 329-335; DOI: https://doi.org/10.1124/dmd.111.042903
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  UDP-Glucuronosyltransferase (UGT) 1A9-Overexpressing HeLa Cells Is an Appropriate Tool to Delineate the Kinetic Interplay between Breast Cancer Resistance Protein (BRCP) and UGT and to Rapidly Identify the Glucuronide Substrates of BCRP

  Wen Jiang, Beibei Xu, Baojian Wu, Rong Yu and Ming Hu

  Drug Metabolism and Disposition February 2012, 40 (2) 336-345; DOI: https://doi.org/10.1124/dmd.111.041467
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  Enzymatic Characterization and Elucidation of the Catalytic Mechanism of a Recombinant Bovine Glycine N-Acyltransferase

  Christoffel P. S. Badenhorst, Maritza Jooste and Alberdina A. van Dijk

  Drug Metabolism and Disposition February 2012, 40 (2) 346-352; DOI: https://doi.org/10.1124/dmd.111.041657
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  Methylation of Catechins and Procyanidins by Rat and Human Catechol-O-Methyltransferase: Metabolite Profiling and Molecular Modeling Studies

  Christoph H. Weinert, Stefanie Wiese, Harshadrai M. Rawel, Tuba Esatbeyoglu, Peter Winterhalter, Thomas Homann and Sabine E. Kulling

  Drug Metabolism and Disposition February 2012, 40 (2) 353-359; DOI: https://doi.org/10.1124/dmd.111.041871
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  Effects of PEGylation and Immune Complex Formation on the Pharmacokinetics and Biodistribution of Recombinant Interleukin 10 in Mice

  Hamsell M. Alvarez, On-Yee So, SuChun Hsieh, Natasha Shinsky-Bjorde, Huiping Ma, Yaoli Song, Yinuo Pang, Melinda Marian and Enrique Escandón

  Drug Metabolism and Disposition February 2012, 40 (2) 360-373; DOI: https://doi.org/10.1124/dmd.111.042531
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  Paraoxonase 1 as a Major Bioactivating Hydrolase for Olmesartan Medoxomil in Human Blood Circulation: Molecular Identification and Contribution to Plasma Metabolism

  Tomoko Ishizuka, Izumi Fujimori, Atsuko Nishida, Hidetaka Sakurai, Yasushi Yoshigae, Kaori Nakahara, Atsushi Kurihara, Toshihiko Ikeda and Takashi Izumi

  Drug Metabolism and Disposition February 2012, 40 (2) 374-380; DOI: https://doi.org/10.1124/dmd.111.041475
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  Increased Systemic Exposure to Rhizoma Coptidis Alkaloids in Lipopolysaccharide-Pretreated Rats Attributable to Enhanced Intestinal Absorption

  Bing-Liang Ma, Meng-Kan Yao, Jie Zhong, Yue-Ming Ma, Cheng-Lu Gao, Jia-Sheng Wu, Fu-Rong Qiu, Chang-Hong Wang and Xin-Hong Wang

  Drug Metabolism and Disposition February 2012, 40 (2) 381-388; DOI: https://doi.org/10.1124/dmd.111.041152
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  Assessment of the Impact of CYP3A Polymorphisms on the Formation of α-Hydroxytamoxifen and N-Desmethyltamoxifen in Human Liver Microsomes

  Ganesh M. Mugundu, Larry Sallans, Yingying Guo, Elizabeth A. Shaughnessy and Pankaj B. Desai

  Drug Metabolism and Disposition February 2012, 40 (2) 389-396; DOI: https://doi.org/10.1124/dmd.111.039388
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  Predicting Phenolic Acid Absorption in Caco-2 Cells: A Theoretical Permeability Model and Mechanistic Study

  Tracy L. Farrell, Laure Poquet, Tristan P. Dew, Stuart Barber and Gary Williamson

  Drug Metabolism and Disposition February 2012, 40 (2) 397-406; DOI: https://doi.org/10.1124/dmd.111.041665