Table of Contents

Articles

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  Stereospecific Metabolism of Itraconazole by CYP3A4: Dioxolane Ring Scission of Azole Antifungals

  Chi-Chi Peng, Wei Shi, Justin D. Lutz, Kent L. Kunze, Jun O. Liu, Wendel L. Nelson and Nina Isoherranen

  Drug Metabolism and Disposition March 2012, 40 (3) 426-435; DOI: https://doi.org/10.1124/dmd.111.042739
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  Human Cytochrome P450scc (CYP11A1) Catalyzes Epoxide Formation with Ergosterol

  Robert C. Tuckey, Minh N. Nguyen, Jianjun Chen, Andrzej T. Slominski, Donna M. Baldisseri, Elaine W. Tieu, Jordan K. Zjawiony and Wei Li

  Drug Metabolism and Disposition March 2012, 40 (3) 436-444; DOI: https://doi.org/10.1124/dmd.111.042515
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  Influence of MK-467, a Peripherally Acting α₂-Adrenoceptor Antagonist on the Disposition of Intravenous Dexmedetomidine in Dogs

  Juhana Honkavaara, Flavia Restitutti, Marja Raekallio, Kati Salla, Erja Kuusela, Ville Ranta-Panula, Valtteri Rinne, Outi Vainio and Mika Scheinin

  Drug Metabolism and Disposition March 2012, 40 (3) 445-449; DOI: https://doi.org/10.1124/dmd.111.042671
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  Molecular Mechanism of Altered Ezetimibe Disposition in Nonalcoholic Steatohepatitis

  Rhiannon N. Hardwick, Craig D. Fisher, Stephanie M. Street, Mark J. Canet and Nathan J. Cherrington

  Drug Metabolism and Disposition March 2012, 40 (3) 450-460; DOI: https://doi.org/10.1124/dmd.111.041095
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  Species Comparison of In Vivo P-Glycoprotein-Mediated Brain Efflux Using mdr1a-Deficient Rats and Mice

  Christoffer Bundgaard, Christian Jes Nyberg Jensen and Mats Garmer

  Drug Metabolism and Disposition March 2012, 40 (3) 461-466; DOI: https://doi.org/10.1124/dmd.111.043083
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  Use of a Multistaged Time-Dependent Inhibition Assay to Assess the Impact of Intestinal Metabolism on Drug-Drug Interaction Potential

  Michael Zientek and Deepak Dalvie

  Drug Metabolism and Disposition March 2012, 40 (3) 467-473; DOI: https://doi.org/10.1124/dmd.111.043257
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  Investigation of Drug-Drug Interactions Caused by Human Pregnane X Receptor-Mediated Induction of CYP3A4 and CYP2C Subfamilies in Chimeric Mice with a Humanized Liver

  Maki Hasegawa, Harunobu Tahara, Ryo Inoue, Masakazu Kakuni, Chise Tateno and Junko Ushiki

  Drug Metabolism and Disposition March 2012, 40 (3) 474-480; DOI: https://doi.org/10.1124/dmd.111.042754
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  Inhibition of Genistein Glucuronidation by Bisphenol A in Human and Rat Liver Microsomes

  Janis L. Coughlin, Paul E. Thomas and Brian Buckley

  Drug Metabolism and Disposition March 2012, 40 (3) 481-485; DOI: https://doi.org/10.1124/dmd.111.042366
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  Unimolecular and Bimolecular Binding System for the Prediction of CYP2D6-Mediated Metabolism

  Kimihiko Sato and Yasushi Yamazoe

  Drug Metabolism and Disposition March 2012, 40 (3) 486-496; DOI: https://doi.org/10.1124/dmd.111.043125
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  Evaluation of Hepatic Glutathione Transferase Mu 1 and Theta 1 Activities in Humans and Mice Using Genotype Information

  Shingo Arakawa, Kazunori Fujimoto, Ayako Kato, Seiko Endo, Aiko Fukahori, Akira Shinagawa, Thomas Fischer, Juergen Mueller and Wataru Takasaki

  Drug Metabolism and Disposition March 2012, 40 (3) 497-503; DOI: https://doi.org/10.1124/dmd.111.042911
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  Inhibition of Heme Oxygenase-1 Partially Reverses the Arsenite-Mediated Decrease of CYP1A1, CYP1A2, CYP3A23, and CYP3A2 Catalytic Activity in Isolated Rat Hepatocytes

  Anwar Anwar-Mohamed, Lars-Oliver Klotz and Ayman O. S. El-Kadi

  Drug Metabolism and Disposition March 2012, 40 (3) 504-514; DOI: https://doi.org/10.1124/dmd.111.042564
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  Oral Availability of Cefadroxil Depends on ABCC3 and ABCC4

  Dirk R. de Waart, Koen van de Wetering, Cindy Kunne, Suzanne Duijst, Coen C. Paulusma and Ronald P. J. Oude Elferink

  Drug Metabolism and Disposition March 2012, 40 (3) 515-521; DOI: https://doi.org/10.1124/dmd.111.041731
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  Clarithromycin Is Absorbed by an Intestinal Uptake Mechanism That Is Sensitive to Major Inhibition by Rifampicin: Results of a Short-Term Drug Interaction Study in Foals

  Jette Peters, Karen Eggers, Stefan Oswald, Wiebke Block, Dieter Lütjohann, Marc Lämmer, Monica Venner and Werner Siegmund

  Drug Metabolism and Disposition March 2012, 40 (3) 522-528; DOI: https://doi.org/10.1124/dmd.111.042267
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  Characterization of Hepatic and Intestinal Glucuronidation of Magnolol: Application of the Relative Activity Factor Approach to Decipher the Contributions of Multiple UDP-Glucuronosyltransferase Isoforms

  Liangliang Zhu, Guangbo Ge, Hongbo Zhang, Huixin Liu, Guiyuan He, Sicheng Liang, Yanyan Zhang, Zhongze Fang, Peipei Dong, Moshe Finel and Ling Yang

  Drug Metabolism and Disposition March 2012, 40 (3) 529-538; DOI: https://doi.org/10.1124/dmd.111.042192
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  Pharmacokinetics, Distribution, and Metabolism of [¹⁴C]Sunitinib in Rats, Monkeys, and Humans

  Bill Speed, Hai-Zhi Bu, William F. Pool, Geoffrey W. Peng, Ellen Y. Wu, Shem Patyna, Carlo Bello and Ping Kang

  Drug Metabolism and Disposition March 2012, 40 (3) 539-555; DOI: https://doi.org/10.1124/dmd.111.042853
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  Metabolism and Pharmacokinetics of Morinidazole in Humans: Identification of Diastereoisomeric Morpholine N⁺-Glucuronides Catalyzed by UDP Glucuronosyltransferase 1A9

  Ruina Gao, Liang Li, Cen Xie, Xingxing Diao, Dafang Zhong and Xiaoyan Chen

  Drug Metabolism and Disposition March 2012, 40 (3) 556-567; DOI: https://doi.org/10.1124/dmd.111.042689
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  Excretion, Metabolism, and Pharmacokinetics of 1-(8-(2-Chlorophenyl)-9-(4-Chlorophenyl)-9H-Purin-6-yl)-4-(Ethylamino)Piperidine-4-Carboxamide, a Selective Cannabinoid Receptor Antagonist, in Healthy Male Volunteers

  Zhuang Miao, Hao Sun, Jennifer Liras and Chandra Prakash

  Drug Metabolism and Disposition March 2012, 40 (3) 568-578; DOI: https://doi.org/10.1124/dmd.111.043273
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  Changes in Expression of Drug-Metabolizing Enzymes by Single-Walled Carbon Nanotubes in Human Respiratory Tract Cells

  Kotaro Hitoshi, Miki Katoh, Tomoko Suzuki, Yoshinori Ando and Masayuki Nadai

  Drug Metabolism and Disposition March 2012, 40 (3) 579-587; DOI: https://doi.org/10.1124/dmd.111.043455
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  Polychlorinated Biphenyl Congeners that Increase the Glucuronidation and Biliary Excretion of Thyroxine Are Distinct from the Congeners that Enhance the Serum Disappearance of Thyroxine

  L. A. Martin, D. T. Wilson, K. R. Reuhl, M. A. Gallo and C. D. Klaassen

  Drug Metabolism and Disposition March 2012, 40 (3) 588-595; DOI: https://doi.org/10.1124/dmd.111.042796
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  Trapping of cis-2-Butene-1,4-dial to Measure Furan Metabolism in Human Liver Microsomes by Cytochrome P450 Enzymes

  Leah A. Gates, Ding Lu and Lisa A. Peterson

  Drug Metabolism and Disposition March 2012, 40 (3) 596-601; DOI: https://doi.org/10.1124/dmd.111.043679
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  In Vivo Biliary Clearance Should Be Predicted by Intrinsic Biliary Clearance in Sandwich-Cultured Hepatocytes

  Masanori Nakakariya, Midori Ono, Nobuyuki Amano, Toshiya Moriwaki, Kazuya Maeda and Yuichi Sugiyama

  Drug Metabolism and Disposition March 2012, 40 (3) 602-609; DOI: https://doi.org/10.1124/dmd.111.042101
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  Complex Drug Interactions of the HIV Protease Inhibitors 3: Effect of Simultaneous or Staggered Dosing of Digoxin and Ritonavir, Nelfinavir, Rifampin, or Bupropion

  Brian J. Kirby, Ann C. Collier, Evan D. Kharasch, Dale Whittington, Kenneth E. Thummel and Jashvant D. Unadkat

  Drug Metabolism and Disposition March 2012, 40 (3) 610-616; DOI: https://doi.org/10.1124/dmd.111.042705
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  Expression of Organic Anion Transporter 2 in the Human Kidney and Its Potential Role in the Tubular Secretion of Guanine-Containing Antiviral Drugs

  Yaofeng Cheng, Arpine Vapurcuyan, Mohammad Shahidullah, Lauren M. Aleksunes and Ryan M. Pelis

  Drug Metabolism and Disposition March 2012, 40 (3) 617-624; DOI: https://doi.org/10.1124/dmd.111.042036
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  Deuterium Isotope Effects on Drug Pharmacokinetics. I. System-Dependent Effects of Specific Deuteration with Aldehyde Oxidase Cleared Drugs

  Raman Sharma, Timothy J. Strelevitz, Hongying Gao, Alan J. Clark, Klaas Schildknegt, R. Scott Obach, Sharon L. Ripp, Douglas K. Spracklin, Larry M. Tremaine and Alfin D. N. Vaz

  Drug Metabolism and Disposition March 2012, 40 (3) 625-634; DOI: https://doi.org/10.1124/dmd.111.042770