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Drug Metabolism & Disposition

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Table of Contents

March 01, 2012; Volume 40,Issue 3

Editorial

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    Editorial
    Edward T. Morgan,
    Drug Metabolism and Disposition March 2012, 40 (3) 413; DOI: https://doi.org/10.1124/dmd.111.000009

Short Communications

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    The Effects of Rosuvastatin and the CYP51A1 Inhibitor LEK-935 on the Proteome of Primary Human Hepatocytes
    Martin Wörner, Katja Melchior, Katalin Monostory, Jean-Marc Pascussi, Christian G. Huber and Rita Bernhardt
    Drug Metabolism and Disposition March 2012, 40 (3) 414-418; DOI: https://doi.org/10.1124/dmd.111.040402
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    Investigation of Figopitant and Its Metabolites in Rat Tissue by Combining Whole-Body Autoradiography with Liquid Extraction Surface Analysis Mass Spectrometry
    Simone Schadt, Susanne Kallbach, Reinaldo Almeida and Jan Sandel
    Drug Metabolism and Disposition March 2012, 40 (3) 419-425; DOI: https://doi.org/10.1124/dmd.111.043562

Articles

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    Stereospecific Metabolism of Itraconazole by CYP3A4: Dioxolane Ring Scission of Azole Antifungals
    Chi-Chi Peng, Wei Shi, Justin D. Lutz, Kent L. Kunze, Jun O. Liu, Wendel L. Nelson and Nina Isoherranen
    Drug Metabolism and Disposition March 2012, 40 (3) 426-435; DOI: https://doi.org/10.1124/dmd.111.042739
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    Human Cytochrome P450scc (CYP11A1) Catalyzes Epoxide Formation with Ergosterol
    Robert C. Tuckey, Minh N. Nguyen, Jianjun Chen, Andrzej T. Slominski, Donna M. Baldisseri, Elaine W. Tieu, Jordan K. Zjawiony and Wei Li
    Drug Metabolism and Disposition March 2012, 40 (3) 436-444; DOI: https://doi.org/10.1124/dmd.111.042515
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    Influence of MK-467, a Peripherally Acting α2-Adrenoceptor Antagonist on the Disposition of Intravenous Dexmedetomidine in Dogs
    Juhana Honkavaara, Flavia Restitutti, Marja Raekallio, Kati Salla, Erja Kuusela, Ville Ranta-Panula, Valtteri Rinne, Outi Vainio and Mika Scheinin
    Drug Metabolism and Disposition March 2012, 40 (3) 445-449; DOI: https://doi.org/10.1124/dmd.111.042671
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    Molecular Mechanism of Altered Ezetimibe Disposition in Nonalcoholic Steatohepatitis
    Rhiannon N. Hardwick, Craig D. Fisher, Stephanie M. Street, Mark J. Canet and Nathan J. Cherrington
    Drug Metabolism and Disposition March 2012, 40 (3) 450-460; DOI: https://doi.org/10.1124/dmd.111.041095
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    Species Comparison of In Vivo P-Glycoprotein-Mediated Brain Efflux Using mdr1a-Deficient Rats and Mice
    Christoffer Bundgaard, Christian Jes Nyberg Jensen and Mats Garmer
    Drug Metabolism and Disposition March 2012, 40 (3) 461-466; DOI: https://doi.org/10.1124/dmd.111.043083
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    Use of a Multistaged Time-Dependent Inhibition Assay to Assess the Impact of Intestinal Metabolism on Drug-Drug Interaction Potential
    Michael Zientek and Deepak Dalvie
    Drug Metabolism and Disposition March 2012, 40 (3) 467-473; DOI: https://doi.org/10.1124/dmd.111.043257
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    Investigation of Drug-Drug Interactions Caused by Human Pregnane X Receptor-Mediated Induction of CYP3A4 and CYP2C Subfamilies in Chimeric Mice with a Humanized Liver
    Maki Hasegawa, Harunobu Tahara, Ryo Inoue, Masakazu Kakuni, Chise Tateno and Junko Ushiki
    Drug Metabolism and Disposition March 2012, 40 (3) 474-480; DOI: https://doi.org/10.1124/dmd.111.042754
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    Inhibition of Genistein Glucuronidation by Bisphenol A in Human and Rat Liver Microsomes
    Janis L. Coughlin, Paul E. Thomas and Brian Buckley
    Drug Metabolism and Disposition March 2012, 40 (3) 481-485; DOI: https://doi.org/10.1124/dmd.111.042366
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    Unimolecular and Bimolecular Binding System for the Prediction of CYP2D6-Mediated Metabolism
    Kimihiko Sato and Yasushi Yamazoe
    Drug Metabolism and Disposition March 2012, 40 (3) 486-496; DOI: https://doi.org/10.1124/dmd.111.043125
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    Evaluation of Hepatic Glutathione Transferase Mu 1 and Theta 1 Activities in Humans and Mice Using Genotype Information
    Shingo Arakawa, Kazunori Fujimoto, Ayako Kato, Seiko Endo, Aiko Fukahori, Akira Shinagawa, Thomas Fischer, Juergen Mueller and Wataru Takasaki
    Drug Metabolism and Disposition March 2012, 40 (3) 497-503; DOI: https://doi.org/10.1124/dmd.111.042911
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    Inhibition of Heme Oxygenase-1 Partially Reverses the Arsenite-Mediated Decrease of CYP1A1, CYP1A2, CYP3A23, and CYP3A2 Catalytic Activity in Isolated Rat Hepatocytes
    Anwar Anwar-Mohamed, Lars-Oliver Klotz and Ayman O. S. El-Kadi
    Drug Metabolism and Disposition March 2012, 40 (3) 504-514; DOI: https://doi.org/10.1124/dmd.111.042564
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    Oral Availability of Cefadroxil Depends on ABCC3 and ABCC4
    Dirk R. de Waart, Koen van de Wetering, Cindy Kunne, Suzanne Duijst, Coen C. Paulusma and Ronald P. J. Oude Elferink
    Drug Metabolism and Disposition March 2012, 40 (3) 515-521; DOI: https://doi.org/10.1124/dmd.111.041731
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    Clarithromycin Is Absorbed by an Intestinal Uptake Mechanism That Is Sensitive to Major Inhibition by Rifampicin: Results of a Short-Term Drug Interaction Study in Foals
    Jette Peters, Karen Eggers, Stefan Oswald, Wiebke Block, Dieter Lütjohann, Marc Lämmer, Monica Venner and Werner Siegmund
    Drug Metabolism and Disposition March 2012, 40 (3) 522-528; DOI: https://doi.org/10.1124/dmd.111.042267
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    Characterization of Hepatic and Intestinal Glucuronidation of Magnolol: Application of the Relative Activity Factor Approach to Decipher the Contributions of Multiple UDP-Glucuronosyltransferase Isoforms
    Liangliang Zhu, Guangbo Ge, Hongbo Zhang, Huixin Liu, Guiyuan He, Sicheng Liang, Yanyan Zhang, Zhongze Fang, Peipei Dong, Moshe Finel and Ling Yang
    Drug Metabolism and Disposition March 2012, 40 (3) 529-538; DOI: https://doi.org/10.1124/dmd.111.042192
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    Pharmacokinetics, Distribution, and Metabolism of [14C]Sunitinib in Rats, Monkeys, and Humans
    Bill Speed, Hai-Zhi Bu, William F. Pool, Geoffrey W. Peng, Ellen Y. Wu, Shem Patyna, Carlo Bello and Ping Kang
    Drug Metabolism and Disposition March 2012, 40 (3) 539-555; DOI: https://doi.org/10.1124/dmd.111.042853
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    Metabolism and Pharmacokinetics of Morinidazole in Humans: Identification of Diastereoisomeric Morpholine N+-Glucuronides Catalyzed by UDP Glucuronosyltransferase 1A9
    Ruina Gao, Liang Li, Cen Xie, Xingxing Diao, Dafang Zhong and Xiaoyan Chen
    Drug Metabolism and Disposition March 2012, 40 (3) 556-567; DOI: https://doi.org/10.1124/dmd.111.042689
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    Excretion, Metabolism, and Pharmacokinetics of 1-(8-(2-Chlorophenyl)-9-(4-Chlorophenyl)-9H-Purin-6-yl)-4-(Ethylamino)Piperidine-4-Carboxamide, a Selective Cannabinoid Receptor Antagonist, in Healthy Male Volunteers
    Zhuang Miao, Hao Sun, Jennifer Liras and Chandra Prakash
    Drug Metabolism and Disposition March 2012, 40 (3) 568-578; DOI: https://doi.org/10.1124/dmd.111.043273
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    Changes in Expression of Drug-Metabolizing Enzymes by Single-Walled Carbon Nanotubes in Human Respiratory Tract Cells
    Kotaro Hitoshi, Miki Katoh, Tomoko Suzuki, Yoshinori Ando and Masayuki Nadai
    Drug Metabolism and Disposition March 2012, 40 (3) 579-587; DOI: https://doi.org/10.1124/dmd.111.043455
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    Polychlorinated Biphenyl Congeners that Increase the Glucuronidation and Biliary Excretion of Thyroxine Are Distinct from the Congeners that Enhance the Serum Disappearance of Thyroxine
    L. A. Martin, D. T. Wilson, K. R. Reuhl, M. A. Gallo and C. D. Klaassen
    Drug Metabolism and Disposition March 2012, 40 (3) 588-595; DOI: https://doi.org/10.1124/dmd.111.042796
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    Trapping of cis-2-Butene-1,4-dial to Measure Furan Metabolism in Human Liver Microsomes by Cytochrome P450 Enzymes
    Leah A. Gates, Ding Lu and Lisa A. Peterson
    Drug Metabolism and Disposition March 2012, 40 (3) 596-601; DOI: https://doi.org/10.1124/dmd.111.043679
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    In Vivo Biliary Clearance Should Be Predicted by Intrinsic Biliary Clearance in Sandwich-Cultured Hepatocytes
    Masanori Nakakariya, Midori Ono, Nobuyuki Amano, Toshiya Moriwaki, Kazuya Maeda and Yuichi Sugiyama
    Drug Metabolism and Disposition March 2012, 40 (3) 602-609; DOI: https://doi.org/10.1124/dmd.111.042101
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    Complex Drug Interactions of the HIV Protease Inhibitors 3: Effect of Simultaneous or Staggered Dosing of Digoxin and Ritonavir, Nelfinavir, Rifampin, or Bupropion
    Brian J. Kirby, Ann C. Collier, Evan D. Kharasch, Dale Whittington, Kenneth E. Thummel and Jashvant D. Unadkat
    Drug Metabolism and Disposition March 2012, 40 (3) 610-616; DOI: https://doi.org/10.1124/dmd.111.042705
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    Expression of Organic Anion Transporter 2 in the Human Kidney and Its Potential Role in the Tubular Secretion of Guanine-Containing Antiviral Drugs
    Yaofeng Cheng, Arpine Vapurcuyan, Mohammad Shahidullah, Lauren M. Aleksunes and Ryan M. Pelis
    Drug Metabolism and Disposition March 2012, 40 (3) 617-624; DOI: https://doi.org/10.1124/dmd.111.042036
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    Deuterium Isotope Effects on Drug Pharmacokinetics. I. System-Dependent Effects of Specific Deuteration with Aldehyde Oxidase Cleared Drugs
    Raman Sharma, Timothy J. Strelevitz, Hongying Gao, Alan J. Clark, Klaas Schildknegt, R. Scott Obach, Sharon L. Ripp, Douglas K. Spracklin, Larry M. Tremaine and Alfin D. N. Vaz
    Drug Metabolism and Disposition March 2012, 40 (3) 625-634; DOI: https://doi.org/10.1124/dmd.111.042770

Letter to the Editor

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    Which CYP2B6 Variants Have Functional Consequences for Cyclophosphamide Bioactivation?
    Nuala A. Helsby and Malcolm D. Tingle
    Drug Metabolism and Disposition March 2012, 40 (3) 635-637; DOI: https://doi.org/10.1124/dmd.111.043646
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Drug Metabolism and Disposition: 40 (3)
Drug Metabolism and Disposition
Vol. 40, Issue 3
1 Mar 2012
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