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Index by author

March 01, 2012; Volume 40,Issue 3

A

  1. Aleksunes, Lauren M.

    1. Expression of Organic Anion Transporter 2 in the Human Kidney and Its Potential Role in the Tubular Secretion of Guanine-Containing Antiviral Drugs
      Yaofeng Cheng, Arpine Vapurcuyan, Mohammad Shahidullah, Lauren M. Aleksunes and Ryan M. Pelis
      Drug Metabolism and Disposition March 2012, 40 (3) 617-624; DOI: https://doi.org/10.1124/dmd.111.042036

  2. Almeida, Reinaldo

    1. Investigation of Figopitant and Its Metabolites in Rat Tissue by Combining Whole-Body Autoradiography with Liquid Extraction Surface Analysis Mass Spectrometry
      Simone Schadt, Susanne Kallbach, Reinaldo Almeida and Jan Sandel
      Drug Metabolism and Disposition March 2012, 40 (3) 419-425; DOI: https://doi.org/10.1124/dmd.111.043562

  3. Amano, Nobuyuki

    1. In Vivo Biliary Clearance Should Be Predicted by Intrinsic Biliary Clearance in Sandwich-Cultured Hepatocytes
      Masanori Nakakariya, Midori Ono, Nobuyuki Amano, Toshiya Moriwaki, Kazuya Maeda and Yuichi Sugiyama
      Drug Metabolism and Disposition March 2012, 40 (3) 602-609; DOI: https://doi.org/10.1124/dmd.111.042101

  4. Ando, Yoshinori

    1. Changes in Expression of Drug-Metabolizing Enzymes by Single-Walled Carbon Nanotubes in Human Respiratory Tract Cells
      Kotaro Hitoshi, Miki Katoh, Tomoko Suzuki, Yoshinori Ando and Masayuki Nadai
      Drug Metabolism and Disposition March 2012, 40 (3) 579-587; DOI: https://doi.org/10.1124/dmd.111.043455

  5. Anwar-Mohamed, Anwar

    1. Inhibition of Heme Oxygenase-1 Partially Reverses the Arsenite-Mediated Decrease of CYP1A1, CYP1A2, CYP3A23, and CYP3A2 Catalytic Activity in Isolated Rat Hepatocytes
      Anwar Anwar-Mohamed, Lars-Oliver Klotz and Ayman O. S. El-Kadi
      Drug Metabolism and Disposition March 2012, 40 (3) 504-514; DOI: https://doi.org/10.1124/dmd.111.042564

  6. Arakawa, Shingo

    1. Evaluation of Hepatic Glutathione Transferase Mu 1 and Theta 1 Activities in Humans and Mice Using Genotype Information
      Shingo Arakawa, Kazunori Fujimoto, Ayako Kato, Seiko Endo, Aiko Fukahori, Akira Shinagawa, Thomas Fischer, Juergen Mueller and Wataru Takasaki
      Drug Metabolism and Disposition March 2012, 40 (3) 497-503; DOI: https://doi.org/10.1124/dmd.111.042911

B

  1. Baldisseri, Donna M.

    1. Human Cytochrome P450scc (CYP11A1) Catalyzes Epoxide Formation with Ergosterol
      Robert C. Tuckey, Minh N. Nguyen, Jianjun Chen, Andrzej T. Slominski, Donna M. Baldisseri, Elaine W. Tieu, Jordan K. Zjawiony and Wei Li
      Drug Metabolism and Disposition March 2012, 40 (3) 436-444; DOI: https://doi.org/10.1124/dmd.111.042515

  2. Bello, Carlo

    1. Pharmacokinetics, Distribution, and Metabolism of [14C]Sunitinib in Rats, Monkeys, and Humans
      Bill Speed, Hai-Zhi Bu, William F. Pool, Geoffrey W. Peng, Ellen Y. Wu, Shem Patyna, Carlo Bello and Ping Kang
      Drug Metabolism and Disposition March 2012, 40 (3) 539-555; DOI: https://doi.org/10.1124/dmd.111.042853

  3. Bernhardt, Rita

    1. The Effects of Rosuvastatin and the CYP51A1 Inhibitor LEK-935 on the Proteome of Primary Human Hepatocytes
      Martin Wörner, Katja Melchior, Katalin Monostory, Jean-Marc Pascussi, Christian G. Huber and Rita Bernhardt
      Drug Metabolism and Disposition March 2012, 40 (3) 414-418; DOI: https://doi.org/10.1124/dmd.111.040402

  4. Block, Wiebke

    1. Clarithromycin Is Absorbed by an Intestinal Uptake Mechanism That Is Sensitive to Major Inhibition by Rifampicin: Results of a Short-Term Drug Interaction Study in Foals
      Jette Peters, Karen Eggers, Stefan Oswald, Wiebke Block, Dieter Lütjohann, Marc Lämmer, Monica Venner and Werner Siegmund
      Drug Metabolism and Disposition March 2012, 40 (3) 522-528; DOI: https://doi.org/10.1124/dmd.111.042267

  5. Bu, Hai-Zhi

    1. Pharmacokinetics, Distribution, and Metabolism of [14C]Sunitinib in Rats, Monkeys, and Humans
      Bill Speed, Hai-Zhi Bu, William F. Pool, Geoffrey W. Peng, Ellen Y. Wu, Shem Patyna, Carlo Bello and Ping Kang
      Drug Metabolism and Disposition March 2012, 40 (3) 539-555; DOI: https://doi.org/10.1124/dmd.111.042853

  6. Buckley, Brian

    1. Inhibition of Genistein Glucuronidation by Bisphenol A in Human and Rat Liver Microsomes
      Janis L. Coughlin, Paul E. Thomas and Brian Buckley
      Drug Metabolism and Disposition March 2012, 40 (3) 481-485; DOI: https://doi.org/10.1124/dmd.111.042366

  7. Bundgaard, Christoffer

    1. Species Comparison of In Vivo P-Glycoprotein-Mediated Brain Efflux Using mdr1a-Deficient Rats and Mice
      Christoffer Bundgaard, Christian Jes Nyberg Jensen and Mats Garmer
      Drug Metabolism and Disposition March 2012, 40 (3) 461-466; DOI: https://doi.org/10.1124/dmd.111.043083

C

  1. Canet, Mark J.

    1. Molecular Mechanism of Altered Ezetimibe Disposition in Nonalcoholic Steatohepatitis
      Rhiannon N. Hardwick, Craig D. Fisher, Stephanie M. Street, Mark J. Canet and Nathan J. Cherrington
      Drug Metabolism and Disposition March 2012, 40 (3) 450-460; DOI: https://doi.org/10.1124/dmd.111.041095

  2. Chen, Jianjun

    1. Human Cytochrome P450scc (CYP11A1) Catalyzes Epoxide Formation with Ergosterol
      Robert C. Tuckey, Minh N. Nguyen, Jianjun Chen, Andrzej T. Slominski, Donna M. Baldisseri, Elaine W. Tieu, Jordan K. Zjawiony and Wei Li
      Drug Metabolism and Disposition March 2012, 40 (3) 436-444; DOI: https://doi.org/10.1124/dmd.111.042515

  3. Chen, Xiaoyan

    1. Metabolism and Pharmacokinetics of Morinidazole in Humans: Identification of Diastereoisomeric Morpholine N+-Glucuronides Catalyzed by UDP Glucuronosyltransferase 1A9
      Ruina Gao, Liang Li, Cen Xie, Xingxing Diao, Dafang Zhong and Xiaoyan Chen
      Drug Metabolism and Disposition March 2012, 40 (3) 556-567; DOI: https://doi.org/10.1124/dmd.111.042689

  4. Cheng, Yaofeng

    1. Expression of Organic Anion Transporter 2 in the Human Kidney and Its Potential Role in the Tubular Secretion of Guanine-Containing Antiviral Drugs
      Yaofeng Cheng, Arpine Vapurcuyan, Mohammad Shahidullah, Lauren M. Aleksunes and Ryan M. Pelis
      Drug Metabolism and Disposition March 2012, 40 (3) 617-624; DOI: https://doi.org/10.1124/dmd.111.042036

  5. Cherrington, Nathan J.

    1. Molecular Mechanism of Altered Ezetimibe Disposition in Nonalcoholic Steatohepatitis
      Rhiannon N. Hardwick, Craig D. Fisher, Stephanie M. Street, Mark J. Canet and Nathan J. Cherrington
      Drug Metabolism and Disposition March 2012, 40 (3) 450-460; DOI: https://doi.org/10.1124/dmd.111.041095

  6. Clark, Alan J.

    1. Deuterium Isotope Effects on Drug Pharmacokinetics. I. System-Dependent Effects of Specific Deuteration with Aldehyde Oxidase Cleared Drugs
      Raman Sharma, Timothy J. Strelevitz, Hongying Gao, Alan J. Clark, Klaas Schildknegt, R. Scott Obach, Sharon L. Ripp, Douglas K. Spracklin, Larry M. Tremaine and Alfin D. N. Vaz
      Drug Metabolism and Disposition March 2012, 40 (3) 625-634; DOI: https://doi.org/10.1124/dmd.111.042770

  7. Collier, Ann C.

    1. Complex Drug Interactions of the HIV Protease Inhibitors 3: Effect of Simultaneous or Staggered Dosing of Digoxin and Ritonavir, Nelfinavir, Rifampin, or Bupropion
      Brian J. Kirby, Ann C. Collier, Evan D. Kharasch, Dale Whittington, Kenneth E. Thummel and Jashvant D. Unadkat
      Drug Metabolism and Disposition March 2012, 40 (3) 610-616; DOI: https://doi.org/10.1124/dmd.111.042705

  8. Coughlin, Janis L.

    1. Inhibition of Genistein Glucuronidation by Bisphenol A in Human and Rat Liver Microsomes
      Janis L. Coughlin, Paul E. Thomas and Brian Buckley
      Drug Metabolism and Disposition March 2012, 40 (3) 481-485; DOI: https://doi.org/10.1124/dmd.111.042366

D

  1. Dalvie, Deepak

    1. Use of a Multistaged Time-Dependent Inhibition Assay to Assess the Impact of Intestinal Metabolism on Drug-Drug Interaction Potential
      Michael Zientek and Deepak Dalvie
      Drug Metabolism and Disposition March 2012, 40 (3) 467-473; DOI: https://doi.org/10.1124/dmd.111.043257

  2. de Waart, Dirk R.

    1. Oral Availability of Cefadroxil Depends on ABCC3 and ABCC4
      Dirk R. de Waart, Koen van de Wetering, Cindy Kunne, Suzanne Duijst, Coen C. Paulusma and Ronald P. J. Oude Elferink
      Drug Metabolism and Disposition March 2012, 40 (3) 515-521; DOI: https://doi.org/10.1124/dmd.111.041731

  3. Diao, Xingxing

    1. Metabolism and Pharmacokinetics of Morinidazole in Humans: Identification of Diastereoisomeric Morpholine N+-Glucuronides Catalyzed by UDP Glucuronosyltransferase 1A9
      Ruina Gao, Liang Li, Cen Xie, Xingxing Diao, Dafang Zhong and Xiaoyan Chen
      Drug Metabolism and Disposition March 2012, 40 (3) 556-567; DOI: https://doi.org/10.1124/dmd.111.042689

  4. Dong, Peipei

    1. Characterization of Hepatic and Intestinal Glucuronidation of Magnolol: Application of the Relative Activity Factor Approach to Decipher the Contributions of Multiple UDP-Glucuronosyltransferase Isoforms
      Liangliang Zhu, Guangbo Ge, Hongbo Zhang, Huixin Liu, Guiyuan He, Sicheng Liang, Yanyan Zhang, Zhongze Fang, Peipei Dong, Moshe Finel and Ling Yang
      Drug Metabolism and Disposition March 2012, 40 (3) 529-538; DOI: https://doi.org/10.1124/dmd.111.042192

  5. Duijst, Suzanne

    1. Oral Availability of Cefadroxil Depends on ABCC3 and ABCC4
      Dirk R. de Waart, Koen van de Wetering, Cindy Kunne, Suzanne Duijst, Coen C. Paulusma and Ronald P. J. Oude Elferink
      Drug Metabolism and Disposition March 2012, 40 (3) 515-521; DOI: https://doi.org/10.1124/dmd.111.041731

E

  1. Eggers, Karen

    1. Clarithromycin Is Absorbed by an Intestinal Uptake Mechanism That Is Sensitive to Major Inhibition by Rifampicin: Results of a Short-Term Drug Interaction Study in Foals
      Jette Peters, Karen Eggers, Stefan Oswald, Wiebke Block, Dieter Lütjohann, Marc Lämmer, Monica Venner and Werner Siegmund
      Drug Metabolism and Disposition March 2012, 40 (3) 522-528; DOI: https://doi.org/10.1124/dmd.111.042267

  2. El-Kadi, Ayman O. S.

    1. Inhibition of Heme Oxygenase-1 Partially Reverses the Arsenite-Mediated Decrease of CYP1A1, CYP1A2, CYP3A23, and CYP3A2 Catalytic Activity in Isolated Rat Hepatocytes
      Anwar Anwar-Mohamed, Lars-Oliver Klotz and Ayman O. S. El-Kadi
      Drug Metabolism and Disposition March 2012, 40 (3) 504-514; DOI: https://doi.org/10.1124/dmd.111.042564

  3. Endo, Seiko

    1. Evaluation of Hepatic Glutathione Transferase Mu 1 and Theta 1 Activities in Humans and Mice Using Genotype Information
      Shingo Arakawa, Kazunori Fujimoto, Ayako Kato, Seiko Endo, Aiko Fukahori, Akira Shinagawa, Thomas Fischer, Juergen Mueller and Wataru Takasaki
      Drug Metabolism and Disposition March 2012, 40 (3) 497-503; DOI: https://doi.org/10.1124/dmd.111.042911

F

  1. Fang, Zhongze

    1. Characterization of Hepatic and Intestinal Glucuronidation of Magnolol: Application of the Relative Activity Factor Approach to Decipher the Contributions of Multiple UDP-Glucuronosyltransferase Isoforms
      Liangliang Zhu, Guangbo Ge, Hongbo Zhang, Huixin Liu, Guiyuan He, Sicheng Liang, Yanyan Zhang, Zhongze Fang, Peipei Dong, Moshe Finel and Ling Yang
      Drug Metabolism and Disposition March 2012, 40 (3) 529-538; DOI: https://doi.org/10.1124/dmd.111.042192

  2. Finel, Moshe

    1. Characterization of Hepatic and Intestinal Glucuronidation of Magnolol: Application of the Relative Activity Factor Approach to Decipher the Contributions of Multiple UDP-Glucuronosyltransferase Isoforms
      Liangliang Zhu, Guangbo Ge, Hongbo Zhang, Huixin Liu, Guiyuan He, Sicheng Liang, Yanyan Zhang, Zhongze Fang, Peipei Dong, Moshe Finel and Ling Yang
      Drug Metabolism and Disposition March 2012, 40 (3) 529-538; DOI: https://doi.org/10.1124/dmd.111.042192

  3. Fischer, Thomas

    1. Evaluation of Hepatic Glutathione Transferase Mu 1 and Theta 1 Activities in Humans and Mice Using Genotype Information
      Shingo Arakawa, Kazunori Fujimoto, Ayako Kato, Seiko Endo, Aiko Fukahori, Akira Shinagawa, Thomas Fischer, Juergen Mueller and Wataru Takasaki
      Drug Metabolism and Disposition March 2012, 40 (3) 497-503; DOI: https://doi.org/10.1124/dmd.111.042911

  4. Fisher, Craig D.

    1. Molecular Mechanism of Altered Ezetimibe Disposition in Nonalcoholic Steatohepatitis
      Rhiannon N. Hardwick, Craig D. Fisher, Stephanie M. Street, Mark J. Canet and Nathan J. Cherrington
      Drug Metabolism and Disposition March 2012, 40 (3) 450-460; DOI: https://doi.org/10.1124/dmd.111.041095

  5. Fujimoto, Kazunori

    1. Evaluation of Hepatic Glutathione Transferase Mu 1 and Theta 1 Activities in Humans and Mice Using Genotype Information
      Shingo Arakawa, Kazunori Fujimoto, Ayako Kato, Seiko Endo, Aiko Fukahori, Akira Shinagawa, Thomas Fischer, Juergen Mueller and Wataru Takasaki
      Drug Metabolism and Disposition March 2012, 40 (3) 497-503; DOI: https://doi.org/10.1124/dmd.111.042911

  6. Fukahori, Aiko

    1. Evaluation of Hepatic Glutathione Transferase Mu 1 and Theta 1 Activities in Humans and Mice Using Genotype Information
      Shingo Arakawa, Kazunori Fujimoto, Ayako Kato, Seiko Endo, Aiko Fukahori, Akira Shinagawa, Thomas Fischer, Juergen Mueller and Wataru Takasaki
      Drug Metabolism and Disposition March 2012, 40 (3) 497-503; DOI: https://doi.org/10.1124/dmd.111.042911

G

  1. Gallo, M. A.

    1. Polychlorinated Biphenyl Congeners that Increase the Glucuronidation and Biliary Excretion of Thyroxine Are Distinct from the Congeners that Enhance the Serum Disappearance of Thyroxine
      L. A. Martin, D. T. Wilson, K. R. Reuhl, M. A. Gallo and C. D. Klaassen
      Drug Metabolism and Disposition March 2012, 40 (3) 588-595; DOI: https://doi.org/10.1124/dmd.111.042796

  2. Gao, Hongying

    1. Deuterium Isotope Effects on Drug Pharmacokinetics. I. System-Dependent Effects of Specific Deuteration with Aldehyde Oxidase Cleared Drugs
      Raman Sharma, Timothy J. Strelevitz, Hongying Gao, Alan J. Clark, Klaas Schildknegt, R. Scott Obach, Sharon L. Ripp, Douglas K. Spracklin, Larry M. Tremaine and Alfin D. N. Vaz
      Drug Metabolism and Disposition March 2012, 40 (3) 625-634; DOI: https://doi.org/10.1124/dmd.111.042770

  3. Gao, Ruina

    1. Metabolism and Pharmacokinetics of Morinidazole in Humans: Identification of Diastereoisomeric Morpholine N+-Glucuronides Catalyzed by UDP Glucuronosyltransferase 1A9
      Ruina Gao, Liang Li, Cen Xie, Xingxing Diao, Dafang Zhong and Xiaoyan Chen
      Drug Metabolism and Disposition March 2012, 40 (3) 556-567; DOI: https://doi.org/10.1124/dmd.111.042689

  4. Garmer, Mats

    1. Species Comparison of In Vivo P-Glycoprotein-Mediated Brain Efflux Using mdr1a-Deficient Rats and Mice
      Christoffer Bundgaard, Christian Jes Nyberg Jensen and Mats Garmer
      Drug Metabolism and Disposition March 2012, 40 (3) 461-466; DOI: https://doi.org/10.1124/dmd.111.043083

  5. Gates, Leah A.

    1. Trapping of cis-2-Butene-1,4-dial to Measure Furan Metabolism in Human Liver Microsomes by Cytochrome P450 Enzymes
      Leah A. Gates, Ding Lu and Lisa A. Peterson
      Drug Metabolism and Disposition March 2012, 40 (3) 596-601; DOI: https://doi.org/10.1124/dmd.111.043679

  6. Ge, Guangbo

    1. Characterization of Hepatic and Intestinal Glucuronidation of Magnolol: Application of the Relative Activity Factor Approach to Decipher the Contributions of Multiple UDP-Glucuronosyltransferase Isoforms
      Liangliang Zhu, Guangbo Ge, Hongbo Zhang, Huixin Liu, Guiyuan He, Sicheng Liang, Yanyan Zhang, Zhongze Fang, Peipei Dong, Moshe Finel and Ling Yang
      Drug Metabolism and Disposition March 2012, 40 (3) 529-538; DOI: https://doi.org/10.1124/dmd.111.042192

H

  1. Hardwick, Rhiannon N.

    1. Molecular Mechanism of Altered Ezetimibe Disposition in Nonalcoholic Steatohepatitis
      Rhiannon N. Hardwick, Craig D. Fisher, Stephanie M. Street, Mark J. Canet and Nathan J. Cherrington
      Drug Metabolism and Disposition March 2012, 40 (3) 450-460; DOI: https://doi.org/10.1124/dmd.111.041095

  2. Hasegawa, Maki

    1. Investigation of Drug-Drug Interactions Caused by Human Pregnane X Receptor-Mediated Induction of CYP3A4 and CYP2C Subfamilies in Chimeric Mice with a Humanized Liver
      Maki Hasegawa, Harunobu Tahara, Ryo Inoue, Masakazu Kakuni, Chise Tateno and Junko Ushiki
      Drug Metabolism and Disposition March 2012, 40 (3) 474-480; DOI: https://doi.org/10.1124/dmd.111.042754

  3. He, Guiyuan

    1. Characterization of Hepatic and Intestinal Glucuronidation of Magnolol: Application of the Relative Activity Factor Approach to Decipher the Contributions of Multiple UDP-Glucuronosyltransferase Isoforms
      Liangliang Zhu, Guangbo Ge, Hongbo Zhang, Huixin Liu, Guiyuan He, Sicheng Liang, Yanyan Zhang, Zhongze Fang, Peipei Dong, Moshe Finel and Ling Yang
      Drug Metabolism and Disposition March 2012, 40 (3) 529-538; DOI: https://doi.org/10.1124/dmd.111.042192

  4. Helsby, Nuala A.

    1. Which CYP2B6 Variants Have Functional Consequences for Cyclophosphamide Bioactivation?
      Nuala A. Helsby and Malcolm D. Tingle
      Drug Metabolism and Disposition March 2012, 40 (3) 635-637; DOI: https://doi.org/10.1124/dmd.111.043646

  5. Hitoshi, Kotaro

    1. Changes in Expression of Drug-Metabolizing Enzymes by Single-Walled Carbon Nanotubes in Human Respiratory Tract Cells
      Kotaro Hitoshi, Miki Katoh, Tomoko Suzuki, Yoshinori Ando and Masayuki Nadai
      Drug Metabolism and Disposition March 2012, 40 (3) 579-587; DOI: https://doi.org/10.1124/dmd.111.043455

  6. Honkavaara, Juhana

    1. Influence of MK-467, a Peripherally Acting α2-Adrenoceptor Antagonist on the Disposition of Intravenous Dexmedetomidine in Dogs
      Juhana Honkavaara, Flavia Restitutti, Marja Raekallio, Kati Salla, Erja Kuusela, Ville Ranta-Panula, Valtteri Rinne, Outi Vainio and Mika Scheinin
      Drug Metabolism and Disposition March 2012, 40 (3) 445-449; DOI: https://doi.org/10.1124/dmd.111.042671

  7. Huber, Christian G.

    1. The Effects of Rosuvastatin and the CYP51A1 Inhibitor LEK-935 on the Proteome of Primary Human Hepatocytes
      Martin Wörner, Katja Melchior, Katalin Monostory, Jean-Marc Pascussi, Christian G. Huber and Rita Bernhardt
      Drug Metabolism and Disposition March 2012, 40 (3) 414-418; DOI: https://doi.org/10.1124/dmd.111.040402

I

  1. Inoue, Ryo

    1. Investigation of Drug-Drug Interactions Caused by Human Pregnane X Receptor-Mediated Induction of CYP3A4 and CYP2C Subfamilies in Chimeric Mice with a Humanized Liver
      Maki Hasegawa, Harunobu Tahara, Ryo Inoue, Masakazu Kakuni, Chise Tateno and Junko Ushiki
      Drug Metabolism and Disposition March 2012, 40 (3) 474-480; DOI: https://doi.org/10.1124/dmd.111.042754

  2. Isoherranen, Nina

    1. Stereospecific Metabolism of Itraconazole by CYP3A4: Dioxolane Ring Scission of Azole Antifungals
      Chi-Chi Peng, Wei Shi, Justin D. Lutz, Kent L. Kunze, Jun O. Liu, Wendel L. Nelson and Nina Isoherranen
      Drug Metabolism and Disposition March 2012, 40 (3) 426-435; DOI: https://doi.org/10.1124/dmd.111.042739

J

  1. Jensen, Christian Jes Nyberg

    1. Species Comparison of In Vivo P-Glycoprotein-Mediated Brain Efflux Using mdr1a-Deficient Rats and Mice
      Christoffer Bundgaard, Christian Jes Nyberg Jensen and Mats Garmer
      Drug Metabolism and Disposition March 2012, 40 (3) 461-466; DOI: https://doi.org/10.1124/dmd.111.043083

K

  1. Kakuni, Masakazu

    1. Investigation of Drug-Drug Interactions Caused by Human Pregnane X Receptor-Mediated Induction of CYP3A4 and CYP2C Subfamilies in Chimeric Mice with a Humanized Liver
      Maki Hasegawa, Harunobu Tahara, Ryo Inoue, Masakazu Kakuni, Chise Tateno and Junko Ushiki
      Drug Metabolism and Disposition March 2012, 40 (3) 474-480; DOI: https://doi.org/10.1124/dmd.111.042754

  2. Kallbach, Susanne

    1. Investigation of Figopitant and Its Metabolites in Rat Tissue by Combining Whole-Body Autoradiography with Liquid Extraction Surface Analysis Mass Spectrometry
      Simone Schadt, Susanne Kallbach, Reinaldo Almeida and Jan Sandel
      Drug Metabolism and Disposition March 2012, 40 (3) 419-425; DOI: https://doi.org/10.1124/dmd.111.043562

  3. Kang, Ping

    1. Pharmacokinetics, Distribution, and Metabolism of [14C]Sunitinib in Rats, Monkeys, and Humans
      Bill Speed, Hai-Zhi Bu, William F. Pool, Geoffrey W. Peng, Ellen Y. Wu, Shem Patyna, Carlo Bello and Ping Kang
      Drug Metabolism and Disposition March 2012, 40 (3) 539-555; DOI: https://doi.org/10.1124/dmd.111.042853

  4. Kato, Ayako

    1. Evaluation of Hepatic Glutathione Transferase Mu 1 and Theta 1 Activities in Humans and Mice Using Genotype Information
      Shingo Arakawa, Kazunori Fujimoto, Ayako Kato, Seiko Endo, Aiko Fukahori, Akira Shinagawa, Thomas Fischer, Juergen Mueller and Wataru Takasaki
      Drug Metabolism and Disposition March 2012, 40 (3) 497-503; DOI: https://doi.org/10.1124/dmd.111.042911

  5. Katoh, Miki

    1. Changes in Expression of Drug-Metabolizing Enzymes by Single-Walled Carbon Nanotubes in Human Respiratory Tract Cells
      Kotaro Hitoshi, Miki Katoh, Tomoko Suzuki, Yoshinori Ando and Masayuki Nadai
      Drug Metabolism and Disposition March 2012, 40 (3) 579-587; DOI: https://doi.org/10.1124/dmd.111.043455

  6. Kharasch, Evan D.

    1. Complex Drug Interactions of the HIV Protease Inhibitors 3: Effect of Simultaneous or Staggered Dosing of Digoxin and Ritonavir, Nelfinavir, Rifampin, or Bupropion
      Brian J. Kirby, Ann C. Collier, Evan D. Kharasch, Dale Whittington, Kenneth E. Thummel and Jashvant D. Unadkat
      Drug Metabolism and Disposition March 2012, 40 (3) 610-616; DOI: https://doi.org/10.1124/dmd.111.042705

  7. Kirby, Brian J.

    1. Complex Drug Interactions of the HIV Protease Inhibitors 3: Effect of Simultaneous or Staggered Dosing of Digoxin and Ritonavir, Nelfinavir, Rifampin, or Bupropion
      Brian J. Kirby, Ann C. Collier, Evan D. Kharasch, Dale Whittington, Kenneth E. Thummel and Jashvant D. Unadkat
      Drug Metabolism and Disposition March 2012, 40 (3) 610-616; DOI: https://doi.org/10.1124/dmd.111.042705

  8. Klaassen, C. D.

    1. Polychlorinated Biphenyl Congeners that Increase the Glucuronidation and Biliary Excretion of Thyroxine Are Distinct from the Congeners that Enhance the Serum Disappearance of Thyroxine
      L. A. Martin, D. T. Wilson, K. R. Reuhl, M. A. Gallo and C. D. Klaassen
      Drug Metabolism and Disposition March 2012, 40 (3) 588-595; DOI: https://doi.org/10.1124/dmd.111.042796

  9. Klotz, Lars-Oliver

    1. Inhibition of Heme Oxygenase-1 Partially Reverses the Arsenite-Mediated Decrease of CYP1A1, CYP1A2, CYP3A23, and CYP3A2 Catalytic Activity in Isolated Rat Hepatocytes
      Anwar Anwar-Mohamed, Lars-Oliver Klotz and Ayman O. S. El-Kadi
      Drug Metabolism and Disposition March 2012, 40 (3) 504-514; DOI: https://doi.org/10.1124/dmd.111.042564

  10. Kunne, Cindy

    1. Oral Availability of Cefadroxil Depends on ABCC3 and ABCC4
      Dirk R. de Waart, Koen van de Wetering, Cindy Kunne, Suzanne Duijst, Coen C. Paulusma and Ronald P. J. Oude Elferink
      Drug Metabolism and Disposition March 2012, 40 (3) 515-521; DOI: https://doi.org/10.1124/dmd.111.041731

  11. Kunze, Kent L.

    1. Stereospecific Metabolism of Itraconazole by CYP3A4: Dioxolane Ring Scission of Azole Antifungals
      Chi-Chi Peng, Wei Shi, Justin D. Lutz, Kent L. Kunze, Jun O. Liu, Wendel L. Nelson and Nina Isoherranen
      Drug Metabolism and Disposition March 2012, 40 (3) 426-435; DOI: https://doi.org/10.1124/dmd.111.042739

  12. Kuusela, Erja

    1. Influence of MK-467, a Peripherally Acting α2-Adrenoceptor Antagonist on the Disposition of Intravenous Dexmedetomidine in Dogs
      Juhana Honkavaara, Flavia Restitutti, Marja Raekallio, Kati Salla, Erja Kuusela, Ville Ranta-Panula, Valtteri Rinne, Outi Vainio and Mika Scheinin
      Drug Metabolism and Disposition March 2012, 40 (3) 445-449; DOI: https://doi.org/10.1124/dmd.111.042671

L

  1. Lämmer, Marc

    1. Clarithromycin Is Absorbed by an Intestinal Uptake Mechanism That Is Sensitive to Major Inhibition by Rifampicin: Results of a Short-Term Drug Interaction Study in Foals
      Jette Peters, Karen Eggers, Stefan Oswald, Wiebke Block, Dieter Lütjohann, Marc Lämmer, Monica Venner and Werner Siegmund
      Drug Metabolism and Disposition March 2012, 40 (3) 522-528; DOI: https://doi.org/10.1124/dmd.111.042267

  2. Li, Liang

    1. Metabolism and Pharmacokinetics of Morinidazole in Humans: Identification of Diastereoisomeric Morpholine N+-Glucuronides Catalyzed by UDP Glucuronosyltransferase 1A9
      Ruina Gao, Liang Li, Cen Xie, Xingxing Diao, Dafang Zhong and Xiaoyan Chen
      Drug Metabolism and Disposition March 2012, 40 (3) 556-567; DOI: https://doi.org/10.1124/dmd.111.042689

  3. Li, Wei

    1. Human Cytochrome P450scc (CYP11A1) Catalyzes Epoxide Formation with Ergosterol
      Robert C. Tuckey, Minh N. Nguyen, Jianjun Chen, Andrzej T. Slominski, Donna M. Baldisseri, Elaine W. Tieu, Jordan K. Zjawiony and Wei Li
      Drug Metabolism and Disposition March 2012, 40 (3) 436-444; DOI: https://doi.org/10.1124/dmd.111.042515

  4. Liang, Sicheng

    1. Characterization of Hepatic and Intestinal Glucuronidation of Magnolol: Application of the Relative Activity Factor Approach to Decipher the Contributions of Multiple UDP-Glucuronosyltransferase Isoforms
      Liangliang Zhu, Guangbo Ge, Hongbo Zhang, Huixin Liu, Guiyuan He, Sicheng Liang, Yanyan Zhang, Zhongze Fang, Peipei Dong, Moshe Finel and Ling Yang
      Drug Metabolism and Disposition March 2012, 40 (3) 529-538; DOI: https://doi.org/10.1124/dmd.111.042192

  5. Liras, Jennifer

    1. Excretion, Metabolism, and Pharmacokinetics of 1-(8-(2-Chlorophenyl)-9-(4-Chlorophenyl)-9H-Purin-6-yl)-4-(Ethylamino)Piperidine-4-Carboxamide, a Selective Cannabinoid Receptor Antagonist, in Healthy Male Volunteers
      Zhuang Miao, Hao Sun, Jennifer Liras and Chandra Prakash
      Drug Metabolism and Disposition March 2012, 40 (3) 568-578; DOI: https://doi.org/10.1124/dmd.111.043273

  6. Liu, Huixin

    1. Characterization of Hepatic and Intestinal Glucuronidation of Magnolol: Application of the Relative Activity Factor Approach to Decipher the Contributions of Multiple UDP-Glucuronosyltransferase Isoforms
      Liangliang Zhu, Guangbo Ge, Hongbo Zhang, Huixin Liu, Guiyuan He, Sicheng Liang, Yanyan Zhang, Zhongze Fang, Peipei Dong, Moshe Finel and Ling Yang
      Drug Metabolism and Disposition March 2012, 40 (3) 529-538; DOI: https://doi.org/10.1124/dmd.111.042192

  7. Liu, Jun O.

    1. Stereospecific Metabolism of Itraconazole by CYP3A4: Dioxolane Ring Scission of Azole Antifungals
      Chi-Chi Peng, Wei Shi, Justin D. Lutz, Kent L. Kunze, Jun O. Liu, Wendel L. Nelson and Nina Isoherranen
      Drug Metabolism and Disposition March 2012, 40 (3) 426-435; DOI: https://doi.org/10.1124/dmd.111.042739

  8. Lu, Ding

    1. Trapping of cis-2-Butene-1,4-dial to Measure Furan Metabolism in Human Liver Microsomes by Cytochrome P450 Enzymes
      Leah A. Gates, Ding Lu and Lisa A. Peterson
      Drug Metabolism and Disposition March 2012, 40 (3) 596-601; DOI: https://doi.org/10.1124/dmd.111.043679

  9. Lütjohann, Dieter

    1. Clarithromycin Is Absorbed by an Intestinal Uptake Mechanism That Is Sensitive to Major Inhibition by Rifampicin: Results of a Short-Term Drug Interaction Study in Foals
      Jette Peters, Karen Eggers, Stefan Oswald, Wiebke Block, Dieter Lütjohann, Marc Lämmer, Monica Venner and Werner Siegmund
      Drug Metabolism and Disposition March 2012, 40 (3) 522-528; DOI: https://doi.org/10.1124/dmd.111.042267

  10. Lutz, Justin D.

    1. Stereospecific Metabolism of Itraconazole by CYP3A4: Dioxolane Ring Scission of Azole Antifungals
      Chi-Chi Peng, Wei Shi, Justin D. Lutz, Kent L. Kunze, Jun O. Liu, Wendel L. Nelson and Nina Isoherranen
      Drug Metabolism and Disposition March 2012, 40 (3) 426-435; DOI: https://doi.org/10.1124/dmd.111.042739

M

  1. Maeda, Kazuya

    1. In Vivo Biliary Clearance Should Be Predicted by Intrinsic Biliary Clearance in Sandwich-Cultured Hepatocytes
      Masanori Nakakariya, Midori Ono, Nobuyuki Amano, Toshiya Moriwaki, Kazuya Maeda and Yuichi Sugiyama
      Drug Metabolism and Disposition March 2012, 40 (3) 602-609; DOI: https://doi.org/10.1124/dmd.111.042101

  2. Martin, L. A.

    1. Polychlorinated Biphenyl Congeners that Increase the Glucuronidation and Biliary Excretion of Thyroxine Are Distinct from the Congeners that Enhance the Serum Disappearance of Thyroxine
      L. A. Martin, D. T. Wilson, K. R. Reuhl, M. A. Gallo and C. D. Klaassen
      Drug Metabolism and Disposition March 2012, 40 (3) 588-595; DOI: https://doi.org/10.1124/dmd.111.042796

  3. Melchior, Katja

    1. The Effects of Rosuvastatin and the CYP51A1 Inhibitor LEK-935 on the Proteome of Primary Human Hepatocytes
      Martin Wörner, Katja Melchior, Katalin Monostory, Jean-Marc Pascussi, Christian G. Huber and Rita Bernhardt
      Drug Metabolism and Disposition March 2012, 40 (3) 414-418; DOI: https://doi.org/10.1124/dmd.111.040402

  4. Miao, Zhuang

    1. Excretion, Metabolism, and Pharmacokinetics of 1-(8-(2-Chlorophenyl)-9-(4-Chlorophenyl)-9H-Purin-6-yl)-4-(Ethylamino)Piperidine-4-Carboxamide, a Selective Cannabinoid Receptor Antagonist, in Healthy Male Volunteers
      Zhuang Miao, Hao Sun, Jennifer Liras and Chandra Prakash
      Drug Metabolism and Disposition March 2012, 40 (3) 568-578; DOI: https://doi.org/10.1124/dmd.111.043273

  5. Monostory, Katalin

    1. The Effects of Rosuvastatin and the CYP51A1 Inhibitor LEK-935 on the Proteome of Primary Human Hepatocytes
      Martin Wörner, Katja Melchior, Katalin Monostory, Jean-Marc Pascussi, Christian G. Huber and Rita Bernhardt
      Drug Metabolism and Disposition March 2012, 40 (3) 414-418; DOI: https://doi.org/10.1124/dmd.111.040402

  6. Morgan, Edward T.

    1. Editorial
      Edward T. Morgan,
      Drug Metabolism and Disposition March 2012, 40 (3) 413; DOI: https://doi.org/10.1124/dmd.111.000009

  7. Moriwaki, Toshiya

    1. In Vivo Biliary Clearance Should Be Predicted by Intrinsic Biliary Clearance in Sandwich-Cultured Hepatocytes
      Masanori Nakakariya, Midori Ono, Nobuyuki Amano, Toshiya Moriwaki, Kazuya Maeda and Yuichi Sugiyama
      Drug Metabolism and Disposition March 2012, 40 (3) 602-609; DOI: https://doi.org/10.1124/dmd.111.042101

  8. Mueller, Juergen

    1. Evaluation of Hepatic Glutathione Transferase Mu 1 and Theta 1 Activities in Humans and Mice Using Genotype Information
      Shingo Arakawa, Kazunori Fujimoto, Ayako Kato, Seiko Endo, Aiko Fukahori, Akira Shinagawa, Thomas Fischer, Juergen Mueller and Wataru Takasaki
      Drug Metabolism and Disposition March 2012, 40 (3) 497-503; DOI: https://doi.org/10.1124/dmd.111.042911

N

  1. Nadai, Masayuki

    1. Changes in Expression of Drug-Metabolizing Enzymes by Single-Walled Carbon Nanotubes in Human Respiratory Tract Cells
      Kotaro Hitoshi, Miki Katoh, Tomoko Suzuki, Yoshinori Ando and Masayuki Nadai
      Drug Metabolism and Disposition March 2012, 40 (3) 579-587; DOI: https://doi.org/10.1124/dmd.111.043455

  2. Nakakariya, Masanori

    1. In Vivo Biliary Clearance Should Be Predicted by Intrinsic Biliary Clearance in Sandwich-Cultured Hepatocytes
      Masanori Nakakariya, Midori Ono, Nobuyuki Amano, Toshiya Moriwaki, Kazuya Maeda and Yuichi Sugiyama
      Drug Metabolism and Disposition March 2012, 40 (3) 602-609; DOI: https://doi.org/10.1124/dmd.111.042101

  3. Nelson, Wendel L.

    1. Stereospecific Metabolism of Itraconazole by CYP3A4: Dioxolane Ring Scission of Azole Antifungals
      Chi-Chi Peng, Wei Shi, Justin D. Lutz, Kent L. Kunze, Jun O. Liu, Wendel L. Nelson and Nina Isoherranen
      Drug Metabolism and Disposition March 2012, 40 (3) 426-435; DOI: https://doi.org/10.1124/dmd.111.042739

  4. Nguyen, Minh N.

    1. Human Cytochrome P450scc (CYP11A1) Catalyzes Epoxide Formation with Ergosterol
      Robert C. Tuckey, Minh N. Nguyen, Jianjun Chen, Andrzej T. Slominski, Donna M. Baldisseri, Elaine W. Tieu, Jordan K. Zjawiony and Wei Li
      Drug Metabolism and Disposition March 2012, 40 (3) 436-444; DOI: https://doi.org/10.1124/dmd.111.042515

O

  1. Obach, R. Scott

    1. Deuterium Isotope Effects on Drug Pharmacokinetics. I. System-Dependent Effects of Specific Deuteration with Aldehyde Oxidase Cleared Drugs
      Raman Sharma, Timothy J. Strelevitz, Hongying Gao, Alan J. Clark, Klaas Schildknegt, R. Scott Obach, Sharon L. Ripp, Douglas K. Spracklin, Larry M. Tremaine and Alfin D. N. Vaz
      Drug Metabolism and Disposition March 2012, 40 (3) 625-634; DOI: https://doi.org/10.1124/dmd.111.042770

  2. Ono, Midori

    1. In Vivo Biliary Clearance Should Be Predicted by Intrinsic Biliary Clearance in Sandwich-Cultured Hepatocytes
      Masanori Nakakariya, Midori Ono, Nobuyuki Amano, Toshiya Moriwaki, Kazuya Maeda and Yuichi Sugiyama
      Drug Metabolism and Disposition March 2012, 40 (3) 602-609; DOI: https://doi.org/10.1124/dmd.111.042101

  3. Oswald, Stefan

    1. Clarithromycin Is Absorbed by an Intestinal Uptake Mechanism That Is Sensitive to Major Inhibition by Rifampicin: Results of a Short-Term Drug Interaction Study in Foals
      Jette Peters, Karen Eggers, Stefan Oswald, Wiebke Block, Dieter Lütjohann, Marc Lämmer, Monica Venner and Werner Siegmund
      Drug Metabolism and Disposition March 2012, 40 (3) 522-528; DOI: https://doi.org/10.1124/dmd.111.042267

  4. Oude Elferink, Ronald P. J.

    1. Oral Availability of Cefadroxil Depends on ABCC3 and ABCC4
      Dirk R. de Waart, Koen van de Wetering, Cindy Kunne, Suzanne Duijst, Coen C. Paulusma and Ronald P. J. Oude Elferink
      Drug Metabolism and Disposition March 2012, 40 (3) 515-521; DOI: https://doi.org/10.1124/dmd.111.041731

P

  1. Pascussi, Jean-Marc

    1. The Effects of Rosuvastatin and the CYP51A1 Inhibitor LEK-935 on the Proteome of Primary Human Hepatocytes
      Martin Wörner, Katja Melchior, Katalin Monostory, Jean-Marc Pascussi, Christian G. Huber and Rita Bernhardt
      Drug Metabolism and Disposition March 2012, 40 (3) 414-418; DOI: https://doi.org/10.1124/dmd.111.040402

  2. Patyna, Shem

    1. Pharmacokinetics, Distribution, and Metabolism of [14C]Sunitinib in Rats, Monkeys, and Humans
      Bill Speed, Hai-Zhi Bu, William F. Pool, Geoffrey W. Peng, Ellen Y. Wu, Shem Patyna, Carlo Bello and Ping Kang
      Drug Metabolism and Disposition March 2012, 40 (3) 539-555; DOI: https://doi.org/10.1124/dmd.111.042853

  3. Paulusma, Coen C.

    1. Oral Availability of Cefadroxil Depends on ABCC3 and ABCC4
      Dirk R. de Waart, Koen van de Wetering, Cindy Kunne, Suzanne Duijst, Coen C. Paulusma and Ronald P. J. Oude Elferink
      Drug Metabolism and Disposition March 2012, 40 (3) 515-521; DOI: https://doi.org/10.1124/dmd.111.041731

  4. Pelis, Ryan M.

    1. Expression of Organic Anion Transporter 2 in the Human Kidney and Its Potential Role in the Tubular Secretion of Guanine-Containing Antiviral Drugs
      Yaofeng Cheng, Arpine Vapurcuyan, Mohammad Shahidullah, Lauren M. Aleksunes and Ryan M. Pelis
      Drug Metabolism and Disposition March 2012, 40 (3) 617-624; DOI: https://doi.org/10.1124/dmd.111.042036

  5. Peng, Chi-Chi

    1. Stereospecific Metabolism of Itraconazole by CYP3A4: Dioxolane Ring Scission of Azole Antifungals
      Chi-Chi Peng, Wei Shi, Justin D. Lutz, Kent L. Kunze, Jun O. Liu, Wendel L. Nelson and Nina Isoherranen
      Drug Metabolism and Disposition March 2012, 40 (3) 426-435; DOI: https://doi.org/10.1124/dmd.111.042739

  6. Peng, Geoffrey W.

    1. Pharmacokinetics, Distribution, and Metabolism of [14C]Sunitinib in Rats, Monkeys, and Humans
      Bill Speed, Hai-Zhi Bu, William F. Pool, Geoffrey W. Peng, Ellen Y. Wu, Shem Patyna, Carlo Bello and Ping Kang
      Drug Metabolism and Disposition March 2012, 40 (3) 539-555; DOI: https://doi.org/10.1124/dmd.111.042853

  7. Peters, Jette

    1. Clarithromycin Is Absorbed by an Intestinal Uptake Mechanism That Is Sensitive to Major Inhibition by Rifampicin: Results of a Short-Term Drug Interaction Study in Foals
      Jette Peters, Karen Eggers, Stefan Oswald, Wiebke Block, Dieter Lütjohann, Marc Lämmer, Monica Venner and Werner Siegmund
      Drug Metabolism and Disposition March 2012, 40 (3) 522-528; DOI: https://doi.org/10.1124/dmd.111.042267

  8. Peterson, Lisa A.

    1. Trapping of cis-2-Butene-1,4-dial to Measure Furan Metabolism in Human Liver Microsomes by Cytochrome P450 Enzymes
      Leah A. Gates, Ding Lu and Lisa A. Peterson
      Drug Metabolism and Disposition March 2012, 40 (3) 596-601; DOI: https://doi.org/10.1124/dmd.111.043679

  9. Pool, William F.

    1. Pharmacokinetics, Distribution, and Metabolism of [14C]Sunitinib in Rats, Monkeys, and Humans
      Bill Speed, Hai-Zhi Bu, William F. Pool, Geoffrey W. Peng, Ellen Y. Wu, Shem Patyna, Carlo Bello and Ping Kang
      Drug Metabolism and Disposition March 2012, 40 (3) 539-555; DOI: https://doi.org/10.1124/dmd.111.042853

  10. Prakash, Chandra

    1. Excretion, Metabolism, and Pharmacokinetics of 1-(8-(2-Chlorophenyl)-9-(4-Chlorophenyl)-9H-Purin-6-yl)-4-(Ethylamino)Piperidine-4-Carboxamide, a Selective Cannabinoid Receptor Antagonist, in Healthy Male Volunteers
      Zhuang Miao, Hao Sun, Jennifer Liras and Chandra Prakash
      Drug Metabolism and Disposition March 2012, 40 (3) 568-578; DOI: https://doi.org/10.1124/dmd.111.043273

R

  1. Raekallio, Marja

    1. Influence of MK-467, a Peripherally Acting α2-Adrenoceptor Antagonist on the Disposition of Intravenous Dexmedetomidine in Dogs
      Juhana Honkavaara, Flavia Restitutti, Marja Raekallio, Kati Salla, Erja Kuusela, Ville Ranta-Panula, Valtteri Rinne, Outi Vainio and Mika Scheinin
      Drug Metabolism and Disposition March 2012, 40 (3) 445-449; DOI: https://doi.org/10.1124/dmd.111.042671

  2. Ranta-Panula, Ville

    1. Influence of MK-467, a Peripherally Acting α2-Adrenoceptor Antagonist on the Disposition of Intravenous Dexmedetomidine in Dogs
      Juhana Honkavaara, Flavia Restitutti, Marja Raekallio, Kati Salla, Erja Kuusela, Ville Ranta-Panula, Valtteri Rinne, Outi Vainio and Mika Scheinin
      Drug Metabolism and Disposition March 2012, 40 (3) 445-449; DOI: https://doi.org/10.1124/dmd.111.042671

  3. Restitutti, Flavia

    1. Influence of MK-467, a Peripherally Acting α2-Adrenoceptor Antagonist on the Disposition of Intravenous Dexmedetomidine in Dogs
      Juhana Honkavaara, Flavia Restitutti, Marja Raekallio, Kati Salla, Erja Kuusela, Ville Ranta-Panula, Valtteri Rinne, Outi Vainio and Mika Scheinin
      Drug Metabolism and Disposition March 2012, 40 (3) 445-449; DOI: https://doi.org/10.1124/dmd.111.042671

  4. Reuhl, K. R.

    1. Polychlorinated Biphenyl Congeners that Increase the Glucuronidation and Biliary Excretion of Thyroxine Are Distinct from the Congeners that Enhance the Serum Disappearance of Thyroxine
      L. A. Martin, D. T. Wilson, K. R. Reuhl, M. A. Gallo and C. D. Klaassen
      Drug Metabolism and Disposition March 2012, 40 (3) 588-595; DOI: https://doi.org/10.1124/dmd.111.042796

  5. Rinne, Valtteri

    1. Influence of MK-467, a Peripherally Acting α2-Adrenoceptor Antagonist on the Disposition of Intravenous Dexmedetomidine in Dogs
      Juhana Honkavaara, Flavia Restitutti, Marja Raekallio, Kati Salla, Erja Kuusela, Ville Ranta-Panula, Valtteri Rinne, Outi Vainio and Mika Scheinin
      Drug Metabolism and Disposition March 2012, 40 (3) 445-449; DOI: https://doi.org/10.1124/dmd.111.042671

  6. Ripp, Sharon L.

    1. Deuterium Isotope Effects on Drug Pharmacokinetics. I. System-Dependent Effects of Specific Deuteration with Aldehyde Oxidase Cleared Drugs
      Raman Sharma, Timothy J. Strelevitz, Hongying Gao, Alan J. Clark, Klaas Schildknegt, R. Scott Obach, Sharon L. Ripp, Douglas K. Spracklin, Larry M. Tremaine and Alfin D. N. Vaz
      Drug Metabolism and Disposition March 2012, 40 (3) 625-634; DOI: https://doi.org/10.1124/dmd.111.042770

S

  1. Salla, Kati

    1. Influence of MK-467, a Peripherally Acting α2-Adrenoceptor Antagonist on the Disposition of Intravenous Dexmedetomidine in Dogs
      Juhana Honkavaara, Flavia Restitutti, Marja Raekallio, Kati Salla, Erja Kuusela, Ville Ranta-Panula, Valtteri Rinne, Outi Vainio and Mika Scheinin
      Drug Metabolism and Disposition March 2012, 40 (3) 445-449; DOI: https://doi.org/10.1124/dmd.111.042671

  2. Sandel, Jan

    1. Investigation of Figopitant and Its Metabolites in Rat Tissue by Combining Whole-Body Autoradiography with Liquid Extraction Surface Analysis Mass Spectrometry
      Simone Schadt, Susanne Kallbach, Reinaldo Almeida and Jan Sandel
      Drug Metabolism and Disposition March 2012, 40 (3) 419-425; DOI: https://doi.org/10.1124/dmd.111.043562

  3. Sato, Kimihiko

    1. Unimolecular and Bimolecular Binding System for the Prediction of CYP2D6-Mediated Metabolism
      Kimihiko Sato and Yasushi Yamazoe
      Drug Metabolism and Disposition March 2012, 40 (3) 486-496; DOI: https://doi.org/10.1124/dmd.111.043125

  4. Schadt, Simone

    1. Investigation of Figopitant and Its Metabolites in Rat Tissue by Combining Whole-Body Autoradiography with Liquid Extraction Surface Analysis Mass Spectrometry
      Simone Schadt, Susanne Kallbach, Reinaldo Almeida and Jan Sandel
      Drug Metabolism and Disposition March 2012, 40 (3) 419-425; DOI: https://doi.org/10.1124/dmd.111.043562

  5. Scheinin, Mika

    1. Influence of MK-467, a Peripherally Acting α2-Adrenoceptor Antagonist on the Disposition of Intravenous Dexmedetomidine in Dogs
      Juhana Honkavaara, Flavia Restitutti, Marja Raekallio, Kati Salla, Erja Kuusela, Ville Ranta-Panula, Valtteri Rinne, Outi Vainio and Mika Scheinin
      Drug Metabolism and Disposition March 2012, 40 (3) 445-449; DOI: https://doi.org/10.1124/dmd.111.042671

  6. Schildknegt, Klaas

    1. Deuterium Isotope Effects on Drug Pharmacokinetics. I. System-Dependent Effects of Specific Deuteration with Aldehyde Oxidase Cleared Drugs
      Raman Sharma, Timothy J. Strelevitz, Hongying Gao, Alan J. Clark, Klaas Schildknegt, R. Scott Obach, Sharon L. Ripp, Douglas K. Spracklin, Larry M. Tremaine and Alfin D. N. Vaz
      Drug Metabolism and Disposition March 2012, 40 (3) 625-634; DOI: https://doi.org/10.1124/dmd.111.042770

  7. Shahidullah, Mohammad

    1. Expression of Organic Anion Transporter 2 in the Human Kidney and Its Potential Role in the Tubular Secretion of Guanine-Containing Antiviral Drugs
      Yaofeng Cheng, Arpine Vapurcuyan, Mohammad Shahidullah, Lauren M. Aleksunes and Ryan M. Pelis
      Drug Metabolism and Disposition March 2012, 40 (3) 617-624; DOI: https://doi.org/10.1124/dmd.111.042036

  8. Sharma, Raman

    1. Deuterium Isotope Effects on Drug Pharmacokinetics. I. System-Dependent Effects of Specific Deuteration with Aldehyde Oxidase Cleared Drugs
      Raman Sharma, Timothy J. Strelevitz, Hongying Gao, Alan J. Clark, Klaas Schildknegt, R. Scott Obach, Sharon L. Ripp, Douglas K. Spracklin, Larry M. Tremaine and Alfin D. N. Vaz
      Drug Metabolism and Disposition March 2012, 40 (3) 625-634; DOI: https://doi.org/10.1124/dmd.111.042770

  9. Shi, Wei

    1. Stereospecific Metabolism of Itraconazole by CYP3A4: Dioxolane Ring Scission of Azole Antifungals
      Chi-Chi Peng, Wei Shi, Justin D. Lutz, Kent L. Kunze, Jun O. Liu, Wendel L. Nelson and Nina Isoherranen
      Drug Metabolism and Disposition March 2012, 40 (3) 426-435; DOI: https://doi.org/10.1124/dmd.111.042739

  10. Shinagawa, Akira

    1. Evaluation of Hepatic Glutathione Transferase Mu 1 and Theta 1 Activities in Humans and Mice Using Genotype Information
      Shingo Arakawa, Kazunori Fujimoto, Ayako Kato, Seiko Endo, Aiko Fukahori, Akira Shinagawa, Thomas Fischer, Juergen Mueller and Wataru Takasaki
      Drug Metabolism and Disposition March 2012, 40 (3) 497-503; DOI: https://doi.org/10.1124/dmd.111.042911

  11. Siegmund, Werner

    1. Clarithromycin Is Absorbed by an Intestinal Uptake Mechanism That Is Sensitive to Major Inhibition by Rifampicin: Results of a Short-Term Drug Interaction Study in Foals
      Jette Peters, Karen Eggers, Stefan Oswald, Wiebke Block, Dieter Lütjohann, Marc Lämmer, Monica Venner and Werner Siegmund
      Drug Metabolism and Disposition March 2012, 40 (3) 522-528; DOI: https://doi.org/10.1124/dmd.111.042267

  12. Slominski, Andrzej T.

    1. Human Cytochrome P450scc (CYP11A1) Catalyzes Epoxide Formation with Ergosterol
      Robert C. Tuckey, Minh N. Nguyen, Jianjun Chen, Andrzej T. Slominski, Donna M. Baldisseri, Elaine W. Tieu, Jordan K. Zjawiony and Wei Li
      Drug Metabolism and Disposition March 2012, 40 (3) 436-444; DOI: https://doi.org/10.1124/dmd.111.042515

  13. Speed, Bill

    1. Pharmacokinetics, Distribution, and Metabolism of [14C]Sunitinib in Rats, Monkeys, and Humans
      Bill Speed, Hai-Zhi Bu, William F. Pool, Geoffrey W. Peng, Ellen Y. Wu, Shem Patyna, Carlo Bello and Ping Kang
      Drug Metabolism and Disposition March 2012, 40 (3) 539-555; DOI: https://doi.org/10.1124/dmd.111.042853

  14. Spracklin, Douglas K.

    1. Deuterium Isotope Effects on Drug Pharmacokinetics. I. System-Dependent Effects of Specific Deuteration with Aldehyde Oxidase Cleared Drugs
      Raman Sharma, Timothy J. Strelevitz, Hongying Gao, Alan J. Clark, Klaas Schildknegt, R. Scott Obach, Sharon L. Ripp, Douglas K. Spracklin, Larry M. Tremaine and Alfin D. N. Vaz
      Drug Metabolism and Disposition March 2012, 40 (3) 625-634; DOI: https://doi.org/10.1124/dmd.111.042770

  15. Street, Stephanie M.

    1. Molecular Mechanism of Altered Ezetimibe Disposition in Nonalcoholic Steatohepatitis
      Rhiannon N. Hardwick, Craig D. Fisher, Stephanie M. Street, Mark J. Canet and Nathan J. Cherrington
      Drug Metabolism and Disposition March 2012, 40 (3) 450-460; DOI: https://doi.org/10.1124/dmd.111.041095

  16. Strelevitz, Timothy J.

    1. Deuterium Isotope Effects on Drug Pharmacokinetics. I. System-Dependent Effects of Specific Deuteration with Aldehyde Oxidase Cleared Drugs
      Raman Sharma, Timothy J. Strelevitz, Hongying Gao, Alan J. Clark, Klaas Schildknegt, R. Scott Obach, Sharon L. Ripp, Douglas K. Spracklin, Larry M. Tremaine and Alfin D. N. Vaz
      Drug Metabolism and Disposition March 2012, 40 (3) 625-634; DOI: https://doi.org/10.1124/dmd.111.042770

  17. Sugiyama, Yuichi

    1. In Vivo Biliary Clearance Should Be Predicted by Intrinsic Biliary Clearance in Sandwich-Cultured Hepatocytes
      Masanori Nakakariya, Midori Ono, Nobuyuki Amano, Toshiya Moriwaki, Kazuya Maeda and Yuichi Sugiyama
      Drug Metabolism and Disposition March 2012, 40 (3) 602-609; DOI: https://doi.org/10.1124/dmd.111.042101

  18. Sun, Hao

    1. Excretion, Metabolism, and Pharmacokinetics of 1-(8-(2-Chlorophenyl)-9-(4-Chlorophenyl)-9H-Purin-6-yl)-4-(Ethylamino)Piperidine-4-Carboxamide, a Selective Cannabinoid Receptor Antagonist, in Healthy Male Volunteers
      Zhuang Miao, Hao Sun, Jennifer Liras and Chandra Prakash
      Drug Metabolism and Disposition March 2012, 40 (3) 568-578; DOI: https://doi.org/10.1124/dmd.111.043273

  19. Suzuki, Tomoko

    1. Changes in Expression of Drug-Metabolizing Enzymes by Single-Walled Carbon Nanotubes in Human Respiratory Tract Cells
      Kotaro Hitoshi, Miki Katoh, Tomoko Suzuki, Yoshinori Ando and Masayuki Nadai
      Drug Metabolism and Disposition March 2012, 40 (3) 579-587; DOI: https://doi.org/10.1124/dmd.111.043455

T

  1. Tahara, Harunobu

    1. Investigation of Drug-Drug Interactions Caused by Human Pregnane X Receptor-Mediated Induction of CYP3A4 and CYP2C Subfamilies in Chimeric Mice with a Humanized Liver
      Maki Hasegawa, Harunobu Tahara, Ryo Inoue, Masakazu Kakuni, Chise Tateno and Junko Ushiki
      Drug Metabolism and Disposition March 2012, 40 (3) 474-480; DOI: https://doi.org/10.1124/dmd.111.042754

  2. Takasaki, Wataru

    1. Evaluation of Hepatic Glutathione Transferase Mu 1 and Theta 1 Activities in Humans and Mice Using Genotype Information
      Shingo Arakawa, Kazunori Fujimoto, Ayako Kato, Seiko Endo, Aiko Fukahori, Akira Shinagawa, Thomas Fischer, Juergen Mueller and Wataru Takasaki
      Drug Metabolism and Disposition March 2012, 40 (3) 497-503; DOI: https://doi.org/10.1124/dmd.111.042911

  3. Tateno, Chise

    1. Investigation of Drug-Drug Interactions Caused by Human Pregnane X Receptor-Mediated Induction of CYP3A4 and CYP2C Subfamilies in Chimeric Mice with a Humanized Liver
      Maki Hasegawa, Harunobu Tahara, Ryo Inoue, Masakazu Kakuni, Chise Tateno and Junko Ushiki
      Drug Metabolism and Disposition March 2012, 40 (3) 474-480; DOI: https://doi.org/10.1124/dmd.111.042754

  4. Thomas, Paul E.

    1. Inhibition of Genistein Glucuronidation by Bisphenol A in Human and Rat Liver Microsomes
      Janis L. Coughlin, Paul E. Thomas and Brian Buckley
      Drug Metabolism and Disposition March 2012, 40 (3) 481-485; DOI: https://doi.org/10.1124/dmd.111.042366

  5. Thummel, Kenneth E.

    1. Complex Drug Interactions of the HIV Protease Inhibitors 3: Effect of Simultaneous or Staggered Dosing of Digoxin and Ritonavir, Nelfinavir, Rifampin, or Bupropion
      Brian J. Kirby, Ann C. Collier, Evan D. Kharasch, Dale Whittington, Kenneth E. Thummel and Jashvant D. Unadkat
      Drug Metabolism and Disposition March 2012, 40 (3) 610-616; DOI: https://doi.org/10.1124/dmd.111.042705

  6. Tieu, Elaine W.

    1. Human Cytochrome P450scc (CYP11A1) Catalyzes Epoxide Formation with Ergosterol
      Robert C. Tuckey, Minh N. Nguyen, Jianjun Chen, Andrzej T. Slominski, Donna M. Baldisseri, Elaine W. Tieu, Jordan K. Zjawiony and Wei Li
      Drug Metabolism and Disposition March 2012, 40 (3) 436-444; DOI: https://doi.org/10.1124/dmd.111.042515

  7. Tingle, Malcolm D.

    1. Which CYP2B6 Variants Have Functional Consequences for Cyclophosphamide Bioactivation?
      Nuala A. Helsby and Malcolm D. Tingle
      Drug Metabolism and Disposition March 2012, 40 (3) 635-637; DOI: https://doi.org/10.1124/dmd.111.043646

  8. Tremaine, Larry M.

    1. Deuterium Isotope Effects on Drug Pharmacokinetics. I. System-Dependent Effects of Specific Deuteration with Aldehyde Oxidase Cleared Drugs
      Raman Sharma, Timothy J. Strelevitz, Hongying Gao, Alan J. Clark, Klaas Schildknegt, R. Scott Obach, Sharon L. Ripp, Douglas K. Spracklin, Larry M. Tremaine and Alfin D. N. Vaz
      Drug Metabolism and Disposition March 2012, 40 (3) 625-634; DOI: https://doi.org/10.1124/dmd.111.042770

  9. Tuckey, Robert C.

    1. Human Cytochrome P450scc (CYP11A1) Catalyzes Epoxide Formation with Ergosterol
      Robert C. Tuckey, Minh N. Nguyen, Jianjun Chen, Andrzej T. Slominski, Donna M. Baldisseri, Elaine W. Tieu, Jordan K. Zjawiony and Wei Li
      Drug Metabolism and Disposition March 2012, 40 (3) 436-444; DOI: https://doi.org/10.1124/dmd.111.042515

U

  1. Unadkat, Jashvant D.

    1. Complex Drug Interactions of the HIV Protease Inhibitors 3: Effect of Simultaneous or Staggered Dosing of Digoxin and Ritonavir, Nelfinavir, Rifampin, or Bupropion
      Brian J. Kirby, Ann C. Collier, Evan D. Kharasch, Dale Whittington, Kenneth E. Thummel and Jashvant D. Unadkat
      Drug Metabolism and Disposition March 2012, 40 (3) 610-616; DOI: https://doi.org/10.1124/dmd.111.042705

  2. Ushiki, Junko

    1. Investigation of Drug-Drug Interactions Caused by Human Pregnane X Receptor-Mediated Induction of CYP3A4 and CYP2C Subfamilies in Chimeric Mice with a Humanized Liver
      Maki Hasegawa, Harunobu Tahara, Ryo Inoue, Masakazu Kakuni, Chise Tateno and Junko Ushiki
      Drug Metabolism and Disposition March 2012, 40 (3) 474-480; DOI: https://doi.org/10.1124/dmd.111.042754

V

  1. Vainio, Outi

    1. Influence of MK-467, a Peripherally Acting α2-Adrenoceptor Antagonist on the Disposition of Intravenous Dexmedetomidine in Dogs
      Juhana Honkavaara, Flavia Restitutti, Marja Raekallio, Kati Salla, Erja Kuusela, Ville Ranta-Panula, Valtteri Rinne, Outi Vainio and Mika Scheinin
      Drug Metabolism and Disposition March 2012, 40 (3) 445-449; DOI: https://doi.org/10.1124/dmd.111.042671

  2. van de Wetering, Koen

    1. Oral Availability of Cefadroxil Depends on ABCC3 and ABCC4
      Dirk R. de Waart, Koen van de Wetering, Cindy Kunne, Suzanne Duijst, Coen C. Paulusma and Ronald P. J. Oude Elferink
      Drug Metabolism and Disposition March 2012, 40 (3) 515-521; DOI: https://doi.org/10.1124/dmd.111.041731

  3. Vapurcuyan, Arpine

    1. Expression of Organic Anion Transporter 2 in the Human Kidney and Its Potential Role in the Tubular Secretion of Guanine-Containing Antiviral Drugs
      Yaofeng Cheng, Arpine Vapurcuyan, Mohammad Shahidullah, Lauren M. Aleksunes and Ryan M. Pelis
      Drug Metabolism and Disposition March 2012, 40 (3) 617-624; DOI: https://doi.org/10.1124/dmd.111.042036

  4. Vaz, Alfin D. N.

    1. Deuterium Isotope Effects on Drug Pharmacokinetics. I. System-Dependent Effects of Specific Deuteration with Aldehyde Oxidase Cleared Drugs
      Raman Sharma, Timothy J. Strelevitz, Hongying Gao, Alan J. Clark, Klaas Schildknegt, R. Scott Obach, Sharon L. Ripp, Douglas K. Spracklin, Larry M. Tremaine and Alfin D. N. Vaz
      Drug Metabolism and Disposition March 2012, 40 (3) 625-634; DOI: https://doi.org/10.1124/dmd.111.042770

  5. Venner, Monica

    1. Clarithromycin Is Absorbed by an Intestinal Uptake Mechanism That Is Sensitive to Major Inhibition by Rifampicin: Results of a Short-Term Drug Interaction Study in Foals
      Jette Peters, Karen Eggers, Stefan Oswald, Wiebke Block, Dieter Lütjohann, Marc Lämmer, Monica Venner and Werner Siegmund
      Drug Metabolism and Disposition March 2012, 40 (3) 522-528; DOI: https://doi.org/10.1124/dmd.111.042267

W

  1. Whittington, Dale

    1. Complex Drug Interactions of the HIV Protease Inhibitors 3: Effect of Simultaneous or Staggered Dosing of Digoxin and Ritonavir, Nelfinavir, Rifampin, or Bupropion
      Brian J. Kirby, Ann C. Collier, Evan D. Kharasch, Dale Whittington, Kenneth E. Thummel and Jashvant D. Unadkat
      Drug Metabolism and Disposition March 2012, 40 (3) 610-616; DOI: https://doi.org/10.1124/dmd.111.042705

  2. Wilson, D. T.

    1. Polychlorinated Biphenyl Congeners that Increase the Glucuronidation and Biliary Excretion of Thyroxine Are Distinct from the Congeners that Enhance the Serum Disappearance of Thyroxine
      L. A. Martin, D. T. Wilson, K. R. Reuhl, M. A. Gallo and C. D. Klaassen
      Drug Metabolism and Disposition March 2012, 40 (3) 588-595; DOI: https://doi.org/10.1124/dmd.111.042796

  3. Wörner, Martin

    1. The Effects of Rosuvastatin and the CYP51A1 Inhibitor LEK-935 on the Proteome of Primary Human Hepatocytes
      Martin Wörner, Katja Melchior, Katalin Monostory, Jean-Marc Pascussi, Christian G. Huber and Rita Bernhardt
      Drug Metabolism and Disposition March 2012, 40 (3) 414-418; DOI: https://doi.org/10.1124/dmd.111.040402

  4. Wu, Ellen Y.

    1. Pharmacokinetics, Distribution, and Metabolism of [14C]Sunitinib in Rats, Monkeys, and Humans
      Bill Speed, Hai-Zhi Bu, William F. Pool, Geoffrey W. Peng, Ellen Y. Wu, Shem Patyna, Carlo Bello and Ping Kang
      Drug Metabolism and Disposition March 2012, 40 (3) 539-555; DOI: https://doi.org/10.1124/dmd.111.042853

X

  1. Xie, Cen

    1. Metabolism and Pharmacokinetics of Morinidazole in Humans: Identification of Diastereoisomeric Morpholine N+-Glucuronides Catalyzed by UDP Glucuronosyltransferase 1A9
      Ruina Gao, Liang Li, Cen Xie, Xingxing Diao, Dafang Zhong and Xiaoyan Chen
      Drug Metabolism and Disposition March 2012, 40 (3) 556-567; DOI: https://doi.org/10.1124/dmd.111.042689

Y

  1. Yamazoe, Yasushi

    1. Unimolecular and Bimolecular Binding System for the Prediction of CYP2D6-Mediated Metabolism
      Kimihiko Sato and Yasushi Yamazoe
      Drug Metabolism and Disposition March 2012, 40 (3) 486-496; DOI: https://doi.org/10.1124/dmd.111.043125

  2. Yang, Ling

    1. Characterization of Hepatic and Intestinal Glucuronidation of Magnolol: Application of the Relative Activity Factor Approach to Decipher the Contributions of Multiple UDP-Glucuronosyltransferase Isoforms
      Liangliang Zhu, Guangbo Ge, Hongbo Zhang, Huixin Liu, Guiyuan He, Sicheng Liang, Yanyan Zhang, Zhongze Fang, Peipei Dong, Moshe Finel and Ling Yang
      Drug Metabolism and Disposition March 2012, 40 (3) 529-538; DOI: https://doi.org/10.1124/dmd.111.042192

Z

  1. Zhang, Hongbo

    1. Characterization of Hepatic and Intestinal Glucuronidation of Magnolol: Application of the Relative Activity Factor Approach to Decipher the Contributions of Multiple UDP-Glucuronosyltransferase Isoforms
      Liangliang Zhu, Guangbo Ge, Hongbo Zhang, Huixin Liu, Guiyuan He, Sicheng Liang, Yanyan Zhang, Zhongze Fang, Peipei Dong, Moshe Finel and Ling Yang
      Drug Metabolism and Disposition March 2012, 40 (3) 529-538; DOI: https://doi.org/10.1124/dmd.111.042192

  2. Zhang, Yanyan

    1. Characterization of Hepatic and Intestinal Glucuronidation of Magnolol: Application of the Relative Activity Factor Approach to Decipher the Contributions of Multiple UDP-Glucuronosyltransferase Isoforms
      Liangliang Zhu, Guangbo Ge, Hongbo Zhang, Huixin Liu, Guiyuan He, Sicheng Liang, Yanyan Zhang, Zhongze Fang, Peipei Dong, Moshe Finel and Ling Yang
      Drug Metabolism and Disposition March 2012, 40 (3) 529-538; DOI: https://doi.org/10.1124/dmd.111.042192

  3. Zhong, Dafang

    1. Metabolism and Pharmacokinetics of Morinidazole in Humans: Identification of Diastereoisomeric Morpholine N+-Glucuronides Catalyzed by UDP Glucuronosyltransferase 1A9
      Ruina Gao, Liang Li, Cen Xie, Xingxing Diao, Dafang Zhong and Xiaoyan Chen
      Drug Metabolism and Disposition March 2012, 40 (3) 556-567; DOI: https://doi.org/10.1124/dmd.111.042689

  4. Zhu, Liangliang

    1. Characterization of Hepatic and Intestinal Glucuronidation of Magnolol: Application of the Relative Activity Factor Approach to Decipher the Contributions of Multiple UDP-Glucuronosyltransferase Isoforms
      Liangliang Zhu, Guangbo Ge, Hongbo Zhang, Huixin Liu, Guiyuan He, Sicheng Liang, Yanyan Zhang, Zhongze Fang, Peipei Dong, Moshe Finel and Ling Yang
      Drug Metabolism and Disposition March 2012, 40 (3) 529-538; DOI: https://doi.org/10.1124/dmd.111.042192

  5. Zientek, Michael

    1. Use of a Multistaged Time-Dependent Inhibition Assay to Assess the Impact of Intestinal Metabolism on Drug-Drug Interaction Potential
      Michael Zientek and Deepak Dalvie
      Drug Metabolism and Disposition March 2012, 40 (3) 467-473; DOI: https://doi.org/10.1124/dmd.111.043257

  6. Zjawiony, Jordan K.

    1. Human Cytochrome P450scc (CYP11A1) Catalyzes Epoxide Formation with Ergosterol
      Robert C. Tuckey, Minh N. Nguyen, Jianjun Chen, Andrzej T. Slominski, Donna M. Baldisseri, Elaine W. Tieu, Jordan K. Zjawiony and Wei Li
      Drug Metabolism and Disposition March 2012, 40 (3) 436-444; DOI: https://doi.org/10.1124/dmd.111.042515
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