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Investigation of Drug-Drug Interactions Caused by Human Pregnane X Receptor-Mediated Induction of CYP3A4 and CYP2C Subfamilies in Chimeric Mice with a Humanized Liver

Maki Hasegawa, Harunobu Tahara, Ryo Inoue, Masakazu Kakuni, Chise Tateno and Junko Ushiki
Drug Metabolism and Disposition March 2012, 40 (3) 474-480; DOI: https://doi.org/10.1124/dmd.111.042754

Article Information

vol. 40 no. 3 474-480
DOI 
https://doi.org/10.1124/dmd.111.042754
PubMed 
22126990
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received September 14, 2011
  • Accepted November 29, 2011
  • Published online February 15, 2012.

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Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Maki Hasegawa,
  2. Harunobu Tahara,
  3. Ryo Inoue,
  4. Masakazu Kakuni,
  5. Chise Tateno and
  6. Junko Ushiki
  1. Kyowa Hakko Kirin Co., Ltd., Nagaizumi-cho, Sunto-gun, Shizuoka, Japan (M.H., H.T., J.U.); and PhoenixBio, Co., Ltd., Higashihiroshima-shi, Hiroshima, Japan (R.I., M.K., C.T.)
  1. Address correspondence to:
    Dr. Maki Hasegawa, Kyowa Hakko Kirin Co., Ltd., 1188 Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8731, Japan. E-mail: maki.hasegawa{at}kyowa-kirin.co.jp
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INDUCTION OF CYP3A4 AND CYP2C SUBFAMILIES IN PXB MICE

Maki Hasegawa, Harunobu Tahara, Ryo Inoue, Masakazu Kakuni, Chise Tateno and Junko Ushiki
Drug Metabolism and Disposition March 1, 2012, 40 (3) 474-480; DOI: https://doi.org/10.1124/dmd.111.042754
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