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Drug Metabolism & Disposition

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Table of Contents

April 01, 2012; Volume 40,Issue 4

Short Communications

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    CYP3A5 Genotype-Phenotype Analysis in the Human Kidney Reveals a Strong Site-Specific Expression of CYP3A5 in the Proximal Tubule in Carriers of the CYP3A5*1 Allele
    Juliane Bolbrinker, Stefanie Seeberg, Martin Schostak, Carsten Kempkensteffen, Hans Baelde, Emile de Heer and Reinhold Kreutz
    Drug Metabolism and Disposition April 2012, 40 (4) 639-641; DOI: https://doi.org/10.1124/dmd.111.042648
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    Respective Roles of CYP2A5 and CYP2F2 in the Bioactivation of 3-Methylindole in Mouse Olfactory Mucosa and Lung: Studies Using Cyp2a5-Null and Cyp2f2-Null Mouse Models
    Xin Zhou, Jaime D'Agostino, Lei Li, Chad D. Moore, Garold S. Yost and Xinxin Ding
    Drug Metabolism and Disposition April 2012, 40 (4) 642-647; DOI: https://doi.org/10.1124/dmd.111.044081

Articles

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    Differences in the Pharmacokinetics of 4-Amino-3-Chlorophenyl Hydrogen Sulfate, a Metabolite of Resatorvid, in Rats and Dogs
    Fumihiro Jinno, Toshiyuki Takeuchi, Yoshihiko Tagawa, Takahiro Kondo, Tomoo Itoh and Satoru Asahi
    Drug Metabolism and Disposition April 2012, 40 (4) 648-654; DOI: https://doi.org/10.1124/dmd.111.043729
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    Cyclosporine A- and Tacrolimus-Mediated Inhibition of CYP3A4 and CYP3A5 In Vitro
    Rune Amundsen, Anders Åsberg, Ingrid Kristine Ohm and Hege Christensen
    Drug Metabolism and Disposition April 2012, 40 (4) 655-661; DOI: https://doi.org/10.1124/dmd.111.043018
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    Unique Metabolic Pathway of [14C]Lenvatinib after Oral Administration to Male Cynomolgus Monkey
    Kazuko Inoue, Naoki Asai, Hitoshi Mizuo, Katsuyuki Fukuda, Kazutomi Kusano and Tsutomu Yoshimura
    Drug Metabolism and Disposition April 2012, 40 (4) 662-670; DOI: https://doi.org/10.1124/dmd.111.043281
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    Species Differences in Tissue Distribution and Enzyme Activities of Arylacetamide Deacetylase in Human, Rat, and Mouse
    Yuki Kobayashi, Tatsuki Fukami, Akinori Nakajima, Akinobu Watanabe, Miki Nakajima and Tsuyoshi Yokoi
    Drug Metabolism and Disposition April 2012, 40 (4) 671-679; DOI: https://doi.org/10.1124/dmd.111.043067
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    In Vitro Metabolism of BIIB021, an Inhibitor of Heat Shock Protein 90, in Liver Microsomes and Hepatocytes of Rats, Dogs, and Humans and Recombinant Human Cytochrome P450 Isoforms
    Lin Xu, Caroline Woodward, Samina Khan and Chandra Prakash
    Drug Metabolism and Disposition April 2012, 40 (4) 680-693; DOI: https://doi.org/10.1124/dmd.111.043000
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    Gene Expression Profiling of Systems Involved in the Metabolism and the Disposition of Xenobiotics: Comparison between Human Intestinal Biopsy Samples and Colon Cell Lines
    Joanna Bourgine, Ingrid Billaut-Laden, Mélanie Happillon, Jean-Marc Lo-Guidice, Vincent Maunoury, Michel Imbenotte and Franck Broly
    Drug Metabolism and Disposition April 2012, 40 (4) 694-705; DOI: https://doi.org/10.1124/dmd.111.042465
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    Predictions of Cytochrome P450-Mediated Drug-Drug Interactions Using Cryopreserved Human Hepatocytes: Comparison of Plasma and Protein-Free Media Incubation Conditions
    Jialin Mao, Michael A. Mohutsky, John P. Harrelson, Steven A. Wrighton and Stephen D. Hall
    Drug Metabolism and Disposition April 2012, 40 (4) 706-716; DOI: https://doi.org/10.1124/dmd.111.043158
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    Effects of the CYP2B6*6 Allele on Catalytic Properties and Inhibition of CYP2B6 In Vitro: Implication for the Mechanism of Reduced Efavirenz Metabolism and Other CYP2B6 Substrates In Vivo
    Cong Xu, Evan T. Ogburn, Yingying Guo and Zeruesenay Desta
    Drug Metabolism and Disposition April 2012, 40 (4) 717-725; DOI: https://doi.org/10.1124/dmd.111.042416
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    In Silico and In Vitro Identification of MicroRNAs That Regulate Hepatic Nuclear Factor 4α Expression
    Anuradha Ramamoorthy, Lang Li, Andrea Gaedigk, L. DiAnne Bradford, Eric A. Benson, David A. Flockhart and Todd C. Skaar
    Drug Metabolism and Disposition April 2012, 40 (4) 726-733; DOI: https://doi.org/10.1124/dmd.111.040329
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    Glucuronidation of Edaravone by Human Liver and Kidney Microsomes: Biphasic Kinetics and Identification of UGT1A9 as the Major UDP-Glucuronosyltransferase Isoform
    Liping Ma, Jianguo Sun, Ying Peng, Rong Zhang, Feng Shao, Xiaoling Hu, Jianping Zhu, Xiaojin Wang, Xuefang Cheng, Yinci Zhu, Ping Wan, Dong Feng, Hui Wu and Guangji Wang
    Drug Metabolism and Disposition April 2012, 40 (4) 734-741; DOI: https://doi.org/10.1124/dmd.111.043356
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    Metabolism of [6]-Shogaol in Mice and in Cancer Cells
    Huadong Chen, Lishuang Lv, Dominique Soroka, Renaud F. Warin, Tiffany A. Parks, Yuhui Hu, Yingdong Zhu, Xiaoxin Chen and Shengmin Sang
    Drug Metabolism and Disposition April 2012, 40 (4) 742-753; DOI: https://doi.org/10.1124/dmd.111.043331
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    Altered Human CYP3A4 Activity Caused by Antley-Bixler Syndrome-Related Variants of NADPH-Cytochrome P450 Oxidoreductase Measured in a Robust In Vitro System
    Daniela Moutinho, Christopher C. Marohnic, Satya P. Panda, José Rueff, Bettie Sue Masters and Michel Kranendonk
    Drug Metabolism and Disposition April 2012, 40 (4) 754-760; DOI: https://doi.org/10.1124/dmd.111.042820
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    Identification of Human Cytochrome P450 and Flavin-Containing Monooxygenase Enzymes Involved in the Metabolism of Lorcaserin, a Novel Selective Human 5-Hydroxytryptamine 2C Agonist
    Khawja A. Usmani, Weichao G. Chen and Abu J.M. Sadeque
    Drug Metabolism and Disposition April 2012, 40 (4) 761-771; DOI: https://doi.org/10.1124/dmd.111.043414
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    Identification of Human UDP-Glucuronosyltransferases Involved in N-Carbamoyl Glucuronidation of Lorcaserin
    Abu J. M. Sadeque, Khawja A. Usmani, Safet Palamar, Matthew A. Cerny and Weichao G. Chen
    Drug Metabolism and Disposition April 2012, 40 (4) 772-778; DOI: https://doi.org/10.1124/dmd.111.043448
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    Cerebrospinal Fluid Can Be Used as a Surrogate to Assess Brain Exposures of Breast Cancer Resistance Protein and P-Glycoprotein Substrates
    Guangqing Xiao, Cheryl Black, Gregg Hetu, Eric Sands, Joy Wang, Robin Caputo, Ellen Rohde and Liang-Shang L. Gan
    Drug Metabolism and Disposition April 2012, 40 (4) 779-787; DOI: https://doi.org/10.1124/dmd.111.043703
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    Carbonyl Reduction of Mequindox by Chicken and Porcine Cytosol and Cloned Carbonyl Reductase 1
    Xianqing Tang, Peiqiang Mu, Jun Wu, Jun Jiang, Caihui Zhang, Ming Zheng and Yiqun Deng
    Drug Metabolism and Disposition April 2012, 40 (4) 788-795; DOI: https://doi.org/10.1124/dmd.111.043547
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    Cytochrome P450 Dysregulations in Thioacetamide-Induced Liver Cirrhosis in Rats and the Counteracting Effects of Hepatoprotective Agents
    Yuan Xie, Guangji Wang, Hong Wang, Xilin Yao, Shan Jiang, An Kang, Fang Zhou, Tong Xie and Haiping Hao
    Drug Metabolism and Disposition April 2012, 40 (4) 796-802; DOI: https://doi.org/10.1124/dmd.111.043539
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    Biotransformation of the Antiretroviral Drug Etravirine: Metabolite Identification, Reaction Phenotyping, and Characterization of Autoinduction of Cytochrome P450-Dependent Metabolism
    Lindsay J. Yanakakis and Namandjé N. Bumpus
    Drug Metabolism and Disposition April 2012, 40 (4) 803-814; DOI: https://doi.org/10.1124/dmd.111.044404
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    Absorption, Metabolism and Excretion of [14C]Mirabegron (YM178), a Potent and Selective β3-Adrenoceptor Agonist, after Oral Administration to Healthy Male Volunteers
    Shin Takusagawa, Jan Jaap van Lier, Katsuhiro Suzuki, Masanori Nagata, John Meijer, Walter Krauwinkel, Marloes Schaddelee, Mitsuhiro Sekiguchi, Aiji Miyashita, Takafumi Iwatsubo, Marcel van Gelderen and Takashi Usui
    Drug Metabolism and Disposition April 2012, 40 (4) 815-824; DOI: https://doi.org/10.1124/dmd.111.043588
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    Characterization of In Vitro Glucuronidation Clearance of a Range of Drugs in Human Kidney Microsomes: Comparison with Liver and Intestinal Glucuronidation and Impact of Albumin
    Katherine L. Gill, J. Brian Houston and Aleksandra Galetin
    Drug Metabolism and Disposition April 2012, 40 (4) 825-835; DOI: https://doi.org/10.1124/dmd.111.043984
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    Development of an In Vitro System with Human Liver Microsomes for Phenotyping of CYP2C9 Genetic Polymorphisms with a Mechanism-Based Inactivator
    Darcy R. Flora and Timothy S. Tracy
    Drug Metabolism and Disposition April 2012, 40 (4) 836-842; DOI: https://doi.org/10.1124/dmd.111.043372
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In this issue

Drug Metabolism and Disposition: 40 (4)
Drug Metabolism and Disposition
Vol. 40, Issue 4
1 Apr 2012
  • Table of Contents
  • Table of Contents (PDF)
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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