Table of Contents

Articles

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  Differences in the Pharmacokinetics of 4-Amino-3-Chlorophenyl Hydrogen Sulfate, a Metabolite of Resatorvid, in Rats and Dogs

  Fumihiro Jinno, Toshiyuki Takeuchi, Yoshihiko Tagawa, Takahiro Kondo, Tomoo Itoh and Satoru Asahi

  Drug Metabolism and Disposition April 2012, 40 (4) 648-654; DOI: https://doi.org/10.1124/dmd.111.043729
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  Cyclosporine A- and Tacrolimus-Mediated Inhibition of CYP3A4 and CYP3A5 In Vitro

  Rune Amundsen, Anders Åsberg, Ingrid Kristine Ohm and Hege Christensen

  Drug Metabolism and Disposition April 2012, 40 (4) 655-661; DOI: https://doi.org/10.1124/dmd.111.043018
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  Unique Metabolic Pathway of [¹⁴C]Lenvatinib after Oral Administration to Male Cynomolgus Monkey

  Kazuko Inoue, Naoki Asai, Hitoshi Mizuo, Katsuyuki Fukuda, Kazutomi Kusano and Tsutomu Yoshimura

  Drug Metabolism and Disposition April 2012, 40 (4) 662-670; DOI: https://doi.org/10.1124/dmd.111.043281
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  Species Differences in Tissue Distribution and Enzyme Activities of Arylacetamide Deacetylase in Human, Rat, and Mouse

  Yuki Kobayashi, Tatsuki Fukami, Akinori Nakajima, Akinobu Watanabe, Miki Nakajima and Tsuyoshi Yokoi

  Drug Metabolism and Disposition April 2012, 40 (4) 671-679; DOI: https://doi.org/10.1124/dmd.111.043067
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  In Vitro Metabolism of BIIB021, an Inhibitor of Heat Shock Protein 90, in Liver Microsomes and Hepatocytes of Rats, Dogs, and Humans and Recombinant Human Cytochrome P450 Isoforms

  Lin Xu, Caroline Woodward, Samina Khan and Chandra Prakash

  Drug Metabolism and Disposition April 2012, 40 (4) 680-693; DOI: https://doi.org/10.1124/dmd.111.043000
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  Gene Expression Profiling of Systems Involved in the Metabolism and the Disposition of Xenobiotics: Comparison between Human Intestinal Biopsy Samples and Colon Cell Lines

  Joanna Bourgine, Ingrid Billaut-Laden, Mélanie Happillon, Jean-Marc Lo-Guidice, Vincent Maunoury, Michel Imbenotte and Franck Broly

  Drug Metabolism and Disposition April 2012, 40 (4) 694-705; DOI: https://doi.org/10.1124/dmd.111.042465
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  Predictions of Cytochrome P450-Mediated Drug-Drug Interactions Using Cryopreserved Human Hepatocytes: Comparison of Plasma and Protein-Free Media Incubation Conditions

  Jialin Mao, Michael A. Mohutsky, John P. Harrelson, Steven A. Wrighton and Stephen D. Hall

  Drug Metabolism and Disposition April 2012, 40 (4) 706-716; DOI: https://doi.org/10.1124/dmd.111.043158
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  Effects of the CYP2B6*6 Allele on Catalytic Properties and Inhibition of CYP2B6 In Vitro: Implication for the Mechanism of Reduced Efavirenz Metabolism and Other CYP2B6 Substrates In Vivo

  Cong Xu, Evan T. Ogburn, Yingying Guo and Zeruesenay Desta

  Drug Metabolism and Disposition April 2012, 40 (4) 717-725; DOI: https://doi.org/10.1124/dmd.111.042416
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  In Silico and In Vitro Identification of MicroRNAs That Regulate Hepatic Nuclear Factor 4α Expression

  Anuradha Ramamoorthy, Lang Li, Andrea Gaedigk, L. DiAnne Bradford, Eric A. Benson, David A. Flockhart and Todd C. Skaar

  Drug Metabolism and Disposition April 2012, 40 (4) 726-733; DOI: https://doi.org/10.1124/dmd.111.040329
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  Glucuronidation of Edaravone by Human Liver and Kidney Microsomes: Biphasic Kinetics and Identification of UGT1A9 as the Major UDP-Glucuronosyltransferase Isoform

  Liping Ma, Jianguo Sun, Ying Peng, Rong Zhang, Feng Shao, Xiaoling Hu, Jianping Zhu, Xiaojin Wang, Xuefang Cheng, Yinci Zhu, Ping Wan, Dong Feng, Hui Wu and Guangji Wang

  Drug Metabolism and Disposition April 2012, 40 (4) 734-741; DOI: https://doi.org/10.1124/dmd.111.043356
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  Metabolism of [6]-Shogaol in Mice and in Cancer Cells

  Huadong Chen, Lishuang Lv, Dominique Soroka, Renaud F. Warin, Tiffany A. Parks, Yuhui Hu, Yingdong Zhu, Xiaoxin Chen and Shengmin Sang

  Drug Metabolism and Disposition April 2012, 40 (4) 742-753; DOI: https://doi.org/10.1124/dmd.111.043331
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  Altered Human CYP3A4 Activity Caused by Antley-Bixler Syndrome-Related Variants of NADPH-Cytochrome P450 Oxidoreductase Measured in a Robust In Vitro System

  Daniela Moutinho, Christopher C. Marohnic, Satya P. Panda, José Rueff, Bettie Sue Masters and Michel Kranendonk

  Drug Metabolism and Disposition April 2012, 40 (4) 754-760; DOI: https://doi.org/10.1124/dmd.111.042820
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  Identification of Human Cytochrome P450 and Flavin-Containing Monooxygenase Enzymes Involved in the Metabolism of Lorcaserin, a Novel Selective Human 5-Hydroxytryptamine 2C Agonist

  Khawja A. Usmani, Weichao G. Chen and Abu J.M. Sadeque

  Drug Metabolism and Disposition April 2012, 40 (4) 761-771; DOI: https://doi.org/10.1124/dmd.111.043414
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  Identification of Human UDP-Glucuronosyltransferases Involved in N-Carbamoyl Glucuronidation of Lorcaserin

  Abu J. M. Sadeque, Khawja A. Usmani, Safet Palamar, Matthew A. Cerny and Weichao G. Chen

  Drug Metabolism and Disposition April 2012, 40 (4) 772-778; DOI: https://doi.org/10.1124/dmd.111.043448
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  Cerebrospinal Fluid Can Be Used as a Surrogate to Assess Brain Exposures of Breast Cancer Resistance Protein and P-Glycoprotein Substrates

  Guangqing Xiao, Cheryl Black, Gregg Hetu, Eric Sands, Joy Wang, Robin Caputo, Ellen Rohde and Liang-Shang L. Gan

  Drug Metabolism and Disposition April 2012, 40 (4) 779-787; DOI: https://doi.org/10.1124/dmd.111.043703
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  Carbonyl Reduction of Mequindox by Chicken and Porcine Cytosol and Cloned Carbonyl Reductase 1

  Xianqing Tang, Peiqiang Mu, Jun Wu, Jun Jiang, Caihui Zhang, Ming Zheng and Yiqun Deng

  Drug Metabolism and Disposition April 2012, 40 (4) 788-795; DOI: https://doi.org/10.1124/dmd.111.043547
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  Cytochrome P450 Dysregulations in Thioacetamide-Induced Liver Cirrhosis in Rats and the Counteracting Effects of Hepatoprotective Agents

  Yuan Xie, Guangji Wang, Hong Wang, Xilin Yao, Shan Jiang, An Kang, Fang Zhou, Tong Xie and Haiping Hao

  Drug Metabolism and Disposition April 2012, 40 (4) 796-802; DOI: https://doi.org/10.1124/dmd.111.043539
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  Biotransformation of the Antiretroviral Drug Etravirine: Metabolite Identification, Reaction Phenotyping, and Characterization of Autoinduction of Cytochrome P450-Dependent Metabolism

  Lindsay J. Yanakakis and Namandjé N. Bumpus

  Drug Metabolism and Disposition April 2012, 40 (4) 803-814; DOI: https://doi.org/10.1124/dmd.111.044404
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  Absorption, Metabolism and Excretion of [¹⁴C]Mirabegron (YM178), a Potent and Selective β₃-Adrenoceptor Agonist, after Oral Administration to Healthy Male Volunteers

  Shin Takusagawa, Jan Jaap van Lier, Katsuhiro Suzuki, Masanori Nagata, John Meijer, Walter Krauwinkel, Marloes Schaddelee, Mitsuhiro Sekiguchi, Aiji Miyashita, Takafumi Iwatsubo, Marcel van Gelderen and Takashi Usui

  Drug Metabolism and Disposition April 2012, 40 (4) 815-824; DOI: https://doi.org/10.1124/dmd.111.043588
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  Characterization of In Vitro Glucuronidation Clearance of a Range of Drugs in Human Kidney Microsomes: Comparison with Liver and Intestinal Glucuronidation and Impact of Albumin

  Katherine L. Gill, J. Brian Houston and Aleksandra Galetin

  Drug Metabolism and Disposition April 2012, 40 (4) 825-835; DOI: https://doi.org/10.1124/dmd.111.043984
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  Development of an In Vitro System with Human Liver Microsomes for Phenotyping of CYP2C9 Genetic Polymorphisms with a Mechanism-Based Inactivator

  Darcy R. Flora and Timothy S. Tracy

  Drug Metabolism and Disposition April 2012, 40 (4) 836-842; DOI: https://doi.org/10.1124/dmd.111.043372