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In Vitro Metabolism of BIIB021, an Inhibitor of Heat Shock Protein 90, in Liver Microsomes and Hepatocytes of Rats, Dogs, and Humans and Recombinant Human Cytochrome P450 Isoforms

Lin Xu, Caroline Woodward, Samina Khan and Chandra Prakash
Drug Metabolism and Disposition April 2012, 40 (4) 680-693; DOI: https://doi.org/10.1124/dmd.111.043000

Article Information

vol. 40 no. 4 680-693
DOI 
https://doi.org/10.1124/dmd.111.043000
PubMed 
22217465
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received September 26, 2011
  • Accepted December 29, 2011
  • Published online March 15, 2012.

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Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Lin Xu,
  2. Caroline Woodward,
  3. Samina Khan and
  4. Chandra Prakash
  1. Drug Metabolism and Preclinical Safety, Biogen Idec, Cambridge, Massachusetts
  1. Address correspondence to:
    Dr. Lin Xu, Drug Metabolism and Preclinical Safety, Biogen Idec, Cambridge, MA 02142. E-mail address: lin.xu{at}biogenidec.com
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METABOLISM OF A PYRIDINYLMETHYL-9H-PURIN-2-YLAMINE ANALOG

Lin Xu, Caroline Woodward, Samina Khan and Chandra Prakash
Drug Metabolism and Disposition April 1, 2012, 40 (4) 680-693; DOI: https://doi.org/10.1124/dmd.111.043000
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