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Effects of the CYP2B6*6 Allele on Catalytic Properties and Inhibition of CYP2B6 In Vitro: Implication for the Mechanism of Reduced Efavirenz Metabolism and Other CYP2B6 Substrates In Vivo

Cong Xu, Evan T. Ogburn, Yingying Guo and Zeruesenay Desta
Drug Metabolism and Disposition April 2012, 40 (4) 717-725; DOI: https://doi.org/10.1124/dmd.111.042416

Article Information

vol. 40 no. 4 717-725
DOI 
https://doi.org/10.1124/dmd.111.042416
PubMed 
22232427
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received August 17, 2011
  • Accepted January 9, 2012
  • Published online March 15, 2012.

Article Versions

Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Cong Xu,
  2. Evan T. Ogburn1,
  3. Yingying Guo and
  4. Zeruesenay Desta
  1. Indiana University School of Medicine, Indianapolis, Indiana (C.X., E.T.O., Z.D.); and Drug Disposition Laboratories and Business Operations, Lilly Research Laboratories, Indianapolis, Indiana (Y.G.)
  1. Address correspondence to:
    Dr. Zeruesenay Desta, Associate Professor of Medicine, Pharmacology and Toxicology, Department of Medicine/Division of Clinical Pharmacology, Indiana University School of Medicine, 1001 West 10th Street, WD Myers Bldg., W7123, Indianapolis, IN 46202. E-mail: zdesta{at}iupui.edu

  • ↵1 Current affiliation: SSCI, West Lafayette, Indiana.

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CATALYTIC PROPERTIES OF THE CYP2B6*6 ALLELE

Cong Xu, Evan T. Ogburn, Yingying Guo and Zeruesenay Desta
Drug Metabolism and Disposition April 1, 2012, 40 (4) 717-725; DOI: https://doi.org/10.1124/dmd.111.042416
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