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Research ArticleArticle

Identification of Human Cytochrome P450 and Flavin-Containing Monooxygenase Enzymes Involved in the Metabolism of Lorcaserin, a Novel Selective Human 5-Hydroxytryptamine 2C Agonist

Khawja A. Usmani, Weichao G. Chen and Abu J.M. Sadeque
Drug Metabolism and Disposition April 2012, 40 (4) 761-771; DOI: https://doi.org/10.1124/dmd.111.043414
Khawja A. Usmani
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Weichao G. Chen
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Abu J.M. Sadeque
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Article Information

vol. 40 no. 4 761-771
DOI 
https://doi.org/10.1124/dmd.111.043414
PubMed 
22266842

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received October 19, 2011
  • Accepted January 20, 2012
  • Published online March 15, 2012.

Article Versions

  • Earlier version (January 20, 2012 - 08:46).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Khawja A. Usmani,
  2. Weichao G. Chen1 and
  3. Abu J.M. Sadeque
  1. Arena Pharmaceuticals, Inc., Department of Drug Metabolism and Pharmacokinetics, San Diego, California
  1. Address correspondence to:
    Khawja A. Usmani, Arena Pharmaceuticals, Inc., 6166 Nancy Ridge Drive, San Diego, CA 92121. E-mail: kusmani{at}arenapharm.com
  1. Parts of this work were presented at the following conference: Usmani KA, Sadeque AJM, Flodin F, Ma M, and Chen W (2008) Identification of human liver cytochrome P450 isoforms involved in the metabolism of lorcaserin. The 15th North American International Society for the Study of Xenobiotics Meeting; 2008 Oct 12–16; San Diego, CA. International Society for the Study of Xenobiotics, Washington, DC.

  • ↵1 Current affiliation: DMPK, Vertex Pharmaceuticals, San Diego, California.

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Drug Metabolism and Disposition: 40 (4)
Drug Metabolism and Disposition
Vol. 40, Issue 4
1 Apr 2012
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Research ArticleArticle

HUMAN P450 AND FMO INVOLVED IN LORCASERIN METABOLISM

Khawja A. Usmani, Weichao G. Chen and Abu J.M. Sadeque
Drug Metabolism and Disposition April 1, 2012, 40 (4) 761-771; DOI: https://doi.org/10.1124/dmd.111.043414

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Research ArticleArticle

HUMAN P450 AND FMO INVOLVED IN LORCASERIN METABOLISM

Khawja A. Usmani, Weichao G. Chen and Abu J.M. Sadeque
Drug Metabolism and Disposition April 1, 2012, 40 (4) 761-771; DOI: https://doi.org/10.1124/dmd.111.043414
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