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Research ArticleArticle

Identification of Human UDP-Glucuronosyltransferases Involved in N-Carbamoyl Glucuronidation of Lorcaserin

Abu J. M. Sadeque, Khawja A. Usmani, Safet Palamar, Matthew A. Cerny and Weichao G. Chen
Drug Metabolism and Disposition April 2012, 40 (4) 772-778; DOI: https://doi.org/10.1124/dmd.111.043448

Article Information

vol. 40 no. 4 772-778
DOI 
https://doi.org/10.1124/dmd.111.043448
PubMed 
22259019
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received October 20, 2011
  • Accepted January 17, 2012
  • Published online March 15, 2012.

Article Versions

Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Abu J. M. Sadeque,
  2. Khawja A. Usmani,
  3. Safet Palamar1,
  4. Matthew A. Cerny2 and
  5. Weichao G. Chen3
  1. Department of Drug Metabolism and Pharmacokinetics, Arena Pharmaceuticals, Inc., San Diego, California
  1. Address correspondence to:
    Abu J. M. Sadeque, Arena Pharmaceuticals, Inc., 6166 Nancy Ridge Drive, San Diego, CA 92121. E-mail: asadeque{at}arenapharm.com

  1. Part of this work was previously presented as follows: Cerny MA, Palamar S, Chen W, and Sadeque AJM (2008) Formation of N-carbamoyl glucuronide metabolic lorcaserin. 15th ISSX North American Regional Meeting; 2008 Oct 12–16; San Diego, CA. International Society for the Study of Xenobiotics, Washington, DC.

  • ↵1 Current affiliation: Novartis Institutes for BioMedical Research East, Hanover, New Jersey.

  • ↵2 Current affiliation: Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut.

  • ↵3 Current affiliation: Vertex Pharmaceuticals, San Diego, California.

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Research ArticleArticle

HUMAN UGT INVOLVED IN LORCASERIN N-CARBAMOYL GLUCURONIDATION

Abu J. M. Sadeque, Khawja A. Usmani, Safet Palamar, Matthew A. Cerny and Weichao G. Chen
Drug Metabolism and Disposition April 1, 2012, 40 (4) 772-778; DOI: https://doi.org/10.1124/dmd.111.043448
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