Table of Contents

Articles

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  The Impact of Single Nucleotide Polymorphisms on Human Aldehyde Oxidase

  Tobias Hartmann, Mineko Terao, Enrico Garattini, Christian Teutloff, Joshua F. Alfaro, Jeffrey P. Jones and Silke Leimkühler

  Drug Metabolism and Disposition May 2012, 40 (5) 856-864; DOI: https://doi.org/10.1124/dmd.111.043828
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  Models to Predict Unbound Intracellular Drug Concentrations in the Presence of Transporters

  Ken R. Korzekwa, Swati Nagar, Jalia Tucker, Erica A. Weiskircher, Siddhartha Bhoopathy and Ismael J. Hidalgo

  Drug Metabolism and Disposition May 2012, 40 (5) 865-876; DOI: https://doi.org/10.1124/dmd.111.044289
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  Exploratory Translational Modeling Approach in Drug Development to Predict Human Brain Pharmacokinetics and Pharmacologically Relevant Clinical Doses

  W. Kielbasa and R. E. Stratford

  Drug Metabolism and Disposition May 2012, 40 (5) 877-883; DOI: https://doi.org/10.1124/dmd.111.043554
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  CYP2C9 Promoter Variable Number Tandem Repeat Polymorphism Regulates mRNA Expression in Human Livers

  Danxin Wang, Xiaochun Sun, Yan Gong, Brian E. Gawronski, Taimour Y. Langaee, Mohamed Hossam A. Shahin, Sherief I. Khalifa and Julie A. Johnson

  Drug Metabolism and Disposition May 2012, 40 (5) 884-891; DOI: https://doi.org/10.1124/dmd.111.044255
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  Using Expression Data for Quantification of Active Processes in Physiologically Based Pharmacokinetic Modeling

  Michaela Meyer, Sebastian Schneckener, Bernd Ludewig, Lars Kuepfer and Joerg Lippert

  Drug Metabolism and Disposition May 2012, 40 (5) 892-901; DOI: https://doi.org/10.1124/dmd.111.043174
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  Conclusive Identification of the Oxybutynin-Hydrolyzing Enzyme in Human Liver

  Yuichiro Sato, Aiji Miyashita, Takafumi Iwatsubo and Takashi Usui

  Drug Metabolism and Disposition May 2012, 40 (5) 902-906; DOI: https://doi.org/10.1124/dmd.111.043208
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  Cytochrome P450 3A-Mediated Microsomal Biotransformation of 1α,25-Dihydroxyvitamin D₃ in Mouse and Human Liver: Drug-Related Induction and Inhibition of Catabolism

  Subrata Deb, Mitali Pandey, Hans Adomat and Emma S. Tomlinson Guns

  Drug Metabolism and Disposition May 2012, 40 (5) 907-918; DOI: https://doi.org/10.1124/dmd.111.041681
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  Preclinical Disposition of GDC-0973 and Prospective and Retrospective Analysis of Human Dose and Efficacy Predictions

  Edna F. Choo, Marcia Belvin, Jason Boggs, Yuzhong Deng, Klaus P. Hoeflich, Justin Ly, Mark Merchant, Christine Orr, Emile Plise, Kirk Robarge, Jean F. Martini, Robert Kassees, Ron G. Aoyama, Atulkumar Ramaiya and Stuart H. Johnston

  Drug Metabolism and Disposition May 2012, 40 (5) 919-927; DOI: https://doi.org/10.1124/dmd.111.043778
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  Regiospecific and Stereospecific Triangulation of the Structures of Metabolites Formed by Sequential Metabolism at Multiple Prochiral Centers

  Robert J. Greene, John A. Davis, Raju Subramanian, Molly R. Deane, Maurice G. Emery and J. Greg Slatter

  Drug Metabolism and Disposition May 2012, 40 (5) 928-942; DOI: https://doi.org/10.1124/dmd.111.043166
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  Identifying a Selective Substrate and Inhibitor Pair for the Evaluation of CYP2J2 Activity

  Caroline A. Lee, J. P. Jones, Jonathan Katayama, Rüdiger Kaspera, Ying Jiang, Sascha Freiwald, Evan Smith, Gregory S. Walker and Rheem A. Totah

  Drug Metabolism and Disposition May 2012, 40 (5) 943-951; DOI: https://doi.org/10.1124/dmd.111.043505
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  Lymphatic Transport and Catabolism of Therapeutic Proteins after Subcutaneous Administration to Rats and Dogs

  Weirong Wang, Nancy Chen, Xiaolan Shen, Paul Cunningham, Scott Fauty, Kimberly Michel, Bo Wang, Xuening Hong, Christine Adreani, Christian N. Nunes, Chris V. Johnson, Kuo-chang Yin, Michelle Groff, Yan Zou, Liming Liu, Lora Hamuro and Thomayant Prueksaritanont

  Drug Metabolism and Disposition May 2012, 40 (5) 952-962; DOI: https://doi.org/10.1124/dmd.111.043604
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  Use of the Cassette-Dosing Approach to Assess Brain Penetration in Drug Discovery

  Xingrong Liu, Xiao Ding, Gauri Deshmukh, Bianca M. Liederer and Cornelis E. C. A. Hop

  Drug Metabolism and Disposition May 2012, 40 (5) 963-969; DOI: https://doi.org/10.1124/dmd.111.044420
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  Metabolism, Pharmacokinetics, Tissue Distribution, and Stability Studies of the Prodrug Analog of an Anti-Hepatitis B Virus Dinucleoside Phosphorothioate

  John E. Coughlin, Rajendra K. Pandey, Seetharamaiyer Padmanabhan, Kathleen G. O'Loughlin, Judith Marquis, Carol E. Green, Jon C. Mirsalis and Radhakrishnan P. Iyer

  Drug Metabolism and Disposition May 2012, 40 (5) 970-981; DOI: https://doi.org/10.1124/dmd.111.044446
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  Effect of Albumin on Human Liver Microsomal and Recombinant CYP1A2 Activities: Impact on In Vitro-In Vivo Extrapolation of Drug Clearance

  Nitsupa Wattanachai, Wichittra Tassaneeyakul, Andrew Rowland, David J. Elliot, Kushari Bowalgaha, Kathleen M. Knights and John O. Miners

  Drug Metabolism and Disposition May 2012, 40 (5) 982-989; DOI: https://doi.org/10.1124/dmd.111.044057
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  Target-Mediated Pharmacokinetic and Pharmacodynamic Model of Exendin-4 in Rats, Monkeys, and Humans

  Wei Gao and William J. Jusko

  Drug Metabolism and Disposition May 2012, 40 (5) 990-997; DOI: https://doi.org/10.1124/dmd.111.042291
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  Identification of the Residue in Human CYP3A4 That Is Covalently Modified by Bergamottin and the Reactive Intermediate That Contributes to the Grapefruit Juice Effect

  Hsia-lien Lin, Cesar Kenaan and Paul F. Hollenberg

  Drug Metabolism and Disposition May 2012, 40 (5) 998-1006; DOI: https://doi.org/10.1124/dmd.112.044560
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  Mechanistic Pharmacokinetic Modeling for the Prediction of Transporter-Mediated Disposition in Humans from Sandwich Culture Human Hepatocyte Data

  Hannah M. Jones, Hugh A. Barton, Yurong Lai, Yi-an Bi, Emi Kimoto, Sarah Kempshall, Sonya C. Tate, Ayman El-Kattan, J. Brian Houston, Aleksandra Galetin and Katherine S. Fenner

  Drug Metabolism and Disposition May 2012, 40 (5) 1007-1017; DOI: https://doi.org/10.1124/dmd.111.042994
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  Stereoselective Interaction of Pantoprazole with ABCG2. I. Drug Accumulation in Rat Milk

  Lipeng Wang and Patrick J. McNamara

  Drug Metabolism and Disposition May 2012, 40 (5) 1018-1023; DOI: https://doi.org/10.1124/dmd.111.041608
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  Stereoselective Interaction of Pantoprazole with ABCG2. II. In Vitro Flux Analysis

  Lipeng Wang, Markos Leggas, Philip E. Empey and Patrick J. McNamara

  Drug Metabolism and Disposition May 2012, 40 (5) 1024-1031; DOI: https://doi.org/10.1124/dmd.111.041616
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  p-Anilinoaniline Enhancement of Dioxin-Induced CYP1A1 Transcription and Aryl Hydrocarbon Receptor Occupancy of CYP1A1 Promoter: Role of the Cell Cycle

  Althea Elliott, Aby Joiakim, Patricia A. Mathieu, Zofia Duniec-Dmuchowski, Thomas A. Kocarek and John J. Reiners

  Drug Metabolism and Disposition May 2012, 40 (5) 1032-1040; DOI: https://doi.org/10.1124/dmd.111.042549
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  Biocatalytic Synthesis and Structure Elucidation of Cyclized Metabolites of the Deacetylase Inhibitor Panobinostat (LBH589)

  Andreas Fredenhagen, Matthias Kittelmann, Lukas Oberer, Anton Kuhn, Jürgen Kühnöl, Thierry Délémonté, Reiner Aichholz, Ping Wang, Peter Atadja and Michael D. Shultz

  Drug Metabolism and Disposition May 2012, 40 (5) 1041-1050; DOI: https://doi.org/10.1124/dmd.111.043620
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  Optimized Assays for Human UDP-Glucuronosyltransferase (UGT) Activities: Altered Alamethicin Concentration and Utility to Screen for UGT Inhibitors

  Robert L. Walsky, Jonathan N. Bauman, Karine Bourcier, Georgina Giddens, Kimberly Lapham, Andre Negahban, Tim F. Ryder, R. Scott Obach, Ruth Hyland and Theunis C. Goosen

  Drug Metabolism and Disposition May 2012, 40 (5) 1051-1065; DOI: https://doi.org/10.1124/dmd.111.043117