Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Drug Metabolism & Disposition
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Drug Metabolism & Disposition

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit dmd on Facebook
  • Follow dmd on Twitter
  • Follow ASPET on LinkedIn

Table of Contents

May 01, 2012; Volume 40,Issue 5

Short Communications

  • You have access
    N-Isopropyl-p-iodoamphetamine Hydrochloride Is Predominantly Metabolized by CYP2C19
    Ken-ichi Fujita, Minako Sugiyama, Yuko Akiyama, Kazuhito Hioki, Munetaka Kunishima, Kodai Nishi, Masato Kobayashi, Keiichi Kawai and Yasutsuna Sasaki
    Drug Metabolism and Disposition May 2012, 40 (5) 843-846; DOI: https://doi.org/10.1124/dmd.111.043893
  • You have access
    An Investigation of the Catalytic Activity of CYP2A13*4 with Coumarin and Polymorphisms of CYP2A13 in a Chinese Han Population
    Ting Liu, Yanjun Hong, Zhaohui Li, Junyan Hong, Su Zeng, Mingyue Zheng and Shuqing Chen
    Drug Metabolism and Disposition May 2012, 40 (5) 847-851; DOI: https://doi.org/10.1124/dmd.111.044016
  • You have access
    Interindividual Variability in Hepatic Expression of the Multidrug Resistance-Associated Protein 2 (MRP2/ABCC2): Quantification by Liquid Chromatography/Tandem Mass Spectrometry
    Anand K. Deo, Bhagwat Prasad, Larissa Balogh, Yurong Lai and Jashvant D. Unadkat
    Drug Metabolism and Disposition May 2012, 40 (5) 852-855; DOI: https://doi.org/10.1124/dmd.111.043810

Articles

  • You have access
    The Impact of Single Nucleotide Polymorphisms on Human Aldehyde Oxidase
    Tobias Hartmann, Mineko Terao, Enrico Garattini, Christian Teutloff, Joshua F. Alfaro, Jeffrey P. Jones and Silke Leimkühler
    Drug Metabolism and Disposition May 2012, 40 (5) 856-864; DOI: https://doi.org/10.1124/dmd.111.043828
  • You have access
    Models to Predict Unbound Intracellular Drug Concentrations in the Presence of Transporters
    Ken R. Korzekwa, Swati Nagar, Jalia Tucker, Erica A. Weiskircher, Siddhartha Bhoopathy and Ismael J. Hidalgo
    Drug Metabolism and Disposition May 2012, 40 (5) 865-876; DOI: https://doi.org/10.1124/dmd.111.044289
  • You have access
    Exploratory Translational Modeling Approach in Drug Development to Predict Human Brain Pharmacokinetics and Pharmacologically Relevant Clinical Doses
    W. Kielbasa and R. E. Stratford
    Drug Metabolism and Disposition May 2012, 40 (5) 877-883; DOI: https://doi.org/10.1124/dmd.111.043554
  • You have access
    CYP2C9 Promoter Variable Number Tandem Repeat Polymorphism Regulates mRNA Expression in Human Livers
    Danxin Wang, Xiaochun Sun, Yan Gong, Brian E. Gawronski, Taimour Y. Langaee, Mohamed Hossam A. Shahin, Sherief I. Khalifa and Julie A. Johnson
    Drug Metabolism and Disposition May 2012, 40 (5) 884-891; DOI: https://doi.org/10.1124/dmd.111.044255
  • You have access
    Using Expression Data for Quantification of Active Processes in Physiologically Based Pharmacokinetic Modeling
    Michaela Meyer, Sebastian Schneckener, Bernd Ludewig, Lars Kuepfer and Joerg Lippert
    Drug Metabolism and Disposition May 2012, 40 (5) 892-901; DOI: https://doi.org/10.1124/dmd.111.043174
  • You have access
    Conclusive Identification of the Oxybutynin-Hydrolyzing Enzyme in Human Liver
    Yuichiro Sato, Aiji Miyashita, Takafumi Iwatsubo and Takashi Usui
    Drug Metabolism and Disposition May 2012, 40 (5) 902-906; DOI: https://doi.org/10.1124/dmd.111.043208
  • You have access
    Cytochrome P450 3A-Mediated Microsomal Biotransformation of 1α,25-Dihydroxyvitamin D3 in Mouse and Human Liver: Drug-Related Induction and Inhibition of Catabolism
    Subrata Deb, Mitali Pandey, Hans Adomat and Emma S. Tomlinson Guns
    Drug Metabolism and Disposition May 2012, 40 (5) 907-918; DOI: https://doi.org/10.1124/dmd.111.041681
  • You have access
    Preclinical Disposition of GDC-0973 and Prospective and Retrospective Analysis of Human Dose and Efficacy Predictions
    Edna F. Choo, Marcia Belvin, Jason Boggs, Yuzhong Deng, Klaus P. Hoeflich, Justin Ly, Mark Merchant, Christine Orr, Emile Plise, Kirk Robarge, Jean F. Martini, Robert Kassees, Ron G. Aoyama, Atulkumar Ramaiya and Stuart H. Johnston
    Drug Metabolism and Disposition May 2012, 40 (5) 919-927; DOI: https://doi.org/10.1124/dmd.111.043778
  • You have access
    Regiospecific and Stereospecific Triangulation of the Structures of Metabolites Formed by Sequential Metabolism at Multiple Prochiral Centers
    Robert J. Greene, John A. Davis, Raju Subramanian, Molly R. Deane, Maurice G. Emery and J. Greg Slatter
    Drug Metabolism and Disposition May 2012, 40 (5) 928-942; DOI: https://doi.org/10.1124/dmd.111.043166
  • You have access
    Identifying a Selective Substrate and Inhibitor Pair for the Evaluation of CYP2J2 Activity
    Caroline A. Lee, J. P. Jones, Jonathan Katayama, Rüdiger Kaspera, Ying Jiang, Sascha Freiwald, Evan Smith, Gregory S. Walker and Rheem A. Totah
    Drug Metabolism and Disposition May 2012, 40 (5) 943-951; DOI: https://doi.org/10.1124/dmd.111.043505
  • You have access
    Lymphatic Transport and Catabolism of Therapeutic Proteins after Subcutaneous Administration to Rats and Dogs
    Weirong Wang, Nancy Chen, Xiaolan Shen, Paul Cunningham, Scott Fauty, Kimberly Michel, Bo Wang, Xuening Hong, Christine Adreani, Christian N. Nunes, Chris V. Johnson, Kuo-chang Yin, Michelle Groff, Yan Zou, Liming Liu, Lora Hamuro and Thomayant Prueksaritanont
    Drug Metabolism and Disposition May 2012, 40 (5) 952-962; DOI: https://doi.org/10.1124/dmd.111.043604
  • You have access
    Use of the Cassette-Dosing Approach to Assess Brain Penetration in Drug Discovery
    Xingrong Liu, Xiao Ding, Gauri Deshmukh, Bianca M. Liederer and Cornelis E. C. A. Hop
    Drug Metabolism and Disposition May 2012, 40 (5) 963-969; DOI: https://doi.org/10.1124/dmd.111.044420
  • You have access
    Metabolism, Pharmacokinetics, Tissue Distribution, and Stability Studies of the Prodrug Analog of an Anti-Hepatitis B Virus Dinucleoside Phosphorothioate
    John E. Coughlin, Rajendra K. Pandey, Seetharamaiyer Padmanabhan, Kathleen G. O'Loughlin, Judith Marquis, Carol E. Green, Jon C. Mirsalis and Radhakrishnan P. Iyer
    Drug Metabolism and Disposition May 2012, 40 (5) 970-981; DOI: https://doi.org/10.1124/dmd.111.044446
  • You have access
    Effect of Albumin on Human Liver Microsomal and Recombinant CYP1A2 Activities: Impact on In Vitro-In Vivo Extrapolation of Drug Clearance
    Nitsupa Wattanachai, Wichittra Tassaneeyakul, Andrew Rowland, David J. Elliot, Kushari Bowalgaha, Kathleen M. Knights and John O. Miners
    Drug Metabolism and Disposition May 2012, 40 (5) 982-989; DOI: https://doi.org/10.1124/dmd.111.044057
  • You have access
    Target-Mediated Pharmacokinetic and Pharmacodynamic Model of Exendin-4 in Rats, Monkeys, and Humans
    Wei Gao and William J. Jusko
    Drug Metabolism and Disposition May 2012, 40 (5) 990-997; DOI: https://doi.org/10.1124/dmd.111.042291
  • You have access
    Identification of the Residue in Human CYP3A4 That Is Covalently Modified by Bergamottin and the Reactive Intermediate That Contributes to the Grapefruit Juice Effect
    Hsia-lien Lin, Cesar Kenaan and Paul F. Hollenberg
    Drug Metabolism and Disposition May 2012, 40 (5) 998-1006; DOI: https://doi.org/10.1124/dmd.112.044560
  • You have access
    Mechanistic Pharmacokinetic Modeling for the Prediction of Transporter-Mediated Disposition in Humans from Sandwich Culture Human Hepatocyte Data
    Hannah M. Jones, Hugh A. Barton, Yurong Lai, Yi-an Bi, Emi Kimoto, Sarah Kempshall, Sonya C. Tate, Ayman El-Kattan, J. Brian Houston, Aleksandra Galetin and Katherine S. Fenner
    Drug Metabolism and Disposition May 2012, 40 (5) 1007-1017; DOI: https://doi.org/10.1124/dmd.111.042994
  • You have access
    Stereoselective Interaction of Pantoprazole with ABCG2. I. Drug Accumulation in Rat Milk
    Lipeng Wang and Patrick J. McNamara
    Drug Metabolism and Disposition May 2012, 40 (5) 1018-1023; DOI: https://doi.org/10.1124/dmd.111.041608
  • You have access
    Stereoselective Interaction of Pantoprazole with ABCG2. II. In Vitro Flux Analysis
    Lipeng Wang, Markos Leggas, Philip E. Empey and Patrick J. McNamara
    Drug Metabolism and Disposition May 2012, 40 (5) 1024-1031; DOI: https://doi.org/10.1124/dmd.111.041616
  • You have access
    p-Anilinoaniline Enhancement of Dioxin-Induced CYP1A1 Transcription and Aryl Hydrocarbon Receptor Occupancy of CYP1A1 Promoter: Role of the Cell Cycle
    Althea Elliott, Aby Joiakim, Patricia A. Mathieu, Zofia Duniec-Dmuchowski, Thomas A. Kocarek and John J. Reiners
    Drug Metabolism and Disposition May 2012, 40 (5) 1032-1040; DOI: https://doi.org/10.1124/dmd.111.042549
  • You have access
    Biocatalytic Synthesis and Structure Elucidation of Cyclized Metabolites of the Deacetylase Inhibitor Panobinostat (LBH589)
    Andreas Fredenhagen, Matthias Kittelmann, Lukas Oberer, Anton Kuhn, Jürgen Kühnöl, Thierry Délémonté, Reiner Aichholz, Ping Wang, Peter Atadja and Michael D. Shultz
    Drug Metabolism and Disposition May 2012, 40 (5) 1041-1050; DOI: https://doi.org/10.1124/dmd.111.043620
  • You have access
    Optimized Assays for Human UDP-Glucuronosyltransferase (UGT) Activities: Altered Alamethicin Concentration and Utility to Screen for UGT Inhibitors
    Robert L. Walsky, Jonathan N. Bauman, Karine Bourcier, Georgina Giddens, Kimberly Lapham, Andre Negahban, Tim F. Ryder, R. Scott Obach, Ruth Hyland and Theunis C. Goosen
    Drug Metabolism and Disposition May 2012, 40 (5) 1051-1065; DOI: https://doi.org/10.1124/dmd.111.043117
Back to top
PreviousNext

In this issue

Drug Metabolism and Disposition: 40 (5)
Drug Metabolism and Disposition
Vol. 40, Issue 5
1 May 2012
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Sign up for alerts

Jump to

  • Short Communications
  • Articles
  • Most Read
Loading
  • Predictable Cross-Species Translation of GalNAc-Conjugated siRNA
  • Cannabinoid Metabolites as CYP450 Inhibitors
  • ADME of Therapeutic Proteins
  • PK and Biodistribution of Therapeutic Proteins
  • An IQ Perspective of Therapeutic Protein Biotransformation
More...
Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About DMD
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-009X (Online)

Copyright © 2022 by the American Society for Pharmacology and Experimental Therapeutics