Mechanistic Pharmacokinetic Modeling for the Prediction of Transporter-Mediated Disposition in Humans from Sandwich Culture Human Hepatocyte Data

Pfizer Worldwide R&D, Department of Pharmacokinetics, Dynamics and Metabolism, Sandwich, Kent, United Kingdom (H.M.J., S.K., K.S.F.); Pfizer Worldwide R&D, Department of Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut (H.A.B., Y.L., Y.B., E.K., A.E.-K.); and Centre for Applied Pharmacokinetic Research, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom (S.C.T., J.B.H., A.G.)

Address correspondence to:
Dr. Hannah M. Jones, Pfizer Worldwide R&D, Department of Pharmacokinetics, Dynamics and Metabolism, 35 Cambridgepark Dr., Cambridge, MA 02140. E-mail: hannah.jones{at}pfizer.com

↵¹ Current affiliation: Pfizer Worldwide R&D, Department of Pharmacokinetics, Dynamics and Metabolism, Cambridge, Massachusetts.

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