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Drug Metabolism & Disposition

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Table of Contents

June 01, 2012; Volume 40,Issue 6

Perspective

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    Immune-Mediated Agranulocytosis Caused by the Cocaine Adulterant Levamisole: A Case for Reactive Metabolite(s) Involvement
    Angela Wolford, Thomas S. McDonald, Heather Eng, Steven Hansel, Yue Chen, Jonathan Bauman, Raman Sharma and Amit S. Kalgutkar
    Drug Metabolism and Disposition June 2012, 40 (6) 1067-1075; DOI: https://doi.org/10.1124/dmd.112.045021

Short Communications

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    Transport of the Coumarin Metabolite 7-Hydroxycoumarin Glucuronide Is Mediated via Multidrug Resistance-Associated Proteins 3 and 4
    Hanneke G. M. Wittgen, Jeroen J. M. W. van den Heuvel, Petra H. H. van den Broek, Sanna Siissalo, Geny M. M. Groothuis, Inge A. M. de Graaf, Jan B. Koenderink and Frans G. M. Russel
    Drug Metabolism and Disposition June 2012, 40 (6) 1076-1079; DOI: https://doi.org/10.1124/dmd.111.044438
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    Contributions of Arylacetamide Deacetylase and Carboxylesterase 2 to Flutamide Hydrolysis in Human Liver
    Yuki Kobayashi, Tatsuki Fukami, Mai Shimizu, Miki Nakajima and Tsuyoshi Yokoi
    Drug Metabolism and Disposition June 2012, 40 (6) 1080-1084; DOI: https://doi.org/10.1124/dmd.112.044537

Articles

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    In Vitro Evaluation of Hepatic Transporter-Mediated Clinical Drug-Drug Interactions: Hepatocyte Model Optimization and Retrospective Investigation
    Yi-an Bi, Emi Kimoto, Samantha Sevidal, Hannah M. Jones, Hugh A. Barton, Sarah Kempshall, Kevin M. Whalen, Hui Zhang, Chengjie Ji, Katherine S. Fenner, Ayman F. El-Kattan and Yurong Lai
    Drug Metabolism and Disposition June 2012, 40 (6) 1085-1092; DOI: https://doi.org/10.1124/dmd.111.043489
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    In Vitro and In Vivo Metabolism and Pharmacokinetics of BMS-562086, a Potent and Orally Bioavailable Corticotropin-Releasing Factor-1 Receptor Antagonist
    Lian Zhou, Randy C. Dockens, Peggy Liu-Kreyche, Scott J. Grossman and Ramaswamy A. Iyer
    Drug Metabolism and Disposition June 2012, 40 (6) 1093-1103; DOI: https://doi.org/10.1124/dmd.111.043596
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    Combined Contributions of Impaired Hepatic CYP2C11 and Intestinal Breast Cancer Resistance Protein Activities and Expression to Increased Oral Glibenclamide Exposure in Rats with Streptozotocin-Induced Diabetes Mellitus
    Haiyan Liu, Li Liu, Jia Li, Dan Mei, Ru Duan, Nan Hu, Haifang Guo, Zeyu Zhong and Xiaodong Liu
    Drug Metabolism and Disposition June 2012, 40 (6) 1104-1112; DOI: https://doi.org/10.1124/dmd.111.043513
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    Selective Agonism of Human Pregnane X Receptor by Individual Ginkgolides
    Aik Jiang Lau, Guixiang Yang, Chun Wei Yap and Thomas K. H. Chang
    Drug Metabolism and Disposition June 2012, 40 (6) 1113-1121; DOI: https://doi.org/10.1124/dmd.112.045013
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    Metabolic Switching of BILR 355 in the Presence of Ritonavir. I. Identifying an Unexpected Disproportionate Human Metabolite
    Yongmei Li, W. George Lai, Andrea Whitcher-Johnstone, Carl A. Busacca, Magnus C. Eriksson, Jon C. Lorenz and Donald J. Tweedie
    Drug Metabolism and Disposition June 2012, 40 (6) 1122-1129; DOI: https://doi.org/10.1124/dmd.111.044354
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    Metabolic Switching of BILR 355 in the Presence of Ritonavir. II. Uncovering Novel Contributions by Gut Bacteria and Aldehyde Oxidase
    Yongmei Li, Jun Xu, W. George Lai, Andrea Whitcher-Johnstone and Donald J. Tweedie
    Drug Metabolism and Disposition June 2012, 40 (6) 1130-1137; DOI: https://doi.org/10.1124/dmd.111.044362
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    Electrophysiological Characterization of the Polyspecific Organic Cation Transporter Plasma Membrane Monoamine Transporter
    Shiro Itagaki, Vadivel Ganapathy, Horace T. B. Ho, Mingyan Zhou, Ellappan Babu and Joanne Wang
    Drug Metabolism and Disposition June 2012, 40 (6) 1138-1143; DOI: https://doi.org/10.1124/dmd.111.042432
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    Generation and Characterization of a CYP2A13/2B6/2F1-Transgenic Mouse Model
    Yuan Wei, Hong Wu, Lei Li, Zhihua Liu, Xin Zhou, Qing-Yu Zhang, Yan Weng, Jaime D'Agostino, Guoyu Ling, Xiuling Zhang, Kerri Kluetzman, Yunyi Yao and Xinxin Ding
    Drug Metabolism and Disposition June 2012, 40 (6) 1144-1150; DOI: https://doi.org/10.1124/dmd.112.044826
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    Metabolism of a G Protein-Coupled Receptor Modulator, Including Two Major 1,2,4-Oxadiazole Ring-Opened Metabolites and a Rearranged Cysteine-Piperazine Adduct
    Chungang Gu, Charles S. Elmore, Jianrong Lin, Diansong Zhou, Rick Luzietti, Peter Dorff and Scott W. Grimm
    Drug Metabolism and Disposition June 2012, 40 (6) 1151-1163; DOI: https://doi.org/10.1124/dmd.112.044636
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    Quantitative Proteomics of Transporter Expression in Brain Capillary Endothelial Cells Isolated from P-Glycoprotein (P-gp), Breast Cancer Resistance Protein (Bcrp), and P-gp/Bcrp Knockout Mice
    Sagar Agarwal, Yasuo Uchida, Rajendar K. Mittapalli, Ramola Sane, Tetsuya Terasaki and William F. Elmquist
    Drug Metabolism and Disposition June 2012, 40 (6) 1164-1169; DOI: https://doi.org/10.1124/dmd.112.044719
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    Ablation of Both Organic Cation Transporter (Oct)1 and Oct2 Alters Metformin Pharmacokinetics but Has No Effect on Tissue Drug Exposure and Pharmacodynamics
    J. William Higgins, David W. Bedwell and Maciej J. Zamek-Gliszczynski
    Drug Metabolism and Disposition June 2012, 40 (6) 1170-1177; DOI: https://doi.org/10.1124/dmd.112.044875
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    Drug Interaction of Efavirenz and Midazolam: Efavirenz Activates the CYP3A-Mediated Midazolam 1′-Hydroxylation In Vitro
    Anja Keubler, Johanna Weiss, Walter E. Haefeli, Gerd Mikus and Jürgen Burhenne
    Drug Metabolism and Disposition June 2012, 40 (6) 1178-1182; DOI: https://doi.org/10.1124/dmd.111.043844
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    A Novel Polymorphic Allele of Human Arylacetamide Deacetylase Leads to Decreased Enzyme Activity
    Mai Shimizu, Tatsuki Fukami, Yuki Kobayashi, Masataka Takamiya, Yasuhiro Aoki, Miki Nakajima and Tsuyoshi Yokoi
    Drug Metabolism and Disposition June 2012, 40 (6) 1183-1190; DOI: https://doi.org/10.1124/dmd.112.044883
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    Transcription Factor-Mediated Regulation of Carboxylesterase Enzymes in Livers of Mice
    Youcai Zhang, Xingguo Cheng, Lauren Aleksunes and Curtis D. Klaassen
    Drug Metabolism and Disposition June 2012, 40 (6) 1191-1197; DOI: https://doi.org/10.1124/dmd.111.043877
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    RNA Sequencing Reveals Dynamic Changes of mRNA Abundance of Cytochromes P450 and Their Alternative Transcripts during Mouse Liver Development
    Lai Peng, Byunggil Yoo, Sumedha S. Gunewardena, Hong Lu, Curtis D. Klaassen and Xiao-bo Zhong
    Drug Metabolism and Disposition June 2012, 40 (6) 1198-1209; DOI: https://doi.org/10.1124/dmd.112.045088
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    Sulfation of 4-Hydroxy Toremifene: Individual Variability, Isoform Specificity, and Contribution to Toremifene Pharmacogenomics
    Vineetha Koroth Edavana, Ishwori B. Dhakal, Xinfeng Yu, Suzanne Williams and Susan Kadlubar
    Drug Metabolism and Disposition June 2012, 40 (6) 1210-1215; DOI: https://doi.org/10.1124/dmd.111.044040
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    Effects of Aging on mRNA Profiles for Drug-Metabolizing Enzymes and Transporters in Livers of Male and Female Mice
    Zidong Donna Fu, Iván L. Csanaky and Curtis D. Klaassen
    Drug Metabolism and Disposition June 2012, 40 (6) 1216-1225; DOI: https://doi.org/10.1124/dmd.111.044461
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    Ontogeny of Novel Cytochrome P450 Gene Isoforms during Postnatal Liver Maturation in Mice
    Julia Yue Cui, Helen J. Renaud and Curtis D. Klaassen
    Drug Metabolism and Disposition June 2012, 40 (6) 1226-1237; DOI: https://doi.org/10.1124/dmd.111.042697

Erratum

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    Correction to “Frequency of Undetected CYP2D6 Hybrid Genes in Clinical Samples: Impact on Phenotype Prediction”
    Drug Metabolism and Disposition June 2012, 40 (6) 1238; DOI: https://doi.org/10.1124/dmd.40.6.1238
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Drug Metabolism and Disposition: 40 (6)
Drug Metabolism and Disposition
Vol. 40, Issue 6
1 Jun 2012
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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