Table of Contents

Articles

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  In Vitro Evaluation of Hepatic Transporter-Mediated Clinical Drug-Drug Interactions: Hepatocyte Model Optimization and Retrospective Investigation

  Yi-an Bi, Emi Kimoto, Samantha Sevidal, Hannah M. Jones, Hugh A. Barton, Sarah Kempshall, Kevin M. Whalen, Hui Zhang, Chengjie Ji, Katherine S. Fenner, Ayman F. El-Kattan and Yurong Lai

  Drug Metabolism and Disposition June 2012, 40 (6) 1085-1092; DOI: https://doi.org/10.1124/dmd.111.043489
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  In Vitro and In Vivo Metabolism and Pharmacokinetics of BMS-562086, a Potent and Orally Bioavailable Corticotropin-Releasing Factor-1 Receptor Antagonist

  Lian Zhou, Randy C. Dockens, Peggy Liu-Kreyche, Scott J. Grossman and Ramaswamy A. Iyer

  Drug Metabolism and Disposition June 2012, 40 (6) 1093-1103; DOI: https://doi.org/10.1124/dmd.111.043596
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  Combined Contributions of Impaired Hepatic CYP2C11 and Intestinal Breast Cancer Resistance Protein Activities and Expression to Increased Oral Glibenclamide Exposure in Rats with Streptozotocin-Induced Diabetes Mellitus

  Haiyan Liu, Li Liu, Jia Li, Dan Mei, Ru Duan, Nan Hu, Haifang Guo, Zeyu Zhong and Xiaodong Liu

  Drug Metabolism and Disposition June 2012, 40 (6) 1104-1112; DOI: https://doi.org/10.1124/dmd.111.043513
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  Selective Agonism of Human Pregnane X Receptor by Individual Ginkgolides

  Aik Jiang Lau, Guixiang Yang, Chun Wei Yap and Thomas K. H. Chang

  Drug Metabolism and Disposition June 2012, 40 (6) 1113-1121; DOI: https://doi.org/10.1124/dmd.112.045013
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  Metabolic Switching of BILR 355 in the Presence of Ritonavir. I. Identifying an Unexpected Disproportionate Human Metabolite

  Yongmei Li, W. George Lai, Andrea Whitcher-Johnstone, Carl A. Busacca, Magnus C. Eriksson, Jon C. Lorenz and Donald J. Tweedie

  Drug Metabolism and Disposition June 2012, 40 (6) 1122-1129; DOI: https://doi.org/10.1124/dmd.111.044354
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  Metabolic Switching of BILR 355 in the Presence of Ritonavir. II. Uncovering Novel Contributions by Gut Bacteria and Aldehyde Oxidase

  Yongmei Li, Jun Xu, W. George Lai, Andrea Whitcher-Johnstone and Donald J. Tweedie

  Drug Metabolism and Disposition June 2012, 40 (6) 1130-1137; DOI: https://doi.org/10.1124/dmd.111.044362
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  Electrophysiological Characterization of the Polyspecific Organic Cation Transporter Plasma Membrane Monoamine Transporter

  Shiro Itagaki, Vadivel Ganapathy, Horace T. B. Ho, Mingyan Zhou, Ellappan Babu and Joanne Wang

  Drug Metabolism and Disposition June 2012, 40 (6) 1138-1143; DOI: https://doi.org/10.1124/dmd.111.042432
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  Generation and Characterization of a CYP2A13/2B6/2F1-Transgenic Mouse Model

  Yuan Wei, Hong Wu, Lei Li, Zhihua Liu, Xin Zhou, Qing-Yu Zhang, Yan Weng, Jaime D'Agostino, Guoyu Ling, Xiuling Zhang, Kerri Kluetzman, Yunyi Yao and Xinxin Ding

  Drug Metabolism and Disposition June 2012, 40 (6) 1144-1150; DOI: https://doi.org/10.1124/dmd.112.044826
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  Metabolism of a G Protein-Coupled Receptor Modulator, Including Two Major 1,2,4-Oxadiazole Ring-Opened Metabolites and a Rearranged Cysteine-Piperazine Adduct

  Chungang Gu, Charles S. Elmore, Jianrong Lin, Diansong Zhou, Rick Luzietti, Peter Dorff and Scott W. Grimm

  Drug Metabolism and Disposition June 2012, 40 (6) 1151-1163; DOI: https://doi.org/10.1124/dmd.112.044636
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  Quantitative Proteomics of Transporter Expression in Brain Capillary Endothelial Cells Isolated from P-Glycoprotein (P-gp), Breast Cancer Resistance Protein (Bcrp), and P-gp/Bcrp Knockout Mice

  Sagar Agarwal, Yasuo Uchida, Rajendar K. Mittapalli, Ramola Sane, Tetsuya Terasaki and William F. Elmquist

  Drug Metabolism and Disposition June 2012, 40 (6) 1164-1169; DOI: https://doi.org/10.1124/dmd.112.044719
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  Ablation of Both Organic Cation Transporter (Oct)1 and Oct2 Alters Metformin Pharmacokinetics but Has No Effect on Tissue Drug Exposure and Pharmacodynamics

  J. William Higgins, David W. Bedwell and Maciej J. Zamek-Gliszczynski

  Drug Metabolism and Disposition June 2012, 40 (6) 1170-1177; DOI: https://doi.org/10.1124/dmd.112.044875
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  Drug Interaction of Efavirenz and Midazolam: Efavirenz Activates the CYP3A-Mediated Midazolam 1′-Hydroxylation In Vitro

  Anja Keubler, Johanna Weiss, Walter E. Haefeli, Gerd Mikus and Jürgen Burhenne

  Drug Metabolism and Disposition June 2012, 40 (6) 1178-1182; DOI: https://doi.org/10.1124/dmd.111.043844
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  A Novel Polymorphic Allele of Human Arylacetamide Deacetylase Leads to Decreased Enzyme Activity

  Mai Shimizu, Tatsuki Fukami, Yuki Kobayashi, Masataka Takamiya, Yasuhiro Aoki, Miki Nakajima and Tsuyoshi Yokoi

  Drug Metabolism and Disposition June 2012, 40 (6) 1183-1190; DOI: https://doi.org/10.1124/dmd.112.044883
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  Transcription Factor-Mediated Regulation of Carboxylesterase Enzymes in Livers of Mice

  Youcai Zhang, Xingguo Cheng, Lauren Aleksunes and Curtis D. Klaassen

  Drug Metabolism and Disposition June 2012, 40 (6) 1191-1197; DOI: https://doi.org/10.1124/dmd.111.043877
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  RNA Sequencing Reveals Dynamic Changes of mRNA Abundance of Cytochromes P450 and Their Alternative Transcripts during Mouse Liver Development

  Lai Peng, Byunggil Yoo, Sumedha S. Gunewardena, Hong Lu, Curtis D. Klaassen and Xiao-bo Zhong

  Drug Metabolism and Disposition June 2012, 40 (6) 1198-1209; DOI: https://doi.org/10.1124/dmd.112.045088
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  Sulfation of 4-Hydroxy Toremifene: Individual Variability, Isoform Specificity, and Contribution to Toremifene Pharmacogenomics

  Vineetha Koroth Edavana, Ishwori B. Dhakal, Xinfeng Yu, Suzanne Williams and Susan Kadlubar

  Drug Metabolism and Disposition June 2012, 40 (6) 1210-1215; DOI: https://doi.org/10.1124/dmd.111.044040
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  Effects of Aging on mRNA Profiles for Drug-Metabolizing Enzymes and Transporters in Livers of Male and Female Mice

  Zidong Donna Fu, Iván L. Csanaky and Curtis D. Klaassen

  Drug Metabolism and Disposition June 2012, 40 (6) 1216-1225; DOI: https://doi.org/10.1124/dmd.111.044461
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  Ontogeny of Novel Cytochrome P450 Gene Isoforms during Postnatal Liver Maturation in Mice

  Julia Yue Cui, Helen J. Renaud and Curtis D. Klaassen

  Drug Metabolism and Disposition June 2012, 40 (6) 1226-1237; DOI: https://doi.org/10.1124/dmd.111.042697