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Research ArticleArticle

In Vitro Evaluation of Hepatic Transporter-Mediated Clinical Drug-Drug Interactions: Hepatocyte Model Optimization and Retrospective Investigation

Yi-an Bi, Emi Kimoto, Samantha Sevidal, Hannah M. Jones, Hugh A. Barton, Sarah Kempshall, Kevin M. Whalen, Hui Zhang, Chengjie Ji, Katherine S. Fenner, Ayman F. El-Kattan and Yurong Lai
Drug Metabolism and Disposition June 2012, 40 (6) 1085-1092; DOI: https://doi.org/10.1124/dmd.111.043489
Yi-an Bi
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Emi Kimoto
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Samantha Sevidal
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Hannah M. Jones
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Hugh A. Barton
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Sarah Kempshall
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Kevin M. Whalen
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Hui Zhang
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Chengjie Ji
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Katherine S. Fenner
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Ayman F. El-Kattan
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Yurong Lai
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Article Information

vol. 40 no. 6 1085-1092
DOI 
https://doi.org/10.1124/dmd.111.043489
PubMed 
22381335

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received October 28, 2011
  • Accepted March 1, 2012
  • Published online May 16, 2012.

Article Versions

  • Earlier version (March 1, 2012 - 08:46).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yi-an Bi,
  2. Emi Kimoto,
  3. Samantha Sevidal,
  4. Hannah M. Jones,
  5. Hugh A. Barton,
  6. Sarah Kempshall,
  7. Kevin M. Whalen,
  8. Hui Zhang,
  9. Chengjie Ji,
  10. Katherine S. Fenner,
  11. Ayman F. El-Kattan and
  12. Yurong Lai
  1. Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Pfizer, Inc., Groton, Connecticut (Y.B., E.K., H.A.B., K.M.W., H.Z., C.J., A.F.E., Y.L.); La Jolla Laboratories, La Jolla, California (S.S.); and Sandwich Laboratories, Kent, United Kingdom (H.M.J., S.K., K.S.F.)
  1. Address correspondence to:
    Dr. Yurong Lai, Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide Research and Development, Pfizer, Inc., Mailstop 8220-2475, Groton, CT 06340. E-mail: yurong.lai{at}pfizer.com
  1. Y.B. and E.K. contributed equally to this work.

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Drug Metabolism and Disposition: 40 (6)
Drug Metabolism and Disposition
Vol. 40, Issue 6
1 Jun 2012
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Research ArticleArticle

IN VITRO EVALUATION OF OATP-MEDIATED DDI

Yi-an Bi, Emi Kimoto, Samantha Sevidal, Hannah M. Jones, Hugh A. Barton, Sarah Kempshall, Kevin M. Whalen, Hui Zhang, Chengjie Ji, Katherine S. Fenner, Ayman F. El-Kattan and Yurong Lai
Drug Metabolism and Disposition June 1, 2012, 40 (6) 1085-1092; DOI: https://doi.org/10.1124/dmd.111.043489

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Research ArticleArticle

IN VITRO EVALUATION OF OATP-MEDIATED DDI

Yi-an Bi, Emi Kimoto, Samantha Sevidal, Hannah M. Jones, Hugh A. Barton, Sarah Kempshall, Kevin M. Whalen, Hui Zhang, Chengjie Ji, Katherine S. Fenner, Ayman F. El-Kattan and Yurong Lai
Drug Metabolism and Disposition June 1, 2012, 40 (6) 1085-1092; DOI: https://doi.org/10.1124/dmd.111.043489
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