Drug Metabolism and Disposition: 40 (7)

July 01, 2012; Volume 40,Issue 7

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Unusual Glucuronides
Upendra A. Argikar

Drug Metabolism and Disposition July 2012, 40 (7) 1239-1251; DOI: https://doi.org/10.1124/dmd.112.045096

Short Communications

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Effect of Glucagon-Like Peptide 2 on Hepatic, Renal, and Intestinal Disposition of 1-Chloro-2,4-dinitrobenzene
Silvina S. M. Villanueva, Virginia G. Perdomo, María L. Ruiz, Juan P. Rigalli, Agostina Arias, Marcelo G. Luquita, Mary Vore, Viviana A. Catania and Aldo D. Mottino

Drug Metabolism and Disposition July 2012, 40 (7) 1252-1258; DOI: https://doi.org/10.1124/dmd.111.044339
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Reevaluation of a Quantitative Structure Pharmacokinetic Model for Biliary Excretion in Rats
Yash A. Gandhi and Marilyn E. Morris

Drug Metabolism and Disposition July 2012, 40 (7) 1259-1262; DOI: https://doi.org/10.1124/dmd.112.044842
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In Vitro Hepatotoxicity and Cytochrome P450 Induction and Inhibition Characteristics of Carnosic Acid, a Dietary Supplement with Antiadipogenic Properties
Leslie J. Dickmann, Brooke M. VandenBrink and Yvonne S. Lin

Drug Metabolism and Disposition July 2012, 40 (7) 1263-1267; DOI: https://doi.org/10.1124/dmd.112.044909

Articles

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In Vitro Evaluation of the Interaction Potential of Irosustat with Drug-Metabolizing Enzymes
Verònica Ventura, Josep Solà, Concepción Peraire, Françoise Brée and Rosendo Obach

Drug Metabolism and Disposition July 2012, 40 (7) 1268-1278; DOI: https://doi.org/10.1124/dmd.111.044271
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A Comprehensive Assessment of Repaglinide Metabolic Pathways: Impact of Choice of In Vitro System and Relative Enzyme Contribution to In Vitro Clearance
Carolina Säll, J. Brian Houston and Aleksandra Galetin

Drug Metabolism and Disposition July 2012, 40 (7) 1279-1289; DOI: https://doi.org/10.1124/dmd.112.045286
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A Simple Liquid Chromatography-Tandem Mass Spectrometry Method to Determine Relative Plasma Exposures of Drug Metabolites across Species for Metabolite Safety Assessments (Metabolites in Safety Testing). II. Application to Unstable Metabolites
Hongying Gao and R. Scott Obach

Drug Metabolism and Disposition July 2012, 40 (7) 1290-1296; DOI: https://doi.org/10.1124/dmd.112.044552
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Metabolite Profiling of Bendamustine in Urine of Cancer Patients after Administration of [¹⁴C]Bendamustine
Anne-Charlotte Dubbelman, Robert S. Jansen, Hilde Rosing, Mona Darwish, Edward Hellriegel, Philmore Robertson, Jan H. M. Schellens and Jos H. Beijnen

Drug Metabolism and Disposition July 2012, 40 (7) 1297-1307; DOI: https://doi.org/10.1124/dmd.112.045229
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Assessment of Exposure of Metabolites in Preclinical Species and Humans at Steady State from the Single-Dose Radiolabeled Absorption, Distribution, Metabolism, and Excretion Studies: A Case Study
Chandra Prakash, Zhaoyang Li, Cesare Orlandi and Lewis Klunk

Drug Metabolism and Disposition July 2012, 40 (7) 1308-1320; DOI: https://doi.org/10.1124/dmd.112.044933
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Neonatal Development of Hepatic UGT1A9: Implications of Pediatric Pharmacokinetics
Shogo J. Miyagi, Alison M. Milne, Michael W. H. Coughtrie and Abby C. Collier

Drug Metabolism and Disposition July 2012, 40 (7) 1321-1327; DOI: https://doi.org/10.1124/dmd.111.043752
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Species-Dependent Uptake of Glycylsarcosine but Not Oseltamivir in Pichia pastoris Expressing the Rat, Mouse, and Human Intestinal Peptide Transporter PEPT1
Yongjun Hu, Xiaomei Chen and David E. Smith

Drug Metabolism and Disposition July 2012, 40 (7) 1328-1335; DOI: https://doi.org/10.1124/dmd.111.044263
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Time-Dependent Inhibition and Estimation of CYP3A Clinical Pharmacokinetic Drug-Drug Interactions Using Plated Human Cell Systems
Daniel R. Albaugh, Cody L. Fullenwider, Michael B. Fisher and J. Matthew Hutzler

Drug Metabolism and Disposition July 2012, 40 (7) 1336-1344; DOI: https://doi.org/10.1124/dmd.112.044644
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Characterization of the In Vitro and In Vivo Metabolism and Disposition and Cytochrome P450 Inhibition/Induction Profile of Saxagliptin in Human
Hong Su, David W. Boulton, Anthony Barros, Lifei Wang, Kai Cao, Samuel J. Bonacorsi, Ramaswamy A. Iyer, W. Griffith Humphreys and Lisa J. Christopher

Drug Metabolism and Disposition July 2012, 40 (7) 1345-1356; DOI: https://doi.org/10.1124/dmd.112.045450
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Identification of the Cytochrome P450 and Other Enzymes Involved in the In Vitro Oxidative Metabolism of a Novel Antidepressant, Lu AA21004
Mette G. Hvenegaard, Benny Bang-Andersen, Henrik Pedersen, Morten Jørgensen, Ask Püschl and Lars Dalgaard

Drug Metabolism and Disposition July 2012, 40 (7) 1357-1365; DOI: https://doi.org/10.1124/dmd.112.044610
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Coordinated Regulation of Hepatic Phase I and II Drug-Metabolizing Genes and Transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-Null Mice
Lauren M. Aleksunes and Curtis D. Klaassen

Drug Metabolism and Disposition July 2012, 40 (7) 1366-1379; DOI: https://doi.org/10.1124/dmd.112.045112
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Nano-Advantage in Enhanced Drug Delivery with Biodegradable Nanoparticles: Contribution of Reduced Clearance
Rajendra S. Kadam, David W. A. Bourne and Uday B. Kompella

Drug Metabolism and Disposition July 2012, 40 (7) 1380-1388; DOI: https://doi.org/10.1124/dmd.112.044925
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Simultaneous Absolute Protein Quantification of Carboxylesterases 1 and 2 in Human Liver Tissue Fractions using Liquid Chromatography-Tandem Mass Spectrometry
Yuichiro Sato, Aiji Miyashita, Takafumi Iwatsubo and Takashi Usui

Drug Metabolism and Disposition July 2012, 40 (7) 1389-1396; DOI: https://doi.org/10.1124/dmd.112.045054
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Probabilistic Orthology Analysis of the ATP-Binding Cassette Transporters: Implications for the Development of Multiple Drug Resistance Phenotype
Ciaran Fisher, Tanya Coleman and Nick Plant

Drug Metabolism and Disposition July 2012, 40 (7) 1397-1402; DOI: https://doi.org/10.1124/dmd.112.045062
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Effect of Multiple Cysteine Substitutions on the Functionality of Human Multidrug Resistance Protein 1 Expressed in Human Embryonic Kidney 293 Cells: Identification of Residues Essential for Function
Lei Qin, Shui-Pang Tam and Roger G. Deeley

Drug Metabolism and Disposition July 2012, 40 (7) 1403-1413; DOI: https://doi.org/10.1124/dmd.112.044867
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Interaction of Lapatinib with Cytochrome P450 3A5
Eric Chun Yong Chan, Lee Sun New, Teck Beng Chua, Chun Wei Yap, Han Kiat Ho and Sidney D. Nelson

Drug Metabolism and Disposition July 2012, 40 (7) 1414-1422; DOI: https://doi.org/10.1124/dmd.112.044958
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Interaction between Two Sulfate-Conjugated Uremic Toxins, p-Cresyl Sulfate and Indoxyl Sulfate, during Binding with Human Serum Albumin
Hiroshi Watanabe, Tsuyoshi Noguchi, Yohei Miyamoto, Daisuke Kadowaki, Shunsuke Kotani, Makoto Nakajima, Shigeyuki Miyamura, Yu Ishima, Masaki Otagiri and Toru Maruyama

Drug Metabolism and Disposition July 2012, 40 (7) 1423-1428; DOI: https://doi.org/10.1124/dmd.112.045617
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Sequential Metabolism of AMG 487, a Novel CXCR3 Antagonist, Results in Formation of Quinone Reactive Metabolites That Covalently Modify CYP3A4 Cys239 and Cause Time-Dependent Inhibition of the Enzyme
Kirk R. Henne, Thuy B. Tran, Brooke M. VandenBrink, Dan A. Rock, Divesh K. Aidasani, Raju Subramanian, Andrew K. Mason, David M. Stresser, Yohannes Teffera, Simon G. Wong, Michael G. Johnson, Xiaoqi Chen, George R. Tonn and Bradley K. Wong

Drug Metabolism and Disposition July 2012, 40 (7) 1429-1440; DOI: https://doi.org/10.1124/dmd.112.045708
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Hydralazine As a Selective Probe Inactivator of Aldehyde Oxidase in Human Hepatocytes: Estimation of the Contribution of Aldehyde Oxidase to Metabolic Clearance
Timothy J. Strelevitz, Christine C. Orozco and R. Scott Obach

Drug Metabolism and Disposition July 2012, 40 (7) 1441-1448; DOI: https://doi.org/10.1124/dmd.112.045195

Errata

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Correction to “A Semiphysiological Population Model for Prediction of the Pharmacokinetics of Drugs under Liver and Renal Disease Conditions”
Drug Metabolism and Disposition July 2012, 40 (7) 1449; DOI: https://doi.org/10.1124/dmd.40.7.1449
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Correction to “Pharmacokinetic Analysis of Continuous Erythropoietin Receptor Activator Disposition in Adult Sheep Using a Target-Mediated, Physiologic Recirculation Model and a Tracer Interaction Methodology”
Drug Metabolism and Disposition July 2012, 40 (7) 1450; DOI: https://doi.org/10.1124/dmd.40.7.1450
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Correction to “Glucuronidation of Polychlorinated Biphenylols and UDP-Glucuronic Acid Concentrations in Channel Catfish Liver and Intestine”
Drug Metabolism and Disposition July 2012, 40 (7) 1451; DOI: https://doi.org/10.1124/dmd.40.7.1451

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