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Assessment of Exposure of Metabolites in Preclinical Species and Humans at Steady State from the Single-Dose Radiolabeled Absorption, Distribution, Metabolism, and Excretion Studies: A Case Study

Chandra Prakash, Zhaoyang Li, Cesare Orlandi and Lewis Klunk
Drug Metabolism and Disposition July 2012, 40 (7) 1308-1320; DOI: https://doi.org/10.1124/dmd.112.044933

Article Information

vol. 40 no. 7 1308-1320
DOI 
https://doi.org/10.1124/dmd.112.044933
PubMed 
22474055
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 6, 2012
  • Accepted April 3, 2012
  • Published online June 20, 2012.

Article Versions

Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Chandra Prakash,
  2. Zhaoyang Li1,
  3. Cesare Orlandi and
  4. Lewis Klunk
  1. Department of Drug Metabolism and Preclinical Safety, Biogen Idec, Cambridge, Massachusetts (C.P., Z.L., L.K.); and Cardiokine, Inc., Philadelphia, Pennsylvania (C.O.)
  1. Address correspondence to:
    Dr. Chandra Prakash, Biogen Idec, Cambridge, MA 02142. E-mail: chandra.prakash{at}biogenidec.com

  • ↵1 Current affiliation: Genzyme, a Sanofi Company, Cambridge, Massachusetts.

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ASSESSMENT OF METABOLITE EXPOSURE AT STEADY STATE

Chandra Prakash, Zhaoyang Li, Cesare Orlandi and Lewis Klunk
Drug Metabolism and Disposition July 1, 2012, 40 (7) 1308-1320; DOI: https://doi.org/10.1124/dmd.112.044933
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