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Time-Dependent Inhibition and Estimation of CYP3A Clinical Pharmacokinetic Drug-Drug Interactions Using Plated Human Cell Systems

Daniel R. Albaugh, Cody L. Fullenwider, Michael B. Fisher and J. Matthew Hutzler
Drug Metabolism and Disposition July 2012, 40 (7) 1336-1344; DOI: https://doi.org/10.1124/dmd.112.044644

Article Information

vol. 40 no. 7 1336-1344
DOI 
https://doi.org/10.1124/dmd.112.044644
PubMed 
22490230
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received January 19, 2012
  • Accepted April 9, 2012
  • Published online June 20, 2012.

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Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Daniel R. Albaugh,
  2. Cody L. Fullenwider,
  3. Michael B. Fisher and
  4. J. Matthew Hutzler
  1. Medicinal Chemistry (Drug Metabolism and Pharmacokinetics), Boehringer-Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut (D.R.A., C.L.F., J.M.H.); and ProPharma Services, Oxford, Connecticut (M.B.F.)
  1. Address correspondence to:
    Daniel R. Albaugh, Boehringer-Ingelheim Pharmaceuticals Inc., Medicinal Chemistry (Drug Metabolism and Pharmacokinetics), 175 Briar Ridge Road, R&D 10574, Ridgefield, CT 06877. E-mail: daniel.albaugh{at}Boehringer-Ingelheim.com
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TIME-DEPENDENT INHIBITION USING PLATED HUMAN CELL SYSTEMS

Daniel R. Albaugh, Cody L. Fullenwider, Michael B. Fisher and J. Matthew Hutzler
Drug Metabolism and Disposition July 1, 2012, 40 (7) 1336-1344; DOI: https://doi.org/10.1124/dmd.112.044644
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