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Hydralazine As a Selective Probe Inactivator of Aldehyde Oxidase in Human Hepatocytes: Estimation of the Contribution of Aldehyde Oxidase to Metabolic Clearance

Timothy J. Strelevitz, Christine C. Orozco and R. Scott Obach
Drug Metabolism and Disposition July 2012, 40 (7) 1441-1448; DOI: https://doi.org/10.1124/dmd.112.045195

Article Information

vol. 40 no. 7 1441-1448
DOI 
https://doi.org/10.1124/dmd.112.045195
PubMed 
22522748
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 22, 2012
  • Accepted April 20, 2012
  • Published online June 20, 2012.

Article Versions

Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Timothy J. Strelevitz,
  2. Christine C. Orozco and
  3. R. Scott Obach
  1. Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Groton, Connecticut
  1. Address correspondence to:
    Timothy Strelevitz, Pfizer Inc., Eastern Pont Rd., Groton, CT 06340. E-mail: timothy.j.strelevitz{at}pfizer.com
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Research ArticleArticle

HYDRALAZINE AS A SELECTIVE AO INHIBITOR IN HEPATOCYTES

Timothy J. Strelevitz, Christine C. Orozco and R. Scott Obach
Drug Metabolism and Disposition July 1, 2012, 40 (7) 1441-1448; DOI: https://doi.org/10.1124/dmd.112.045195
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