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Drug Metabolism & Disposition

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Table of Contents

August 01, 2012; Volume 40,Issue 8

Short Communications

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    The Increased Cellular Uptake and Biliary Excretion of Curcumin by Quercetin: A Possible Role of Albumin Binding Interaction
    Han Gyul Kim, Joo Hyun Lee, Seung Jae Lee, Ju-Hee Oh, Eunji Shin, Young Pyo Jang and Young-Joo Lee
    Drug Metabolism and Disposition August 2012, 40 (8) 1452-1455; DOI: https://doi.org/10.1124/dmd.111.044123
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    A Novel Method for the Determination of the Site of Glucuronidation by Ion Mobility Spectrometry-Mass Spectrometry
    Atsushi Shimizu, Tomoyuki Ohe and Masato Chiba
    Drug Metabolism and Disposition August 2012, 40 (8) 1456-1459; DOI: https://doi.org/10.1124/dmd.112.045435
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    Covalent Modification and Time-Dependent Inhibition of Human CYP2E1 by the meta-Isomer of Acetaminophen
    John P. Harrelson, Brendan D. Stamper, John D. Chapman, David R. Goodlett and Sidney D. Nelson
    Drug Metabolism and Disposition August 2012, 40 (8) 1460-1465; DOI: https://doi.org/10.1124/dmd.112.045492

Articles

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    Effect of Gemfibrozil on the Metabolism of Brivaracetam In Vitro and in Human Subjects
    J.-M. Nicolas, H. Chanteux, M. Rosa, S. Watanabe and A. Stockis
    Drug Metabolism and Disposition August 2012, 40 (8) 1466-1472; DOI: https://doi.org/10.1124/dmd.112.045328
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    Boosting of HIV Protease Inhibitors by Ritonavir in the Intestine: The Relative Role of Cytochrome P450 and P-Glycoprotein Inhibition Based on Caco-2 Monolayers versus In Situ Intestinal Perfusion in Mice
    Nico Holmstock, Pieter Annaert and Patrick Augustijns
    Drug Metabolism and Disposition August 2012, 40 (8) 1473-1477; DOI: https://doi.org/10.1124/dmd.112.044677
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    Reaction of Homopiperazine with Endogenous Formaldehyde: A Carbon Hydrogen Addition Metabolite/Product Identified in Rat Urine and Blood
    Scott Martin, Eva M. Lenz, Dave Temesi, Martin Wild and Malcolm R. Clench
    Drug Metabolism and Disposition August 2012, 40 (8) 1478-1486; DOI: https://doi.org/10.1124/dmd.112.044917
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    In Vivo Information-Guided Prediction Approach for Assessing the Risks of Drug-Drug Interactions Associated with Circulating Inhibitory Metabolites
    Zhe-Yi Hu, Robert B. Parker and S. Casey Laizure
    Drug Metabolism and Disposition August 2012, 40 (8) 1487-1494; DOI: https://doi.org/10.1124/dmd.112.045799
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    Evaluation of the Use of Static and Dynamic Models to Predict Drug-Drug Interaction and Its Associated Variability: Impact on Drug Discovery and Early Development
    Sheila Annie Peters, Patricia E. Schroeder, Nagdeep Giri and Hugues Dolgos
    Drug Metabolism and Disposition August 2012, 40 (8) 1495-1507; DOI: https://doi.org/10.1124/dmd.112.044602
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    Down-Regulation of Hepatic CYP3A and CYP2C Mediated Metabolism in Rats with Moderate Chronic Kidney Disease
    Thomas J. Velenosi, Angel Y. N. Fu, Shuhua Luo, Hao Wang and Bradley L. Urquhart
    Drug Metabolism and Disposition August 2012, 40 (8) 1508-1514; DOI: https://doi.org/10.1124/dmd.112.045245
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    Metabolic Activation of Mefenamic Acid Leading to Mefenamyl-S-Acyl-Glutathione Adduct Formation In Vitro and In Vivo in Rat
    Mark P. Grillo, Michelle Tadano Lohr and Jill C. M. Wait
    Drug Metabolism and Disposition August 2012, 40 (8) 1515-1526; DOI: https://doi.org/10.1124/dmd.112.046102
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    Physicochemical Property Space of Hepatobiliary Transport and Computational Models for Predicting Rat Biliary Excretion
    Manthena V. S. Varma, George Chang, Yurong Lai, Bo Feng, Ayman F. El-Kattan, John Litchfield and Theunis C. Goosen
    Drug Metabolism and Disposition August 2012, 40 (8) 1527-1537; DOI: https://doi.org/10.1124/dmd.112.044628
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    Inhibition of P-Glycoprotein Leads to Improved Oral Bioavailability of Compound K, an Anticancer Metabolite of Red Ginseng Extract Produced by Gut Microflora
    Zhen Yang, Jing-Rong Wang, Tao Niu, Song Gao, Taijun Yin, Ming You, Zhi-Hong Jiang and Ming Hu
    Drug Metabolism and Disposition August 2012, 40 (8) 1538-1544; DOI: https://doi.org/10.1124/dmd.111.044008
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    FcRn Affinity-Pharmacokinetic Relationship of Five Human IgG4 Antibodies Engineered for Improved In Vitro FcRn Binding Properties in Cynomolgus Monkeys
    Amita Datta-Mannan, Chi-Kin Chow, Craig Dickinson, David Driver, Jirong Lu, Derrick R. Witcher and Victor J. Wroblewski
    Drug Metabolism and Disposition August 2012, 40 (8) 1545-1555; DOI: https://doi.org/10.1124/dmd.112.045864
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    Role of the Intestinal Peptide Transporter PEPT1 in Oseltamivir Absorption: In Vitro and In Vivo Studies
    Agnès Poirier, Sara Belli, Christoph Funk, Michael B. Otteneder, Renée Portmann, Katja Heinig, Eric Prinssen, Stanley E. Lazic, Craig R. Rayner, Gerhard Hoffmann, Thomas Singer, David E. Smith and Franz Schuler
    Drug Metabolism and Disposition August 2012, 40 (8) 1556-1565; DOI: https://doi.org/10.1124/dmd.112.044990
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    Metabolism of (2S)-Pterosin A: Identification of the Phase I and Phase II Metabolites in Rat Urine
    Yung-Ping Lee, Feng-Lin Hsu, Jaw-Jou Kang, Chien-Kuang Chen and Shoei-Sheng Lee
    Drug Metabolism and Disposition August 2012, 40 (8) 1566-1574; DOI: https://doi.org/10.1124/dmd.112.045039
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    Effect of Structural Variation on Aldehyde Oxidase-Catalyzed Oxidation of Zoniporide
    Deepak Dalvie, Hao Sun, Cathie Xiang, Qiyue Hu, Ying Jiang and Ping Kang
    Drug Metabolism and Disposition August 2012, 40 (8) 1575-1587; DOI: https://doi.org/10.1124/dmd.112.045823
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    Potent Inhibition of Human Sulfotransferase 1A1 by 17α-Ethinylestradiol: Role of 3′-Phosphoadenosine 5′-Phosphosulfate Binding and Structural Rearrangements in Regulating Inhibition and Activity
    Katie Jo Rohn, Ian T. Cook, Thomas S. Leyh, Susan A. Kadlubar and Charles N. Falany
    Drug Metabolism and Disposition August 2012, 40 (8) 1588-1595; DOI: https://doi.org/10.1124/dmd.112.045583
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    Utility of Drug Depletion-Time Profiles in Isolated Hepatocytes for Accessing Hepatic Uptake Clearance: Identifying Rate-Limiting Steps and Role of Passive Processes
    Emilie Jigorel and J. Brian Houston
    Drug Metabolism and Disposition August 2012, 40 (8) 1596-1602; DOI: https://doi.org/10.1124/dmd.112.045732
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    Expression Profiles of Metabolic Enzymes and Drug Transporters in the Liver and along the Intestine of Beagle Dogs
    Stephanie Haller, Franz Schuler, Stanley E. Lazic, Dalila Bachir-Cherif, Stefanie D. Krämer, Neil J. Parrott, Guido Steiner and Sara Belli
    Drug Metabolism and Disposition August 2012, 40 (8) 1603-1611; DOI: https://doi.org/10.1124/dmd.112.045443
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    Brain Distribution and Bioavailability of Elacridar after Different Routes of Administration in the Mouse
    Ramola Sane, Sagar Agarwal and William F. Elmquist
    Drug Metabolism and Disposition August 2012, 40 (8) 1612-1619; DOI: https://doi.org/10.1124/dmd.112.045930
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    Preparation of a Specific Monoclonal Antibody against Human UDP-Glucuronosyltransferase (UGT) 1A9 and Evaluation of UGT1A9 Protein Levels in Human Tissues
    Shingo Oda, Miki Nakajima, Masahiko Hatakeyama, Tatsuki Fukami and Tsuyoshi Yokoi
    Drug Metabolism and Disposition August 2012, 40 (8) 1620-1627; DOI: https://doi.org/10.1124/dmd.112.045625
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    Identification of the ortho-Benzoquinone Intermediate of 5-O-Caffeoylquinic Acid In Vitro and In Vivo: Comparison of Bioactivation under Normal and Pathological Situations
    Cen Xie, Dafang Zhong and Xiaoyan Chen
    Drug Metabolism and Disposition August 2012, 40 (8) 1628-1640; DOI: https://doi.org/10.1124/dmd.112.045641
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    The Development, Characterization, and Application of an OATP1B1 Inhibition Assay in Drug Discovery
    Matthew G. Soars, Patrick Barton, Manfred Ismair, Rachael Jupp and Robert J. Riley
    Drug Metabolism and Disposition August 2012, 40 (8) 1641-1648; DOI: https://doi.org/10.1124/dmd.111.042382
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Drug Metabolism and Disposition: 40 (8)
Drug Metabolism and Disposition
Vol. 40, Issue 8
1 Aug 2012
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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