Table of Contents

Articles

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  Effect of Gemfibrozil on the Metabolism of Brivaracetam In Vitro and in Human Subjects

  J.-M. Nicolas, H. Chanteux, M. Rosa, S. Watanabe and A. Stockis

  Drug Metabolism and Disposition August 2012, 40 (8) 1466-1472; DOI: https://doi.org/10.1124/dmd.112.045328
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  Boosting of HIV Protease Inhibitors by Ritonavir in the Intestine: The Relative Role of Cytochrome P450 and P-Glycoprotein Inhibition Based on Caco-2 Monolayers versus In Situ Intestinal Perfusion in Mice

  Nico Holmstock, Pieter Annaert and Patrick Augustijns

  Drug Metabolism and Disposition August 2012, 40 (8) 1473-1477; DOI: https://doi.org/10.1124/dmd.112.044677
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  Reaction of Homopiperazine with Endogenous Formaldehyde: A Carbon Hydrogen Addition Metabolite/Product Identified in Rat Urine and Blood

  Scott Martin, Eva M. Lenz, Dave Temesi, Martin Wild and Malcolm R. Clench

  Drug Metabolism and Disposition August 2012, 40 (8) 1478-1486; DOI: https://doi.org/10.1124/dmd.112.044917
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  In Vivo Information-Guided Prediction Approach for Assessing the Risks of Drug-Drug Interactions Associated with Circulating Inhibitory Metabolites

  Zhe-Yi Hu, Robert B. Parker and S. Casey Laizure

  Drug Metabolism and Disposition August 2012, 40 (8) 1487-1494; DOI: https://doi.org/10.1124/dmd.112.045799
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  Evaluation of the Use of Static and Dynamic Models to Predict Drug-Drug Interaction and Its Associated Variability: Impact on Drug Discovery and Early Development

  Sheila Annie Peters, Patricia E. Schroeder, Nagdeep Giri and Hugues Dolgos

  Drug Metabolism and Disposition August 2012, 40 (8) 1495-1507; DOI: https://doi.org/10.1124/dmd.112.044602
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  Down-Regulation of Hepatic CYP3A and CYP2C Mediated Metabolism in Rats with Moderate Chronic Kidney Disease

  Thomas J. Velenosi, Angel Y. N. Fu, Shuhua Luo, Hao Wang and Bradley L. Urquhart

  Drug Metabolism and Disposition August 2012, 40 (8) 1508-1514; DOI: https://doi.org/10.1124/dmd.112.045245
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  Metabolic Activation of Mefenamic Acid Leading to Mefenamyl-S-Acyl-Glutathione Adduct Formation In Vitro and In Vivo in Rat

  Mark P. Grillo, Michelle Tadano Lohr and Jill C. M. Wait

  Drug Metabolism and Disposition August 2012, 40 (8) 1515-1526; DOI: https://doi.org/10.1124/dmd.112.046102
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  Physicochemical Property Space of Hepatobiliary Transport and Computational Models for Predicting Rat Biliary Excretion

  Manthena V. S. Varma, George Chang, Yurong Lai, Bo Feng, Ayman F. El-Kattan, John Litchfield and Theunis C. Goosen

  Drug Metabolism and Disposition August 2012, 40 (8) 1527-1537; DOI: https://doi.org/10.1124/dmd.112.044628
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  Inhibition of P-Glycoprotein Leads to Improved Oral Bioavailability of Compound K, an Anticancer Metabolite of Red Ginseng Extract Produced by Gut Microflora

  Zhen Yang, Jing-Rong Wang, Tao Niu, Song Gao, Taijun Yin, Ming You, Zhi-Hong Jiang and Ming Hu

  Drug Metabolism and Disposition August 2012, 40 (8) 1538-1544; DOI: https://doi.org/10.1124/dmd.111.044008
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  FcRn Affinity-Pharmacokinetic Relationship of Five Human IgG4 Antibodies Engineered for Improved In Vitro FcRn Binding Properties in Cynomolgus Monkeys

  Amita Datta-Mannan, Chi-Kin Chow, Craig Dickinson, David Driver, Jirong Lu, Derrick R. Witcher and Victor J. Wroblewski

  Drug Metabolism and Disposition August 2012, 40 (8) 1545-1555; DOI: https://doi.org/10.1124/dmd.112.045864
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  Role of the Intestinal Peptide Transporter PEPT1 in Oseltamivir Absorption: In Vitro and In Vivo Studies

  Agnès Poirier, Sara Belli, Christoph Funk, Michael B. Otteneder, Renée Portmann, Katja Heinig, Eric Prinssen, Stanley E. Lazic, Craig R. Rayner, Gerhard Hoffmann, Thomas Singer, David E. Smith and Franz Schuler

  Drug Metabolism and Disposition August 2012, 40 (8) 1556-1565; DOI: https://doi.org/10.1124/dmd.112.044990
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  Metabolism of (2S)-Pterosin A: Identification of the Phase I and Phase II Metabolites in Rat Urine

  Yung-Ping Lee, Feng-Lin Hsu, Jaw-Jou Kang, Chien-Kuang Chen and Shoei-Sheng Lee

  Drug Metabolism and Disposition August 2012, 40 (8) 1566-1574; DOI: https://doi.org/10.1124/dmd.112.045039
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  Effect of Structural Variation on Aldehyde Oxidase-Catalyzed Oxidation of Zoniporide

  Deepak Dalvie, Hao Sun, Cathie Xiang, Qiyue Hu, Ying Jiang and Ping Kang

  Drug Metabolism and Disposition August 2012, 40 (8) 1575-1587; DOI: https://doi.org/10.1124/dmd.112.045823
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  Potent Inhibition of Human Sulfotransferase 1A1 by 17α-Ethinylestradiol: Role of 3′-Phosphoadenosine 5′-Phosphosulfate Binding and Structural Rearrangements in Regulating Inhibition and Activity

  Katie Jo Rohn, Ian T. Cook, Thomas S. Leyh, Susan A. Kadlubar and Charles N. Falany

  Drug Metabolism and Disposition August 2012, 40 (8) 1588-1595; DOI: https://doi.org/10.1124/dmd.112.045583
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  Utility of Drug Depletion-Time Profiles in Isolated Hepatocytes for Accessing Hepatic Uptake Clearance: Identifying Rate-Limiting Steps and Role of Passive Processes

  Emilie Jigorel and J. Brian Houston

  Drug Metabolism and Disposition August 2012, 40 (8) 1596-1602; DOI: https://doi.org/10.1124/dmd.112.045732
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  Expression Profiles of Metabolic Enzymes and Drug Transporters in the Liver and along the Intestine of Beagle Dogs

  Stephanie Haller, Franz Schuler, Stanley E. Lazic, Dalila Bachir-Cherif, Stefanie D. Krämer, Neil J. Parrott, Guido Steiner and Sara Belli

  Drug Metabolism and Disposition August 2012, 40 (8) 1603-1611; DOI: https://doi.org/10.1124/dmd.112.045443
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  Brain Distribution and Bioavailability of Elacridar after Different Routes of Administration in the Mouse

  Ramola Sane, Sagar Agarwal and William F. Elmquist

  Drug Metabolism and Disposition August 2012, 40 (8) 1612-1619; DOI: https://doi.org/10.1124/dmd.112.045930
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  Preparation of a Specific Monoclonal Antibody against Human UDP-Glucuronosyltransferase (UGT) 1A9 and Evaluation of UGT1A9 Protein Levels in Human Tissues

  Shingo Oda, Miki Nakajima, Masahiko Hatakeyama, Tatsuki Fukami and Tsuyoshi Yokoi

  Drug Metabolism and Disposition August 2012, 40 (8) 1620-1627; DOI: https://doi.org/10.1124/dmd.112.045625
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  Identification of the ortho-Benzoquinone Intermediate of 5-O-Caffeoylquinic Acid In Vitro and In Vivo: Comparison of Bioactivation under Normal and Pathological Situations

  Cen Xie, Dafang Zhong and Xiaoyan Chen

  Drug Metabolism and Disposition August 2012, 40 (8) 1628-1640; DOI: https://doi.org/10.1124/dmd.112.045641
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  The Development, Characterization, and Application of an OATP1B1 Inhibition Assay in Drug Discovery

  Matthew G. Soars, Patrick Barton, Manfred Ismair, Rachael Jupp and Robert J. Riley

  Drug Metabolism and Disposition August 2012, 40 (8) 1641-1648; DOI: https://doi.org/10.1124/dmd.111.042382