This work was previously presented in part as follows: Peters S, Schroeder P, and Giri N (2011) Evaluation of clinical drug-drug interactions using static and dynamic models: a retrospective analysis. Drug-Drug Interaction Prediction Workshop; 6–7 Jun 2011; Silver Spring, MD. U.S. Food and Drug Administration, Silver Spring, MD, and Leadership Group of the International Consortium for Innovation and Quality in Pharmaceutical Development, http://iqconsortium.com/.