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Research ArticleArticle

Metabolic Activation of Mefenamic Acid Leading to Mefenamyl-S-Acyl-Glutathione Adduct Formation In Vitro and In Vivo in Rat

Mark P. Grillo, Michelle Tadano Lohr and Jill C. M. Wait
Drug Metabolism and Disposition August 2012, 40 (8) 1515-1526; DOI: https://doi.org/10.1124/dmd.112.046102

Article Information

vol. 40 no. 8 1515-1526
DOI 
https://doi.org/10.1124/dmd.112.046102
PubMed 
22577085
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received April 5, 2012
  • Accepted May 10, 2012
  • Published online July 17, 2012.

Article Versions

Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Mark P. Grillo,
  2. Michelle Tadano Lohr1 and
  3. Jill C. M. Wait2
  1. Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California
  1. Address correspondence to:
    Mark P. Grillo, Pharmacokinetics and Drug Metabolism, Amgen Inc., 1120 Veterans Blvd., South San Francisco, CA 94080. E-mail: grillo{at}amgen.com

  1. Parts of this work were previously presented as follows: Grillo MP, Tadano-Lohr M, and Wait JCM (2005) Bioactivation of mefenamic acid in rat hepatocytes. 13th North American ISSX/20th JSSX Meeting; 2005 Oct 23–27; Maui, Hawaii. International Society for the Study of Xenobiotics, Washington, DC.

  • ↵1 Current affiliation: School of Pharmacy, University of California at San Francisco, San Francisco, California.

  • ↵2 Current affiliation: BioMarin Pharmaceutical Inc., Novato, California.

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Research ArticleArticle

MEFENAMIC ACID-S-ACYL-GLUTATHIONE FORMATION

Mark P. Grillo, Michelle Tadano Lohr and Jill C. M. Wait
Drug Metabolism and Disposition August 1, 2012, 40 (8) 1515-1526; DOI: https://doi.org/10.1124/dmd.112.046102
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