Advertisement
Research ArticleArticle

Metabolic Activation of Mefenamic Acid Leading to Mefenamyl-S-Acyl-Glutathione Adduct Formation In Vitro and In Vivo in Rat

Mark P. Grillo, Michelle Tadano Lohr and Jill C. M. Wait
Drug Metabolism and Disposition August 2012, 40 (8) 1515-1526; DOI: https://doi.org/10.1124/dmd.112.046102

Article Information

vol. 40 no. 8 1515-1526
DOI 
https://doi.org/10.1124/dmd.112.046102
PubMed 
22577085
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received April 5, 2012
  • Accepted May 10, 2012
  • Published online July 17, 2012.

Article Versions

Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Mark P. Grillo,
  2. Michelle Tadano Lohr1 and
  3. Jill C. M. Wait2
  1. Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, California
  1. Address correspondence to:
    Mark P. Grillo, Pharmacokinetics and Drug Metabolism, Amgen Inc., 1120 Veterans Blvd., South San Francisco, CA 94080. E-mail: grillo{at}amgen.com

  1. Parts of this work were previously presented as follows: Grillo MP, Tadano-Lohr M, and Wait JCM (2005) Bioactivation of mefenamic acid in rat hepatocytes. 13th North American ISSX/20th JSSX Meeting; 2005 Oct 23–27; Maui, Hawaii. International Society for the Study of Xenobiotics, Washington, DC.

  • ↵1 Current affiliation: School of Pharmacy, University of California at San Francisco, San Francisco, California.

  • ↵2 Current affiliation: BioMarin Pharmaceutical Inc., Novato, California.

View Full Text

Statistics from Altmetric.com

Article usage

Article usage: May 2012 to January 2021

AbstractFullPdf
May 2012334074
Jun 201264027
Jul 20123501154
Aug 20123131944
Sep 20121641823
Oct 20121082029
Nov 20121011931
Dec 201266716
Jan 201395917
Feb 201359914
Mar 201367610
Apr 20133644
May 201344912
Jun 20132947
Jul 20133674
Aug 201348715
Sep 2013681421
Oct 2013632618
Nov 2013401118
Dec 2013211330
Jan 2014181720
Feb 201427108
Mar 2014261112
Apr 2014232619
May 2014202524
Jun 2014271312
Jul 2014392011
Aug 2014111113
Sep 2014211721
Oct 2014251012
Nov 2014171113
Dec 201413126
Jan 201526287
Feb 2015171313
Mar 2015251889
Apr 20152475
May 201514169
Jun 20151548
Jul 201525812
Aug 201516145
Sep 2015191210
Oct 201512206
Nov 201513109
Dec 2015192110
Jan 201615218
Feb 2016101010
Mar 201632316
Apr 2016113118
May 20161169
Jun 20161097
Jul 201691310
Aug 201617196
Sep 20167173
Oct 2016102316
Nov 20160338
Dec 2016193
Jan 20170274
Feb 20175345
Mar 20171315
Apr 20171179
May 201741814
Jun 20173156
Jul 201702219
Aug 201731613
Sep 201753112
Oct 201744314
Nov 201734914
Dec 201742110
Jan 20184197
Feb 201862312
Mar 20180376
Apr 201804710
May 201804610
Jun 201833516
Jul 20181238
Aug 20181234
Sep 20184254
Oct 20180332
Nov 201802210
Dec 20183042
Jan 20191402
Feb 20192512
Mar 20191625
Apr 20192406
May 20191811
Jun 20191136
Jul 20191114
Aug 20191401
Sep 20192301
Oct 20192111
Nov 20192632
Dec 20192613
Jan 20202343
Feb 20201700
Mar 20201001
Apr 20202211
May 20201911
Jun 20201800
Jul 20203200
Aug 20201735
Sep 20201812
Oct 20202602
Nov 20201234
Dec 20202820
Jan 20212442

Back to top

In this issue

Download PDF
Article Alerts
Email Article
Citation Tools
Research ArticleArticle

MEFENAMIC ACID-S-ACYL-GLUTATHIONE FORMATION

Mark P. Grillo, Michelle Tadano Lohr and Jill C. M. Wait
Drug Metabolism and Disposition August 1, 2012, 40 (8) 1515-1526; DOI: https://doi.org/10.1124/dmd.112.046102
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo

Jump to section