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Physicochemical Property Space of Hepatobiliary Transport and Computational Models for Predicting Rat Biliary Excretion

Manthena V. S. Varma, George Chang, Yurong Lai, Bo Feng, Ayman F. El-Kattan, John Litchfield and Theunis C. Goosen
Drug Metabolism and Disposition August 2012, 40 (8) 1527-1537; DOI: https://doi.org/10.1124/dmd.112.044628

Article Information

vol. 40 no. 8 1527-1537
DOI 
https://doi.org/10.1124/dmd.112.044628
PubMed 
22580868
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received January 16, 2012
  • Accepted May 11, 2012
  • Published online July 17, 2012.

Article Versions

Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Manthena V. S. Varma,
  2. George Chang,
  3. Yurong Lai,
  4. Bo Feng,
  5. Ayman F. El-Kattan,
  6. John Litchfield and
  7. Theunis C. Goosen
  1. Pharmacokinetics Dynamics and Metabolism, Pfizer Global Research and Development, Pfizer, Inc., Groton, Connecticut
  1. Address correspondence to:
    Dr. Manthena V. S. Varma, Department of Pharmacokinetics, Dynamics, and Metabolism, MS 8220-2451, Pfizer World Wide Research and Development, Pfizer, Inc., Groton, CT 06340. E-mail: manthena.v.varma{at}pfizer.com
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PHYSICOCHEMICAL SPACE OF HEPATOBILIARY TRANSPORT

Manthena V. S. Varma, George Chang, Yurong Lai, Bo Feng, Ayman F. El-Kattan, John Litchfield and Theunis C. Goosen
Drug Metabolism and Disposition August 1, 2012, 40 (8) 1527-1537; DOI: https://doi.org/10.1124/dmd.112.044628
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