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Research ArticleArticle

Role of the Intestinal Peptide Transporter PEPT1 in Oseltamivir Absorption: In Vitro and In Vivo Studies

Agnès Poirier, Sara Belli, Christoph Funk, Michael B. Otteneder, Renée Portmann, Katja Heinig, Eric Prinssen, Stanley E. Lazic, Craig R. Rayner, Gerhard Hoffmann, Thomas Singer, David E. Smith and Franz Schuler
Drug Metabolism and Disposition August 2012, 40 (8) 1556-1565; DOI: https://doi.org/10.1124/dmd.112.044990

Article Information

vol. 40 no. 8 1556-1565
DOI 
https://doi.org/10.1124/dmd.112.044990
PubMed 
22584254
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 13, 2012
  • Accepted May 14, 2012
  • Published online July 17, 2012.

Article Versions

Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Agnès Poirier,
  2. Sara Belli,
  3. Christoph Funk,
  4. Michael B. Otteneder,
  5. Renée Portmann,
  6. Katja Heinig,
  7. Eric Prinssen,
  8. Stanley E. Lazic,
  9. Craig R. Rayner,
  10. Gerhard Hoffmann,
  11. Thomas Singer,
  12. David E. Smith and
  13. Franz Schuler
  1. Non-Clinical Safety (A.P., S.B., C.F., M.B.O., R.P., K.H., G.H., T.S., F.S.), CNS Discovery (E.P.), and Bioinformatics and Exploratory Data Analysis (S.E.L.), F. Hoffmann-La Roche Ltd., Basel, Switzerland; Roche Products Pty Ltd., Melbourne, Australia (C.R.R.); Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Australia (C.R.R.); and Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan (D.E.S.)
  1. Address correspondence to:
    Franz Schuler, F. Hoffmann-La Roche Ltd., B70/R144, Grenzacherstrasse 124, CH-4070, Basel, Switzerland. E-mail: franz.schuler{at}roche.com
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Research ArticleArticle

ROLE OF PEPT1 IN OSELTAMIVIR ABSORPTION

Agnès Poirier, Sara Belli, Christoph Funk, Michael B. Otteneder, Renée Portmann, Katja Heinig, Eric Prinssen, Stanley E. Lazic, Craig R. Rayner, Gerhard Hoffmann, Thomas Singer, David E. Smith and Franz Schuler
Drug Metabolism and Disposition August 1, 2012, 40 (8) 1556-1565; DOI: https://doi.org/10.1124/dmd.112.044990
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