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Research ArticleArticle

Utility of Drug Depletion-Time Profiles in Isolated Hepatocytes for Accessing Hepatic Uptake Clearance: Identifying Rate-Limiting Steps and Role of Passive Processes

Emilie Jigorel and J. Brian Houston
Drug Metabolism and Disposition August 2012, 40 (8) 1596-1602; DOI: https://doi.org/10.1124/dmd.112.045732

Article Information

vol. 40 no. 8 1596-1602
DOI 
https://doi.org/10.1124/dmd.112.045732
PubMed 
22593038
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received March 16, 2012
  • Accepted May 16, 2012
  • Published online July 17, 2012.

Article Versions

Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Emilie Jigorel1 and
  2. J. Brian Houston
  1. Centre for Applied Pharmacokinetic Research, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom
  1. Address correspondence to:
    J. Brian Houston, Centre for Applied Pharmacokinetic Research, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK. E-mail: brian.houston{at}manchester.ac.uk

  • ↵1 Current affiliation: UCB Pharma SA, Drug Metabolism and Pharmacokinetics, Braine l'Alleud, Belgium.

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DRUG DEPLETION AND HEPATIC UPTAKE CLEARANCE

Emilie Jigorel and J. Brian Houston
Drug Metabolism and Disposition August 1, 2012, 40 (8) 1596-1602; DOI: https://doi.org/10.1124/dmd.112.045732
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