Table of Contents

Articles

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  Progress Curve Mechanistic Modeling Approach for Assessing Time-Dependent Inhibition of CYP3A4

  Howard J. Burt, Henry Pertinez, Carolina Säll, Claire Collins, Ruth Hyland, J. Brian Houston and Aleksandra Galetin

  Drug Metabolism and Disposition September 2012, 40 (9) 1658-1667; DOI: https://doi.org/10.1124/dmd.112.046078
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  A Novel Ring Oxidation of 4- or 5-Substituted 2H-Oxazole to Corresponding 2-Oxazolone Catalyzed by Cytosolic Aldehyde Oxidase

  Vinod K. Arora, Thomas Philip, Stella Huang and Yue-Zhong Shu

  Drug Metabolism and Disposition September 2012, 40 (9) 1668-1676; DOI: https://doi.org/10.1124/dmd.112.044545
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  Development of a Carbon-14 Labeling Approach to Support Disposition Studies with a Pegylated Biologic

  Haiqing Wang, Lifei Wang, Kai Cao, Stuart L. Emanuel, Paul Morin, Zheng Lin, Guoxiang Shen, Jennifer Hosbach, Donglu Zhang, Samuel Bonacorsi, A. David Rodrigues and Zheng Yang

  Drug Metabolism and Disposition September 2012, 40 (9) 1677-1685; DOI: https://doi.org/10.1124/dmd.112.044792
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  Selective Mechanism-Based Inactivation of CYP3A4 by CYP3cide (PF-04981517) and Its Utility as an In Vitro Tool for Delineating the Relative Roles of CYP3A4 versus CYP3A5 in the Metabolism of Drugs

  Robert L. Walsky, R. Scott Obach, Ruth Hyland, Ping Kang, Sue Zhou, Michael West, Kieran F. Geoghegan, Christopher J. Helal, Gregory S. Walker, Theunis C. Goosen and Michael A. Zientek

  Drug Metabolism and Disposition September 2012, 40 (9) 1686-1697; DOI: https://doi.org/10.1124/dmd.112.045302
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  Evaluation of Six Proton Pump Inhibitors As Inhibitors of Various Human Cytochromes P450: Focus on Cytochrome P450 2C19

  Tatyana Zvyaga, Shu-Ying Chang, Cliff Chen, Zheng Yang, Ragini Vuppugalla, Jeremy Hurley, Denise Thorndike, Andrew Wagner, Anjaneya Chimalakonda and A. David Rodrigues

  Drug Metabolism and Disposition September 2012, 40 (9) 1698-1711; DOI: https://doi.org/10.1124/dmd.112.045575
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  Metabolism and Pharmacokinetics of Indacaterol in Humans

  Mark Kagan, Jeremy Dain, Lana Peng and Christine Reynolds

  Drug Metabolism and Disposition September 2012, 40 (9) 1712-1722; DOI: https://doi.org/10.1124/dmd.112.046151
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  Excretion and Metabolism of Milnacipran in Humans after Oral Administration of Milnacipran Hydrochloride

  Fanying Li, Christina Chin, Julie Wangsa and John Ho

  Drug Metabolism and Disposition September 2012, 40 (9) 1723-1735; DOI: https://doi.org/10.1124/dmd.112.045120
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  Role of Human UDP-Glucuronosyltransferases in the Biotransformation of the Triazoloacridinone and Imidazoacridinone Antitumor Agents C-1305 and C-1311: Highly Selective Substrates for UGT1A10

  Barbara Fedejko-Kap, Stacie M. Bratton, Moshe Finel, Anna Radominska-Pandya and Zofia Mazerska

  Drug Metabolism and Disposition September 2012, 40 (9) 1736-1743; DOI: https://doi.org/10.1124/dmd.112.045401
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  Use of Mechanistic Modeling to Assess Interindividual Variability and Interspecies Differences in Active Uptake in Human and Rat Hepatocytes

  Karelle Ménochet, Kathryn E. Kenworthy, J. Brian Houston and Aleksandra Galetin

  Drug Metabolism and Disposition September 2012, 40 (9) 1744-1756; DOI: https://doi.org/10.1124/dmd.112.046193
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  Evaluation of P450 Inhibition and Induction by Artemisinin Antimalarials in Human Liver Microsomes and Primary Human Hepatocytes

  Jie Xing, Brian J. Kirby, Dale Whittington, Yakun Wan and David R. Goodlett

  Drug Metabolism and Disposition September 2012, 40 (9) 1757-1764; DOI: https://doi.org/10.1124/dmd.112.045765
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  Mechanism-Based Inactivation of Cytochrome P450 2B6 by Methadone through Destruction of Prosthetic Heme

  Hemali T. Amunugama, Haoming Zhang and Paul F. Hollenberg

  Drug Metabolism and Disposition September 2012, 40 (9) 1765-1770; DOI: https://doi.org/10.1124/dmd.112.045971
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  Quantitative Prediction of Human Intestinal Glucuronidation Effects on Intestinal Availability of UDP-Glucuronosyltransferase Substrates Using In Vitro Data

  Fumihiro Nakamori, Yoichi Naritomi, Ken-ichi Hosoya, Hiroyuki Moriguchi, Kazuhiro Tetsuka, Takako Furukawa, Keitaro Kadono, Katsuhiro Yamano, Shigeyuki Terashita and Toshio Teramura

  Drug Metabolism and Disposition September 2012, 40 (9) 1771-1777; DOI: https://doi.org/10.1124/dmd.112.045476
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  Metabolism of the Active Metabolite of Quetiapine, N-Desalkylquetiapine In Vitro

  Gry Vibeke Bakken, Espen Molden, Karoline Knutsen, Niclas Lunder and Monica Hermann

  Drug Metabolism and Disposition September 2012, 40 (9) 1778-1784; DOI: https://doi.org/10.1124/dmd.112.045237
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  Preclinical Assessment of the Absorption and Disposition of the Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor GDC-0980 and Prediction of Its Pharmacokinetics and Efficacy in Human

  Laurent Salphati, Jodie Pang, Emile G. Plise, Leslie B. Lee, Alan G. Olivero, Wei Wei Prior, Deepak Sampath, Susan Wong and Xiaolin Zhang

  Drug Metabolism and Disposition September 2012, 40 (9) 1785-1796; DOI: https://doi.org/10.1124/dmd.112.046052
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  Evaluation of Inhibition Selectivity for Human Cytochrome P450 2A Enzymes

  Eva S. Stephens, Agnes A. Walsh and Emily E. Scott

  Drug Metabolism and Disposition September 2012, 40 (9) 1797-1802; DOI: https://doi.org/10.1124/dmd.112.045161
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  Discovery of a Highly Selective CYP3A4 Inhibitor Suitable for Reaction Phenotyping Studies and Differentiation of CYP3A4 and CYP3A5

  Xiaohai Li, Xinyi Song, Theodore M. Kamenecka and Michael D. Cameron

  Drug Metabolism and Disposition September 2012, 40 (9) 1803-1809; DOI: https://doi.org/10.1124/dmd.112.046144
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  Preclinical Evaluation of the Metabolism and Disposition of RRx-001, a Novel Investigative Anticancer Agent

  Jan Scicinski, Bryan Oronsky, Michael Taylor, Gang Luo, Timothy Musick, Joseph Marini, Christopher M. Adams and William L. Fitch

  Drug Metabolism and Disposition September 2012, 40 (9) 1810-1816; DOI: https://doi.org/10.1124/dmd.112.046755
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  Altered Arsenic Disposition in Experimental Nonalcoholic Fatty Liver Disease

  Mark J. Canet, Rhiannon N. Hardwick, April D. Lake, Michael J. Kopplin, George L. Scheffer, Walter T. Klimecki, A. Jay Gandolfi and Nathan J. Cherrington

  Drug Metabolism and Disposition September 2012, 40 (9) 1817-1824; DOI: https://doi.org/10.1124/dmd.112.046177
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  Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 Knockout Rats Using Loperamide, Paclitaxel, Sulfasalazine, and Carboxydichlorofluorescein Pharmacokinetics

  Maciej J. Zamek-Gliszczynski, David W. Bedwell, Jing Q. Bao and J. William Higgins

  Drug Metabolism and Disposition September 2012, 40 (9) 1825-1833; DOI: https://doi.org/10.1124/dmd.112.046508
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  The Role of Aldehyde Oxidase and Xanthine Oxidase in the Biotransformation of a Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5

  Ryan D. Morrison, Anna L. Blobaum, Frank W. Byers, Tammy S. Santomango, Thomas M. Bridges, Donald Stec, Katrina A. Brewer, Raymundo Sanchez-Ponce, Melany M. Corlew, Roger Rush, Andrew S. Felts, Jason Manka, Brittney S. Bates, Daryl F. Venable, Alice L. Rodriguez, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte and J. Scott Daniels

  Drug Metabolism and Disposition September 2012, 40 (9) 1834-1845; DOI: https://doi.org/10.1124/dmd.112.046136
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  Influence of Enterohepatic Recycling on the Time Course of Brain-to-Blood Partitioning of Valproic Acid in Rats

  Jeannie M. Padowski and Gary M. Pollack

  Drug Metabolism and Disposition September 2012, 40 (9) 1846-1853; DOI: https://doi.org/10.1124/dmd.112.045500
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  Glutaredoxin Is Involved in the Formation of the Pharmacologically Active Metabolite of Clopidogrel from Its GSH Conjugate

  Katsunobu Hagihara, Miho Kazui, Atsushi Kurihara, Toshihiko Ikeda and Takashi Izumi

  Drug Metabolism and Disposition September 2012, 40 (9) 1854-1859; DOI: https://doi.org/10.1124/dmd.112.045914