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Index by author

September 01, 2012; Volume 40,Issue 9

A

  1. Adams, Christopher M.

    1. Preclinical Evaluation of the Metabolism and Disposition of RRx-001, a Novel Investigative Anticancer Agent
      Jan Scicinski, Bryan Oronsky, Michael Taylor, Gang Luo, Timothy Musick, Joseph Marini, Christopher M. Adams and William L. Fitch
      Drug Metabolism and Disposition September 2012, 40 (9) 1810-1816; DOI: https://doi.org/10.1124/dmd.112.046755

  2. Amunugama, Hemali T.

    1. Mechanism-Based Inactivation of Cytochrome P450 2B6 by Methadone through Destruction of Prosthetic Heme
      Hemali T. Amunugama, Haoming Zhang and Paul F. Hollenberg
      Drug Metabolism and Disposition September 2012, 40 (9) 1765-1770; DOI: https://doi.org/10.1124/dmd.112.045971

  3. Arora, Vinod K.

    1. A Novel Ring Oxidation of 4- or 5-Substituted 2H-Oxazole to Corresponding 2-Oxazolone Catalyzed by Cytosolic Aldehyde Oxidase
      Vinod K. Arora, Thomas Philip, Stella Huang and Yue-Zhong Shu
      Drug Metabolism and Disposition September 2012, 40 (9) 1668-1676; DOI: https://doi.org/10.1124/dmd.112.044545

  4. Atkinson, Karen

    1. A Novel Relay Method for Determining Low-Clearance Values
      Li Di, Patrick Trapa, R. Scott Obach, Karen Atkinson, Yi-An Bi, Angela C. Wolford, Beijing Tan, Thomas S. McDonald, Yurong Lai and Larry M. Tremaine
      Drug Metabolism and Disposition September 2012, 40 (9) 1860-1865; DOI: https://doi.org/10.1124/dmd.112.046425

B

  1. Bakken, Gry Vibeke

    1. Metabolism of the Active Metabolite of Quetiapine, N-Desalkylquetiapine In Vitro
      Gry Vibeke Bakken, Espen Molden, Karoline Knutsen, Niclas Lunder and Monica Hermann
      Drug Metabolism and Disposition September 2012, 40 (9) 1778-1784; DOI: https://doi.org/10.1124/dmd.112.045237

  2. Bao, Jing Q.

    1. Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 Knockout Rats Using Loperamide, Paclitaxel, Sulfasalazine, and Carboxydichlorofluorescein Pharmacokinetics
      Maciej J. Zamek-Gliszczynski, David W. Bedwell, Jing Q. Bao and J. William Higgins
      Drug Metabolism and Disposition September 2012, 40 (9) 1825-1833; DOI: https://doi.org/10.1124/dmd.112.046508

  3. Bates, Brittney S.

    1. The Role of Aldehyde Oxidase and Xanthine Oxidase in the Biotransformation of a Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5
      Ryan D. Morrison, Anna L. Blobaum, Frank W. Byers, Tammy S. Santomango, Thomas M. Bridges, Donald Stec, Katrina A. Brewer, Raymundo Sanchez-Ponce, Melany M. Corlew, Roger Rush, Andrew S. Felts, Jason Manka, Brittney S. Bates, Daryl F. Venable, Alice L. Rodriguez, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte and J. Scott Daniels
      Drug Metabolism and Disposition September 2012, 40 (9) 1834-1845; DOI: https://doi.org/10.1124/dmd.112.046136

  4. Bedwell, David W.

    1. Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 Knockout Rats Using Loperamide, Paclitaxel, Sulfasalazine, and Carboxydichlorofluorescein Pharmacokinetics
      Maciej J. Zamek-Gliszczynski, David W. Bedwell, Jing Q. Bao and J. William Higgins
      Drug Metabolism and Disposition September 2012, 40 (9) 1825-1833; DOI: https://doi.org/10.1124/dmd.112.046508

  5. Bi, Yi-An

    1. A Novel Relay Method for Determining Low-Clearance Values
      Li Di, Patrick Trapa, R. Scott Obach, Karen Atkinson, Yi-An Bi, Angela C. Wolford, Beijing Tan, Thomas S. McDonald, Yurong Lai and Larry M. Tremaine
      Drug Metabolism and Disposition September 2012, 40 (9) 1860-1865; DOI: https://doi.org/10.1124/dmd.112.046425

  6. Blobaum, Anna L.

    1. The Role of Aldehyde Oxidase and Xanthine Oxidase in the Biotransformation of a Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5
      Ryan D. Morrison, Anna L. Blobaum, Frank W. Byers, Tammy S. Santomango, Thomas M. Bridges, Donald Stec, Katrina A. Brewer, Raymundo Sanchez-Ponce, Melany M. Corlew, Roger Rush, Andrew S. Felts, Jason Manka, Brittney S. Bates, Daryl F. Venable, Alice L. Rodriguez, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte and J. Scott Daniels
      Drug Metabolism and Disposition September 2012, 40 (9) 1834-1845; DOI: https://doi.org/10.1124/dmd.112.046136

  7. Bonacorsi, Samuel

    1. Development of a Carbon-14 Labeling Approach to Support Disposition Studies with a Pegylated Biologic
      Haiqing Wang, Lifei Wang, Kai Cao, Stuart L. Emanuel, Paul Morin, Zheng Lin, Guoxiang Shen, Jennifer Hosbach, Donglu Zhang, Samuel Bonacorsi, A. David Rodrigues and Zheng Yang
      Drug Metabolism and Disposition September 2012, 40 (9) 1677-1685; DOI: https://doi.org/10.1124/dmd.112.044792

  8. Bratton, Stacie M.

    1. Role of Human UDP-Glucuronosyltransferases in the Biotransformation of the Triazoloacridinone and Imidazoacridinone Antitumor Agents C-1305 and C-1311: Highly Selective Substrates for UGT1A10
      Barbara Fedejko-Kap, Stacie M. Bratton, Moshe Finel, Anna Radominska-Pandya and Zofia Mazerska
      Drug Metabolism and Disposition September 2012, 40 (9) 1736-1743; DOI: https://doi.org/10.1124/dmd.112.045401

  9. Brewer, Katrina A.

    1. The Role of Aldehyde Oxidase and Xanthine Oxidase in the Biotransformation of a Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5
      Ryan D. Morrison, Anna L. Blobaum, Frank W. Byers, Tammy S. Santomango, Thomas M. Bridges, Donald Stec, Katrina A. Brewer, Raymundo Sanchez-Ponce, Melany M. Corlew, Roger Rush, Andrew S. Felts, Jason Manka, Brittney S. Bates, Daryl F. Venable, Alice L. Rodriguez, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte and J. Scott Daniels
      Drug Metabolism and Disposition September 2012, 40 (9) 1834-1845; DOI: https://doi.org/10.1124/dmd.112.046136

  10. Bridges, Thomas M.

    1. The Role of Aldehyde Oxidase and Xanthine Oxidase in the Biotransformation of a Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5
      Ryan D. Morrison, Anna L. Blobaum, Frank W. Byers, Tammy S. Santomango, Thomas M. Bridges, Donald Stec, Katrina A. Brewer, Raymundo Sanchez-Ponce, Melany M. Corlew, Roger Rush, Andrew S. Felts, Jason Manka, Brittney S. Bates, Daryl F. Venable, Alice L. Rodriguez, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte and J. Scott Daniels
      Drug Metabolism and Disposition September 2012, 40 (9) 1834-1845; DOI: https://doi.org/10.1124/dmd.112.046136

  11. Burt, Howard J.

    1. Progress Curve Mechanistic Modeling Approach for Assessing Time-Dependent Inhibition of CYP3A4
      Howard J. Burt, Henry Pertinez, Carolina Säll, Claire Collins, Ruth Hyland, J. Brian Houston and Aleksandra Galetin
      Drug Metabolism and Disposition September 2012, 40 (9) 1658-1667; DOI: https://doi.org/10.1124/dmd.112.046078

  12. Byers, Frank W.

    1. The Role of Aldehyde Oxidase and Xanthine Oxidase in the Biotransformation of a Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5
      Ryan D. Morrison, Anna L. Blobaum, Frank W. Byers, Tammy S. Santomango, Thomas M. Bridges, Donald Stec, Katrina A. Brewer, Raymundo Sanchez-Ponce, Melany M. Corlew, Roger Rush, Andrew S. Felts, Jason Manka, Brittney S. Bates, Daryl F. Venable, Alice L. Rodriguez, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte and J. Scott Daniels
      Drug Metabolism and Disposition September 2012, 40 (9) 1834-1845; DOI: https://doi.org/10.1124/dmd.112.046136

C

  1. Cameron, Michael D.

    1. Discovery of a Highly Selective CYP3A4 Inhibitor Suitable for Reaction Phenotyping Studies and Differentiation of CYP3A4 and CYP3A5
      Xiaohai Li, Xinyi Song, Theodore M. Kamenecka and Michael D. Cameron
      Drug Metabolism and Disposition September 2012, 40 (9) 1803-1809; DOI: https://doi.org/10.1124/dmd.112.046144

  2. Canet, Mark J.

    1. Altered Arsenic Disposition in Experimental Nonalcoholic Fatty Liver Disease
      Mark J. Canet, Rhiannon N. Hardwick, April D. Lake, Michael J. Kopplin, George L. Scheffer, Walter T. Klimecki, A. Jay Gandolfi and Nathan J. Cherrington
      Drug Metabolism and Disposition September 2012, 40 (9) 1817-1824; DOI: https://doi.org/10.1124/dmd.112.046177

  3. Cao, Kai

    1. Development of a Carbon-14 Labeling Approach to Support Disposition Studies with a Pegylated Biologic
      Haiqing Wang, Lifei Wang, Kai Cao, Stuart L. Emanuel, Paul Morin, Zheng Lin, Guoxiang Shen, Jennifer Hosbach, Donglu Zhang, Samuel Bonacorsi, A. David Rodrigues and Zheng Yang
      Drug Metabolism and Disposition September 2012, 40 (9) 1677-1685; DOI: https://doi.org/10.1124/dmd.112.044792

  4. Chang, Shu-Ying

    1. Evaluation of Six Proton Pump Inhibitors As Inhibitors of Various Human Cytochromes P450: Focus on Cytochrome P450 2C19
      Tatyana Zvyaga, Shu-Ying Chang, Cliff Chen, Zheng Yang, Ragini Vuppugalla, Jeremy Hurley, Denise Thorndike, Andrew Wagner, Anjaneya Chimalakonda and A. David Rodrigues
      Drug Metabolism and Disposition September 2012, 40 (9) 1698-1711; DOI: https://doi.org/10.1124/dmd.112.045575

  5. Chen, Cliff

    1. Evaluation of Six Proton Pump Inhibitors As Inhibitors of Various Human Cytochromes P450: Focus on Cytochrome P450 2C19
      Tatyana Zvyaga, Shu-Ying Chang, Cliff Chen, Zheng Yang, Ragini Vuppugalla, Jeremy Hurley, Denise Thorndike, Andrew Wagner, Anjaneya Chimalakonda and A. David Rodrigues
      Drug Metabolism and Disposition September 2012, 40 (9) 1698-1711; DOI: https://doi.org/10.1124/dmd.112.045575

  6. Cherrington, Nathan J.

    1. Altered Arsenic Disposition in Experimental Nonalcoholic Fatty Liver Disease
      Mark J. Canet, Rhiannon N. Hardwick, April D. Lake, Michael J. Kopplin, George L. Scheffer, Walter T. Klimecki, A. Jay Gandolfi and Nathan J. Cherrington
      Drug Metabolism and Disposition September 2012, 40 (9) 1817-1824; DOI: https://doi.org/10.1124/dmd.112.046177

  7. Chimalakonda, Anjaneya

    1. Evaluation of Six Proton Pump Inhibitors As Inhibitors of Various Human Cytochromes P450: Focus on Cytochrome P450 2C19
      Tatyana Zvyaga, Shu-Ying Chang, Cliff Chen, Zheng Yang, Ragini Vuppugalla, Jeremy Hurley, Denise Thorndike, Andrew Wagner, Anjaneya Chimalakonda and A. David Rodrigues
      Drug Metabolism and Disposition September 2012, 40 (9) 1698-1711; DOI: https://doi.org/10.1124/dmd.112.045575

  8. Chin, Christina

    1. Excretion and Metabolism of Milnacipran in Humans after Oral Administration of Milnacipran Hydrochloride
      Fanying Li, Christina Chin, Julie Wangsa and John Ho
      Drug Metabolism and Disposition September 2012, 40 (9) 1723-1735; DOI: https://doi.org/10.1124/dmd.112.045120

  9. Collins, Claire

    1. Progress Curve Mechanistic Modeling Approach for Assessing Time-Dependent Inhibition of CYP3A4
      Howard J. Burt, Henry Pertinez, Carolina Säll, Claire Collins, Ruth Hyland, J. Brian Houston and Aleksandra Galetin
      Drug Metabolism and Disposition September 2012, 40 (9) 1658-1667; DOI: https://doi.org/10.1124/dmd.112.046078

  10. Conn, P. Jeffrey

    1. The Role of Aldehyde Oxidase and Xanthine Oxidase in the Biotransformation of a Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5
      Ryan D. Morrison, Anna L. Blobaum, Frank W. Byers, Tammy S. Santomango, Thomas M. Bridges, Donald Stec, Katrina A. Brewer, Raymundo Sanchez-Ponce, Melany M. Corlew, Roger Rush, Andrew S. Felts, Jason Manka, Brittney S. Bates, Daryl F. Venable, Alice L. Rodriguez, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte and J. Scott Daniels
      Drug Metabolism and Disposition September 2012, 40 (9) 1834-1845; DOI: https://doi.org/10.1124/dmd.112.046136

  11. Corlew, Melany M.

    1. The Role of Aldehyde Oxidase and Xanthine Oxidase in the Biotransformation of a Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5
      Ryan D. Morrison, Anna L. Blobaum, Frank W. Byers, Tammy S. Santomango, Thomas M. Bridges, Donald Stec, Katrina A. Brewer, Raymundo Sanchez-Ponce, Melany M. Corlew, Roger Rush, Andrew S. Felts, Jason Manka, Brittney S. Bates, Daryl F. Venable, Alice L. Rodriguez, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte and J. Scott Daniels
      Drug Metabolism and Disposition September 2012, 40 (9) 1834-1845; DOI: https://doi.org/10.1124/dmd.112.046136

D

  1. Dain, Jeremy

    1. Metabolism and Pharmacokinetics of Indacaterol in Humans
      Mark Kagan, Jeremy Dain, Lana Peng and Christine Reynolds
      Drug Metabolism and Disposition September 2012, 40 (9) 1712-1722; DOI: https://doi.org/10.1124/dmd.112.046151

  2. Daniels, J. Scott

    1. The Role of Aldehyde Oxidase and Xanthine Oxidase in the Biotransformation of a Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5
      Ryan D. Morrison, Anna L. Blobaum, Frank W. Byers, Tammy S. Santomango, Thomas M. Bridges, Donald Stec, Katrina A. Brewer, Raymundo Sanchez-Ponce, Melany M. Corlew, Roger Rush, Andrew S. Felts, Jason Manka, Brittney S. Bates, Daryl F. Venable, Alice L. Rodriguez, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte and J. Scott Daniels
      Drug Metabolism and Disposition September 2012, 40 (9) 1834-1845; DOI: https://doi.org/10.1124/dmd.112.046136

  3. Di, Li

    1. A Novel Relay Method for Determining Low-Clearance Values
      Li Di, Patrick Trapa, R. Scott Obach, Karen Atkinson, Yi-An Bi, Angela C. Wolford, Beijing Tan, Thomas S. McDonald, Yurong Lai and Larry M. Tremaine
      Drug Metabolism and Disposition September 2012, 40 (9) 1860-1865; DOI: https://doi.org/10.1124/dmd.112.046425

E

  1. Emanuel, Stuart L.

    1. Development of a Carbon-14 Labeling Approach to Support Disposition Studies with a Pegylated Biologic
      Haiqing Wang, Lifei Wang, Kai Cao, Stuart L. Emanuel, Paul Morin, Zheng Lin, Guoxiang Shen, Jennifer Hosbach, Donglu Zhang, Samuel Bonacorsi, A. David Rodrigues and Zheng Yang
      Drug Metabolism and Disposition September 2012, 40 (9) 1677-1685; DOI: https://doi.org/10.1124/dmd.112.044792

  2. Emmitte, Kyle A.

    1. The Role of Aldehyde Oxidase and Xanthine Oxidase in the Biotransformation of a Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5
      Ryan D. Morrison, Anna L. Blobaum, Frank W. Byers, Tammy S. Santomango, Thomas M. Bridges, Donald Stec, Katrina A. Brewer, Raymundo Sanchez-Ponce, Melany M. Corlew, Roger Rush, Andrew S. Felts, Jason Manka, Brittney S. Bates, Daryl F. Venable, Alice L. Rodriguez, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte and J. Scott Daniels
      Drug Metabolism and Disposition September 2012, 40 (9) 1834-1845; DOI: https://doi.org/10.1124/dmd.112.046136

F

  1. Fedejko-Kap, Barbara

    1. Role of Human UDP-Glucuronosyltransferases in the Biotransformation of the Triazoloacridinone and Imidazoacridinone Antitumor Agents C-1305 and C-1311: Highly Selective Substrates for UGT1A10
      Barbara Fedejko-Kap, Stacie M. Bratton, Moshe Finel, Anna Radominska-Pandya and Zofia Mazerska
      Drug Metabolism and Disposition September 2012, 40 (9) 1736-1743; DOI: https://doi.org/10.1124/dmd.112.045401

  2. Felts, Andrew S.

    1. The Role of Aldehyde Oxidase and Xanthine Oxidase in the Biotransformation of a Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5
      Ryan D. Morrison, Anna L. Blobaum, Frank W. Byers, Tammy S. Santomango, Thomas M. Bridges, Donald Stec, Katrina A. Brewer, Raymundo Sanchez-Ponce, Melany M. Corlew, Roger Rush, Andrew S. Felts, Jason Manka, Brittney S. Bates, Daryl F. Venable, Alice L. Rodriguez, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte and J. Scott Daniels
      Drug Metabolism and Disposition September 2012, 40 (9) 1834-1845; DOI: https://doi.org/10.1124/dmd.112.046136

  3. Finel, Moshe

    1. Role of Human UDP-Glucuronosyltransferases in the Biotransformation of the Triazoloacridinone and Imidazoacridinone Antitumor Agents C-1305 and C-1311: Highly Selective Substrates for UGT1A10
      Barbara Fedejko-Kap, Stacie M. Bratton, Moshe Finel, Anna Radominska-Pandya and Zofia Mazerska
      Drug Metabolism and Disposition September 2012, 40 (9) 1736-1743; DOI: https://doi.org/10.1124/dmd.112.045401

  4. Fitch, William L.

    1. Preclinical Evaluation of the Metabolism and Disposition of RRx-001, a Novel Investigative Anticancer Agent
      Jan Scicinski, Bryan Oronsky, Michael Taylor, Gang Luo, Timothy Musick, Joseph Marini, Christopher M. Adams and William L. Fitch
      Drug Metabolism and Disposition September 2012, 40 (9) 1810-1816; DOI: https://doi.org/10.1124/dmd.112.046755

  5. Fujioka, Yasushi

    1. Risk Assessment of Mechanism-Based Inactivation in Drug-Drug Interactions
      Yasushi Fujioka, Kent L. Kunze and Nina Isoherranen
      Drug Metabolism and Disposition September 2012, 40 (9) 1653-1657; DOI: https://doi.org/10.1124/dmd.112.046649

  6. Furukawa, Takako

    1. Quantitative Prediction of Human Intestinal Glucuronidation Effects on Intestinal Availability of UDP-Glucuronosyltransferase Substrates Using In Vitro Data
      Fumihiro Nakamori, Yoichi Naritomi, Ken-ichi Hosoya, Hiroyuki Moriguchi, Kazuhiro Tetsuka, Takako Furukawa, Keitaro Kadono, Katsuhiro Yamano, Shigeyuki Terashita and Toshio Teramura
      Drug Metabolism and Disposition September 2012, 40 (9) 1771-1777; DOI: https://doi.org/10.1124/dmd.112.045476

G

  1. Galetin, Aleksandra

    1. Progress Curve Mechanistic Modeling Approach for Assessing Time-Dependent Inhibition of CYP3A4
      Howard J. Burt, Henry Pertinez, Carolina Säll, Claire Collins, Ruth Hyland, J. Brian Houston and Aleksandra Galetin
      Drug Metabolism and Disposition September 2012, 40 (9) 1658-1667; DOI: https://doi.org/10.1124/dmd.112.046078
    2. Use of Mechanistic Modeling to Assess Interindividual Variability and Interspecies Differences in Active Uptake in Human and Rat Hepatocytes
      Karelle Ménochet, Kathryn E. Kenworthy, J. Brian Houston and Aleksandra Galetin
      Drug Metabolism and Disposition September 2012, 40 (9) 1744-1756; DOI: https://doi.org/10.1124/dmd.112.046193

  2. Gandolfi, A. Jay

    1. Altered Arsenic Disposition in Experimental Nonalcoholic Fatty Liver Disease
      Mark J. Canet, Rhiannon N. Hardwick, April D. Lake, Michael J. Kopplin, George L. Scheffer, Walter T. Klimecki, A. Jay Gandolfi and Nathan J. Cherrington
      Drug Metabolism and Disposition September 2012, 40 (9) 1817-1824; DOI: https://doi.org/10.1124/dmd.112.046177

  3. Geoghegan, Kieran F.

    1. Selective Mechanism-Based Inactivation of CYP3A4 by CYP3cide (PF-04981517) and Its Utility as an In Vitro Tool for Delineating the Relative Roles of CYP3A4 versus CYP3A5 in the Metabolism of Drugs
      Robert L. Walsky, R. Scott Obach, Ruth Hyland, Ping Kang, Sue Zhou, Michael West, Kieran F. Geoghegan, Christopher J. Helal, Gregory S. Walker, Theunis C. Goosen and Michael A. Zientek
      Drug Metabolism and Disposition September 2012, 40 (9) 1686-1697; DOI: https://doi.org/10.1124/dmd.112.045302

  4. Goodlett, David R.

    1. Evaluation of P450 Inhibition and Induction by Artemisinin Antimalarials in Human Liver Microsomes and Primary Human Hepatocytes
      Jie Xing, Brian J. Kirby, Dale Whittington, Yakun Wan and David R. Goodlett
      Drug Metabolism and Disposition September 2012, 40 (9) 1757-1764; DOI: https://doi.org/10.1124/dmd.112.045765

  5. Goosen, Theunis C.

    1. Selective Mechanism-Based Inactivation of CYP3A4 by CYP3cide (PF-04981517) and Its Utility as an In Vitro Tool for Delineating the Relative Roles of CYP3A4 versus CYP3A5 in the Metabolism of Drugs
      Robert L. Walsky, R. Scott Obach, Ruth Hyland, Ping Kang, Sue Zhou, Michael West, Kieran F. Geoghegan, Christopher J. Helal, Gregory S. Walker, Theunis C. Goosen and Michael A. Zientek
      Drug Metabolism and Disposition September 2012, 40 (9) 1686-1697; DOI: https://doi.org/10.1124/dmd.112.045302

H

  1. Hagihara, Katsunobu

    1. Glutaredoxin Is Involved in the Formation of the Pharmacologically Active Metabolite of Clopidogrel from Its GSH Conjugate
      Katsunobu Hagihara, Miho Kazui, Atsushi Kurihara, Toshihiko Ikeda and Takashi Izumi
      Drug Metabolism and Disposition September 2012, 40 (9) 1854-1859; DOI: https://doi.org/10.1124/dmd.112.045914

  2. Hardwick, Rhiannon N.

    1. Altered Arsenic Disposition in Experimental Nonalcoholic Fatty Liver Disease
      Mark J. Canet, Rhiannon N. Hardwick, April D. Lake, Michael J. Kopplin, George L. Scheffer, Walter T. Klimecki, A. Jay Gandolfi and Nathan J. Cherrington
      Drug Metabolism and Disposition September 2012, 40 (9) 1817-1824; DOI: https://doi.org/10.1124/dmd.112.046177

  3. Helal, Christopher J.

    1. Selective Mechanism-Based Inactivation of CYP3A4 by CYP3cide (PF-04981517) and Its Utility as an In Vitro Tool for Delineating the Relative Roles of CYP3A4 versus CYP3A5 in the Metabolism of Drugs
      Robert L. Walsky, R. Scott Obach, Ruth Hyland, Ping Kang, Sue Zhou, Michael West, Kieran F. Geoghegan, Christopher J. Helal, Gregory S. Walker, Theunis C. Goosen and Michael A. Zientek
      Drug Metabolism and Disposition September 2012, 40 (9) 1686-1697; DOI: https://doi.org/10.1124/dmd.112.045302

  4. Hermann, Monica

    1. Metabolism of the Active Metabolite of Quetiapine, N-Desalkylquetiapine In Vitro
      Gry Vibeke Bakken, Espen Molden, Karoline Knutsen, Niclas Lunder and Monica Hermann
      Drug Metabolism and Disposition September 2012, 40 (9) 1778-1784; DOI: https://doi.org/10.1124/dmd.112.045237

  5. Higgins, J. William

    1. Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 Knockout Rats Using Loperamide, Paclitaxel, Sulfasalazine, and Carboxydichlorofluorescein Pharmacokinetics
      Maciej J. Zamek-Gliszczynski, David W. Bedwell, Jing Q. Bao and J. William Higgins
      Drug Metabolism and Disposition September 2012, 40 (9) 1825-1833; DOI: https://doi.org/10.1124/dmd.112.046508

  6. Ho, John

    1. Excretion and Metabolism of Milnacipran in Humans after Oral Administration of Milnacipran Hydrochloride
      Fanying Li, Christina Chin, Julie Wangsa and John Ho
      Drug Metabolism and Disposition September 2012, 40 (9) 1723-1735; DOI: https://doi.org/10.1124/dmd.112.045120

  7. Hollenberg, Paul F.

    1. Mechanism-Based Inactivation of Cytochrome P450 2B6 by Methadone through Destruction of Prosthetic Heme
      Hemali T. Amunugama, Haoming Zhang and Paul F. Hollenberg
      Drug Metabolism and Disposition September 2012, 40 (9) 1765-1770; DOI: https://doi.org/10.1124/dmd.112.045971

  8. Hosbach, Jennifer

    1. Development of a Carbon-14 Labeling Approach to Support Disposition Studies with a Pegylated Biologic
      Haiqing Wang, Lifei Wang, Kai Cao, Stuart L. Emanuel, Paul Morin, Zheng Lin, Guoxiang Shen, Jennifer Hosbach, Donglu Zhang, Samuel Bonacorsi, A. David Rodrigues and Zheng Yang
      Drug Metabolism and Disposition September 2012, 40 (9) 1677-1685; DOI: https://doi.org/10.1124/dmd.112.044792

  9. Hosoya, Ken-ichi

    1. Quantitative Prediction of Human Intestinal Glucuronidation Effects on Intestinal Availability of UDP-Glucuronosyltransferase Substrates Using In Vitro Data
      Fumihiro Nakamori, Yoichi Naritomi, Ken-ichi Hosoya, Hiroyuki Moriguchi, Kazuhiro Tetsuka, Takako Furukawa, Keitaro Kadono, Katsuhiro Yamano, Shigeyuki Terashita and Toshio Teramura
      Drug Metabolism and Disposition September 2012, 40 (9) 1771-1777; DOI: https://doi.org/10.1124/dmd.112.045476

  10. Houston, J. Brian

    1. Progress Curve Mechanistic Modeling Approach for Assessing Time-Dependent Inhibition of CYP3A4
      Howard J. Burt, Henry Pertinez, Carolina Säll, Claire Collins, Ruth Hyland, J. Brian Houston and Aleksandra Galetin
      Drug Metabolism and Disposition September 2012, 40 (9) 1658-1667; DOI: https://doi.org/10.1124/dmd.112.046078
    2. Use of Mechanistic Modeling to Assess Interindividual Variability and Interspecies Differences in Active Uptake in Human and Rat Hepatocytes
      Karelle Ménochet, Kathryn E. Kenworthy, J. Brian Houston and Aleksandra Galetin
      Drug Metabolism and Disposition September 2012, 40 (9) 1744-1756; DOI: https://doi.org/10.1124/dmd.112.046193

  11. Huang, Stella

    1. A Novel Ring Oxidation of 4- or 5-Substituted 2H-Oxazole to Corresponding 2-Oxazolone Catalyzed by Cytosolic Aldehyde Oxidase
      Vinod K. Arora, Thomas Philip, Stella Huang and Yue-Zhong Shu
      Drug Metabolism and Disposition September 2012, 40 (9) 1668-1676; DOI: https://doi.org/10.1124/dmd.112.044545

  12. Hurley, Jeremy

    1. Evaluation of Six Proton Pump Inhibitors As Inhibitors of Various Human Cytochromes P450: Focus on Cytochrome P450 2C19
      Tatyana Zvyaga, Shu-Ying Chang, Cliff Chen, Zheng Yang, Ragini Vuppugalla, Jeremy Hurley, Denise Thorndike, Andrew Wagner, Anjaneya Chimalakonda and A. David Rodrigues
      Drug Metabolism and Disposition September 2012, 40 (9) 1698-1711; DOI: https://doi.org/10.1124/dmd.112.045575

  13. Hyland, Ruth

    1. Selective Mechanism-Based Inactivation of CYP3A4 by CYP3cide (PF-04981517) and Its Utility as an In Vitro Tool for Delineating the Relative Roles of CYP3A4 versus CYP3A5 in the Metabolism of Drugs
      Robert L. Walsky, R. Scott Obach, Ruth Hyland, Ping Kang, Sue Zhou, Michael West, Kieran F. Geoghegan, Christopher J. Helal, Gregory S. Walker, Theunis C. Goosen and Michael A. Zientek
      Drug Metabolism and Disposition September 2012, 40 (9) 1686-1697; DOI: https://doi.org/10.1124/dmd.112.045302
    2. Progress Curve Mechanistic Modeling Approach for Assessing Time-Dependent Inhibition of CYP3A4
      Howard J. Burt, Henry Pertinez, Carolina Säll, Claire Collins, Ruth Hyland, J. Brian Houston and Aleksandra Galetin
      Drug Metabolism and Disposition September 2012, 40 (9) 1658-1667; DOI: https://doi.org/10.1124/dmd.112.046078

I

  1. Ikeda, Toshihiko

    1. Glutaredoxin Is Involved in the Formation of the Pharmacologically Active Metabolite of Clopidogrel from Its GSH Conjugate
      Katsunobu Hagihara, Miho Kazui, Atsushi Kurihara, Toshihiko Ikeda and Takashi Izumi
      Drug Metabolism and Disposition September 2012, 40 (9) 1854-1859; DOI: https://doi.org/10.1124/dmd.112.045914

  2. Isoherranen, Nina

    1. Risk Assessment of Mechanism-Based Inactivation in Drug-Drug Interactions
      Yasushi Fujioka, Kent L. Kunze and Nina Isoherranen
      Drug Metabolism and Disposition September 2012, 40 (9) 1653-1657; DOI: https://doi.org/10.1124/dmd.112.046649

  3. Izumi, Takashi

    1. Glutaredoxin Is Involved in the Formation of the Pharmacologically Active Metabolite of Clopidogrel from Its GSH Conjugate
      Katsunobu Hagihara, Miho Kazui, Atsushi Kurihara, Toshihiko Ikeda and Takashi Izumi
      Drug Metabolism and Disposition September 2012, 40 (9) 1854-1859; DOI: https://doi.org/10.1124/dmd.112.045914

J

  1. Jones, Carrie K.

    1. The Role of Aldehyde Oxidase and Xanthine Oxidase in the Biotransformation of a Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5
      Ryan D. Morrison, Anna L. Blobaum, Frank W. Byers, Tammy S. Santomango, Thomas M. Bridges, Donald Stec, Katrina A. Brewer, Raymundo Sanchez-Ponce, Melany M. Corlew, Roger Rush, Andrew S. Felts, Jason Manka, Brittney S. Bates, Daryl F. Venable, Alice L. Rodriguez, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte and J. Scott Daniels
      Drug Metabolism and Disposition September 2012, 40 (9) 1834-1845; DOI: https://doi.org/10.1124/dmd.112.046136

K

  1. Kadono, Keitaro

    1. Quantitative Prediction of Human Intestinal Glucuronidation Effects on Intestinal Availability of UDP-Glucuronosyltransferase Substrates Using In Vitro Data
      Fumihiro Nakamori, Yoichi Naritomi, Ken-ichi Hosoya, Hiroyuki Moriguchi, Kazuhiro Tetsuka, Takako Furukawa, Keitaro Kadono, Katsuhiro Yamano, Shigeyuki Terashita and Toshio Teramura
      Drug Metabolism and Disposition September 2012, 40 (9) 1771-1777; DOI: https://doi.org/10.1124/dmd.112.045476

  2. Kagan, Mark

    1. Metabolism and Pharmacokinetics of Indacaterol in Humans
      Mark Kagan, Jeremy Dain, Lana Peng and Christine Reynolds
      Drug Metabolism and Disposition September 2012, 40 (9) 1712-1722; DOI: https://doi.org/10.1124/dmd.112.046151

  3. Kamenecka, Theodore M.

    1. Discovery of a Highly Selective CYP3A4 Inhibitor Suitable for Reaction Phenotyping Studies and Differentiation of CYP3A4 and CYP3A5
      Xiaohai Li, Xinyi Song, Theodore M. Kamenecka and Michael D. Cameron
      Drug Metabolism and Disposition September 2012, 40 (9) 1803-1809; DOI: https://doi.org/10.1124/dmd.112.046144

  4. Kang, Ping

    1. Selective Mechanism-Based Inactivation of CYP3A4 by CYP3cide (PF-04981517) and Its Utility as an In Vitro Tool for Delineating the Relative Roles of CYP3A4 versus CYP3A5 in the Metabolism of Drugs
      Robert L. Walsky, R. Scott Obach, Ruth Hyland, Ping Kang, Sue Zhou, Michael West, Kieran F. Geoghegan, Christopher J. Helal, Gregory S. Walker, Theunis C. Goosen and Michael A. Zientek
      Drug Metabolism and Disposition September 2012, 40 (9) 1686-1697; DOI: https://doi.org/10.1124/dmd.112.045302

  5. Kazui, Miho

    1. Glutaredoxin Is Involved in the Formation of the Pharmacologically Active Metabolite of Clopidogrel from Its GSH Conjugate
      Katsunobu Hagihara, Miho Kazui, Atsushi Kurihara, Toshihiko Ikeda and Takashi Izumi
      Drug Metabolism and Disposition September 2012, 40 (9) 1854-1859; DOI: https://doi.org/10.1124/dmd.112.045914

  6. Kenworthy, Kathryn E.

    1. Use of Mechanistic Modeling to Assess Interindividual Variability and Interspecies Differences in Active Uptake in Human and Rat Hepatocytes
      Karelle Ménochet, Kathryn E. Kenworthy, J. Brian Houston and Aleksandra Galetin
      Drug Metabolism and Disposition September 2012, 40 (9) 1744-1756; DOI: https://doi.org/10.1124/dmd.112.046193

  7. Kirby, Brian J.

    1. Evaluation of P450 Inhibition and Induction by Artemisinin Antimalarials in Human Liver Microsomes and Primary Human Hepatocytes
      Jie Xing, Brian J. Kirby, Dale Whittington, Yakun Wan and David R. Goodlett
      Drug Metabolism and Disposition September 2012, 40 (9) 1757-1764; DOI: https://doi.org/10.1124/dmd.112.045765

  8. Klimecki, Walter T.

    1. Altered Arsenic Disposition in Experimental Nonalcoholic Fatty Liver Disease
      Mark J. Canet, Rhiannon N. Hardwick, April D. Lake, Michael J. Kopplin, George L. Scheffer, Walter T. Klimecki, A. Jay Gandolfi and Nathan J. Cherrington
      Drug Metabolism and Disposition September 2012, 40 (9) 1817-1824; DOI: https://doi.org/10.1124/dmd.112.046177

  9. Knutsen, Karoline

    1. Metabolism of the Active Metabolite of Quetiapine, N-Desalkylquetiapine In Vitro
      Gry Vibeke Bakken, Espen Molden, Karoline Knutsen, Niclas Lunder and Monica Hermann
      Drug Metabolism and Disposition September 2012, 40 (9) 1778-1784; DOI: https://doi.org/10.1124/dmd.112.045237

  10. Kopplin, Michael J.

    1. Altered Arsenic Disposition in Experimental Nonalcoholic Fatty Liver Disease
      Mark J. Canet, Rhiannon N. Hardwick, April D. Lake, Michael J. Kopplin, George L. Scheffer, Walter T. Klimecki, A. Jay Gandolfi and Nathan J. Cherrington
      Drug Metabolism and Disposition September 2012, 40 (9) 1817-1824; DOI: https://doi.org/10.1124/dmd.112.046177

  11. Korzekwa, Ken

    1. Commentary: Nonspecific Protein Binding versus Membrane Partitioning: It Is Not Just Semantics
      Swati Nagar and Ken Korzekwa
      Drug Metabolism and Disposition September 2012, 40 (9) 1649-1652; DOI: https://doi.org/10.1124/dmd.112.046599

  12. Kunze, Kent L.

    1. Risk Assessment of Mechanism-Based Inactivation in Drug-Drug Interactions
      Yasushi Fujioka, Kent L. Kunze and Nina Isoherranen
      Drug Metabolism and Disposition September 2012, 40 (9) 1653-1657; DOI: https://doi.org/10.1124/dmd.112.046649

  13. Kurihara, Atsushi

    1. Glutaredoxin Is Involved in the Formation of the Pharmacologically Active Metabolite of Clopidogrel from Its GSH Conjugate
      Katsunobu Hagihara, Miho Kazui, Atsushi Kurihara, Toshihiko Ikeda and Takashi Izumi
      Drug Metabolism and Disposition September 2012, 40 (9) 1854-1859; DOI: https://doi.org/10.1124/dmd.112.045914

L

  1. Lai, Yurong

    1. A Novel Relay Method for Determining Low-Clearance Values
      Li Di, Patrick Trapa, R. Scott Obach, Karen Atkinson, Yi-An Bi, Angela C. Wolford, Beijing Tan, Thomas S. McDonald, Yurong Lai and Larry M. Tremaine
      Drug Metabolism and Disposition September 2012, 40 (9) 1860-1865; DOI: https://doi.org/10.1124/dmd.112.046425

  2. Lake, April D.

    1. Altered Arsenic Disposition in Experimental Nonalcoholic Fatty Liver Disease
      Mark J. Canet, Rhiannon N. Hardwick, April D. Lake, Michael J. Kopplin, George L. Scheffer, Walter T. Klimecki, A. Jay Gandolfi and Nathan J. Cherrington
      Drug Metabolism and Disposition September 2012, 40 (9) 1817-1824; DOI: https://doi.org/10.1124/dmd.112.046177

  3. Lee, Leslie B.

    1. Preclinical Assessment of the Absorption and Disposition of the Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor GDC-0980 and Prediction of Its Pharmacokinetics and Efficacy in Human
      Laurent Salphati, Jodie Pang, Emile G. Plise, Leslie B. Lee, Alan G. Olivero, Wei Wei Prior, Deepak Sampath, Susan Wong and Xiaolin Zhang
      Drug Metabolism and Disposition September 2012, 40 (9) 1785-1796; DOI: https://doi.org/10.1124/dmd.112.046052

  4. Li, Fanying

    1. Excretion and Metabolism of Milnacipran in Humans after Oral Administration of Milnacipran Hydrochloride
      Fanying Li, Christina Chin, Julie Wangsa and John Ho
      Drug Metabolism and Disposition September 2012, 40 (9) 1723-1735; DOI: https://doi.org/10.1124/dmd.112.045120

  5. Li, Xiaohai

    1. Discovery of a Highly Selective CYP3A4 Inhibitor Suitable for Reaction Phenotyping Studies and Differentiation of CYP3A4 and CYP3A5
      Xiaohai Li, Xinyi Song, Theodore M. Kamenecka and Michael D. Cameron
      Drug Metabolism and Disposition September 2012, 40 (9) 1803-1809; DOI: https://doi.org/10.1124/dmd.112.046144

  6. Lin, Zheng

    1. Development of a Carbon-14 Labeling Approach to Support Disposition Studies with a Pegylated Biologic
      Haiqing Wang, Lifei Wang, Kai Cao, Stuart L. Emanuel, Paul Morin, Zheng Lin, Guoxiang Shen, Jennifer Hosbach, Donglu Zhang, Samuel Bonacorsi, A. David Rodrigues and Zheng Yang
      Drug Metabolism and Disposition September 2012, 40 (9) 1677-1685; DOI: https://doi.org/10.1124/dmd.112.044792

  7. Lindsley, Craig W.

    1. The Role of Aldehyde Oxidase and Xanthine Oxidase in the Biotransformation of a Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5
      Ryan D. Morrison, Anna L. Blobaum, Frank W. Byers, Tammy S. Santomango, Thomas M. Bridges, Donald Stec, Katrina A. Brewer, Raymundo Sanchez-Ponce, Melany M. Corlew, Roger Rush, Andrew S. Felts, Jason Manka, Brittney S. Bates, Daryl F. Venable, Alice L. Rodriguez, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte and J. Scott Daniels
      Drug Metabolism and Disposition September 2012, 40 (9) 1834-1845; DOI: https://doi.org/10.1124/dmd.112.046136

  8. Lunder, Niclas

    1. Metabolism of the Active Metabolite of Quetiapine, N-Desalkylquetiapine In Vitro
      Gry Vibeke Bakken, Espen Molden, Karoline Knutsen, Niclas Lunder and Monica Hermann
      Drug Metabolism and Disposition September 2012, 40 (9) 1778-1784; DOI: https://doi.org/10.1124/dmd.112.045237

  9. Luo, Gang

    1. Preclinical Evaluation of the Metabolism and Disposition of RRx-001, a Novel Investigative Anticancer Agent
      Jan Scicinski, Bryan Oronsky, Michael Taylor, Gang Luo, Timothy Musick, Joseph Marini, Christopher M. Adams and William L. Fitch
      Drug Metabolism and Disposition September 2012, 40 (9) 1810-1816; DOI: https://doi.org/10.1124/dmd.112.046755

M

  1. Manka, Jason

    1. The Role of Aldehyde Oxidase and Xanthine Oxidase in the Biotransformation of a Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5
      Ryan D. Morrison, Anna L. Blobaum, Frank W. Byers, Tammy S. Santomango, Thomas M. Bridges, Donald Stec, Katrina A. Brewer, Raymundo Sanchez-Ponce, Melany M. Corlew, Roger Rush, Andrew S. Felts, Jason Manka, Brittney S. Bates, Daryl F. Venable, Alice L. Rodriguez, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte and J. Scott Daniels
      Drug Metabolism and Disposition September 2012, 40 (9) 1834-1845; DOI: https://doi.org/10.1124/dmd.112.046136

  2. Marini, Joseph

    1. Preclinical Evaluation of the Metabolism and Disposition of RRx-001, a Novel Investigative Anticancer Agent
      Jan Scicinski, Bryan Oronsky, Michael Taylor, Gang Luo, Timothy Musick, Joseph Marini, Christopher M. Adams and William L. Fitch
      Drug Metabolism and Disposition September 2012, 40 (9) 1810-1816; DOI: https://doi.org/10.1124/dmd.112.046755

  3. Mazerska, Zofia

    1. Role of Human UDP-Glucuronosyltransferases in the Biotransformation of the Triazoloacridinone and Imidazoacridinone Antitumor Agents C-1305 and C-1311: Highly Selective Substrates for UGT1A10
      Barbara Fedejko-Kap, Stacie M. Bratton, Moshe Finel, Anna Radominska-Pandya and Zofia Mazerska
      Drug Metabolism and Disposition September 2012, 40 (9) 1736-1743; DOI: https://doi.org/10.1124/dmd.112.045401

  4. McDonald, Thomas S.

    1. A Novel Relay Method for Determining Low-Clearance Values
      Li Di, Patrick Trapa, R. Scott Obach, Karen Atkinson, Yi-An Bi, Angela C. Wolford, Beijing Tan, Thomas S. McDonald, Yurong Lai and Larry M. Tremaine
      Drug Metabolism and Disposition September 2012, 40 (9) 1860-1865; DOI: https://doi.org/10.1124/dmd.112.046425

  5. Ménochet, Karelle

    1. Use of Mechanistic Modeling to Assess Interindividual Variability and Interspecies Differences in Active Uptake in Human and Rat Hepatocytes
      Karelle Ménochet, Kathryn E. Kenworthy, J. Brian Houston and Aleksandra Galetin
      Drug Metabolism and Disposition September 2012, 40 (9) 1744-1756; DOI: https://doi.org/10.1124/dmd.112.046193

  6. Molden, Espen

    1. Metabolism of the Active Metabolite of Quetiapine, N-Desalkylquetiapine In Vitro
      Gry Vibeke Bakken, Espen Molden, Karoline Knutsen, Niclas Lunder and Monica Hermann
      Drug Metabolism and Disposition September 2012, 40 (9) 1778-1784; DOI: https://doi.org/10.1124/dmd.112.045237

  7. Moriguchi, Hiroyuki

    1. Quantitative Prediction of Human Intestinal Glucuronidation Effects on Intestinal Availability of UDP-Glucuronosyltransferase Substrates Using In Vitro Data
      Fumihiro Nakamori, Yoichi Naritomi, Ken-ichi Hosoya, Hiroyuki Moriguchi, Kazuhiro Tetsuka, Takako Furukawa, Keitaro Kadono, Katsuhiro Yamano, Shigeyuki Terashita and Toshio Teramura
      Drug Metabolism and Disposition September 2012, 40 (9) 1771-1777; DOI: https://doi.org/10.1124/dmd.112.045476

  8. Morin, Paul

    1. Development of a Carbon-14 Labeling Approach to Support Disposition Studies with a Pegylated Biologic
      Haiqing Wang, Lifei Wang, Kai Cao, Stuart L. Emanuel, Paul Morin, Zheng Lin, Guoxiang Shen, Jennifer Hosbach, Donglu Zhang, Samuel Bonacorsi, A. David Rodrigues and Zheng Yang
      Drug Metabolism and Disposition September 2012, 40 (9) 1677-1685; DOI: https://doi.org/10.1124/dmd.112.044792

  9. Morrison, Ryan D.

    1. The Role of Aldehyde Oxidase and Xanthine Oxidase in the Biotransformation of a Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5
      Ryan D. Morrison, Anna L. Blobaum, Frank W. Byers, Tammy S. Santomango, Thomas M. Bridges, Donald Stec, Katrina A. Brewer, Raymundo Sanchez-Ponce, Melany M. Corlew, Roger Rush, Andrew S. Felts, Jason Manka, Brittney S. Bates, Daryl F. Venable, Alice L. Rodriguez, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte and J. Scott Daniels
      Drug Metabolism and Disposition September 2012, 40 (9) 1834-1845; DOI: https://doi.org/10.1124/dmd.112.046136

  10. Musick, Timothy

    1. Preclinical Evaluation of the Metabolism and Disposition of RRx-001, a Novel Investigative Anticancer Agent
      Jan Scicinski, Bryan Oronsky, Michael Taylor, Gang Luo, Timothy Musick, Joseph Marini, Christopher M. Adams and William L. Fitch
      Drug Metabolism and Disposition September 2012, 40 (9) 1810-1816; DOI: https://doi.org/10.1124/dmd.112.046755

N

  1. Nagar, Swati

    1. Commentary: Nonspecific Protein Binding versus Membrane Partitioning: It Is Not Just Semantics
      Swati Nagar and Ken Korzekwa
      Drug Metabolism and Disposition September 2012, 40 (9) 1649-1652; DOI: https://doi.org/10.1124/dmd.112.046599

  2. Nakamori, Fumihiro

    1. Quantitative Prediction of Human Intestinal Glucuronidation Effects on Intestinal Availability of UDP-Glucuronosyltransferase Substrates Using In Vitro Data
      Fumihiro Nakamori, Yoichi Naritomi, Ken-ichi Hosoya, Hiroyuki Moriguchi, Kazuhiro Tetsuka, Takako Furukawa, Keitaro Kadono, Katsuhiro Yamano, Shigeyuki Terashita and Toshio Teramura
      Drug Metabolism and Disposition September 2012, 40 (9) 1771-1777; DOI: https://doi.org/10.1124/dmd.112.045476

  3. Naritomi, Yoichi

    1. Quantitative Prediction of Human Intestinal Glucuronidation Effects on Intestinal Availability of UDP-Glucuronosyltransferase Substrates Using In Vitro Data
      Fumihiro Nakamori, Yoichi Naritomi, Ken-ichi Hosoya, Hiroyuki Moriguchi, Kazuhiro Tetsuka, Takako Furukawa, Keitaro Kadono, Katsuhiro Yamano, Shigeyuki Terashita and Toshio Teramura
      Drug Metabolism and Disposition September 2012, 40 (9) 1771-1777; DOI: https://doi.org/10.1124/dmd.112.045476

  4. Niswender, Colleen M.

    1. The Role of Aldehyde Oxidase and Xanthine Oxidase in the Biotransformation of a Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5
      Ryan D. Morrison, Anna L. Blobaum, Frank W. Byers, Tammy S. Santomango, Thomas M. Bridges, Donald Stec, Katrina A. Brewer, Raymundo Sanchez-Ponce, Melany M. Corlew, Roger Rush, Andrew S. Felts, Jason Manka, Brittney S. Bates, Daryl F. Venable, Alice L. Rodriguez, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte and J. Scott Daniels
      Drug Metabolism and Disposition September 2012, 40 (9) 1834-1845; DOI: https://doi.org/10.1124/dmd.112.046136

O

  1. Obach, R. Scott

    1. A Novel Relay Method for Determining Low-Clearance Values
      Li Di, Patrick Trapa, R. Scott Obach, Karen Atkinson, Yi-An Bi, Angela C. Wolford, Beijing Tan, Thomas S. McDonald, Yurong Lai and Larry M. Tremaine
      Drug Metabolism and Disposition September 2012, 40 (9) 1860-1865; DOI: https://doi.org/10.1124/dmd.112.046425
    2. Selective Mechanism-Based Inactivation of CYP3A4 by CYP3cide (PF-04981517) and Its Utility as an In Vitro Tool for Delineating the Relative Roles of CYP3A4 versus CYP3A5 in the Metabolism of Drugs
      Robert L. Walsky, R. Scott Obach, Ruth Hyland, Ping Kang, Sue Zhou, Michael West, Kieran F. Geoghegan, Christopher J. Helal, Gregory S. Walker, Theunis C. Goosen and Michael A. Zientek
      Drug Metabolism and Disposition September 2012, 40 (9) 1686-1697; DOI: https://doi.org/10.1124/dmd.112.045302

  2. Olivero, Alan G.

    1. Preclinical Assessment of the Absorption and Disposition of the Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor GDC-0980 and Prediction of Its Pharmacokinetics and Efficacy in Human
      Laurent Salphati, Jodie Pang, Emile G. Plise, Leslie B. Lee, Alan G. Olivero, Wei Wei Prior, Deepak Sampath, Susan Wong and Xiaolin Zhang
      Drug Metabolism and Disposition September 2012, 40 (9) 1785-1796; DOI: https://doi.org/10.1124/dmd.112.046052

  3. Oronsky, Bryan

    1. Preclinical Evaluation of the Metabolism and Disposition of RRx-001, a Novel Investigative Anticancer Agent
      Jan Scicinski, Bryan Oronsky, Michael Taylor, Gang Luo, Timothy Musick, Joseph Marini, Christopher M. Adams and William L. Fitch
      Drug Metabolism and Disposition September 2012, 40 (9) 1810-1816; DOI: https://doi.org/10.1124/dmd.112.046755

P

  1. Padowski, Jeannie M.

    1. Influence of Enterohepatic Recycling on the Time Course of Brain-to-Blood Partitioning of Valproic Acid in Rats
      Jeannie M. Padowski and Gary M. Pollack
      Drug Metabolism and Disposition September 2012, 40 (9) 1846-1853; DOI: https://doi.org/10.1124/dmd.112.045500

  2. Pang, Jodie

    1. Preclinical Assessment of the Absorption and Disposition of the Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor GDC-0980 and Prediction of Its Pharmacokinetics and Efficacy in Human
      Laurent Salphati, Jodie Pang, Emile G. Plise, Leslie B. Lee, Alan G. Olivero, Wei Wei Prior, Deepak Sampath, Susan Wong and Xiaolin Zhang
      Drug Metabolism and Disposition September 2012, 40 (9) 1785-1796; DOI: https://doi.org/10.1124/dmd.112.046052

  3. Peng, Lana

    1. Metabolism and Pharmacokinetics of Indacaterol in Humans
      Mark Kagan, Jeremy Dain, Lana Peng and Christine Reynolds
      Drug Metabolism and Disposition September 2012, 40 (9) 1712-1722; DOI: https://doi.org/10.1124/dmd.112.046151

  4. Pertinez, Henry

    1. Progress Curve Mechanistic Modeling Approach for Assessing Time-Dependent Inhibition of CYP3A4
      Howard J. Burt, Henry Pertinez, Carolina Säll, Claire Collins, Ruth Hyland, J. Brian Houston and Aleksandra Galetin
      Drug Metabolism and Disposition September 2012, 40 (9) 1658-1667; DOI: https://doi.org/10.1124/dmd.112.046078

  5. Philip, Thomas

    1. A Novel Ring Oxidation of 4- or 5-Substituted 2H-Oxazole to Corresponding 2-Oxazolone Catalyzed by Cytosolic Aldehyde Oxidase
      Vinod K. Arora, Thomas Philip, Stella Huang and Yue-Zhong Shu
      Drug Metabolism and Disposition September 2012, 40 (9) 1668-1676; DOI: https://doi.org/10.1124/dmd.112.044545

  6. Plise, Emile G.

    1. Preclinical Assessment of the Absorption and Disposition of the Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor GDC-0980 and Prediction of Its Pharmacokinetics and Efficacy in Human
      Laurent Salphati, Jodie Pang, Emile G. Plise, Leslie B. Lee, Alan G. Olivero, Wei Wei Prior, Deepak Sampath, Susan Wong and Xiaolin Zhang
      Drug Metabolism and Disposition September 2012, 40 (9) 1785-1796; DOI: https://doi.org/10.1124/dmd.112.046052

  7. Pollack, Gary M.

    1. Influence of Enterohepatic Recycling on the Time Course of Brain-to-Blood Partitioning of Valproic Acid in Rats
      Jeannie M. Padowski and Gary M. Pollack
      Drug Metabolism and Disposition September 2012, 40 (9) 1846-1853; DOI: https://doi.org/10.1124/dmd.112.045500

  8. Prior, Wei Wei

    1. Preclinical Assessment of the Absorption and Disposition of the Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor GDC-0980 and Prediction of Its Pharmacokinetics and Efficacy in Human
      Laurent Salphati, Jodie Pang, Emile G. Plise, Leslie B. Lee, Alan G. Olivero, Wei Wei Prior, Deepak Sampath, Susan Wong and Xiaolin Zhang
      Drug Metabolism and Disposition September 2012, 40 (9) 1785-1796; DOI: https://doi.org/10.1124/dmd.112.046052

R

  1. Radominska-Pandya, Anna

    1. Role of Human UDP-Glucuronosyltransferases in the Biotransformation of the Triazoloacridinone and Imidazoacridinone Antitumor Agents C-1305 and C-1311: Highly Selective Substrates for UGT1A10
      Barbara Fedejko-Kap, Stacie M. Bratton, Moshe Finel, Anna Radominska-Pandya and Zofia Mazerska
      Drug Metabolism and Disposition September 2012, 40 (9) 1736-1743; DOI: https://doi.org/10.1124/dmd.112.045401

  2. Reynolds, Christine

    1. Metabolism and Pharmacokinetics of Indacaterol in Humans
      Mark Kagan, Jeremy Dain, Lana Peng and Christine Reynolds
      Drug Metabolism and Disposition September 2012, 40 (9) 1712-1722; DOI: https://doi.org/10.1124/dmd.112.046151

  3. Rodrigues, A. David

    1. Development of a Carbon-14 Labeling Approach to Support Disposition Studies with a Pegylated Biologic
      Haiqing Wang, Lifei Wang, Kai Cao, Stuart L. Emanuel, Paul Morin, Zheng Lin, Guoxiang Shen, Jennifer Hosbach, Donglu Zhang, Samuel Bonacorsi, A. David Rodrigues and Zheng Yang
      Drug Metabolism and Disposition September 2012, 40 (9) 1677-1685; DOI: https://doi.org/10.1124/dmd.112.044792
    2. Evaluation of Six Proton Pump Inhibitors As Inhibitors of Various Human Cytochromes P450: Focus on Cytochrome P450 2C19
      Tatyana Zvyaga, Shu-Ying Chang, Cliff Chen, Zheng Yang, Ragini Vuppugalla, Jeremy Hurley, Denise Thorndike, Andrew Wagner, Anjaneya Chimalakonda and A. David Rodrigues
      Drug Metabolism and Disposition September 2012, 40 (9) 1698-1711; DOI: https://doi.org/10.1124/dmd.112.045575

  4. Rodriguez, Alice L.

    1. The Role of Aldehyde Oxidase and Xanthine Oxidase in the Biotransformation of a Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5
      Ryan D. Morrison, Anna L. Blobaum, Frank W. Byers, Tammy S. Santomango, Thomas M. Bridges, Donald Stec, Katrina A. Brewer, Raymundo Sanchez-Ponce, Melany M. Corlew, Roger Rush, Andrew S. Felts, Jason Manka, Brittney S. Bates, Daryl F. Venable, Alice L. Rodriguez, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte and J. Scott Daniels
      Drug Metabolism and Disposition September 2012, 40 (9) 1834-1845; DOI: https://doi.org/10.1124/dmd.112.046136

  5. Rush, Roger

    1. The Role of Aldehyde Oxidase and Xanthine Oxidase in the Biotransformation of a Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5
      Ryan D. Morrison, Anna L. Blobaum, Frank W. Byers, Tammy S. Santomango, Thomas M. Bridges, Donald Stec, Katrina A. Brewer, Raymundo Sanchez-Ponce, Melany M. Corlew, Roger Rush, Andrew S. Felts, Jason Manka, Brittney S. Bates, Daryl F. Venable, Alice L. Rodriguez, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte and J. Scott Daniels
      Drug Metabolism and Disposition September 2012, 40 (9) 1834-1845; DOI: https://doi.org/10.1124/dmd.112.046136

S

  1. Säll, Carolina

    1. Progress Curve Mechanistic Modeling Approach for Assessing Time-Dependent Inhibition of CYP3A4
      Howard J. Burt, Henry Pertinez, Carolina Säll, Claire Collins, Ruth Hyland, J. Brian Houston and Aleksandra Galetin
      Drug Metabolism and Disposition September 2012, 40 (9) 1658-1667; DOI: https://doi.org/10.1124/dmd.112.046078

  2. Salphati, Laurent

    1. Preclinical Assessment of the Absorption and Disposition of the Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor GDC-0980 and Prediction of Its Pharmacokinetics and Efficacy in Human
      Laurent Salphati, Jodie Pang, Emile G. Plise, Leslie B. Lee, Alan G. Olivero, Wei Wei Prior, Deepak Sampath, Susan Wong and Xiaolin Zhang
      Drug Metabolism and Disposition September 2012, 40 (9) 1785-1796; DOI: https://doi.org/10.1124/dmd.112.046052

  3. Sampath, Deepak

    1. Preclinical Assessment of the Absorption and Disposition of the Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor GDC-0980 and Prediction of Its Pharmacokinetics and Efficacy in Human
      Laurent Salphati, Jodie Pang, Emile G. Plise, Leslie B. Lee, Alan G. Olivero, Wei Wei Prior, Deepak Sampath, Susan Wong and Xiaolin Zhang
      Drug Metabolism and Disposition September 2012, 40 (9) 1785-1796; DOI: https://doi.org/10.1124/dmd.112.046052

  4. Sanchez-Ponce, Raymundo

    1. The Role of Aldehyde Oxidase and Xanthine Oxidase in the Biotransformation of a Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5
      Ryan D. Morrison, Anna L. Blobaum, Frank W. Byers, Tammy S. Santomango, Thomas M. Bridges, Donald Stec, Katrina A. Brewer, Raymundo Sanchez-Ponce, Melany M. Corlew, Roger Rush, Andrew S. Felts, Jason Manka, Brittney S. Bates, Daryl F. Venable, Alice L. Rodriguez, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte and J. Scott Daniels
      Drug Metabolism and Disposition September 2012, 40 (9) 1834-1845; DOI: https://doi.org/10.1124/dmd.112.046136

  5. Santomango, Tammy S.

    1. The Role of Aldehyde Oxidase and Xanthine Oxidase in the Biotransformation of a Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5
      Ryan D. Morrison, Anna L. Blobaum, Frank W. Byers, Tammy S. Santomango, Thomas M. Bridges, Donald Stec, Katrina A. Brewer, Raymundo Sanchez-Ponce, Melany M. Corlew, Roger Rush, Andrew S. Felts, Jason Manka, Brittney S. Bates, Daryl F. Venable, Alice L. Rodriguez, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte and J. Scott Daniels
      Drug Metabolism and Disposition September 2012, 40 (9) 1834-1845; DOI: https://doi.org/10.1124/dmd.112.046136

  6. Scheffer, George L.

    1. Altered Arsenic Disposition in Experimental Nonalcoholic Fatty Liver Disease
      Mark J. Canet, Rhiannon N. Hardwick, April D. Lake, Michael J. Kopplin, George L. Scheffer, Walter T. Klimecki, A. Jay Gandolfi and Nathan J. Cherrington
      Drug Metabolism and Disposition September 2012, 40 (9) 1817-1824; DOI: https://doi.org/10.1124/dmd.112.046177

  7. Scicinski, Jan

    1. Preclinical Evaluation of the Metabolism and Disposition of RRx-001, a Novel Investigative Anticancer Agent
      Jan Scicinski, Bryan Oronsky, Michael Taylor, Gang Luo, Timothy Musick, Joseph Marini, Christopher M. Adams and William L. Fitch
      Drug Metabolism and Disposition September 2012, 40 (9) 1810-1816; DOI: https://doi.org/10.1124/dmd.112.046755

  8. Scott, Emily E.

    1. Evaluation of Inhibition Selectivity for Human Cytochrome P450 2A Enzymes
      Eva S. Stephens, Agnes A. Walsh and Emily E. Scott
      Drug Metabolism and Disposition September 2012, 40 (9) 1797-1802; DOI: https://doi.org/10.1124/dmd.112.045161

  9. Shen, Guoxiang

    1. Development of a Carbon-14 Labeling Approach to Support Disposition Studies with a Pegylated Biologic
      Haiqing Wang, Lifei Wang, Kai Cao, Stuart L. Emanuel, Paul Morin, Zheng Lin, Guoxiang Shen, Jennifer Hosbach, Donglu Zhang, Samuel Bonacorsi, A. David Rodrigues and Zheng Yang
      Drug Metabolism and Disposition September 2012, 40 (9) 1677-1685; DOI: https://doi.org/10.1124/dmd.112.044792

  10. Shu, Yue-Zhong

    1. A Novel Ring Oxidation of 4- or 5-Substituted 2H-Oxazole to Corresponding 2-Oxazolone Catalyzed by Cytosolic Aldehyde Oxidase
      Vinod K. Arora, Thomas Philip, Stella Huang and Yue-Zhong Shu
      Drug Metabolism and Disposition September 2012, 40 (9) 1668-1676; DOI: https://doi.org/10.1124/dmd.112.044545

  11. Song, Xinyi

    1. Discovery of a Highly Selective CYP3A4 Inhibitor Suitable for Reaction Phenotyping Studies and Differentiation of CYP3A4 and CYP3A5
      Xiaohai Li, Xinyi Song, Theodore M. Kamenecka and Michael D. Cameron
      Drug Metabolism and Disposition September 2012, 40 (9) 1803-1809; DOI: https://doi.org/10.1124/dmd.112.046144

  12. Stec, Donald

    1. The Role of Aldehyde Oxidase and Xanthine Oxidase in the Biotransformation of a Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5
      Ryan D. Morrison, Anna L. Blobaum, Frank W. Byers, Tammy S. Santomango, Thomas M. Bridges, Donald Stec, Katrina A. Brewer, Raymundo Sanchez-Ponce, Melany M. Corlew, Roger Rush, Andrew S. Felts, Jason Manka, Brittney S. Bates, Daryl F. Venable, Alice L. Rodriguez, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte and J. Scott Daniels
      Drug Metabolism and Disposition September 2012, 40 (9) 1834-1845; DOI: https://doi.org/10.1124/dmd.112.046136

  13. Stephens, Eva S.

    1. Evaluation of Inhibition Selectivity for Human Cytochrome P450 2A Enzymes
      Eva S. Stephens, Agnes A. Walsh and Emily E. Scott
      Drug Metabolism and Disposition September 2012, 40 (9) 1797-1802; DOI: https://doi.org/10.1124/dmd.112.045161

T

  1. Tan, Beijing

    1. A Novel Relay Method for Determining Low-Clearance Values
      Li Di, Patrick Trapa, R. Scott Obach, Karen Atkinson, Yi-An Bi, Angela C. Wolford, Beijing Tan, Thomas S. McDonald, Yurong Lai and Larry M. Tremaine
      Drug Metabolism and Disposition September 2012, 40 (9) 1860-1865; DOI: https://doi.org/10.1124/dmd.112.046425

  2. Taylor, Michael

    1. Preclinical Evaluation of the Metabolism and Disposition of RRx-001, a Novel Investigative Anticancer Agent
      Jan Scicinski, Bryan Oronsky, Michael Taylor, Gang Luo, Timothy Musick, Joseph Marini, Christopher M. Adams and William L. Fitch
      Drug Metabolism and Disposition September 2012, 40 (9) 1810-1816; DOI: https://doi.org/10.1124/dmd.112.046755

  3. Teramura, Toshio

    1. Quantitative Prediction of Human Intestinal Glucuronidation Effects on Intestinal Availability of UDP-Glucuronosyltransferase Substrates Using In Vitro Data
      Fumihiro Nakamori, Yoichi Naritomi, Ken-ichi Hosoya, Hiroyuki Moriguchi, Kazuhiro Tetsuka, Takako Furukawa, Keitaro Kadono, Katsuhiro Yamano, Shigeyuki Terashita and Toshio Teramura
      Drug Metabolism and Disposition September 2012, 40 (9) 1771-1777; DOI: https://doi.org/10.1124/dmd.112.045476

  4. Terashita, Shigeyuki

    1. Quantitative Prediction of Human Intestinal Glucuronidation Effects on Intestinal Availability of UDP-Glucuronosyltransferase Substrates Using In Vitro Data
      Fumihiro Nakamori, Yoichi Naritomi, Ken-ichi Hosoya, Hiroyuki Moriguchi, Kazuhiro Tetsuka, Takako Furukawa, Keitaro Kadono, Katsuhiro Yamano, Shigeyuki Terashita and Toshio Teramura
      Drug Metabolism and Disposition September 2012, 40 (9) 1771-1777; DOI: https://doi.org/10.1124/dmd.112.045476

  5. Tetsuka, Kazuhiro

    1. Quantitative Prediction of Human Intestinal Glucuronidation Effects on Intestinal Availability of UDP-Glucuronosyltransferase Substrates Using In Vitro Data
      Fumihiro Nakamori, Yoichi Naritomi, Ken-ichi Hosoya, Hiroyuki Moriguchi, Kazuhiro Tetsuka, Takako Furukawa, Keitaro Kadono, Katsuhiro Yamano, Shigeyuki Terashita and Toshio Teramura
      Drug Metabolism and Disposition September 2012, 40 (9) 1771-1777; DOI: https://doi.org/10.1124/dmd.112.045476

  6. Thorndike, Denise

    1. Evaluation of Six Proton Pump Inhibitors As Inhibitors of Various Human Cytochromes P450: Focus on Cytochrome P450 2C19
      Tatyana Zvyaga, Shu-Ying Chang, Cliff Chen, Zheng Yang, Ragini Vuppugalla, Jeremy Hurley, Denise Thorndike, Andrew Wagner, Anjaneya Chimalakonda and A. David Rodrigues
      Drug Metabolism and Disposition September 2012, 40 (9) 1698-1711; DOI: https://doi.org/10.1124/dmd.112.045575

  7. Trapa, Patrick

    1. A Novel Relay Method for Determining Low-Clearance Values
      Li Di, Patrick Trapa, R. Scott Obach, Karen Atkinson, Yi-An Bi, Angela C. Wolford, Beijing Tan, Thomas S. McDonald, Yurong Lai and Larry M. Tremaine
      Drug Metabolism and Disposition September 2012, 40 (9) 1860-1865; DOI: https://doi.org/10.1124/dmd.112.046425

  8. Tremaine, Larry M.

    1. A Novel Relay Method for Determining Low-Clearance Values
      Li Di, Patrick Trapa, R. Scott Obach, Karen Atkinson, Yi-An Bi, Angela C. Wolford, Beijing Tan, Thomas S. McDonald, Yurong Lai and Larry M. Tremaine
      Drug Metabolism and Disposition September 2012, 40 (9) 1860-1865; DOI: https://doi.org/10.1124/dmd.112.046425

V

  1. Venable, Daryl F.

    1. The Role of Aldehyde Oxidase and Xanthine Oxidase in the Biotransformation of a Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5
      Ryan D. Morrison, Anna L. Blobaum, Frank W. Byers, Tammy S. Santomango, Thomas M. Bridges, Donald Stec, Katrina A. Brewer, Raymundo Sanchez-Ponce, Melany M. Corlew, Roger Rush, Andrew S. Felts, Jason Manka, Brittney S. Bates, Daryl F. Venable, Alice L. Rodriguez, Carrie K. Jones, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte and J. Scott Daniels
      Drug Metabolism and Disposition September 2012, 40 (9) 1834-1845; DOI: https://doi.org/10.1124/dmd.112.046136

  2. Vuppugalla, Ragini

    1. Evaluation of Six Proton Pump Inhibitors As Inhibitors of Various Human Cytochromes P450: Focus on Cytochrome P450 2C19
      Tatyana Zvyaga, Shu-Ying Chang, Cliff Chen, Zheng Yang, Ragini Vuppugalla, Jeremy Hurley, Denise Thorndike, Andrew Wagner, Anjaneya Chimalakonda and A. David Rodrigues
      Drug Metabolism and Disposition September 2012, 40 (9) 1698-1711; DOI: https://doi.org/10.1124/dmd.112.045575

W

  1. Wagner, Andrew

    1. Evaluation of Six Proton Pump Inhibitors As Inhibitors of Various Human Cytochromes P450: Focus on Cytochrome P450 2C19
      Tatyana Zvyaga, Shu-Ying Chang, Cliff Chen, Zheng Yang, Ragini Vuppugalla, Jeremy Hurley, Denise Thorndike, Andrew Wagner, Anjaneya Chimalakonda and A. David Rodrigues
      Drug Metabolism and Disposition September 2012, 40 (9) 1698-1711; DOI: https://doi.org/10.1124/dmd.112.045575

  2. Walker, Gregory S.

    1. Selective Mechanism-Based Inactivation of CYP3A4 by CYP3cide (PF-04981517) and Its Utility as an In Vitro Tool for Delineating the Relative Roles of CYP3A4 versus CYP3A5 in the Metabolism of Drugs
      Robert L. Walsky, R. Scott Obach, Ruth Hyland, Ping Kang, Sue Zhou, Michael West, Kieran F. Geoghegan, Christopher J. Helal, Gregory S. Walker, Theunis C. Goosen and Michael A. Zientek
      Drug Metabolism and Disposition September 2012, 40 (9) 1686-1697; DOI: https://doi.org/10.1124/dmd.112.045302

  3. Walsh, Agnes A.

    1. Evaluation of Inhibition Selectivity for Human Cytochrome P450 2A Enzymes
      Eva S. Stephens, Agnes A. Walsh and Emily E. Scott
      Drug Metabolism and Disposition September 2012, 40 (9) 1797-1802; DOI: https://doi.org/10.1124/dmd.112.045161

  4. Walsky, Robert L.

    1. Selective Mechanism-Based Inactivation of CYP3A4 by CYP3cide (PF-04981517) and Its Utility as an In Vitro Tool for Delineating the Relative Roles of CYP3A4 versus CYP3A5 in the Metabolism of Drugs
      Robert L. Walsky, R. Scott Obach, Ruth Hyland, Ping Kang, Sue Zhou, Michael West, Kieran F. Geoghegan, Christopher J. Helal, Gregory S. Walker, Theunis C. Goosen and Michael A. Zientek
      Drug Metabolism and Disposition September 2012, 40 (9) 1686-1697; DOI: https://doi.org/10.1124/dmd.112.045302

  5. Wan, Yakun

    1. Evaluation of P450 Inhibition and Induction by Artemisinin Antimalarials in Human Liver Microsomes and Primary Human Hepatocytes
      Jie Xing, Brian J. Kirby, Dale Whittington, Yakun Wan and David R. Goodlett
      Drug Metabolism and Disposition September 2012, 40 (9) 1757-1764; DOI: https://doi.org/10.1124/dmd.112.045765

  6. Wang, Haiqing

    1. Development of a Carbon-14 Labeling Approach to Support Disposition Studies with a Pegylated Biologic
      Haiqing Wang, Lifei Wang, Kai Cao, Stuart L. Emanuel, Paul Morin, Zheng Lin, Guoxiang Shen, Jennifer Hosbach, Donglu Zhang, Samuel Bonacorsi, A. David Rodrigues and Zheng Yang
      Drug Metabolism and Disposition September 2012, 40 (9) 1677-1685; DOI: https://doi.org/10.1124/dmd.112.044792

  7. Wang, Lifei

    1. Development of a Carbon-14 Labeling Approach to Support Disposition Studies with a Pegylated Biologic
      Haiqing Wang, Lifei Wang, Kai Cao, Stuart L. Emanuel, Paul Morin, Zheng Lin, Guoxiang Shen, Jennifer Hosbach, Donglu Zhang, Samuel Bonacorsi, A. David Rodrigues and Zheng Yang
      Drug Metabolism and Disposition September 2012, 40 (9) 1677-1685; DOI: https://doi.org/10.1124/dmd.112.044792

  8. Wangsa, Julie

    1. Excretion and Metabolism of Milnacipran in Humans after Oral Administration of Milnacipran Hydrochloride
      Fanying Li, Christina Chin, Julie Wangsa and John Ho
      Drug Metabolism and Disposition September 2012, 40 (9) 1723-1735; DOI: https://doi.org/10.1124/dmd.112.045120

  9. West, Michael

    1. Selective Mechanism-Based Inactivation of CYP3A4 by CYP3cide (PF-04981517) and Its Utility as an In Vitro Tool for Delineating the Relative Roles of CYP3A4 versus CYP3A5 in the Metabolism of Drugs
      Robert L. Walsky, R. Scott Obach, Ruth Hyland, Ping Kang, Sue Zhou, Michael West, Kieran F. Geoghegan, Christopher J. Helal, Gregory S. Walker, Theunis C. Goosen and Michael A. Zientek
      Drug Metabolism and Disposition September 2012, 40 (9) 1686-1697; DOI: https://doi.org/10.1124/dmd.112.045302

  10. Whittington, Dale

    1. Evaluation of P450 Inhibition and Induction by Artemisinin Antimalarials in Human Liver Microsomes and Primary Human Hepatocytes
      Jie Xing, Brian J. Kirby, Dale Whittington, Yakun Wan and David R. Goodlett
      Drug Metabolism and Disposition September 2012, 40 (9) 1757-1764; DOI: https://doi.org/10.1124/dmd.112.045765

  11. Wolford, Angela C.

    1. A Novel Relay Method for Determining Low-Clearance Values
      Li Di, Patrick Trapa, R. Scott Obach, Karen Atkinson, Yi-An Bi, Angela C. Wolford, Beijing Tan, Thomas S. McDonald, Yurong Lai and Larry M. Tremaine
      Drug Metabolism and Disposition September 2012, 40 (9) 1860-1865; DOI: https://doi.org/10.1124/dmd.112.046425

  12. Wong, Susan

    1. Preclinical Assessment of the Absorption and Disposition of the Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor GDC-0980 and Prediction of Its Pharmacokinetics and Efficacy in Human
      Laurent Salphati, Jodie Pang, Emile G. Plise, Leslie B. Lee, Alan G. Olivero, Wei Wei Prior, Deepak Sampath, Susan Wong and Xiaolin Zhang
      Drug Metabolism and Disposition September 2012, 40 (9) 1785-1796; DOI: https://doi.org/10.1124/dmd.112.046052

X

  1. Xing, Jie

    1. Evaluation of P450 Inhibition and Induction by Artemisinin Antimalarials in Human Liver Microsomes and Primary Human Hepatocytes
      Jie Xing, Brian J. Kirby, Dale Whittington, Yakun Wan and David R. Goodlett
      Drug Metabolism and Disposition September 2012, 40 (9) 1757-1764; DOI: https://doi.org/10.1124/dmd.112.045765

Y

  1. Yamano, Katsuhiro

    1. Quantitative Prediction of Human Intestinal Glucuronidation Effects on Intestinal Availability of UDP-Glucuronosyltransferase Substrates Using In Vitro Data
      Fumihiro Nakamori, Yoichi Naritomi, Ken-ichi Hosoya, Hiroyuki Moriguchi, Kazuhiro Tetsuka, Takako Furukawa, Keitaro Kadono, Katsuhiro Yamano, Shigeyuki Terashita and Toshio Teramura
      Drug Metabolism and Disposition September 2012, 40 (9) 1771-1777; DOI: https://doi.org/10.1124/dmd.112.045476

  2. Yang, Zheng

    1. Development of a Carbon-14 Labeling Approach to Support Disposition Studies with a Pegylated Biologic
      Haiqing Wang, Lifei Wang, Kai Cao, Stuart L. Emanuel, Paul Morin, Zheng Lin, Guoxiang Shen, Jennifer Hosbach, Donglu Zhang, Samuel Bonacorsi, A. David Rodrigues and Zheng Yang
      Drug Metabolism and Disposition September 2012, 40 (9) 1677-1685; DOI: https://doi.org/10.1124/dmd.112.044792
    2. Evaluation of Six Proton Pump Inhibitors As Inhibitors of Various Human Cytochromes P450: Focus on Cytochrome P450 2C19
      Tatyana Zvyaga, Shu-Ying Chang, Cliff Chen, Zheng Yang, Ragini Vuppugalla, Jeremy Hurley, Denise Thorndike, Andrew Wagner, Anjaneya Chimalakonda and A. David Rodrigues
      Drug Metabolism and Disposition September 2012, 40 (9) 1698-1711; DOI: https://doi.org/10.1124/dmd.112.045575

Z

  1. Zamek-Gliszczynski, Maciej J.

    1. Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 Knockout Rats Using Loperamide, Paclitaxel, Sulfasalazine, and Carboxydichlorofluorescein Pharmacokinetics
      Maciej J. Zamek-Gliszczynski, David W. Bedwell, Jing Q. Bao and J. William Higgins
      Drug Metabolism and Disposition September 2012, 40 (9) 1825-1833; DOI: https://doi.org/10.1124/dmd.112.046508

  2. Zhang, Donglu

    1. Development of a Carbon-14 Labeling Approach to Support Disposition Studies with a Pegylated Biologic
      Haiqing Wang, Lifei Wang, Kai Cao, Stuart L. Emanuel, Paul Morin, Zheng Lin, Guoxiang Shen, Jennifer Hosbach, Donglu Zhang, Samuel Bonacorsi, A. David Rodrigues and Zheng Yang
      Drug Metabolism and Disposition September 2012, 40 (9) 1677-1685; DOI: https://doi.org/10.1124/dmd.112.044792

  3. Zhang, Haoming

    1. Mechanism-Based Inactivation of Cytochrome P450 2B6 by Methadone through Destruction of Prosthetic Heme
      Hemali T. Amunugama, Haoming Zhang and Paul F. Hollenberg
      Drug Metabolism and Disposition September 2012, 40 (9) 1765-1770; DOI: https://doi.org/10.1124/dmd.112.045971

  4. Zhang, Xiaolin

    1. Preclinical Assessment of the Absorption and Disposition of the Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor GDC-0980 and Prediction of Its Pharmacokinetics and Efficacy in Human
      Laurent Salphati, Jodie Pang, Emile G. Plise, Leslie B. Lee, Alan G. Olivero, Wei Wei Prior, Deepak Sampath, Susan Wong and Xiaolin Zhang
      Drug Metabolism and Disposition September 2012, 40 (9) 1785-1796; DOI: https://doi.org/10.1124/dmd.112.046052

  5. Zhou, Sue

    1. Selective Mechanism-Based Inactivation of CYP3A4 by CYP3cide (PF-04981517) and Its Utility as an In Vitro Tool for Delineating the Relative Roles of CYP3A4 versus CYP3A5 in the Metabolism of Drugs
      Robert L. Walsky, R. Scott Obach, Ruth Hyland, Ping Kang, Sue Zhou, Michael West, Kieran F. Geoghegan, Christopher J. Helal, Gregory S. Walker, Theunis C. Goosen and Michael A. Zientek
      Drug Metabolism and Disposition September 2012, 40 (9) 1686-1697; DOI: https://doi.org/10.1124/dmd.112.045302

  6. Zientek, Michael A.

    1. Selective Mechanism-Based Inactivation of CYP3A4 by CYP3cide (PF-04981517) and Its Utility as an In Vitro Tool for Delineating the Relative Roles of CYP3A4 versus CYP3A5 in the Metabolism of Drugs
      Robert L. Walsky, R. Scott Obach, Ruth Hyland, Ping Kang, Sue Zhou, Michael West, Kieran F. Geoghegan, Christopher J. Helal, Gregory S. Walker, Theunis C. Goosen and Michael A. Zientek
      Drug Metabolism and Disposition September 2012, 40 (9) 1686-1697; DOI: https://doi.org/10.1124/dmd.112.045302

  7. Zvyaga, Tatyana

    1. Evaluation of Six Proton Pump Inhibitors As Inhibitors of Various Human Cytochromes P450: Focus on Cytochrome P450 2C19
      Tatyana Zvyaga, Shu-Ying Chang, Cliff Chen, Zheng Yang, Ragini Vuppugalla, Jeremy Hurley, Denise Thorndike, Andrew Wagner, Anjaneya Chimalakonda and A. David Rodrigues
      Drug Metabolism and Disposition September 2012, 40 (9) 1698-1711; DOI: https://doi.org/10.1124/dmd.112.045575
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