Advertisement
Research ArticleArticle

Progress Curve Mechanistic Modeling Approach for Assessing Time-Dependent Inhibition of CYP3A4

Howard J. Burt, Henry Pertinez, Carolina Säll, Claire Collins, Ruth Hyland, J. Brian Houston and Aleksandra Galetin
Drug Metabolism and Disposition September 2012, 40 (9) 1658-1667; DOI: https://doi.org/10.1124/dmd.112.046078

Article Information

vol. 40 no. 9 1658-1667
DOI 
https://doi.org/10.1124/dmd.112.046078
PubMed 
22621802
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received April 5, 2012
  • Accepted May 23, 2012
  • Published online August 17, 2012.

Article Versions

Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Howard J. Burt1,
  2. Henry Pertinez,
  3. Carolina Säll,
  4. Claire Collins,
  5. Ruth Hyland,
  6. J. Brian Houston and
  7. Aleksandra Galetin
  1. Centre for Applied Pharmacokinetic Research, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom (H.J.B., H.P., C.S., J.B.H., A.G.); and Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Global Research and Development, Sandwich, Kent, United Kingdom (C.C., R.H.)
  1. Address correspondence to:
    Dr. Aleksandra Galetin, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK. E-mail: Aleksandra.Galetin{at}manchester.ac.uk

  • ↵1 Current affiliation: Simcyp Limited, Sheffield, United Kingdom.

View Full Text

Statistics from Altmetric.com

Article usage

Article usage: May 2012 to May 2021

AbstractFullPdf
May 2012301071
Jun 2012166066
Jul 2012101053
Aug 201276233158
Sep 201264020106
Oct 20122061439
Nov 20121331733
Dec 2012118919
Jan 20131193024
Feb 2013102721
Mar 201366819
Apr 201367910
May 2013621322
Jun 201336912
Jul 20135569
Aug 20134998
Sep 2013962722
Oct 2013542415
Nov 2013341722
Dec 2013211318
Jan 2014181819
Feb 2014401420
Mar 2014291212
Apr 2014331919
May 2014253118
Jun 2014281622
Jul 2014352114
Aug 201414148
Sep 2014292320
Oct 2014221419
Nov 2014132113
Dec 2014122011
Jan 201512216
Feb 201517199
Mar 201521266
Apr 2015222219
May 2015151217
Jun 2015161813
Jul 2015252216
Aug 2015132612
Sep 201524178
Oct 2015181414
Nov 201581713
Dec 2015161819
Jan 2016231019
Feb 201671712
Mar 201614926
Apr 20166215
May 201681010
Jun 2016111115
Jul 2016141122
Aug 2016211221
Sep 2016111526
Oct 201682521
Nov 201664217
Dec 201642819
Jan 201712513
Feb 201702314
Mar 201714122
Apr 201702915
May 201702410
Jun 2017044
Jul 20171154
Aug 201741714
Sep 201712015
Oct 201702517
Nov 2017013212
Dec 2017153511
Jan 201804539
Feb 2018527423
Mar 201861828
Apr 201809715
May 20180588
Jun 201824111
Jul 20180205
Aug 20181226
Sep 20181204
Oct 201808314
Nov 2018110716
Dec 2018107268
Jan 20199148
Feb 201988411
Mar 20192142
Apr 201929210
May 20191376
Jun 20191424
Jul 20191406
Aug 20191358
Sep 20191335
Oct 201940515
Nov 20192502
Dec 20193546
Jan 202024212
Feb 20201744
Mar 20202094
Apr 20201312
May 202018112
Jun 20201544
Jul 20201024
Aug 20207210
Sep 20201036
Oct 20201036
Nov 202022310
Dec 20202053
Jan 20212459
Feb 202149119
Mar 20212451
Apr 20213147
May 20211010

Back to top

In this issue

Download PDF
Article Alerts
Email Article
Citation Tools

Research ArticleArticle

PROGRESS CURVE ASSESSMENT OF TIME-DEPENDENT INHIBITION

Howard J. Burt, Henry Pertinez, Carolina Säll, Claire Collins, Ruth Hyland, J. Brian Houston and Aleksandra Galetin
Drug Metabolism and Disposition September 1, 2012, 40 (9) 1658-1667; DOI: https://doi.org/10.1124/dmd.112.046078
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo

Jump to section

Advertisement