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Research ArticleArticle

Evaluation of Six Proton Pump Inhibitors As Inhibitors of Various Human Cytochromes P450: Focus on Cytochrome P450 2C19

Tatyana Zvyaga, Shu-Ying Chang, Cliff Chen, Zheng Yang, Ragini Vuppugalla, Jeremy Hurley, Denise Thorndike, Andrew Wagner, Anjaneya Chimalakonda and A. David Rodrigues
Drug Metabolism and Disposition September 2012, 40 (9) 1698-1711; DOI: https://doi.org/10.1124/dmd.112.045575
Tatyana Zvyaga
Lead Profiling (T.Z., J.H., D.T.), and Bioanalytical Technologies (A.W.), Bristol-Myers Squibb, Wallingford, Connecticut; and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Princeton, New Jersey (S.-Y.C., C.C., Z.Y., R.V., A.C., A.D.R.)
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Shu-Ying Chang
Lead Profiling (T.Z., J.H., D.T.), and Bioanalytical Technologies (A.W.), Bristol-Myers Squibb, Wallingford, Connecticut; and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Princeton, New Jersey (S.-Y.C., C.C., Z.Y., R.V., A.C., A.D.R.)
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Cliff Chen
Lead Profiling (T.Z., J.H., D.T.), and Bioanalytical Technologies (A.W.), Bristol-Myers Squibb, Wallingford, Connecticut; and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Princeton, New Jersey (S.-Y.C., C.C., Z.Y., R.V., A.C., A.D.R.)
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Zheng Yang
Lead Profiling (T.Z., J.H., D.T.), and Bioanalytical Technologies (A.W.), Bristol-Myers Squibb, Wallingford, Connecticut; and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Princeton, New Jersey (S.-Y.C., C.C., Z.Y., R.V., A.C., A.D.R.)
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Ragini Vuppugalla
Lead Profiling (T.Z., J.H., D.T.), and Bioanalytical Technologies (A.W.), Bristol-Myers Squibb, Wallingford, Connecticut; and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Princeton, New Jersey (S.-Y.C., C.C., Z.Y., R.V., A.C., A.D.R.)
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Jeremy Hurley
Lead Profiling (T.Z., J.H., D.T.), and Bioanalytical Technologies (A.W.), Bristol-Myers Squibb, Wallingford, Connecticut; and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Princeton, New Jersey (S.-Y.C., C.C., Z.Y., R.V., A.C., A.D.R.)
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Denise Thorndike
Lead Profiling (T.Z., J.H., D.T.), and Bioanalytical Technologies (A.W.), Bristol-Myers Squibb, Wallingford, Connecticut; and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Princeton, New Jersey (S.-Y.C., C.C., Z.Y., R.V., A.C., A.D.R.)
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Andrew Wagner
Lead Profiling (T.Z., J.H., D.T.), and Bioanalytical Technologies (A.W.), Bristol-Myers Squibb, Wallingford, Connecticut; and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Princeton, New Jersey (S.-Y.C., C.C., Z.Y., R.V., A.C., A.D.R.)
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Anjaneya Chimalakonda
Lead Profiling (T.Z., J.H., D.T.), and Bioanalytical Technologies (A.W.), Bristol-Myers Squibb, Wallingford, Connecticut; and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Princeton, New Jersey (S.-Y.C., C.C., Z.Y., R.V., A.C., A.D.R.)
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A. David Rodrigues
Lead Profiling (T.Z., J.H., D.T.), and Bioanalytical Technologies (A.W.), Bristol-Myers Squibb, Wallingford, Connecticut; and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Princeton, New Jersey (S.-Y.C., C.C., Z.Y., R.V., A.C., A.D.R.)
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Article Information

vol. 40 no. 9 1698-1711
DOI 
https://doi.org/10.1124/dmd.112.045575
PubMed 
22648560

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received March 7, 2012
  • Accepted May 30, 2012
  • Published online August 17, 2012.

Article Versions

  • Earlier version (May 30, 2012 - 08:39).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2012 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Tatyana Zvyaga,
  2. Shu-Ying Chang,
  3. Cliff Chen,
  4. Zheng Yang,
  5. Ragini Vuppugalla,
  6. Jeremy Hurley,
  7. Denise Thorndike,
  8. Andrew Wagner,
  9. Anjaneya Chimalakonda and
  10. A. David Rodrigues
  1. Lead Profiling (T.Z., J.H., D.T.), and Bioanalytical Technologies (A.W.), Bristol-Myers Squibb, Wallingford, Connecticut; and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Princeton, New Jersey (S.-Y.C., C.C., Z.Y., R.V., A.C., A.D.R.)
  1. Address correspondence to:
    Dr. Tatyana Zvyaga, Bristol-Myers Squibb, 5 Research Parkway, Wallingford, CT 06492. E-mail: tatyana.zvyaga{at}bms.com
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Drug Metabolism and Disposition: 40 (9)
Drug Metabolism and Disposition
Vol. 40, Issue 9
1 Sep 2012
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Research ArticleArticle

PPIs AS INHIBITORS OF HUMAN P450s

Tatyana Zvyaga, Shu-Ying Chang, Cliff Chen, Zheng Yang, Ragini Vuppugalla, Jeremy Hurley, Denise Thorndike, Andrew Wagner, Anjaneya Chimalakonda and A. David Rodrigues
Drug Metabolism and Disposition September 1, 2012, 40 (9) 1698-1711; DOI: https://doi.org/10.1124/dmd.112.045575

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Research ArticleArticle

PPIs AS INHIBITORS OF HUMAN P450s

Tatyana Zvyaga, Shu-Ying Chang, Cliff Chen, Zheng Yang, Ragini Vuppugalla, Jeremy Hurley, Denise Thorndike, Andrew Wagner, Anjaneya Chimalakonda and A. David Rodrigues
Drug Metabolism and Disposition September 1, 2012, 40 (9) 1698-1711; DOI: https://doi.org/10.1124/dmd.112.045575
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