Research ArticleArticle
Quantitative Prediction of Human Intestinal Glucuronidation Effects on Intestinal Availability of UDP-Glucuronosyltransferase Substrates Using In Vitro Data
Fumihiro Nakamori, Yoichi Naritomi, Ken-ichi Hosoya, Hiroyuki Moriguchi, Kazuhiro Tetsuka, Takako Furukawa, Keitaro Kadono, Katsuhiro Yamano, Shigeyuki Terashita and Toshio Teramura
Drug Metabolism and Disposition September 2012, 40 (9) 1771-1777; DOI: https://doi.org/10.1124/dmd.112.045476
Fumihiro Nakamori
Analysis and Pharmacokinetics Research Laboratories, Discovery Drug Metabolism and Pharmacokinetics, Astellas Pharma, Inc., Ibaraki, Japan (F.N., Y.N., H.M., K.T., T.F., K.K., K.Y., S.T., T.T.); and Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan (F.N., K.H.)
Yoichi Naritomi
Analysis and Pharmacokinetics Research Laboratories, Discovery Drug Metabolism and Pharmacokinetics, Astellas Pharma, Inc., Ibaraki, Japan (F.N., Y.N., H.M., K.T., T.F., K.K., K.Y., S.T., T.T.); and Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan (F.N., K.H.)
Ken-ichi Hosoya
Analysis and Pharmacokinetics Research Laboratories, Discovery Drug Metabolism and Pharmacokinetics, Astellas Pharma, Inc., Ibaraki, Japan (F.N., Y.N., H.M., K.T., T.F., K.K., K.Y., S.T., T.T.); and Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan (F.N., K.H.)
Hiroyuki Moriguchi
Analysis and Pharmacokinetics Research Laboratories, Discovery Drug Metabolism and Pharmacokinetics, Astellas Pharma, Inc., Ibaraki, Japan (F.N., Y.N., H.M., K.T., T.F., K.K., K.Y., S.T., T.T.); and Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan (F.N., K.H.)
Kazuhiro Tetsuka
Analysis and Pharmacokinetics Research Laboratories, Discovery Drug Metabolism and Pharmacokinetics, Astellas Pharma, Inc., Ibaraki, Japan (F.N., Y.N., H.M., K.T., T.F., K.K., K.Y., S.T., T.T.); and Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan (F.N., K.H.)
Takako Furukawa
Analysis and Pharmacokinetics Research Laboratories, Discovery Drug Metabolism and Pharmacokinetics, Astellas Pharma, Inc., Ibaraki, Japan (F.N., Y.N., H.M., K.T., T.F., K.K., K.Y., S.T., T.T.); and Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan (F.N., K.H.)
Keitaro Kadono
Analysis and Pharmacokinetics Research Laboratories, Discovery Drug Metabolism and Pharmacokinetics, Astellas Pharma, Inc., Ibaraki, Japan (F.N., Y.N., H.M., K.T., T.F., K.K., K.Y., S.T., T.T.); and Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan (F.N., K.H.)
Katsuhiro Yamano
Analysis and Pharmacokinetics Research Laboratories, Discovery Drug Metabolism and Pharmacokinetics, Astellas Pharma, Inc., Ibaraki, Japan (F.N., Y.N., H.M., K.T., T.F., K.K., K.Y., S.T., T.T.); and Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan (F.N., K.H.)
Shigeyuki Terashita
Analysis and Pharmacokinetics Research Laboratories, Discovery Drug Metabolism and Pharmacokinetics, Astellas Pharma, Inc., Ibaraki, Japan (F.N., Y.N., H.M., K.T., T.F., K.K., K.Y., S.T., T.T.); and Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan (F.N., K.H.)
Toshio Teramura
Analysis and Pharmacokinetics Research Laboratories, Discovery Drug Metabolism and Pharmacokinetics, Astellas Pharma, Inc., Ibaraki, Japan (F.N., Y.N., H.M., K.T., T.F., K.K., K.Y., S.T., T.T.); and Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan (F.N., K.H.)
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Research ArticleArticle
QUANTITATIVE PREDICTION OF HUMAN INTESTINAL GLUCURONIDATION
Fumihiro Nakamori, Yoichi Naritomi, Ken-ichi Hosoya, Hiroyuki Moriguchi, Kazuhiro Tetsuka, Takako Furukawa, Keitaro Kadono, Katsuhiro Yamano, Shigeyuki Terashita and Toshio Teramura
Drug Metabolism and Disposition September 1, 2012, 40 (9) 1771-1777; DOI: https://doi.org/10.1124/dmd.112.045476
Research ArticleArticle
QUANTITATIVE PREDICTION OF HUMAN INTESTINAL GLUCURONIDATION
Fumihiro Nakamori, Yoichi Naritomi, Ken-ichi Hosoya, Hiroyuki Moriguchi, Kazuhiro Tetsuka, Takako Furukawa, Keitaro Kadono, Katsuhiro Yamano, Shigeyuki Terashita and Toshio Teramura
Drug Metabolism and Disposition September 1, 2012, 40 (9) 1771-1777; DOI: https://doi.org/10.1124/dmd.112.045476
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